Clinical trials: Coronary Arterial Disease (CAD)
Coronary Artery Disease, Coronary Occlusion
Safety and Efficacy of Drug-Coated Balloon Angioplasty for the Treatment of Chronic Total Occlusions
The purpose of this study is to investigate the safety and efficacy of drug-coated balloon angioplasty for the treatment of chronic total occlusions patients with chronic total occlusion (CTO) lesion.
- Conditions
- Coronary Artery Disease, Coronary Occlusion, Percutaneous Coronary Intervention, Chronic Total Occlusion of Coronary Artery
- Trial name
- NCT04744571
- Testing
- aspirin, betaloc, atorvastatin, rosuvastatin, clopidogrel, ticagrelor, coronary wires. or coronary balloons, drug-coated balloon
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital
Myocardial Infarction
Safety and Feasibility of Using a Single Transradial Guiding Catheter for Primary PCI
The Rapid Trial is a randomized-controlled trial proposed to test the hypothesis that using a single guiding catheter for left and right coronary angiography and intervention in patients with ST elevation myocardial infarction…
- Trial name
- RAPID (NCT01759043)
- Testing
- guiding catheter, diagnostic catheter
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Beijing Luhe Hospital
Coronary Artery Disease, Stent Restenosis
Intracoronary Optical Coherence Tomography Guidance Vs. Angiography Only Guidance for Treatment of Coronary In-stent Restenosis
Although advances in drug-eluting stents (DES) have substantially reduced the risk of coronary in-stent restenosis (ISR) and the need for target lesion revascularisation (TLR), ISR persists.
- Conditions
- Coronary Artery Disease, Stent Restenosis, STENT
- Trial name
- INSIDE OCT (NCT06779110)
- Testing
- Percutaneous Coronary Intervention
- Where
- 12 sites in Italy
- Volunteers
- 360 people
- Sponsor
- San Luigi Gonzaga Hospital
Coronary Heart Disease, Diabetes
OPtimized Stenting Using Intravascular Ultrasound(IVUS) in Long lEsion: Rationale for Simplified criteriA
Rationale IVUS has shown to be efficient for bare metal stent deployment, but has not been specifically studied for Drug Eluting Stents.
- Conditions
- Coronary Heart Disease, Diabetes, Vascular Lesions, Chronic Total Occlusion of Coronary Artery
- Trial name
- OPERA (NCT01861860)
- Testing
- TAXUS™ Element long stent
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Coronary Artery Disease, Percutaneous Coronary Intervention
Different Doses of Colchicine on hsCRP
Colchicine reduced atherothrombotic cardiovascular events in the COLCOT and LoDoCo2 studies. US Food and Drug Administration approved colchicine as the first anti-inflammatory drug for cardiovascular diseases on June, 2023.
- Trial name
- NCT06078904
- Testing
- Colchicine 0.5 MG, Colchicine 0.375 MG, Colchicine 0.25 MG
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Heart Failure, Coronary Artery Disease
Ultrastructural Characteristics of Mitochondria in Cardiomyocytes in Heart Failure
According to modern concepts, mitochondrial dysfunction may be the fundamental basis for the development and progression of CHF, including in patients undergoing myocardial revascularization.
- Trial name
- MITOCH-HF (NCT05770349)
- Testing
- coronary artery bypass grafting
- Where
- Russia
- Volunteers
- 45 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Coronary Artery Disease
Ivabradine to Improve Endothelial Function in Patients With Coronary Artery Disease
This study evaluates the effect of ivabradine on endothelial function in patients with coronary artery disease (CAD) after complete revascularization with percutaneous coronary angioplasty (PCI).
- Trial name
- RIVENDEL (NCT02681978)
- Testing
- Ivabradine, Standard medical therapy
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Campus Bio-Medico University
Coronary Artery Disease, Brain Injury
Neuroprotective Effect of Mild Hypothermia Versus Normothermia During Cardiopulmonary Bypass of Coronary Artery Surgery
In high-income countries, coronary artery bypass grafting (CABG) remains a common procedure, with approximately 36.7 operations per 100,000 inhabitants annually, corresponding to about 136,000 procedures in the European Union.
- Trial name
- HYPNOCABG (NCT07316868)
- Testing
- Normothermic cardiopulmonary bypass, Hypothermic cardiopulmonary bypass
- Where
- Finland
- Volunteers
- 160 people
- Sponsor
- Turku University Hospital
Coronary Artery Stenosis
Coronary Laser Atherectomy System for Treatment of Coronary Artery Stenosis (SHINE)
This prospective, multi-center clinical trial evaluates the safety and efficacy of the Coronary Laser Atherectomy System for the pretreatment of coronary artery stenosis.
- Trial name
- SHINE (NCT07697638)
- Testing
- Coronary Laser Atherectomy System, CVX300 Laser System
- Volunteers
- 218 people
- Sponsor
- Shanghai MicroPort Rhythm MedTech Co., Ltd.
