Clinical trials: Coronary Angioplasty
Stents, Coronary Artery Disease
First-in-Man Study: Safety and Efficacy of INC-1 Bare Metal Stent in the Novo Coronary Lesions.
This is a First In Man study with the aim to know the safety and effectiveness of a novel bare metal stent (INC-1) in the treatment of de novo coronary lesions in patients with stable coronary angina and unique coronary lessions.
- Conditions
- Stents, Coronary Artery Disease, Angioplasty, Humans
- Trial name
- NCT03375411
- Testing
- Stent INC1
- Where
- Mexico
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Coronary Artery Disease
Smart Angioplasty Research Team-Optimal Strategy for Side Branch Stenting in Coronary Bifurcation Lesion With Drug-Coated Balloon
A prospective, multi-center, open-label, randomized controlled, superiority trial. The aim of the study is to compare clinical outcomes between upfront 2-stenting strategy versus upfront drug-coated balloon (DCB)-based hybrid…
- Trial name
- SMART-DCB (NCT07019350)
- Testing
- Upfront DCB-based hybrid strategy, Upfront 2-stenting strategy
- Where
- 3 sites in South Korea
- Volunteers
- 520 people
- Sponsor
- Samsung Medical Center
Coronary Syndrome
The Effect of Rosuvastatin and Olmesartan on the Progression of Coronary Atherosclerotic Disease
1. Stains have demonstrated consistent benefits to reduce cardiovascular events in several primary and secondary prevention trials.
- Trial name
- NCT02516826
- Testing
- Rosuvastatin, Olmesartan, Combination
- Where
- South Korea
- Volunteers
- 504 people
- Sponsor
- Samsung Medical Center
Ischaemic Heart Disease
Outcomes of Drug Coated Balloon Angioplasty, A UK Real Life Experience From 2009 to 2015
This is a single center, retrospective, observational cohort study to assess the safety and efficacy of drug coated balloon (DCB) angioplasty in all forms of coronary artery disease.
- Trial name
- DCBNORWICH (NCT03603210)
- Testing
- Drug coated balloon angioplasty
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Coronary Angiography, Coronary Angioplasty
DIstal vs Proximal Radial Artery Access for Cath
This single-center, prospective, randomized study will evaluate distal radial artery (dRA) vs. proximal radial artery access (pRA) in regards to hand function and radial artery occlusion.
- Trial name
- DIPRA (NCT04318990)
- Testing
- Distal radial artery access, Proximal radial artery surgery
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Baylor Research Institute
Acute Coronary Syndrome
Angioplasty to Blunt the Rise of Troponin in Acute Coronary Syndrome (ACS)
Release of troponin evaluated by the peak of troponin during the hospital phase.Because of its sensitivity and specificity as well as its widespread use in routine practice, rise in troponin levels is the main assessment criteria…
- Trial name
- ABOARD (NCT00442949)
- Testing
- Catheterization immediate PCI, delayed PCI
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Artery Disease
Infinnium-Core™ Registry for the Treatment of Patients With De Novo Coronary Lesions
The primary objective of Infinnium-Core™ Registry is to assess the safety and efficacy of the Infinnium-Core™ Paclitaxel Eluting Coronary Stent System in de novo Coronary Lesions.
- Trial name
- NCT00936780
- Testing
- Infinnium-Core™ Paclitaxel eluting Coronary Stent
- Where
- 7 sites in India
- Volunteers
- 67 people
- Sponsor
- Sahajanand Medical Technologies Limited
Coronary Artery Disease
The PICCOLETO IX PHENO Study
To investigate whether pre-procedural OCT-derived de novo coronary lesion phenotype (lipid-rich, fibrotic, calcific; and ACS mechanisms such as plaque rupture/erosion/calcified nodule) is associated with clinical outcomes after…
- Trial name
- PIX-PHENO (NCT07390994)
- Volunteers
- 600 people
- Sponsor
- Fondazione Ricerca e Innovazione Cardiovascolare ETS
Acute Coronary Syndrome
Direct Angioplasty for Non ST Elevation Acute Coronary Events: DANCE Pilot Study
This is a pilot feasibility study to evaluate if patients with ST depression Acute Coronary Syndrome who are taken directly to the catheter laboratory for angiogram and angioplasty +/- stents will fare better that patients who…
- Trial name
- DANCE (NCT01172990)
- Testing
- Immediate Invasive Management, Conventional Management
- Where
- United Kingdom
- Volunteers
- 108 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Acute Coronary Syndromes, Angioplasty, Transluminal, Percutaneous Coronary
Randomized Comparison of Radiological Exposure With TRIPTable® in Patients With Acute Coronary Syndromes
Excessive radiation received by the operator has been described as a possible drawback of the radial catheterization technique when compared with the femoral access.
- Trial name
- TRIPTABLE (NCT02200783)
- Testing
- TripTable, Radial, Femoral
- Where
- Brazil
- Volunteers
- 99 people
- Sponsor
- Marilia Medicine School
Coronary Artery Disease
Assessment of Cutting-Balloon Angioplasty With Everolimus-Eluting Stent(EES) in the Treatment of Coronary Calcified Lesion(CCL) Guided by Intravascular Ultrasonography(IVUS)
The study seeks to address the clinical question of how effectively a novel cutting balloon (Wolverine™) can modify calcified lesions for stent implantation in comparison with a non-compliant (NC) balloon, particularly when used…
- Trial name
- NCT06177808
- Testing
- Wolverine cutting balloon, Non-compliant balloon
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Soonchunhyang University Hospital
Acute Myocardial Infarction
A Safety/Efficacy Study of Intra-coronary Tenecteplase During Balloon Angioplasty to Treat Heart Attacks
The primary objective of this study is to gather preliminary data regarding the angiographic efficacy of the administration of low-dose adjunctive intracoronary (IC) tenecteplase during balloon angioplasty for heart attacks.
