Clinical trials: Coronary Artery Bypass
Heart Failure
Is Sacubitril-valsartan Superior to Dapagliflozin in Improving Myocardial Function Performance
The aim of this study is to assess whether sacubitril-valsartan is more effective than dapagliflozin in improving function, myocardial performance in patients undergoing CABG operation or not
- Trial name
- NCT06090487
- Testing
- myocardial function after surgery
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Coronary Arterial Disease (CAD), Bypass Graft Occlusion
Cardiac Computed Tomography Based 3-D Printing for Optimized Coronary Artery Bypass Graft Surgery
Coronary artery bypass graft surgery (CABG) is a preferred surgical treatment in patients with widespread coronary artery disease.
- Trial name
- 3DCABG (NCT07039838)
- Testing
- 3D print of coronary arteries
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Jesper James Linde
IHD, LV Dysfunction
Coronary Artery Bypass Grafts or Percutaneous Coronary Intervention for High Risk Patients
Most patients with Left Ventricular Systolic Dysfunction (LVSD) or heart failure (HF) have coronary artery disease (CAD) while some patients also have renal disease.
- Trial name
- NCT05534698
- Testing
- PCI, CABG
- Where
- Denmark
- Volunteers
- 1,550 people
- Sponsor
- Danish Study Group
Heart Valve Disease, Coronary Artery Disease
RiaSTAP vs. Conventional Transfusion in Patients Having Heart Valve Surgery
Heart surgery involving valve replacement often involves the use of the heart-lung machine for over 90 minutes, and bleeding tendency is frequently seen.
- Trial name
- RiaCT (NCT01283321)
- Testing
- Human fibrinogen concentrate, apheresis platelets
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Emory University
Surgical Wound Infection, Cystitis
The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study
All surgical procedures carry with them the risk of infection. Even a minor infection can extend the hospitalization after cardiac surgery. The average minimum increase in length of stay for a single infection is three days.
- Conditions
- Surgical Wound Infection, Cystitis, Bacteremia, Pneumonia
- Trial name
- NCT00164099
- Testing
- Synbiotic 2000
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Beth Israel Medical Center
Coronary Disease, Cardiovascular Diseases
Prospective Russian Evaluation of Lp(a) Role in cardiovascUlar DiseasE
The purpose of this study is to explore the role of lipoprotein(a) and apolipoprotein(a) phenotype in fatal and non-fatal cardiovascular disease (CVD) events risk in coronary disease patients divided on the basis of management…
- Trial name
- PRELUDE (NCT02515747)
- Testing
- percutaneous coronary intervention, coronary artery bypass grafting
- Volunteers
- 1,400 people
- Sponsor
- Russian Cardiology Research and Production Center
Coronary Artery Bypass
Short-Stay Intensive Care for Coronary Artery Bypass Patients
Objective: To evaluate the safety and cost-effectiveness of Short Stay Intensive Care (SSIC) treatment for low-risk coronary artery bypass patients Design: Randomized clinical equivalence trial Setting: University Hospital…
- Trial name
- NCT00707044
- Testing
- Control group (usual care), Short-Stay Intensive Care treatment (SSIC)
- Where
- Netherlands
- Volunteers
- 597 people
- Sponsor
- Maastricht University Medical Center
Ischemic Cardiomyopathy, Heart Failure
Evaluation of Prophylactic Use of a Preoperative IABP in High-Risk Coronary Artery Bypass Graft Surgery
Background: The intra-aortic balloon balloon pump (IABP) has been used as a method of percutaneous circulatory assistance high surgical risk patients undergoing coronary artery bypass graft surgery (CABG); Although its…
- Trial name
- IABP-HR (NCT03857906)
- Testing
- Intra-Aortic Ballon Pump insertion
- Volunteers
- 129 people
- Sponsor
- CMN "20 de Noviembre"
Stress Hyperglycemia
Exenatide for Stress Hyperglycemia
Stress hyperglycemia is a common phenomenon in cardiac surgery that concerns diabetic and non diabetic patients. It has been shown that perioperative hyperglycemia is an independent risk factor of postoperative mortality and…
- Trial name
- ExSTRESS (NCT01969149)
- Testing
- Exenatide, Insulin
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Microcirculation, Fluid Therapy
Effects of Fluid Therapy on Microcirculatory Reactivity
Through preoperative fluid therapy, to investigate whether it can alleviate the microcirculation dysfunction after induction of anesthesia, and reduce the incidence of perioperative fluid therapy-related complications, thereby…
- Trial name
- NCT04982016
- Testing
- crystal therapy, colloid therapy
- Volunteers
- 126 people
- Sponsor
- Beijing Anzhen Hospital
Post Induction Hypotension
Comparing the Hemodynamic Effects of Volume Loading vs Non-loading During Induction of Anesthesia in Fluid Responder Patients With Coronary Artery Disease Undergoing Elective Coronary Artery Bypass Graft Surgery: a Randomized Controlled Study.