Type 2 Diabetes Mellitus, Coronary Artery Disease
Aspirin Dosing in Diabetic Patients
Since diabetic platelets are characterized by an enhanced turnover rate, it may be hypothesized that an increase in the frequency, rather than the dose, of drug administration may be a more effective strategy to inhibit platelet…
- Trial name
- NCT01201785
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Coronary Artery Disease
Portuguese Study on The Evaluation of FFR Guided Treatment of Coronary Disease
Functional evaluation of coronary lesions, through the evaluation of fractional flow reserve (FFR) with pressure-wire in patients with coronary artery disease (CAD) was evaluated in a randomised trial - the FAME trial - where it…
- Trial name
- POST-IT (NCT01835808)
- Testing
- Fractional flow reserve (St. Jude Medical pressure-wire)
- Where
- Portugal
- Volunteers
- 918 people
- Sponsor
- Portuguese Society of Cardiology
Coronary Artery Disease
Routine Angiography Follow-Up After Percutaneous Coronary Intervention in High-Risk Patients
Comparison of clinical outcomes between routine angiography follow-up and routine clinical follow-up after percutaneous coronary intervention in high-risk patients.
- Trial name
- NCT05923489
- Testing
- Routine Angiography Follow-up, Routine Clinical Follow-up
- Where
- China
- Volunteers
- 2,618 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Coronary Artery Disease, Stenosis
Clinical Usefulness of Fractional Flow Reserve Measurement for Significant Stenosis in Proximal Coronary Artery
Fractional flow reserve (FFR) is a pressure-wire-based index that is used during coronary angiography to assess the potential of a coronary stenosis to induce myocardial ischemia.
- Trial name
- NCT02475291
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- Yonsei University
Angioplasty, Transluminal, Percutaneous Coronary, Coronary Arteriosclerosis
ECLIPSE Feasibility Trial (Ensure's Vascular Closure Device Speeds Hemostasis Trial) EU
To assess the safety and feasibility of the 7F Ensure Medical Vascular Closure Devices to facilitate hemostasis in patients undergoing diagnostic or interventional procedures.
- Trial name
- ECLIPSE (NCT00574691)
- Testing
- 7F Ensure Medical Vascular Closure Device
- Where
- Germany
- Volunteers
- 93 people
- Sponsor
- Cordis US Corp.
Healthy, Diabetes Type 2
Assessment of Three Instruments for the Non-invasive Measurement of Arterial Stiffness.
The ASI Non-Invasive Arterial Stiffness Screening Device (ASI Device) is an investigational device under development for the non-invasive assessment of arterial stiffness.
- Conditions
- Healthy, Diabetes Type 2, Obesity, Coronary Artery Disease
- Trial name
- ASI-2012 (NCT01722474)
- Testing
- ASI Device
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Coronary Artery Diseases
BIOFLOW-III UK Satellite Registry Orsiro Stent System
Clinical evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES). 500 subjects will be enrolled in this registry.
- Trial name
- NCT02257710
- Testing
- Orsiro
- Where
- 4 sites in United Kingdom
- Volunteers
- 500 people
- Sponsor
- Biotronik UK Ltd.
Coronary Artery Disease, Acute Coronary Syndrome
PET/CT for the Quantification of Atherosclerotic Plaque Inflammation
This is a single-centre prospective trial with 140 patients employing [18F]-fluorodeoxyglucose positron emission computed tomography (FDG PET/CT) and advance motion correction and image fusion algorithms to create motion frozen…
- Trial name
- QAEK (NCT01553513)
- Testing
- [18F]-FDG positron emission computed tomography, Invasive coronary angiography, Intravascular ultrasound and virtual histology
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Coronary Artery Disease (CAD), Bypass, Cardiopulmonary
Multivessel Minimally Invasive Coronary Bypass Grafting as HYBRID Revascularization Versus Conventional Off-pump Coronary Artery Bypass Grafting
The MICRA-HYBRID trial is a prospective, multicenter, randomized controlled study comparing multivessel hybrid coronary revascularization (HCR) as minimally invasive arterial bypass grafting to left-sided coronary targets (LAD…
- Conditions
- Coronary Artery Disease (CAD), Bypass, Cardiopulmonary, Minimally Invasive Coronary Revascularization Surgery, Off-pump Coronary Artery Bypass
- Trial name
- MICRA-HYBRID (NCT07314138)
- Testing
- Multivessel Hybrid Coronary Revascularization, Off-pump coronary arterial bypass grafting (OPCAB)
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Coronary Artery Disease, Coronary Restenosis
Absorb BVS vs. Drug Coated Balloon for Treatment Of ISR
AbsorbISR is a randomized, controlled trial, single center, prospective, not blinded to evaluate two strategies of in stent restenosis treatment: Implantation of drug eluting bioresorbable stent scaffold Absorb® vs.
- Trial name
- AbsorbISR (NCT02474485)
- Testing
- BVS Absorb implantation., DEB Sequent Please inflation., Control coronary angiography.
- Where
- Switzerland
- Volunteers
- 53 people
- Sponsor
- SIS Medical AG
Coronary Artery Disease
Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation
Narrowing of coronary arteries interferes with blood flow and can cause chest pain. But patients may have more than one narrowing and studies have shown that not all narrowings need to be treated.
- Trial name
- DEFINE-FLAIR (NCT02053038)
- Testing
- iFR, FFR
- Where
- 50 sites in United States, Australia and 15 more
- Volunteers
- 2,500 people
- Sponsor
- Imperial College London
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