Clinical trials: Coronary Arterioscleroses
Acute Coronary Syndromes (ACS), Recent Myocardial Infarction
The Pharmacokinetics and Pharmacodynamics Study of Evategrel CG-0255 Besylate）and Plavix® in Healthy Participants
CG-0255 is a novel investigational prodrug of the active metabolite of Plavix®， but with different active metabolite conversion routes.
- Conditions
- Acute Coronary Syndromes (ACS), Recent Myocardial Infarction, Recent Stroke, Peripheral Arterial Disease
- Trial name
- NCT07619885
- Testing
- CG-0255 Besylate for Injection, CG-0255 Besylate Capsule, Clopidogrel
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Shanghai CureGene Pharmaceutical Co., Ltd.
Angina Pectoris
CT Perfusion Added to CT Angiography
Background In the differential diagnosis of unstable angina versus non-anginal chest pain, an exercise test is often the modality of choice for further investigation.
- Trial name
- PERFeCT (NCT02773615)
- Testing
- Cardiac computed tomography
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Acute Coronary Syndrome
The Acute Coronary Syndrome Study
The investigators will make a prospective study in which they will look at the economics and security of the treatment of patients with acute coronary syndrome. The investigators want to do a randomized trial.
- Trial name
- ACS (NCT01027026)
- Testing
- Early discharge, Care as usual. No intervention. (Control group)
- Where
- Norway
- Volunteers
- 400 people
- Sponsor
- Ullevaal University Hospital
Coronary Disease
Smart Phone Application in the Secondary Clinical Prevention Management for Chinese Patients
The purpose of the study is to investigate the effects of smart phone app on the secondary prevention for patients with coronary heart disease post percutaneous coronary intervention.
- Trial name
- SPASCPM (NCT02847078)
- Testing
- smart phone app, A guideline booklet
- Volunteers
- 86 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Hyperoxia, Myocardial Infarction
Intraoperative Hyperoxia and MINS
Oxygen therapy is administered to all patients during general anesthesia to maintain tissue oxygenation and prevent hypoxia and ischemia.
- Conditions
- Hyperoxia, Myocardial Infarction, Myocardial Injury
- Trial name
- NCT04540276
- Testing
- Inspiratory oxygen fraction
- Where
- 8 sites in United States, Canada and 6 more
- Volunteers
- 7,700 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Spinal Cord Injury
Coronary Artery Calcification Score and Risk Factors for Coronary Artery Disease in Persons With Spinal Cord Injury
Although conventional risk factors for coronary heart disease (CHD) have been identified and routinely used to determine risk for CHD in the general population, a systematic approach to determine population-specific risk for CHD…
- Trial name
- CAC (NCT02007226)
- Where
- 2 sites in United States
- Volunteers
- 83 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Coronary Artery Disease
PROMUS Element Plus US Post-Approval Study
This study is designed to observe clinical outcomes in patients receiving the PROMUS Element Plus Everolimus-Eluting Platinum Chromium Coronary Stent System in routine clinical practice.
- Trial name
- NCT01589978
- Testing
- PROMUS Element Plus Coronary Stent System, Aspirin, P2Y12 antagonist
- Where
- 52 sites in United States
- Volunteers
- 2,681 people
- Sponsor
- Boston Scientific Corporation
Ischemic Preconditioning, Coronary Disease
Remote Ischaemic Conditioning and Coronary Endothelial Function (RIC-COR)
Intermittent arm cuff inflation reduces the extent of heart muscle injury at the time of cardiovascular injury. The intervention is known as remote ischaemic conditioning (RIC) however the mechanisms by which RIC acts are…
- Trial name
- RIC-COR (NCT02666235)
- Testing
- Remote ischaemic conditioning, Arm cuff placement, no inflation;
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- NHS National Waiting Times Centre Board
Stable Coronary Artery Disease
An Asian Study to Assess the Properties and Profile of Ticagrelor in Patients With Stable Coronary Artery Disease
The purpose of the study is to determine the drug characteristics of Ticagrelor, and to determine if 4 weeks treatment will reduce the blood clotting.
- Trial name
- NCT01118325
- Testing
- ticagrelor, clopidogrel
- Where
- 13 sites in Japan, Philippines
- Volunteers
- 146 people
- Sponsor
- AstraZeneca
Myocardial Reperfusion Injury, Hypoxia
Effects of Hypoxic-hyperoxic Preconditioning in Cardio-surgical Patients
Coronary artery bypass grafting (CABG) with cardiopulmonary bypass is a common surgical therapy for patients suffering from coronary artery diseases.
- Conditions
- Myocardial Reperfusion Injury, Hypoxia, Hyperoxia, Coronary Artery Disease
- Trial name
- NCT05354648
- Testing
- Hypoxic-hyperoxic preconditioning
- Volunteers
- 120 people
- Sponsor
- Alexander Averyanov
Coronary Artery Disease, Ischaemic Heart Disease
Echocardiography: Value and Accuracy at REst and STress
EVAREST will identify and validate novel blood and imaging biomarkers of potential value for consistent and accurate interpretation of stress echocardiography.
