Clinical trials: Coronary Artery Bypass
Coronary Artery Disease
Study to Improve Long Term Vein Graft Patency After Coronary Bypass Surgery by Using a Novel Endoscopic Harvesting Technique
The purpose of this study is to demonstrate improved vein graft patency rates at 12 months for endoscopically harvested saphenous vein grafts.
- Trial name
- NCT01540422
- Where
- 2 sites in United States
- Volunteers
- 93 people
- Sponsor
- Baylor Research Institute
Coronary Artery Bypass Grafting
Comparing Point of Care Clotting Tests in the OR Versus Standard Laboratory Clotting Tests
The purpose of this study is determine the agreement of point of care (POC) clotting tests (INR and aPTT) by the POC device by Hemochron Jr versus standard laboratory clotting tests (INR and aPTT) in patients undergoing elective…
- Trial name
- NCT00892905
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Aortic Stenosis, Coronary Heart Disease
The Effect of Glucose-Insulin-Potassium Infusion in Patients Undergoing Cardiac Surgery
The purpose of this study is to evaluate the cardioprotective effects of a short term infusion of glucose-insulin-potassium (GIK) during heart surgery.
- Conditions
- Aortic Stenosis, Coronary Heart Disease, Heart Failure
- Trial name
- NCT00788242
- Testing
- Glucose-insulin-potassium
- Where
- 2 sites in Switzerland
- Volunteers
- 200 people
- Sponsor
- Christoph Ellenberger
Type 2 Diabetes
Can Enhanced Glycemic Control in Type II Diabetics Improve Myocardial Protection During Coronary Artery Bypass Grafting?
The investigators have previously demonstrated that the administration of insulin in the form of an infusion with additional sugar and potassium may improve cardiovascular performance and reduce biochemical evidence of heart…
- Trial name
- GUIDE (NCT00899483)
- Testing
- Glucose potassium insulin solution
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham
Complication of Coronary Artery Bypass Graft, Surgical Wound Infection
Effectiveness of Triclosan Coated Sutures in Preventing Leg Wound Infection After Coronary Artery Bypass Surgery
The purpose of this study is to assess whether triclosan-coated sutures reduces wound infections compared to regular non-coated sutures, after saphenous vein harvesting in CABG patients.
- Trial name
- NCT01457859
- Testing
- Triclosan, Conventional non-coated surgical sutures
- Where
- Israel
- Volunteers
- 410 people
- Sponsor
- Rambam Health Care Campus
Coronary Artery Bypass
Study of Roxadustat for Reducing the Incidence of Acute Kidney Injury After Coronary Artery Bypass Grafting
Acute kidney injury is a frequent complication after coronary artery bypass grafting (CABG). Roxadustat is a prolyl hydroxylase inhibitor (PHI) which can stabilize hypoxia-inducible factor (HIF) and improve the hypoxic tolerance…
- Trial name
- NCT05010460
- Testing
- Roxadustat
- Where
- 2 sites in China
- Volunteers
- 98 people
- Sponsor
- Peking Union Medical College Hospital
Cardiac Surgical Procedures
The REPLICCAR Registry and The Statewide Quality Improvement Initiative
Cardiovascular diseases remain the leading cause of death for the healthcare system and cardiac surgery has an important impact on their resolubility.
- Trial name
- REPLICCAR (NCT05363696)
- Testing
- Coronary artery bypass grafting (CABG), Heart valve surgery
- Where
- 2 sites in Brazil
- Volunteers
- 9,723 people
- Sponsor
- University of Sao Paulo General Hospital
Coronary Artery Disease, Aortic Valve Stenosis
Comparative Analysis of the Microcirculation During Cardiac Surgery With Minimal Invasive Versus Conventional Extracorporeal Circulation
The aim of the proposed study is to evaluate microcirculatory alterations in patients undergoing open heart surgery with minimal invasive versus conventional extracorporeal circulation.
- Conditions
- Coronary Artery Disease, Aortic Valve Stenosis, Mitral Disease
- Trial name
- NCT05479188
- Testing
- Sublingual microscopy
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aristotle University Of Thessaloniki
Reperfusion Injury
Cardiac REperfusion With Intralipid® at Reperfusion
This study will evaluate the benefit of Intralipid® or placebo administered prior to reperfusion to limit ischemia reperfusion injury as measured by the geometric mean difference of the release of troponin I over 72 hours after…
- Trial name
- CREW-I (NCT02807727)
- Testing
- Intralipid 20%, Modified Ringers Lactate
- Where
- South Africa
- Volunteers
- 30 people
- Sponsor
- Nkanyiso Hadebe
Cerebral Autoregulation Impairment, Postoperative Cognitive Dysfunction
BrainProtect-guided, Real-time Cerebral Autoregulation Monitoring and Protection of Brain During Cardiac Surgery With Cardiopulmonary Bypass Requiring Heart-lung Machine
The purpose of this clinical investigation is to evaluate the clinical performance, safety, and clinical benefit of the BrainProtect System in reducing early postoperative neurological complications in adult participants…
- Conditions
- Cerebral Autoregulation Impairment, Postoperative Cognitive Dysfunction, Postoperative Delirium
- Trial name
- BrainProtect (NCT07872982)
- Testing
- BrainProtect System, Standard perioperative management
- Where
- 4 sites in United States, Austria and 2 more
- Volunteers
- 304 people
- Sponsor
- Scienceforbrain, UAB
Surgical Wound Infection, Cystitis
The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study
All surgical procedures carry with them the risk of infection. Even a minor infection can extend the hospitalization after cardiac surgery. The average minimum increase in length of stay for a single infection is three days.
