Clinical trials: Coronary Arterioscleroses
Acute Coronary Syndrome
Variation Between Hospitals in Short-term Mortality After Acute Coronary Syndromes: A CALIBER Study
We seek to investigate whether hospitals in England and Wales vary in their rate of mortality following admission for heart attack or unstable angina, the extent of such variation, whether discharge diagnosis affects the extent…
- Trial name
- NCT01111071
- Where
- United Kingdom
- Volunteers
- 316,648 people
- Sponsor
- University College, London
Coronary Heart Disease
Estimating Peak Oxygen Uptake in People Living With Coronary Heart Disease
In people living with coronary heart disease (CHD), V̇O2 peak predicts all-cause mortality. V̇O2 peak increases with regular exercise training.
- Trial name
- NCT05505344
- Testing
- VentriJect Seismofit validation
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Sheffield Hallam University
Acute Coronary Syndrome, Depressive Symptoms
Comparison of Depression Identification After Acute Coronary Syndrome: Quality of Life and Cost Outcomes
The purpose of this study is to examine, in a randomized controlled trial, the benefits and costs of the American Heart Association's (AHA) advisory for depression screen and treatment of post-acute coronary syndrome patients.
- Trial name
- CODIACSQoL (NCT01993017)
- Testing
- Cognitive Behavioral Therapy (CBT), Antidepressant Medication, Standard Care
- Where
- 4 sites in United States
- Volunteers
- 1,501 people
- Sponsor
- Columbia University
Myocardial Ischemia
Sex and Gender Differences in Ischemic Heart Disease - Endocrine Vascular Disease Approach
The application of sex-gender medicine is strongly recommended by World Health Organization and other international organization.
- Trial name
- EVA (NCT02737982)
- Testing
- percutaneous coronary intervention
- Where
- Italy
- Volunteers
- 509 people
- Sponsor
- University of Roma La Sapienza
Abdominal Aortic Aneurysm
Prevalence and Screening of Abdominal Aortic Aneurysms Among Men With Coronary Artery Disease
The purpose of this study is to investigate the prevalence of abdominal aortic aneurysms (AAA) among male patients with coronary artery disease (CAD) verified in coronary angiography.
- Trial name
- CAD-AAA (NCT01897623)
- Testing
- ultrasound of aorta
- Where
- Finland
- Sponsor
- North Karelia Central Hospital
Coronary Artery Disease
Determinants of Cardiac Risk Factor Modification in Latinos With Coronary Artery Disease
This is an observational study among Latino patients who have coronary artery disease. The goal of the study is to determine the association between having depressive symptoms and the ability to modify one's health behavior.
- Trial name
- NCT00248859
- Where
- United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Myocardial Infarction, Intracoronary Thrombus
Intracoronary Thrombus Assessed by OFDI After Successful Fibrinolysis And Its Impact On Myocardial Reperfusion
The pharmacoinvasive approach after thrombolysis is the standard treatment of myocardial infarction when deadlines are too long for primary angioplasty.
- Trial name
- AODIS (NCT02850315)
- Testing
- optimal coherence tomography
- Where
- France
- Volunteers
- 29 people
- Sponsor
- University Hospital, Caen
Coronary Artery Disease
PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm
This purpose of this trial is to demonstrate 30 day safety and effectiveness outcomes of the KARDION CORY P4 System in subjects who require hemodynamic support during a high-risk PCI procedure.
- Trial name
- NCT06445608
- Testing
- Percutaneous Mechanical Circulatory Support
- Where
- 18 sites in United States
- Volunteers
- 310 people
- Sponsor
- Kardion Inc
Dyslipidemias
Nicotinic Acid Composition of HDL and Arterial Endothelium Function in Premature Coronary Heart Disease and High HDL
Patients with premature ischemic heart disease (PIHD) and elevated levels of HDL-C present an altered composition of high-density lipoproteins (HDL) which is associated with a loss of their anti-atherogenic effects and of their…
- Trial name
- 11MSP011 (NCT01450410)
- Testing
- Nicotinic acid
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Xavier Pinto Sala
Coronary Heart Disease (CHD), Anxiety Disorders
Closed-Loop Neurofeedback Targeting the Right Dorsolateral Prefrontal Cortex for Cardiac Autonomic Modulation in Coronary Artery Disease With Anxiety
The goal of this clinical trial is to test whether real-time fNIRS-BCI neurofeedback targeting the right dorsolateral prefrontal cortex (right DLPFC), using active volitional control during a slow-wave auditory acoustic paradigm…
- Trial name
- HEART-SET-1 (NCT07238920)
- Testing
- Real-time fNIRS-ECG neurofeedback
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Shenyang Medical College
No-Reflow Phenomenon, STEMI - ST Elevation Myocardial Infarction
NGAL and Its Association With the No-reflow Phenomenon in ST-elevation Myocardial Infarction
The aim of this study is to investigate the association between NGAL plasma levels in ST-elevation myocardial infarction and the no-reflow phenomenon, adverse events during hospitalization and at 30-day follow-up.