All preoperative cardiac medications will be continued till the morning of the surgery, except angiotensin converting enzyme inhibitors.
- Trial name
- NCT05462847
- Testing
- Ringer acetate
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Kasr El Aini Hospital
Coronary Artery Bypass Grafting, Remote Ischemic Conditioning
Safety and Efficacy of Remote Ischemic Conditioning for Patients Taking Off-pump Coronary Artery Bypass Grafting
Remote ischemic conditioning (RIC) is the process of repeated ischemia and reperfusion in the peripheral vessels, which is proved in reducing IRI in vital organs.
- Conditions
- Coronary Artery Bypass Grafting, Remote Ischemic Conditioning, Ischemia-Reperfusion Injury
- Trial name
- IMPROVE (NCT06141525)
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 648 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Pened Chest Surgery for Programmes Coronary Bypass
Mesenchymal Stem Cells: Alterations in Genome
The aim is to study small genetic alterations induced by cell culture in human mesenchymal stem cells in GMP condition.
- Trial name
- MESSAGE (NCT00836732)
- Testing
- harvest of a small bone marrow sample
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Nantes University Hospital
Degenerative Cardiac Valve Disease, Coronary Artery Bypass Surgery Patients
Rate of Microbial Colonization Over Native Calcified Cardiac Valves
The purpose of this observational, exploratory study in patients undergoing any cardiac valve replacement or repair is to assess the rate of bacterial colonization over native degenerative calcified cardiac valves.
- Trial name
- NCT01409525
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Rambam Health Care Campus
Coronary Artery Bypass Graft Surgery (CABG)
Investigation of the Effect of Nursing-Led Rehabilitation Interventions on Patient Care Outcomes in Patients Undergoing Coronary Artery Bypass Graft Surgery
Cardiovascular diseases are one of the leading causes of death globally. In addition to medical treatment and lifestyle changes, open heart surgery treatment also has an important place in the treatment of cardiovascular…
- Trial name
- CABG (NCT07838116)
- Testing
- The study aims to investigate the effects of nursing-led rehabilitative interventions in patients undergoing CABG surgery and to evaluate patient monitoring. It aims to determine the perceived stress
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Coronary Artery Disease
In-human Validation of a Technique for Measuring Central Aortic Hemodynamics With Peripheral Arterial Waveforms
Central aortic blood pressure (BP) and flow are generally more informative about the health condition of the heart and the arterial system compared with BP measured in peripheral locations (e.g. arm or leg).
- Trial name
- NCT01567748
- Testing
- BP Measurements at aorta, radial and femoral locations
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Coronary Artery Disease, Acute Myocardial Infarction
Beta Blocker De-prescription Following Coronary Artery Bypass Graft Surgery (BEEFBURGER Trial).
Beta-blockers have the greatest cardiovascular impact in patients with reduced heart function/heart failure and in reducing the peri-operative risk of atrial fibrillation.
- Conditions
- Coronary Artery Disease, Acute Myocardial Infarction, Coronary Artery Stenosis, ST Elevation Myocardial Infarction
- Trial name
- BEEFBURGER (NCT04788186)
- Testing
- De-prescribe beta blocker therapy
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Saskatchewan
Post-operative Atrial Fibrillation, CABG
Empagliflozin to Prevent Post-Operative Atrial Fibrillation
This is an interventional, double-blind, placebo controlled, multicenter, randomized clinical trial with allocation sequence concealment and blinded endpoint adjudication.
- Trial name
- EMPOAF (NCT06124937)
- Testing
- Empagliflozin 10 MG
- Where
- 2 sites in Iran
- Volunteers
- 492 people
- Sponsor
- Rajaie Cardiovascular Medical and Research Center
Ischemic Heart Disease
Optimum Platelet Inhibition After Coronary Bypass Surgery
To investigate the effect of different dosages of aspirin on platelet aggregation and to determine the possible mechanisms of aspirin resistance, we intend to compare the effects of low, medium dose aspirin with clopidogrel (an…
- Trial name
- NCT00262275
- Testing
- Aspirin, Clopidogrel
- Where
- United Kingdom
- Sponsor
- Papworth Hospital NHS Foundation Trust
Coronary Artery Bypass Grafting
Tissue Oxygenation During Heart Surgery
The goal of this study is to determine if off-pump CABG surgery is associated with better cerebral tissue oxygenation when compared with on-pump CABG.
- Trial name
- NCT01347827
- Testing
- measurements of brain tissue oxygenation
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
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