Clinical trials: Coronary Artery Bypass
Postoperative Cognitive Dysfunction, Cognitive Impairment
Exploration of Neuroimaging and Biochemical Prognostic Indicators for POCD
Postoperative cognitive dysfunction (POCD) may lead to serious consequences. But the underlying mechanisms are still unclear. Blood Oxygen Level Dependent (BOLD) fMRI and biochemical indicators will be used to explore the…
- Trial name
- NCT02164669
- Where
- China
- Volunteers
- 20 people
- Sponsor
- wangqiang
Coronary Stenosis, Coronary Artery Disease
Long-term Follow-up of a Randomized Comparison of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Surgery
This is a long-term follow-up of a completed clinical trial which compared percutaneous coronary intervention (PCI) using sirolimus-eluting stents and coronary artery bypass grafting (CABG) in patients with unprotected left main…
- Trial name
- NCT05963620
- Testing
- percutaneous coronary intervention vs bypass graft surgery
- Where
- 4 sites in Germany
- Volunteers
- 201 people
- Sponsor
- Heart Center Leipzig - University Hospital
Cardiovascular Disease
Phase II Study To Evaluate The Safety and Efficacy of Hemoglobin Raffimer in Patients Undergoing First Time CABG Surgery
To evaluate the efficacy of Hemolink™ in combination with Intraoperative Autologous Donation (IAD) versus control (IAD alone) in facilitating avoidance of allogeneic RBC transfusion during and following primary CABG surgery
- Trial name
- NCT00038454
- Testing
- Hemolink (hemoglobin raffimer IV solution)
- Where
- 28 sites in United States, Canada and 1 more
- Volunteers
- 180 people
- Sponsor
- Hemosol
Coronary Artery Disease
Quantitative Flow Ratio on Radial Artery Graft Outcome After Coronary Artery Bypass Grafting
In coronary artery bypass grafting (CABG), the use of radial artery (RA) is recommended by the guidelines only to significantly stenosed vessel, due to its high vulnerability to competitive flow.
- Trial name
- ASRAB-QUARGO (NCT05556590)
- Where
- China
- Volunteers
- 135 people
- Sponsor
- Ruijin Hospital
Diabetes
Intensive Insulin Therapy in Patients Undergoing Coronary Artery Bypass Surgery
High blood glucose levels (hyperglycemia) in cardiac surgery patients with diabetes are associated with increased risk of hospital complications.
- Trial name
- CABG (NCT01361594)
- Testing
- Regular insulin (intensive treatment), Regular Insulin (conventional treatment)
- Where
- United States
- Volunteers
- 338 people
- Sponsor
- Emory University
Coronary Artery Disease
Assessing Myocardial Blood Flow and Blood Flow Reserve by Transoesophageal Echocardiography (TEE)
Until today it was not possible to reliably assess the function of a new bypass, i.e., to measure myocardial perfusion. Measuring intramyocardial blood flow directly after revascularisation would greatly improve the assessment of…
- Trial name
- NCT00286559
- Testing
- SonoVue, Optison
- Sponsor
- University Hospital, Basel, Switzerland
Coronary Artery Disease
On-pump Versus Off-pump Coronary Artery Bypass Grafting , Short Term Outcomes , Sohag Experience
Coronary artery disease (CAD) and its sequlae, such as myocardial infarction, arrhythmia and heart failure, are among the leading causes of death around the world .
- Trial name
- NCT06069986
- Testing
- coronary artery bypass graft CABG
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Sohag University
Coronary Artery Bypass Graft Triple Vessel
Effect of Prewarming on Microcirculatory Response
Intraoperative hypothermia may affect tissue microcirculation and can induce myocardial injury, wound infection, and coagulopathy.
- Trial name
- NCT02186210
- Testing
- prewarming
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
CABG
Effects of E-care Protocol in Patients With Coronary Artery Bypass Graft
Coronary artery disease (CAD) is a heart disease caused by the buildup of plaque inside the coronary arteries that restricts blood flow to the heart which leads to heart attack.
- Trial name
- CABG (NCT07574411)
- Testing
- IMT Threshold device
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Coronary Artery Bypass Grafting Surgery
Study of the Therapeutic Effects of Intercessory Prayer (STEP)
Intercessory prayer is widely believed to influence recovery from illness, but claims of benefits are not supported by well-controlled clinical trials.
- Trial name
- NCT00179491
- Testing
- Intercessory Prayer
- Volunteers
- 1,802 people
- Sponsor
- Beth Israel Deaconess Medical Center
Congestive Heart Failure
BMAC Enhanced Coronary Artery Bypass Grafting (CABG)
Injection of concentrated bone marrow cells into the myocardium during CABG procedure.
