Clinical trials: Coronary Artery Bypass
Coronary Artery Disease, Anesthesia
Xenon as an Adjuvant to Propofol Anaesthesia in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery.
The investigators hypothesize that the application of 30% xenon as an adjuvant to general anesthesia with a target-controlled infusion of propofol is superior to general anesthesia with propofol alone with respect to hemodynamic…
- Trial name
- NCT01948765
- Testing
- Xenon and propofol, propofol
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Coronary Artery Disease
Ticagrelor and Aspirin for the Prevention of Cardiovascular Events After Coronary Artery Bypass Surgery
Subjects will be consented to the study prior to Coronary Artery Bypass Graft (CABG) and randomly assigned to receive either ticagrelor 90 mg bid or placebo bid starting within 48 hours of surgery.
- Trial name
- TAP-CABG (NCT01373411)
- Testing
- ticagrelor
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Cardiology Research UBC
Coronary Artery Bypass, Myocardial Ischemia
Glutamate for Metabolic Intervention in Coronary Surgery
The main purpose of this study is to determine whether intravenous glutamate infusion given in association with surgery for unstable coronary artery disease can protect the heart from myocardial injury, postoperative heart…
- Conditions
- Coronary Artery Bypass, Myocardial Ischemia, Myocardial Infarction, Coronary Artery Disease
- Trial name
- GLUTAMICS (NCT00489827)
- Testing
- Intravenous infusion of saline, Intravenous glutamate infusion
- Where
- 3 sites in Sweden
- Volunteers
- 865 people
- Sponsor
- University Hospital, Linkoeping
Acute Myocardial Infarction
Emergency Coronary Artery Bypass Graft in Acute Myocardial Infarction
A retrospective study investigating the early outcome of emergency CABG post MI in patients who were operated at Saud Al Babtain Cardiac Center.
- Trial name
- NCT04572061
- Where
- Saudi Arabia
- Volunteers
- 109 people
- Sponsor
- Saud Al Babtain Cardiac Center
Graft Patency, Coronary Artery Bypass Grafting Surgery
ThrombElastoGraphic Haemostatic Status and Antiplatelet Therapy After Coronary Artery Bypass Graft Surgery
The purpose of this study is to determine whether adding clopidogrel to aspirin after coronary bypass operation (CABG) improves graft patency, in patients that have preoperatively increased platelet activity(hypercoagulable) and…
- Conditions
- Graft Patency, Coronary Artery Bypass Grafting Surgery, Hypercoagulability, Thrombosis
- Trial name
- TEG-CABG (NCT01046942)
- Testing
- Clopidogrel+acetylsalicylic acid, acetylsalicylic acid
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Postoperative; Dysfunction Following Cardiac Surgery
Is Six Weeks Too Long for First Outpatient Review After Cardiac Surgery?
Although the first outpatient review following cardiac surgery is conventionally scheduled for six weeks after hospital discharge, there is no evidence to support this practice.
- Trial name
- FORCAST6 (NCT02832427)
- Where
- United Kingdom
- Volunteers
- 85 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Coronary Artery Bypass, Off-Pump, Iron Deficiencies
Effect of Non-anemic Iron Deficiency on Outcome Following Off-pump Coronary Revascularization
This is a single center retrospective study of patients who underwent off pump coronary artery bypass surgery between 2016.11~2023.05.
- Trial name
- NCT06399627
- Where
- South Korea
- Volunteers
- 433 people
- Sponsor
- Yonsei University
Coronary Artery Bypass Grafting, Cardiopulmonary Bypass
Relationship Between Perioperative Carotid Blood Flow Monitoring and Cerebral Function Protection in Cardiac Surgery
Postoperative cognitive dysfunction (POCD) is a common complication of cardiac surgery, mainly manifested as mental confusion, anxiety, personality change and memory impairment, which seriously affects the quality of life of…
- Trial name
- NCT05586347
- Testing
- Nicardipine, normal saline
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Coronary Artery Disease
Decision Support Tool for Revascularisation Options in Coronary Artery Disease
Together with patients and healthcare professionals, we want to design a Decision Support Tool (DST) that will help people with coronary artery disease to understand and choose treatments that best reflect their preferences and…
- Trial name
- DECIDE-CAD (NCT06567626)
- Testing
- Decision Support Tool (DECIDE-CAD)
- Where
- 2 sites in United Kingdom
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Cardiac Surgery, Coronary Artery Bypass Graft CABG
Effects of a Hybrid Model of Cardiac Rehabilitation on Patient Outcomes
Determine if the standard of care at a cardiac rehabilitation center using what the investigators term to be "hybrid model" on the exercise component of cardiac rehabilitation is associated with improved adherence and outcomes.
