Clinical trials: Coronary Arterioscleroses
Coronary Artery Disease, Diabetes Mellitus
Coronary Artery Disease Progression in Patients With Acute Coronary Syndromes and Diabetes Mellitus
A total of 100 patients with non-ST-segment elevation acute coronary syndromes with or without diabetes mellitus will be included.
- Trial name
- PROGRESSION (NCT03890822)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Humanitas Hospital, Italy
Stable Angina, Acute Kidney Injury
CI-AKI in Patients With Stable CAD and Comorbidities. Are we Doing Better?
Patients aged 18-89 with stable CAD and comorbidities receiving optimal medical treatment requiring PCI with iodinated contrast media.
- Conditions
- Stable Angina, Acute Kidney Injury, Contrast-induced Nephropathy
- Trial name
- NCT04014153
- Testing
- Iodinated contrast media
- Volunteers
- 1,023 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Coronary Heart Disease, Stroke
The Copenhagen City Heart Study
The Copenhagen City Heart Study is an ongoing cardiovascular population study initiated in 1976 which has examined approximately 25,000 individuals from the general population.
- Conditions
- Coronary Heart Disease, Stroke, Heart Failure, Cancer
- Trial name
- CCHS (NCT02993172)
- Volunteers
- 23,891 people
- Sponsor
- Bispebjerg Hospital
Coronary Artery Disease, Chronic Total Occlusion of Coronary Artery
Cardiac Cath Lab Staff Radiation Exposure
The objective of this randomized safety and observational study is to demonstrate CorPath GRX chronic total occlusion PCI is safe, and that Cardiac Catheterization Laboratory staff have no additional exposure to radiation when…
- Conditions
- Coronary Artery Disease, Chronic Total Occlusion of Coronary Artery, Percutaneous Coronary Intervention
- Trial name
- SAFE-T (NCT03959072)
- Testing
- Robotic CTO PCI, Conventional (Manual) CTO PCI
- Where
- 3 sites in United States
- Volunteers
- 74 people
- Sponsor
- Siemens Healthineers Endovascular Robotics, Inc.
Atrial Fibrillation
Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease Study
In patients with atrial fibrillation (AF) complicated with coronary artery disease (CAD), antiplatelet drugs are commonly used for the prevention of recurrence of stent thrombosis and cardiovascular events in combination with…
- Trial name
- AFIRE (NCT02642419)
- Testing
- Rivaroxaban and single antiplatelet drug (aspirin, clopidogrel or prasugrel), Rivaroxaban
- Where
- Japan
- Volunteers
- 2,200 people
- Sponsor
- Japan Cardiovascular Research Foundation
Coronary Artery Disease
IRIS-Synergy Cohort in the IRIS-DES Registry
The purpose of this study is to evaluate the relative effectiveness and safety of Synergy stent compared to other drug eluting stents.
- Trial name
- IRIS Synergy (NCT02720419)
- Where
- 28 sites in South Korea
- Volunteers
- 3,000 people
- Sponsor
- Jung-min Ahn
Coronary Artery Disease
hsTnT After Elective Coronary Angiography
A prospective Study, aiming to understand and analyse the key role of the novel High Sensitivity Troponin T (hsTnT) within a group of patients undergoing an uncomplicated coronary angiography without receiving any additional…
- Trial name
- NCT01735500
- Where
- Germany
- Volunteers
- 545 people
- Sponsor
- University Hospital Heidelberg
Myocardial Infarction
The Effect of Exercise Training on Cardiac Structure and Function
Exercise training, as part of cardiac rehabilitation, is effective in improving functional capacity and quality of life in patients with coronary artery disease.
