Clinical trials: Coronary Arterioscleroses
Acute Coronary Syndrome, Platelet Thrombus
Fixed-dose vs. Phenotype-based PrAsugrel Dose to MATCH Therapeutic Zone in Asians With Acute Coronary Syndrome
The purpose of this study is to determine whether the fixed-dose (prasugrel 10 mg/d vs. 5 mg/d) vs. phenotype (platlet function test by VerifyNow P2Y12 assay)-based prasugrel dose adjustment can match therapeutic zone of platelet…
- Conditions
- Acute Coronary Syndrome, Platelet Thrombus, Bleeding
- Trial name
- NCT01951001
- Testing
- Prasugrel
- Where
- South Korea
- Volunteers
- 255 people
- Sponsor
- Gyeongsang National University Hospital
Cardiovascular Diseases, Coronary Disease
Inflammation Markers Over Time in Cardiovascular Disease
To determine inflammation markers over time in cardiovascular disease. To test the hypothesis that measures of coagulation and fibrinolysis correlate with the incidence of coronary heart disease (CHD) and other thrombosis related…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Thrombosis
- Trial name
- NCT00005692
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Events
Social Medical Progression of Coronary Heart Disease With Associated Psychosocial Comorbidity -Interval Rehabilitation.
The purpose of the study is to verfiy the hypothesis if a short intensive psychocardiological interval-intervention, combined with a structured follow up, decreases the rate of disability retirements caused by psychosocial…
- Trial name
- SINKO (NCT01589536)
- Testing
- interval-rehabilitation
- Where
- Germany
- Volunteers
- 480 people
- Sponsor
- Clinic Roderbirken
Cardiac Magnetic Resonance, Myocardial Infarction with Nonobstructive Coronary Arteries
CMR in Myocardial Infarction with Nonobstructive Coronary Arteries
MINOCA is accompanied by a worse prognosis, which is related to the inability to clarify the etiology.CMR has been explicitly recommended by guidelines as an etiologic diagnostic tool for MINOCA.
- Conditions
- Cardiac Magnetic Resonance, Myocardial Infarction with Nonobstructive Coronary Arteries, Strain, Extracellular Volume
- Trial name
- NCT06502899
- Testing
- Cardiac MRI
- Where
- China
- Volunteers
- 387 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Coronary Artery Disease
Domain-specific Aerobic Exercise Training in Coronary Artery Disease
Exercise training in cardiac rehabilitation (rehab) is a key part of managing a patient with heart disease. It has been shown that cardiac patients who increase their aerobic ("cardio") fitness by exercise training live longer…
- Trial name
- DOSE-EX-CAD (NCT06143332)
- Testing
- Aerobic exercise training
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- Western University, Canada
Myocardial Infarction, Anterior Wall
COmprehensive Remote Ischemic Conditioning in Myocardial Infarction
The primary objective of the CORIC-MI trial is to evaluate whether comprehensive (per, post plus delayed) remote ischemic conditioning (CORIC) as an adjunctive therapy in patients with ST-elevation myocardial infarction (STEMI)…
- Trial name
- CORIC-MI (NCT03233919)
- Testing
- comprehensive remote ischaemic conditioning
- Where
- China
- Volunteers
- 200 people
- Sponsor
- China National Center for Cardiovascular Diseases
Cardiogenic Shock
CARDSUP - SWISS Circulatory Support Registry
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing ECMO or Impella implantation at all included sites.
- Trial name
- CARDSUP (NCT04117230)
- Where
- 5 sites in Switzerland
- Volunteers
- 1,500 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hypercholesterolemia
Effect of LDL-apheresis on PTX3 Plasma Levels in Hypercholesterolemic Patients
Inflammation plays a major role in atherosclerosis. Pentraxin 3 (PTX3) a multifunctional pattern-recognition protein, is expressed in many tissues/cells, including innate immunity cells, endothelium and atherosclerotic plaques.
- Trial name
- NCT01678521
- Testing
- LDL-apheresis
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Universita di Verona
Coronary Disease, Atrial Fibrillation
Carvedilol Versus Metoprolol for the Prevention of Atrial Fibrillation After Off-Pump Coronary Bypass Surgery
Postoperative new-onset atrial fibrillation (AF) is the most common complication stemming from coronary artery bypass graft surgery, and is associated with increased early and late mortality risk.
- Trial name
- NCT00198614
- Testing
- Carvedilol versus Metoprolol
- Where
- Japan
- Volunteers
- 650 people
- Sponsor
- Ministry of Health, Labour and Welfare, Japan
Diabetes Type 2, Coronary Artery Disease
Canagliflozin Targeting Vascular Inflammation
CANTOR SING is a pilot single center double blinded randomized study. The investigators will compare the effect of canagliflozin (300 mg daily - intervention arm) vs.
