Clinical trials: Coronary Arteries Calcifications
Coronary Artery Calcification, Calcific Coronary Arteriosclerosis
ClinicAL outComes of IntraVascular Lithotripsy Combined With Conventional Lesion Preparation in Patients With Moderate to Severe Coronary Artery Calcification
The goal of this clinical trial is to investigate whether the clinical outcomes of combined application of intravascular lithotripsy (IVL) following routine preconditioning are superior to those of routine preconditioning alone…
- Trial name
- CALC-IVL (NCT07340294)
- Testing
- Intensive Preconditioning Group, Routine preconditioning strategy
- Where
- 4 sites in China
- Volunteers
- 1,096 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stable Angina, Coronary Artery Disease
Impact of Rotational Atherectomy on Coronary Microcirculation
The purpose of this observational study is to compare the impact of rotational atherectomy to conventional stenting and to investigate how it may affect coronary microcirculation in patients with calcified coronary artery lesions…
- Trial name
- MICRO-ROTA (NCT05771961)
- Testing
- coronary pressure/temperature sensor-tipped guidewire, Angiography-derived index of microcirculatory resistance (IMRangio)
- Where
- Lithuania
- Volunteers
- 300 people
- Sponsor
- Lithuanian University of Health Sciences
Coronary Artery Disease, Carotid Artery Disease
Effects of VitamIN K2 and D3 supplementaTion on PET/MRI in Carotid Artery Disease
Atherosclerosis is a disease of the arteries and is the result of various factors such as high blood cholesterol or diabetes, which lead to accumulations of fats, cells, and calcium deposits (i.e. plaques).
- Trial name
- INTRICATE (NCT04010578)
- Testing
- MK-7 and vitamin D3
- Volunteers
- 52 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Coronary Disease
Detection of Coronary Artery Calcification: Comparison of Volumetric and Electron Beam Computed Tomography
Electron beam computed tomography (EBCT) has been regarded as the state-of-the-art investigation for detecting and quantitating coronary artery calcification.
- Trial name
- NCT00001836
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Coronary Artery Disease, Coronary Disease
Trial of Orbital Atherectomy Versus Standard Strategy in Calcified Bifurcation Lesions
Clinical research with medical devices indicated in accordance with the CE marking, led by researchers, multicenter, open, prospective, randomized and controlled.
- Trial name
- OraBil (NCT06736899)
- Testing
- Orbital Atherectomy System Treatment, Balloon System Treatment
- Where
- 9 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Fundación EPIC
ASCVD, Coronary Artery Calcification
Notification of Incidental Coronary Artery Calcium in Patients With Atherosclerotic Cardiovascular Disease (NOTIFY-ASCVD)
Estimate the impact of notifying both patients and their clinicians of the presence of incidental coronary artery calcium (CAC) on initiation of lipid-lowering therapy in patients with ASCVD who are not receiving lipid-lowering…
- Trial name
- NOTIFY-ASCVD (NCT05858879)
- Testing
- Notification of patients and clinicians
- Where
- United States
- Volunteers
- 233 people
- Sponsor
- Stanford University
Coronary Artery Disease, Coronary Artery Atherosclerosis
Intravascular Imaging Evaluated Calcified Nodule China Registry
What is this study about? This is a nationwide research study in China focused on understanding a specific type of challenging plaque in heart arteries called a Calcified Nodule (CN).
- Conditions
- Coronary Artery Disease, Coronary Artery Atherosclerosis, Coronary Calcified Nodules, Coronary Calcification
- Trial name
- NCT07262359
- Volunteers
- 500 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Artery Disease, Coronary Artery Calcification
Modification of Coronary Calcium With Laser Based Intravascular Lithotripsy for Coronary Artery Disease (FRACTURE)
The FRACTURE Trial is a prospective, non-randomized, single-arm, multicenter, interventional study in US and international centers.
- Trial name
- FRACTURE (NCT06181240)
- Testing
- Intravascular lithotripsy
- Where
- 46 sites in United States, Belgium and 5 more
- Volunteers
- 426 people
- Sponsor
- Bolt Medical
Coronary Artery Disease, Calcification
Post-Marketing Clinical Study of High-Pressure Cutting Balloon
This study is designed as a prospective, multicenter, 1:1 randomized controlled trial. It plans to enroll 280 patients with moderate-to-severe calcified coronary lesions who are candidates for IVUS-guided DES implantation.
- Trial name
- NCT07835178
- Testing
- High pressure cutting balloon, Non-cutting balloon
- Where
- China
- Volunteers
- 280 people
- Sponsor
- BrosMed Medical Co., Ltd
Cardiovascular Diseases, Atherosclerosis
Epidemiology of Coronary Artery Calcification
Using subjects from the Rochester Family Heart Study (RFHS), to characterize predictors of coronary artery calcification (CAC), a potent marker of atherosclerosis, among individuals from the general population.