- Conditions
- Coronary Artery Disease, Ischaemic Heart Disease, Angina Pectoris
- Trial name
- EVAREST (NCT03674255)
- Volunteers
- 23,000 people
- Sponsor
- University of Oxford
Secondary Prevention of Coronary Heart Disease
Intelligent Management Platform for Guiding Exercise Rehabilitation in Coronary Heart Disease Patients
The goal of this clinical trial is to find out if an artificial intelligence (AI)-enabled stratified management platform can help adults with coronary heart disease (CHD) better perform exercise rehabilitation and manage their…
- Trial name
- NCT07259278
- Testing
- AI-Enabled Stratified Management System, Usual post-discharge care
- Where
- China
- Volunteers
- 200 people
- Sponsor
- China National Center for Cardiovascular Diseases
Myocardial Infarction
Cohort of STEMI Patients
Ischemic heart disease is the leading cause of mortality in industrialized countries. ST elevated acute myocardial infarction is one of its most frequent and deadly manifestation.
- Trial name
- STEMI (NCT02822638)
- Testing
- STEMI PATIENT Cohort
- Where
- France
- Volunteers
- 1,204 people
- Sponsor
- Hospices Civils de Lyon
Myocardial Infarction, Angioplasty
Intracoronary Bolus Only Compared With Intravenous Bolus and 12-hours Infusion of Abciximab in Non-ST Elevation Myocardial Infarction.
Intracoronary bolus Abciximab single is non-inferior to intravenous and continuous 12- hours infusion in the size reduction of infarction on cardiac magnetic resonance in Non-ST elevation Myocardial infarction.
- Trial name
- NCT01080638
- Testing
- glycoprotein IIb/IIIa inhibitor (abciximab)
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease
BES, EES, and ZES-R in Real World Practice
The primary objective of this study is to compare the rate of device-oriented composite consisted of cardiac death, myocardial infarction not clearly attributable to a nontarget vessel, and clinically indicated target lesion…
- Trial name
- CHOICE (NCT01397175)
- Testing
- Biolimus-eluting stent, Everolimus-eluting stent, Zotarolimus-eluting stent
- Where
- 5 sites in South Korea
- Volunteers
- 1,960 people
- Sponsor
- Yonsei University
Acute Coronary Syndrome
Prognosis of Treated Acute Coronary Syndrome Patients: a Multicenter Study
The MPCS-ACS Study (Multicenter Prospective Cohort Study on Acute Coronary Syndrome) is a comprehensive, forward-looking research project designed to evaluate the prognostic outcomes of patients diagnosed with acute coronary…
- Trial name
- MPCS-ACS (NCT05164601)
- Testing
- No Intervention - Observational Only
- Where
- 2 sites in China
- Volunteers
- 22,500 people
- Sponsor
- Xiang Xie
Idiopathic Inflammatory Myopathy
A Case-control Study to Assess Risk of Coronary Heart Disease in Idiopathic Inflammatory Myopathy
This study will be co-ordinated by Dr Hector Chinoy, Dr Robert G Cooper (Salford Royal NHS Foundation Trust / The University of Manchester) and Dr Ian N Bruce (Central Manchester University Hospitals NHS Foundation Trust/ The…
- Trial name
- NCT00971828
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Northern Care Alliance NHS Foundation Trust
Coronary Artery Disease
Detection of Coronary Artery Disease Using Analysis of High Frequency QRS: The HyperQ Registry
This will be a registry study that will enroll patients referred for an ECG treadmill test with nuclear myocardial perfusion imaging (MPI).
- Trial name
- HyperQ (NCT01325467)
- Where
- 3 sites in United States
- Volunteers
- 900 people
- Sponsor
- BSP Biological Signal Processing Ltd.
Coronary Artery Disease
OPTImal Management of Antithrombotic Agents: OPTIMA-2 Trial
High on-treatment platelet reactivity (HOPR) is associated with increased risk of cardiovascular events in patients undergoing percutaneous coronary intervention (PCI).
- Trial name
- OPTIMA-2 (NCT01955200)
- Testing
- Clopidogrel, Cilostazol, Ticagrelor
- Where
- China
- Volunteers
- 1,724 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Ischemic Heart Disease
MHealth Intervention to Reduce Perceived Stress in Patients with Ischemic Heart Disease
Stress is highly prevalent in patients with ischemic heart disease (IHD) and is associated with lower health-related quality of life and worsened cardiovascular outcome.
- Trial name
- mStress-IHD (NCT05846334)
- Testing
- mindfulHeart
- Where
- Germany
- Volunteers
- 128 people
- Sponsor
- University Hospital, Essen
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