- Trial name
- NCT03264859
- Testing
- NGAL levels early and post STEMI
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Cardiovascular Diseases, Heart Diseases
Whitehall II - Social and Occupational Influences On Health and Illness
To examine the effect on health and disease of the work environment, psychological workload, control over work pacing and content, opportunity for use of skills, social support at work; the moderating effect on these…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Myocardial Ischemia
- Trial name
- NCT00005680
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Stable Coronary Artery Disease
Precise Percutaneous Coronary Intervention Plan (P3) Study
The PRECISE PERCUTANEOUS CORONARY INTERVENTION (PCI) PLAN STUDY is an investigator-initiated, international and multicenter study of patients with an indication for PCI aiming at assessing the agreement and accuracy of the…
- Trial name
- P3 (NCT03782688)
- Testing
- FFRCT planner
- Where
- Belgium
- Volunteers
- 127 people
- Sponsor
- Onze Lieve Vrouw Hospital
Coronary Artery Disease, Cardiovascular Diseases
Functional Diagnostic Accuracy of Quantitative Flow Ratio in Tandem Lesions and Virtual Stenting
Quantitative Flow Ratio (QFR) is a novel method for evaluating the functional significance of coronary stenosis. Virtual stent implantation technique combined with QFR was recently developed to predict the functional significance…
- Conditions
- Coronary Artery Disease, Cardiovascular Diseases, Myocardial Ischemia, Arterial Occlusive Diseases
- Trial name
- FORTRESS (NCT03405506)
- Testing
- Quantitative Flow Ratio (QFR)
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Pulse Medical Imaging Technology (Shanghai) Co., Ltd
Coronary Artery Disease
Optimization of Percutaenous Coronary Intervention With Liberal Use of Post-dilatation
To achieve optimal long-term clinical results after percutaneous coronary intervention (PCI), adequate deployment of stents is essential.
- Trial name
- OPTIMIZE-PCI (NCT06558474)
- Testing
- Liberal post-dilatation strategy during PCI
- Where
- Netherlands
- Volunteers
- 12,000 people
- Sponsor
- Cathreine BV
Acute Myocardial Infarction Type 1, Myocardial Injury
TROPOnin FRAGMentation in Myocardial Injury Study
Troponin T (TnT) is a part of the troponin protein complex that principally exists in cardiac and skeletal muscle cells and is widely used as diagnostic biomarker for myocardial injury and, thus, myocardial infarction (MI).
- Trial name
- Tropo-Fragm (NCT04465591)
- Testing
- troponin T fragmentation test
- Where
- 2 sites in Finland, Switzerland
- Volunteers
- 1,500 people
- Sponsor
- University of Turku
Coronary Disease, Heart Diseases
Myocardial Contrast Echocardiography (MCE) to Check for Living and Working Heart Muscle
Coronary artery disease (CAD) can cause poor blood flow and supply to the heart muscle. It can result in irreversible damage to the heart muscle and poor function.
- Trial name
- NCT00001891
- Testing
- Myocardial contrast echocardiography, Dobutamine echocardiography
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Coronary Syndromes
ALIGN-ACS Pilot Study
The goal of this observational study is to evaluate the diagnostic performance of the HeartBeam ECG System for detection of acute coronary syndrome.
- Trial name
- ALIGN-ACS (NCT07715474)
- Testing
- ECG
- Where
- Serbia
- Volunteers
- 120 people
- Sponsor
- HeartBeam, Inc.
Coronary Artery Disease
A Single Center Study to Establish the Imaging Protocol of 99mTc-EC-DG in Evaluating the Presence and Severity of Coronary Artery Disease (CAD)
This study will assess the safety and tolerability of the investigational radiolabeled imaging agent technetium-99m-labeled ethylenedicysteine-deoxyglucose (99mTc-EC-DG).
- Trial name
- NCT01778218
- Testing
- Radiolabeled (99Tc) EC-DG (ethylenedicysteine-deoxyglucose
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Cell>Point LLC
Myocardial Ischemia
Multimodality Investigation of Intermediate Culprit Lesion With Negative FFR in NSTE-ACS
Ten-fifteen percent of acute coronary syndromes without ST-segment elevation (NSTE-ACS) are caused by intermediate lesions without signs of unstable plaque.
- Trial name
- SHERLOCK (NCT03205514)
- Testing
- NSTE-ACS with intermediate stenosis and negative FFR
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- University Hospital of Ferrara
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