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Coronary Arteriosclerosis, Heart Diseases
- Trial name
- ECAC (NCT00005349)
- Volunteers
- 1,736 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Coronary Artery Calcification, Ischemic Heart Disease
The Influence of Modifying Highly Calcified Coronary Lesions on Coronary Microcirculation
This is a prospective, single-center, three-arm study to evaluate the impact of severely calcified coronary lesions treatment on microvascular circulation.
- Conditions
- Coronary Artery Calcification, Ischemic Heart Disease, Non-ST-Segment Elevation Myocardial Infarction (NSTEMI), Coronary Artery Disease
- Trial name
- NCT06507449
- Testing
- Lithotripsy, Orbital atherectomy, High-pressure non-compliant balloon
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Medical University of Silesia
End-stage Kidney Disease
Vitamin K to Attenuate Coronary Artery Calcification in Hemodialysis Patients
The purpose of this study is to see if vitamin K supplementation three times per week reduces the progression of coronary artery calcification over 12 months in dialysis patients compared to placebo.
- Trial name
- iPACK-HD (NCT01528800)
- Testing
- Vitamin K1, Microcrystalline Methylcellulose
- Where
- 3 sites in Canada
- Volunteers
- 85 people
- Sponsor
- Dr. Rachel Holden
Coronary Artery Disease
The Prospective Segeberg Registry for Rotational Atherectomy in Coronary Lesion/s
A Prospective Follow-up Assessment in Bad Segeberg with Patients undergoing a Rotational Atherectomy in Coronary Lesion/s
- Trial name
- NCT04011527
- Testing
- Rotational Atherectomy in Coronary Lesion/s
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- Segeberger Kliniken GmbH
Coronary Artery Disease, Coronary Artery Calcification
Coronary Artery Calcification Assessed on PET Scanner (PET : Positron Emission Tomography)
Calcification artery calcium (CAC) scoring is a valuable tool for determining the risk of major adverse cardiac events. It was found that CAC can be quantitatively assessed, by manual scoring or using deep-learning, on low-dose…
- Trial name
- CALCOTEP (NCT06379295)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Coronary Artery Calcification, HIV Infections
French CAC-HIV Cohort Study
Clinical study: Methods: observational transversal two-arm cohort study including adults living with HIV (PLHIV) and HIV negative subjects (HIV-) at intermediate cardiovascular risk.
- Trial name
- CAC-HIV (NCT05563116)
- Testing
- Computed tomography coronary artery calcium (CAC) score (part of routine workup)
- Volunteers
- 689 people
- Sponsor
- Franck Boccara
Coronary Artery Disease
Evaluate the Safety and Efficacy of OAS in Treating Severely Calcified Coronary Lesions
This is a prospective, single-arm, multi-center study to evaluate the safety and performance of the OAS in treating de novo, severely calcified coronary lesions in adult subjects.
- Trial name
- ORBIT II (NCT01092416)
- Testing
- Diamondback 360 Orbital Atherectomy System
- Where
- 51 sites in United States
- Volunteers
- 443 people
- Sponsor
- Abbott Medical Devices
HIV - Human Immunodeficiency Virus
Coronary Artery Calcium Score in HIV Mexican Population (The CACsHIVMex Study)
The risk of atherosclerotic cardiovascular disease is increased in people with HIV infection, including young patients and those with few traditional cardiovascular risk factors.
- Trial name
- CACsHIVMex (NCT07662161)
- Testing
- Simple coronary CT scan
- Where
- Mexico
- Volunteers
- 384 people
- Sponsor
- Instituto Mexicano del Seguro Social
Coronary Artery Disease, Intravascular Lithotripsy
Evaluate the Safety and Efficacy of Intracoronary Lithotripsy Balloon Catheter and Intracoronary Lithotripsy Apparatus
This is a prospective, multi-center, single-group target value clinical trial, which will be carried out in many clinical trial institutions in China.
- Trial name
- NCT05649488
- Testing
- Intracoronary lithotripsy balloon catheter and Intracoronary lithotripsy apparatus, Dragonfly Opstar Imaging Catheter
- Where
- 20 sites in China
- Volunteers
- 184 people
- Sponsor
- Shanghai Bluesail Boyuan Medical Technology Co., Ltd.
Coronary Artery Calcification, Cardiac Disease
Personalization of CM Injection Protocols in Coronary Computed Tomographic Angiography
Cardiac computed tomography (CCT) is one of the standard non-invasive imaging techniques allowing imaging of the heart and coronary arteries with a high temporal and spatial resolution.
- Trial name
- PeopleCT (NCT03292354)
- Testing
- Contrast media administration
- Where
- Netherlands
- Volunteers
- 327 people
- Sponsor
- Maastricht University Medical Center
Coronary Artery Disease, Calcification
Intravascular Lithotripsy for Acute Stent Under-expansion in Calcified Coronary Lesions
Percutaneous coronary intervention (PCI) is the standard treatment for patients with coronary artery disease who have an indication for surgery.
- Trial name
- NCT06669195
- Testing
- Intravascular lithotripsy group, high-pressure balloon group
- Volunteers
- 40 people
- Sponsor
- Xuzhou Third People's Hospital