- Conditions
- Cardiac Surgery, Coronary Artery Bypass Graft CABG, Stent, Valve Replacement
- Trial name
- NCT06030115
- Testing
- Exercise Component Of Cardiac Rehabilitation (Hybrid Model) Intensity Recovery Progression Protocol (IRPP)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Good Shepherd Integrated Healthcare Systems
Cardiovascular Diseases
Effects of the Low-level Laser Therapy on Functional Capacity of the Patients With Coronary Artery Bypass Surgery
The low-level laser therapy (LLLT) has been used in many inflammatory disorders. More recently the LLLT was associated with an improvement in the muscle strength, endurance and functional capacity.But, these effects were…
- Trial name
- NCT02688426
- Testing
- 6J Low-Level Laser Therapy (6J LLLT)
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Coronary Artery Disease, Diabetes
Predictability of Preoperative Hemoglobin A1c in Diabetic Patients Underwent Off-Pump Coronary Artery Bypass Surgery: A Retrospective Study.
The aim of this study is to evaluate evaluated the impact of preoperative HbA1c in diabetic patients on perioperative glycemic variability and outcome after off-pump coronary artery bypass (OPCAB).
- Trial name
- NCT03543449
- Testing
- Off-Pump Coronary Artery Bypass (OPCAB) surgery
- Where
- South Korea
- Volunteers
- 703 people
- Sponsor
- Yonsei University
Coronary Artery Disease, Postoperative Pain
Five Multimodal AI Configurations Versus Expert Anaesthesiologists for Classifying Pecto-Intercostal Fascial Plane Block Spread in CABG
This prospective observational cohort with a nested archived-image reader study compared the sonographic pecto-intercostal fascial plane block classifications of five general-purpose multimodal artificial-intelligence…
- Trial name
- NCT07581678
- Testing
- Pecto-Intercostal Fascial Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Stress Hyperglycemia
Metabolic Phenotyping During Stress Hyperglycemia in Cardiac Surgery Patients
This study is a prospective randomized study to examine the effects of exposure to dulaglutide on the prevention of stress-hyperglycemia and the metabolic inflammatory response in the perioperative period.
- Trial name
- NCT03743025
- Testing
- Dulaglutide Injection, Saline Injection
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Emory University
Stem Cell Transplantation, Ventricular Dysfunction, Left
Prospective Randomized Study of Mesenchymal Stem Cell Therapy in Patients Undergoing Cardiac Surgery (PROMETHEUS)
Heart attacks are a leading cause of death in both men and women in the United States. When a person has a heart attack, blood is unable to reach a certain area of the heart, and if the blood supply is not re-established quickly…
- Trial name
- PROMETHEUS (NCT00587990)
- Testing
- Lower dose mesenchymal stem cell (MSC) injection, Higher dose MSC injection
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Joshua M Hare
Atrial Fibrillation
Impact of Left Atrial Function on Postoperative Atrial Fibrillation
We aimed to demonstrate the impact of left atrial functions which were evaluated by three different echocardiographic modalities , on postoperative atrial fibrillation.
- Trial name
- NCT00646997
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Florence Nightingale Hospital, Istanbul
Intraoperative Hypotension, Postoperative Hypotension
Hypotension Prediction 2 Study in Cardiac Surgery and Postoperative ICU Admission
This trial registration serves as an amendment incorporating the IPD Sharing Statement. This study already has a trial registration (2021 April 30) in the Netherlands Trial Registry (Reference number NL9449…
- Conditions
- Intraoperative Hypotension, Postoperative Hypotension, Hypotension
- Trial name
- HYPE-2 (NCT05821647)
- Testing
- HPI guided treatment advice
- Where
- Netherlands
- Volunteers
- 130 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Diabetes
Real-time Continuous Glucose Monitoring in Diabetic Cardiothoracic Surgery Patients
An increased risk of adverse outcome is noted for diabetic patients admitted in surgery intensive care units (ICU). Tight glycemic control with intensive insulin therapy dramatically reduces in-hospital mortality and adverse…
- Trial name
- MARGE (NCT00878891)
- Testing
- Continuous glucose monitoring for immediate correction of abnormal glycemia
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Bordeaux
Postoperative Cognitive Dysfunction, Cerebrovascular Accident
Neurological Outcome After Minimal Invasive Coronary Artery Bypass Graft
Primary objectives: Assessment of the incidence of postoperative cognitive dysfunction (POCD), cerebrovascular accident (CVA), and delirium after minimal invasive coronary artery bypass grafting (Endo-CABG).
- Conditions
- Postoperative Cognitive Dysfunction, Cerebrovascular Accident, Delirium
- Trial name
- NOMICS (NCT02979782)
- Testing
- Endo-CABG, PCI
- Where
- 2 sites in Belgium
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Jessa Hospital
Blood Loss, Surgical, Ticagrelor
Comparison of CABG Related Bleeding Complications in Patients Treated With Ticagrelor or Clopidogrel
In patients with coronary artery disease, dual antiplatelet therapy (acetylsalicylic acid and a P2Y12-receptor antagonist) is a commonly used method because of its excellent antithrombotic effect.
- Conditions
- Blood Loss, Surgical, Ticagrelor, Clopidogrel
- Trial name
- CABG (NCT04431349)
- Testing
- Ticagrelor 180mg, Clopidogrel 75mg
- Where
- South Korea
- Volunteers
- 1,097 people
- Sponsor
- Ajou University School of Medicine
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