- Trial name
- ICE T-TIMI 49 (NCT00604695)
- Testing
- Tenecteplase, Sterile Saline
- Where
- 8 sites in United States
- Volunteers
- 40 people
- Sponsor
- C. Michael Gibson, MS, MD
Renal Insufficiency, Chronic, Coronary Angiography
Iloprost for Prevention of Contrast-Mediated Nephropathy in High-Risk Patients Undergoing Coronary Angiography and/or Intervention
The prevention of contrast-mediated nephropathy (CMN), which accounts for considerable morbidity and mortality, remains a vexing problem.
- Conditions
- Renal Insufficiency, Chronic, Coronary Angiography, Angioplasty, Transluminal, Percutaneous Coronary
- Trial name
- NCT00345501
- Testing
- Iloprost
- Where
- Greece
- Volunteers
- 208 people
- Sponsor
- Onassis Cardiac Surgery Centre
Heart Diseases, Cardiovascular Diseases
Trial Evaluating New Strategy in the Functional Assessment of 3-vessel Disease Using SYNTAXII Score in Patients With PCI
Clinical study that aims to evaluate a new strategy using the SYNTAX II Score calculator in the functional assessment of patients with new coronary 3-vessel-disease who undergo percutaneous coronary intervention (PCI)
- Conditions
- Heart Diseases, Cardiovascular Diseases, 3 Vessel Coronary Artery Disease
- Trial name
- NCT02015832
- Testing
- Coronary stent, Multi Slice Computed Tomography, instantaneous wave-free ratio
- Where
- 22 sites in Netherlands, Poland and 2 more
- Volunteers
- 454 people
- Sponsor
- ECRI bv
Peripheral Vascular Disease
Oslo Balloon Angioplasty Versus Conservative Treatment
Background: Percutaneous transluminal angioplasty (PTA) has been popularized as a simple, effective and cheap treatment achieving 50-70% symptomatic patency rates in patients with peripheral occlusive disease..
- Trial name
- NCT00222196
- Testing
- lifestyle, PTA
- Volunteers
- 200 people
- Sponsor
- Ullevaal University Hospital
Femoral Artery Stenosis, Popliteal Artery Stenosis
IN.PACT Admiral Drug-Coated Balloon vs. Standard Balloon Angioplasty for the Treatment of Superficial Femoral Artery (SFA) and Proximal Popliteal Artery (PPA)
The purpose of the study is to demonstrate the safety and efficacy of the IN.PACT Admiral drug-coated balloon (DCB) in comparison to any standard balloon for treatment of peripheral arterial disease (PAD) in the superficial…
- Conditions
- Femoral Artery Stenosis, Popliteal Artery Stenosis, Femoral Artery Occlusion, Popliteal Artery Occlusion
- Trial name
- INPACT SFA II (NCT01566461)
- Testing
- Drug-Coated Balloon (DCB), PTA Balloon: Balloon Angioplasty
- Where
- 2 sites in United States
- Volunteers
- 331 people
- Sponsor
- Medtronic Endovascular
Atherosclerosis, Restenosis
Drug Coated Balloons for Prevention of Restenosis
The study will be performed as a randomized, double blind trial (in respect of the primary end point) with treatment of the stenotic lesion using uncoated PTA-catheters as control group.
- Conditions
- Atherosclerosis, Restenosis, Limb Ishemia
- Trial name
- Piccolo (NCT00696956)
- Testing
- Balloon angioplasty (uncoated conventional balloon), Balloon angioplasty (conventional but coated with 3 µg/mm2 paclitaxel)
- Where
- 5 sites in Germany
- Volunteers
- 114 people
- Sponsor
- University Hospital Tuebingen
Coronary Artery Disease, Angioplasty, Transluminal, Percutaneous Coronary
Safety and Efficacy Study of Kaname Coronary Stent System for the Treatment of Patients With Coronary Artery Disease
The purpose of this study is to assess whether the new Kaname coronary stent is safe and effective for the treatment of patients with coronary artery disease.
- Trial name
- KARE (NCT01004575)
- Testing
- implantation of Kaname Cobalt-Chromium coronary stent
- Where
- 17 sites in France, Germany and 3 more
- Volunteers
- 282 people
- Sponsor
- Terumo Europe N.V.
CTEPH
Impact of BPA in CTEPH on Cardiac and Pulmonary Physiology Assessed by CMR-derived 4D Flow Haemodynamics
Patients with CTEPH referred for evaluation and conduction of BPA undergo standard of care diagnostic tests and treatment. This includes conventional echocardiographic, RHC and non-invasive (CT/CMR) or invasive (coronary…
- Trial name
- NCT07299227
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Kerckhoff Klinik
Peripheral Artery Disease, Occlusion of Artery
Atherectomy and Drug-Coated Balloon Angioplasty in Treatment of Long Infrapopliteal Lesions
There is both a poor life expectancy and a poor prognosis of limb salvage in those patience with stenoses or occlusions of the lower limb (TASC Consensus).
- Trial name
- ADCAT (NCT01763476)
- Testing
- paclitaxel-coated balloon angioplasty, atherectomy
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Herz-Zentrums Bad Krozingen