Clinical trials: Coronary Artery Bypass
Sleep Disorder, Coronary Artery Disease
Sleep Quality and Sleep-disordered Breathing in Bypass Surgery Patients
Patients undergoing non-emergency coronary artery bypass surgery (CABG) are included. All patients will be examined for transthoracic echo, blood samples will be collected, and an overnight sleep polygraph will be performed in a…
- Trial name
- UNI-CABG (NCT06453538)
- Where
- Finland
- Volunteers
- 54 people
- Sponsor
- Turku University Hospital
CABG, Coronary Artery Disease
Study of the Use of a Single Dose of Erythropoietin to Treat Acute Myocardial Ischemia
This is a phase 2 study that evaluates the effect of intravenous administration of a bolus EPO on the activation of EPOR-signal transduction cascades and myocardial apoptosis during cardiopulmonary bypass surgery.
- Trial name
- DREAM (NCT00524901)
- Testing
- Epoetin alpha, NaCl 0.9%
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- University Medical Center Groningen
Coronary Artery Disease, Aortic Valve Stenosis
MiECC Versus Conventional Cardiopulmonary Bypass in Cardiac Surgery (MiECS)
MiECS is one of the largest multicentre randomised controlled trials on extracorporeal circulation conducted under the auspices of Minimal Invasive Extracorporeal Technologies International Society (MiECTiS).
- Conditions
- Coronary Artery Disease, Aortic Valve Stenosis, Extracorporeal Circulation; Complications
- Trial name
- MiECS (NCT05487612)
- Testing
- Minimal Invasive Extracorporeal Circulation, Conventional cardiopulmonary bypass
- Where
- 13 sites in Canada, Germany and 4 more
- Volunteers
- 1,300 people
- Sponsor
- Aristotle University Of Thessaloniki
Coronary Artery Bypass Graft Surgery, Presence of Heparin/Platelet Factor 4 Antibody
Significance of Antibodies to Heparin/Platelet Factor 4 Complex in Vein Graft Patency and Potential Role of Argatroban for Prevention of Vein Graft Occlusion
Heparin/Platelet Factor 4 (PF4) antibody testing will be performed in subjects who have just undergone coronary artery bypass grafting (CABG) surgery.
- Trial name
- NCT01246011
- Testing
- Argatroban and warfarin
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Massachusetts General Hospital
Granulocyte Immature Forms, Inflammatory Response Syndrome, Systemic
Bands in Peripheral Blood After Coronary Artery Bypass Grafting With and Without Cardiopulmonary Bypass
Coronary artery bypass graft (CABG) surgery is associated with reperfusion syndrome and activation of inflammatory reaction (SIRS). These are more exaggerated when cardiopulmonary bypass (CPB) is used.
- Trial name
- NCT00563030
- Where
- Poland
- Volunteers
- 44 people
- Sponsor
- Medical University of Gdansk
Coronary Artery Bypass, Antiplatelet Agents
Different Antiplatelet Therapy Strategy After Coronary Artery Bypass Graft Surgery
The study population will include all patients undergoing elective CABG. Consent and randomization will occur before surgery. Total 500 patients undergoing elective CABG will be randomly assigned into three groups with 1:1:1…
- Trial name
- DACAB (NCT02201771)
- Testing
- Aspirin, Ticagrelor
- Where
- 6 sites in China
- Volunteers
- 500 people
- Sponsor
- Ruijin Hospital
Coronary Artery Disease, Graft Failure
Clinical Effect of No-touch Harvesting Technique in OPCABG
This study aims to investigate the clinical effect of the new saphenous vein harvesting technique "No-touch" in off-pump coronary artery bypass grafting(OPCABG), comparing to the conventional technique.
- Trial name
- NCT03729531
- Testing
- Conventional vein harvesting technique, no-touch vein harvesting technique
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital
Diabetes, Coronary Artery Disease
Epicardial Fat and Clinical Outcomes After Coronary Artery Bypass Grafting in Diabetics vs. Non Diabetics
Cardiovascular disease (CVD) is a group of diseases including both the heart and blood vessels, thereby including coronary heart disease (CHD). To date, diabetics have a higher incidence and prevalence of multivessels CHD.
- Trial name
- NCT03360981
- Testing
- Incretins
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Analgesia
Dexmedetomidine for Pain Reduction in CABG
The purpose of this study is to determine whether adjuvant intravenous dexmedetomidine infusion starting after induction of general anesthesia can provide superior pain management (decrease pain scores) and decrease opioid…
- Trial name
- NCT05534230
- Testing
- Dexmedetomidine Injectable Solution, Saline
- Volunteers
- 100 people
- Sponsor
- Wayne State University
Chronic Coronary Syndrome, Coronary Artery Bypass Graft CABG
Antiplatelet Strategy for CCS Patients Undergoing CABG
To evaluate the long-term outcomes of different antiplatelet strategies, including DAPT, aspirin monotherapy, and clopidogrel monotherapy, in CCS patients undergoing CABG.