- Conditions
- Surgical Wound Infection, Cystitis, Bacteremia, Pneumonia
- Trial name
- NCT00164099
- Testing
- Synbiotic 2000
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Beth Israel Medical Center
Myocardial Ischemia, Coronary Arteriosclerosis
Safety and Efficacy of TP10, a Complement Inhibitor, in Adult Women Undergoing Cardiopulmonary Bypass Surgery
The purpose of this study is to determine if the study drug (TP10), which blocks complement release, can reduce such side effects of complement inflammation as chest pain or heart attacks and be taken safely in women who undergo…
- Conditions
- Myocardial Ischemia, Coronary Arteriosclerosis, Aortic Valve Insufficiency, Mitral Valve Insufficiency
- Trial name
- NCT00082121
- Testing
- TP10
- Where
- 18 sites in United States
- Volunteers
- 300 people
- Sponsor
- Avant Immunotherapeutics
Cardiopulmonary Bypass, Cardiac Surgery
Central and Peripheral Arterial Pressure Decoupling In Cardio-Pulmonary Bypass
Central and peripheral arterial pressure decoupling occurs in some clinical conditions like sepsis or cardiopulmonary bypass. This decoupling may leed to unsuitable decisions such as the use of catecholamines.
- Conditions
- Cardiopulmonary Bypass, Cardiac Surgery, Extracorporeal Circulation
- Trial name
- CAPD-CPB (NCT02652858)
- Testing
- Non-invasive blood pressure oscillometer (NIBP) implementation
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Chronic Coronary Disease
One-Month DAPT in CABG Patients
The purpose of this study is to compare the effect of ticagrelor plus low-dose aspirin versus low-dose aspirin alone in patients with chronic coronary disease undergoing coronary artery bypass grafting.
- Trial name
- ODIN (NCT05997693)
- Testing
- Ticagrelor 90 MG, Low-dose aspirin
- Where
- 22 sites in United States, Austria and 4 more
- Volunteers
- 700 people
- Sponsor
- Weill Medical College of Cornell University
Cardiopulmonary Bypass
Post-market Clinical Follow-up Study on the Performance and Safety of Coronary Artery Perfusion Cannula Used During Cardiopulmonary Bypass
Prior to the implementation of the Medical Device Regulation (MDR), clinical evaluation of older devices was carried out by Notified Bodies (MBs) based on clinical data obtained from equivalent devices, and CE certification was…
- Trial name
- NCT07620847
- Testing
- coronary artery perfusion cannula
- Volunteers
- 20 people
- Sponsor
- Bıçakcılar Tıbbi Cihazlar Sanayi ve Ticaret A.Ş.
CHD - Coronary Heart Disease
Assessment of the Usefulness of Hemopatch in Coronary Artery Bypass Graft Surgery
The study aim is to assess polyethylene glycol (PEG) coated collagen patch (Hemopatch) on the quality of drainage after surgery, the length of hospital stay, the number of reoperations due to haemorrhage and treatment cost.
- Trial name
- Hemopatch (NCT03340090)
- Testing
- Medical Device Hemopatch-PEG-coated collagen patch
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Lodz
Cardiac Disease
Cardiac Deformation: Correlation With Conventional Echocardiographic Hemodynamic Variables (An Intraoperative Study)
The aim of this research is to apply cardiac tissue characterization in order to assess left ventricular function in cardiac surgical patients pre and post cardiopulmonary bypass.
- Trial name
- NCT00874991
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- Weill Medical College of Cornell University
Coronary Artery Bypass Grafting
Efficacy of Different Perioperative Statin Regimens on the Protection Against Post Coronary Artery Bypass Grafting Major Adverse Cardio-cerebral Events
This study aims at comparing different perioperative statin regimens for the prevention of post CABG adverse events. This was a randomized, prospective clinical trial.
- Trial name
- NCT02706860
- Testing
- Atorvastatin
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Cairo University
CABG, Ethnic Group
Outcomes of Coronary Artery Bypass Grafting in Israeli Jews and Arabs
Retrospective study of adult patients with multivessel disease undergoing isolated CABG in three centers between January 1st, 2009, and December 31st, 2023.
- Trial name
- NCT06766123
- Testing
- CABG
- Volunteers
- 7,067 people
- Sponsor
- Technion, Israel Institute of Technology
Degenerative Cardiac Valve Disease, Coronary Artery Bypass Surgery Patients
Rate of Microbial Colonization Over Native Calcified Cardiac Valves
The purpose of this observational, exploratory study in patients undergoing any cardiac valve replacement or repair is to assess the rate of bacterial colonization over native degenerative calcified cardiac valves.
- Trial name
- NCT01409525
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Rambam Health Care Campus
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.