- Trial name
- NCT01061580
- Testing
- Harvest SmartPReP2 BMAC System
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Harvest Technologies
Acute Coronary Syndrome
Timing of Coronary Artery Bypass Surgery Among Patients With Acute Coronary Syndromes Initially on Ticagrelor
Ticagrelor, a more potent P2Y12 inhibitor, has been shown to reduce major adverse cardiac events (MACE) in acute coronary syndromes (ACS). It is increasingly used as a first line therapy in ACS.
- Trial name
- RAPID CABG (NCT02668562)
- Testing
- Early CABG (Day 2-3 after ticagrelor discontinuation), Delayed CABG (Day 5-7 after ticagrelor discontinuation)
- Where
- 2 sites in Canada
- Volunteers
- 143 people
- Sponsor
- Ottawa Heart Institute Research Corporation
CABG
Effect of a Preoperative Video Education Program on ICU Delirium After CABG (VIDEO-CABG Trial)
The goal of this clinical trial is to evaluate the effect of a preoperative video-based educational program on postoperative outcomes in adult patients undergoing coronary artery bypass graft (CABG) surgery.
- Trial name
- VIDEO-CABG (NCT07570420)
- Testing
- Video-Based Educational Program
- Where
- Jordan
- Volunteers
- 220 people
- Sponsor
- University of Jordan
Heart Diseases, Coronary Disease
Effects of Respiratory Muscle Training on Postoperative Pulmonary Complications of Cardiac Surgery
This study will evaluate the profilatic effects of inspiratory muscle training (IMT) on functional capacity, respiratory muscle strength, postoperative pulmonary complications and days of hospitalization (PPC) in patients…
- Conditions
- Heart Diseases, Coronary Disease, Cardiovascular Diseases, Coronary Artery Occlusion
- Trial name
- NCT03094923
- Testing
- Inspiratory Muscle Training
- Volunteers
- 32 people
- Sponsor
- University of the State of Santa Catarina
Anemia
Balancing Risk: Red Blood Cell Transfusion Strategies In Cardiac Surgery
The primary purpose of this study is to determine the best blood level to begin transfusing red blood cells in individuals undergoing cardiac surgery.
- Trial name
- NCT00651573
- Testing
- Blood transfusion at hematocrit value less than 24%, Blood transfusion at hematocrit value less than 28%
- Where
- 2 sites in United States, India
- Volunteers
- 722 people
- Sponsor
- The Cleveland Clinic
Coronary Artery Disease, Vascular Access Complication
Left Radial comparEd to Femoral Approach for CORonary Angiography in Patients With Previous CABG StuDy
This randomized, multicenter, prospective study seeks to compare left radial and femoral access during cardiac catheterization of patients with prior history of CABG surgery, with the primary objective of demonstrating that the…
- Trial name
- L-RECORD (NCT03393052)
- Testing
- Coronary Angiography
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- University Hospital of Patras
Heart Diseases, Hypertension, Pulmonary
Study of the Efficacy and Safety of Tezosentan in Patients With Pre-operative Pulmonary Hypertension, Due to Left Heart Disease, Undergoing Open Heart Surgery
Endothelin-1 is a powerful substance that may be involved in causing hemodynamic instability (problems related to unstable blood pressure) during and after open heart surgery.
- Trial name
- NCT00458276
- Testing
- tezosentan
- Where
- 33 sites in United States, Austria and 12 more
- Volunteers
- 274 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Multi Vessel Coronary Artery Disease
Dual Antiplatelet Therapy in Patients With Clopidogrel Resistance Following Off-Pump Coronary Artery Bypass
Ticagrelor, a direct-acting oral P2Y12-receptor antagonist, provides greater and more consistent platelet inhibition than clopidogrel.
- Trial name
- NCT05166538
- Testing
- Ticagrelor, Clopidogrel
- Where
- South Korea
- Volunteers
- 204 people
- Sponsor
- Yonsei University
Ischemic Heart Disease, Angina Pectoris
Investigation of Leukocyte Trafficking Into Skin Blisters During Cardiopulmonary Bypass
The purpose of this study was to see if the heart-lung machine involved in cardiac surgery increases the movement of activated white blood cells from the bloodstream into the patient's tissues and also to see if aprotinin usage…
- Trial name
- NCT00131040
- Testing
- Aprotinin
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Chronic Pain, Postoperative, Sternotomy Pain
Early Screening of Chronic Post-sternotomy Pain Using the DN4-i Questionnaire
Chronic post-sternotomy pain (CPSP) is a common complication after cardiac surgery, with a reported prevalence between 30% and 50%.
- Trial name
- DEPDN4i (NCT07603271)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Institute Arnault Tzanck, France
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