- Trial name
- CABG_DAPT_SAPT (NCT06881901)
- Volunteers
- 29,898 people
- Sponsor
- Samsung Medical Center
Coronary Artery Bypass
One-lung Ventilation During Internal Thoracic Artery Grafting in Cardiac Surgery
Coronary artery bypass grafting is a current cardiac surgery. Internal thoracic artery is usually taking to restore coronary revascularization, and its dissection can lead to accidental or voluntary pleural effusions.
- Trial name
- VUPPAM (NCT02823054)
- Testing
- EZ-Blocker
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Coronary Artery Bypass Graft Surgery (CABG), Patient Education
Determining the Consistency Between Nurses and Artificial Intelligence (ChatGPT-5) in Delivering Scenario-Based Discharge Education to Coronary Artery Bypass Graft Patients: A Methodological Study
This methodological study aims to determine the level of agreement between nurses and an artificial intelligence system (ChatGPT-4.0) in providing scenario-based discharge education for patients who have undergone coronary artery…
- Trial name
- CABG-AI-EDU (NCT07263724)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Obstructive Sleep Apnea, Ischaemic Heart Desease
Impact of Continuous Positive Airway Pressure (CPAP) Therapy on Outcomes in Patients Undergoing Coronary Revascularization
Investigators assume that continuous positive airway pressure (CPAP) therapy can reduce the mortality, stroke rate and secondary coronary surgery in CAD with obstructive sleep apnea (OSA) patients after percutaneous coronary…
- Trial name
- NCT02080156
- Testing
- CPAP
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Obstructive Disease
Relationship Between a Combined Index of Diastolic and Systolic Performance and Intraoperative Hemodynamic Changes During Off-pump Coronary Bypass Surgery
As considering the close relationship between systolic dysfunction and diastolic dysfunction, the EAS index e'/(a' x s') including systolic and diastolic function could be expected to predict hemodynamic changes during off-pump…
- Trial name
- NCT02534103
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Yonsei University
Coronary Artery Disease, Surgery--Complications
Cardiopulmonary Exercise Testing as an Outcome Predictor in Coronary Artery Bypass Surgery
This is a prospective cohort study of patients undergoing coronary artery bypass graft surgery. Prior to surgery, participants will undergo submaximal cardiopulmonary exercise testing on a treadmill.
- Trial name
- NCT03376542
- Testing
- Cardiopulmonary Exercise Testing
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Eduardo Tibirica, MD, PhD
Cardiac Surgery
Dynamic Tests and Parameters to Predict Fluid Responsiveness After OPCAB
Objective: To assess the predictive value of dynamic tests and parameters for evaluation of fluid responsiveness after off-pump coronary artery bypass grafting (OPCAB).
- Trial name
- NCT04482946
- Testing
- Assessment of fluid responsiveness
- Where
- Russia
- Volunteers
- 32 people
- Sponsor
- Northern State Medical University
Acute Kidney Injury
Intraoperative Dexmedetomidine and Coronary Artery Bypass Graft Surgery
This is a prospective randomized clinical trial designed to determine the effect of intraoperative dexmedetomidine administration on renal function after coronary artery bypass graft surgery.
- Trial name
- NCT06378827
- Testing
- Dexmedetomidine
- Where
- Serbia
- Volunteers
- 100 people
- Sponsor
- University of Novi Sad
Stroke Volume Variation
Effect of Wide Pulse Pressure on the Predictability of Stroke Volume Variation for Fluid Responsiveness in Patients Undergoing Off-pump Coronary Artery Bypass Graft
The investigators examined the predictability of stroke volume variation for fluid responsiveness in patients with wide pulse pressure undergoing off-pump coronary artery bypass graft
- Trial name
- NCT01404455
- Testing
- HES 130/0.4 (VoluvenⓇ, Fresenius Kabi, Graz, Austria) 500mL loading
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Severance Hospital
Post Induction Hypotension
Comparing the Hemodynamic Effects of Volume Loading vs Non-loading During Induction of Anesthesia in Fluid Responder Patients With Coronary Artery Disease Undergoing Elective Coronary Artery Bypass Graft Surgery: a Randomized Controlled Study.
All preoperative cardiac medications will be continued till the morning of the surgery, except angiotensin converting enzyme inhibitors.
- Trial name
- NCT05462847
- Testing
- Ringer acetate
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Kasr El Aini Hospital
Saphenectomy, No Touch
Morbidity of Conventional and No-touch Saphenectomy in Coronary Artery Bypass Grafting.
A clinical research project will be carried out that will consist of a non-inferiority study. The objective is to compare the morbidity of two different surgical techniques for the extraction of the internal saphenous vein…
- Conditions
- Saphenectomy, No Touch, Coronary Artery Disease, Cardiovascular Diseases
- Trial name
- TNT (NCT06496321)
- Testing
- Conventional Saphenous vein harvest, No touch Saphenous vein harvest
- Where
- Uruguay
- Volunteers
- 52 people
- Sponsor
- Instituto Nacional de Cirugia Cardiaca, Uruguay
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