- Trial name
- NCT02224495
- Testing
- Structured exercise training
- Where
- Portugal
- Volunteers
- 200 people
- Sponsor
- Gaia Hospital
Early Management, Acute Heart Failure
Early Management Strategies of Acute Heart Failure for Patients With NSTEMI
There are always poor outcomes in patients with acute myocardial infarction(AMI) combined with elevated BNP/NT-proBNP level. An elevated BNP/NT-proBNP level highly indicates acute heart failure(AHF).Levosimendan is recommended in…
- Conditions
- Early Management, Acute Heart Failure, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- EMSAHF (NCT03189901)
- Testing
- Regular management+Levosimendan
- Where
- 14 sites in China
- Volunteers
- 470 people
- Sponsor
- Qilu Hospital of Shandong University
Atherosclerosis, Cardiovascular Diseases
Genetic Mapping of Atherogenic Lipoprotein Phenotypes
To map the major gene influencing low-density lipoprotein subclass phenotypes, denoted atherogenic lipoprotein (ALP) phenotypes, with a long term goal of cloning the ALP gene and understanding its role in genetic susceptibility…
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases
- Trial name
- NCT00005465
- Sponsor
- University of Washington
Coronary Artery Disease
Clopidogrel and Response Variability Investigation Study 2
To evaluate the role of the genetic variant 2C19*2 on the pharmacodynamic response as assessed by optical aggregometry and on the pharmacokinetic response as assessed by measuring active metabolites following an oral…
- Trial name
- CLOVIS2 (NCT00822666)
- Testing
- clopidogrel
- Where
- France
- Volunteers
- 109 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Coronary Syndrome
Hypolipemic Treatment in Acute Coronary Syndrome (ACS): Antithrombotic Effects
The aim of the current study is to evaluate whether treatment with high doses of simvastatin can reduce coagulation activation in patients with acute coronary syndromes and if ezetimibe in conjunction with simvastatin may affect…
- Trial name
- NCT00725829
- Testing
- simvastatin, ezetimibe
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Jagiellonian University
Atrial Fibrillation, Ischemic Stroke
Direct Oral Anticoagulants in Patients With Atrial Fibrillation (DOACs vs Warfarin)
The purpose of this study is to assess safety and effectiveness of direct oral anticoagulants (DOACs) and warfarin for stroke prevention in patients with non-valvular atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation, Ischemic Stroke, Systemic Embolization, Major Bleed
- Trial name
- NCT03596502
- Testing
- Direct oral anticoagulants (DOACs), Warfarin
- Where
- Canada
- Volunteers
- 402,764 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Cardiac Ischemia, Thoracic Cancer
Perioperative Troponin I and NT Pro-BNP in Lung Resection
After lung resection, troponin elevation may be regulated by mechanisms other than myocardial ischemia. Perioperative natriuretic peptides measurement may help identify changes in ventricular function during thoracic surgery.
- Conditions
- Cardiac Ischemia, Thoracic Cancer, Complication,Postoperative
- Trial name
- NCT04749212
- Testing
- serum high-sensitivity Troponin I (TnI) and NT-Pro-Brain Natriuretic Peptide (NT-proBNP)
- Where
- Spain
- Volunteers
- 475 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Stable Angina, Unstable Angina
Pivotal, Single-arm Clinical Trial to Assess the Efficacy and Safety of the MedHub AutocathFFR Software Device
Prospective (analysis of retrospective data), multi-center, observational, single-arm study. This structure was selected as the "worst case" due to the fact that it represents real life usage of invasive FFR measurement is…
- Conditions
- Stable Angina, Unstable Angina, NSTEMI
- Trial name
- AutocathFFR (NCT04861519)
- Testing
- Collecting invasive FFR measurements.
- Where
- 3 sites in Israel
- Volunteers
- 308 people
- Sponsor
- Medhub Ltd.
Acute Coronary Syndrome
IVUS Assessment of Atheroma Burden After Acute Coronary Syndrome
Coronary angioplasty is rather frequently performed in such situations, presumably because, changes in the atherosclerotic plaque under drug treatment, have remained poorly described so far.
- Trial name
- OPTIVUS (NCT01578005)
- Where
- 3 sites in France
- Volunteers
- 79 people
- Sponsor
- University Hospital, Toulouse
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Individualized or Conventional Transfusion Strategies During Peripheral VA-ECMO
This multicenter randomized controlled trial compare two transfusion strategies of red blood cells transfusion in patients supported by veno-arterial extracorporeal membrane oxygenation for refractory cardiogenic shock.
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, Transfusion Related Complication, Anemia
- Trial name
- ICONE (NCT05699005)
- Testing
- Packed Red Blood Cells (PRBCs)
- Where
- 4 sites in France
- Volunteers
- 236 people
- Sponsor
- University Hospital, Lille
Coronary Artery Disease
Impact of Coronary Artery Bypass Graft (CABG) Surgery on Skeletal Muscle Mass and Insulin Sensitivity, Followed by Exercise Intervention
In this study, the investigators want to examine the impact of coronary artery bypass graft (CABG) surgery on skeletal muscle mass, muscle metabolism, and insulin sensitivity in 90 subjects.
- Trial name
- NCT01333839
- Testing
- exercise training
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Hasselt University
Atherosclerosis
Radial Artery Function Following Trans-radial Cardiac Catheterisation
The investigators will study Radial artery injury and endothelial function following trans-radial cardiac catheterisation. Radial artery injury will be quantified pre- and post- angiography using Optical Coherence Tomography.
- Trial name
- NCT02147119
- Testing
- Coronary angiography
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- University of Edinburgh
Angioplasty, Transluminal, Percutaneous Coronary, Coronary Artery Disease
Orsiro™ Drug Eluting Stent in Routine Clinical Practice
The purpose of this study is to evaluate effectiveness and safety of Orsiro™ Drug Eluting Stent in Routine Clinical Practice
- Trial name
- IRIS ORSIRO (NCT02039739)
- Testing
- Orsiro™ Drug Eluting Stent group
- Where
- 18 sites in South Korea
- Volunteers
- 1,007 people
- Sponsor
- Seung-Jung Park
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