- Trial name
- CANTORSING (NCT05427084)
- Testing
- Canagliflozin
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Myocardial Infarction
Studying the Effectiveness of Early Invasive Treatment in Elderly Patients With High-risk Non-ST-segment Elevation Acute Coronary Syndrome.
The goal of this is observational study is to compare about MACE events and predisposing factors related to MACE events in elderly patients with high-risk non-ST acute coronary syndromes receiving early versus late invasive…
- Trial name
- NCT06486233
- Where
- Vietnam
- Volunteers
- 385 people
- Sponsor
- Gia Dinh People Hospital
Coronary Artery Disease, Chronic Kidney Diseases
Intravascular Ultrasound-Guided PCI in Patients With Chronic Kidney Disease
The IVUS-CKD study is a prospective, randomized controlled, multicenter trial to determine whether the intravascular ultrasound (IVUS)-guided percutaneous coronary intervention is superior to the angiography-guidance in chronic…
- Trial name
- IVUS-CKD (NCT06567938)
- Testing
- Percutaneous coronary intervention
- Where
- China
- Volunteers
- 1,528 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Atherosclerosis, Coronary Artery Disease
A Phase 2b Clinical Trial of YN001 in Adults With Coronary Atherosclerosis
This study is designed to evaluate the efficacy and safety of intravenously administered YN001 in patients diagnosed with coronary atherosclerosis, who are receiving background therapy for cardiovascular (CV) risk factors…
- Trial name
- PURIFY-TIMI 81 (NCT07521007)
- Where
- 56 sites in United States, Australia and 2 more
- Volunteers
- 456 people
- Sponsor
- Beijing Inno Medicine Co., Ltd.
Cardiovascular Diseases, Coronary Disease
Anxiety and Vagal Control of the Heart in Coronary Disease
To examine the role of reduced vagal control of heart rate in the increased risk of cardiac mortality associated with anxiety in a population with established coronary artery disease (CAD).
- Conditions
- Cardiovascular Diseases, Coronary Disease, Depression, Heart Diseases
- Trial name
- NCT00006311
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Ischemic Heart Disease
Metabolomic Profile of Patients Undergoing Myocardial Perfusion SPECT
The aim of this study is to analyze metabolomic pattern of patients after cardiac stress in order to detect differences based on the type of stress (physical or pharmacological with adenosine agonists) and result of test…
- Trial name
- METS (NCT02968771)
- Testing
- Non intervention
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Acute Myocardial Infarction
Phase 1 Study of Potential Anti-Inflammatory Effects of Glucose Control During Acute Myocardial Infarction.
The purpose of this study is to determine if intense control of high glucose levels in patients treated with angioplasty for heart attack has anti-inflammatory and anti-thrombotic effects.
- Trial name
- NCT00209144
- Testing
- Intensive insulin therapy
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- Emory University
Frailty Syndrome, Surgery--Complications
Pre-frailty and Rehospitalization in Cardiac Surgery
Background: It has been demonstrated that pre-frailty has more adverse outcomes after cardiac surgery, however, data on prognosis and long-term evolution in pre-frailty patients after cardiac surgery without postoperative…
- Conditions
- Frailty Syndrome, Surgery--Complications, Coronary Artery Disease, Valve Anomalies
- Trial name
- NCT03949439
- Testing
- Elective Cardiac Surgery
- Where
- Brazil
- Volunteers
- 453 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Cardiovascular Diseases, Heart Diseases
Molecular & Clinical Evaluation of Low HDL Syndromes
To study the genetic cause of low HDL-C, a risk factor for premature atherosclerotic vascular disease in patients with normal total cholesterol.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis
- Trial name
- NCT00006295
- Volunteers
- 370 people
- Sponsor
- University of Maryland, Baltimore
Atheroscleroses, Coronary, Microbiota
Gut Microbiota Modulation With Synbiotics After Acute Coronary Syndrome
Acute coronary syndrome (ACS) remains one of the leading causes of morbidity and mortality worldwide despite major advances in acute management and secondary prevention.
- Trial name
- SYMBIO-ACS (NCT07411287)
- Testing
- Pro-B (Bionaturis),, Guideline-Directed Medical Therapy (GDMT)
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier de Bienne
Coronary Disease
The Effects of Diesel Exhaust Inhalation on Vascular Function - the Role of Endothelin
The purpose of this study is to identify the role of endothelin 1 (a natural vasoconstrictor) in the adverse vascular effects demonstrated after exposure to air pollution
- Trial name
- NCT00745693
- Testing
- Endothelin-1, BQ-123 and BQ-788
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
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