Clinical trials: Coronary Artery Bypass
Hemodynamic Instability
Effect of Remimazolam and Propofol on Hemodynamic Stability During Anesthesia Induction in OPCAB Patients
Remimazolam is a novel ultra-short-acting benzodiazepine. Several studies demonstrated that its efficacy as a sedative hypnotics for general anesthesia is non-inferior to propofol.
- Trial name
- NCT05423951
- Testing
- REMIMAZOLAM BESYLATE 2.5 Mg in 1 mL INTRAVENOUS INJECTION, POWDER, LYOPHILIZED, for SOLUTION [BYFAVO], Propofol, Rocuronium
- Where
- South Korea
- Volunteers
- 106 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease, Off-pump Coronary Artery Bypass
The Effects of Preoperative Aspirin on Graft Patency and Cardiac Events in Off-pump Coronary Artery Bypass
Antiplatelet therapy is critical in the management of coronary artery disease.For patients undergoing off-pump coronary artery bypass graft,controversy remains regarding the safety of preoperative antiplatelet therapy.And there…
- Conditions
- Coronary Artery Disease, Off-pump Coronary Artery Bypass, Aspirin
- Trial name
- NCT01268917
- Testing
- aspirin
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Coronary Artery Disease of Significant Bypass Graft, Coronary Syndrome
Implementation of Contemporary Coronary CT Angiography in Clinical Practice
Coronary CT angiography (CCTA) has been recognized as the first-line diagnostic test for most patients with suspected coronary syndrome, often acting as a gatekeeper for invasive coronary angiography.
- Conditions
- Coronary Artery Disease of Significant Bypass Graft, Coronary Syndrome, Coronary Arteriosclerosis
- Trial name
- CONCORDE (NCT06273033)
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Humanitas Hospital, Italy
Coronary Artery Disease
Secondary Prevention After Coronary Bypass Surgery
Despite immediate symptomatic success after coronary bypass surgery in patients with coronary artery disease, this effect is not sustained over time since risk factors for coronary artery disease are still in place.
- Trial name
- NCT00843089
- Testing
- Education
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Jeffrey Kramer, MD
Three Vessel Coronary Artery Disease
Association of Carotid Arterial Circumferential Strain With Left Ventricular Function and Hemodynamic Compromise During Off-pump Coronary Artery Bypass Surgery
This study is aimed to evaluate the association of common carotid artery circumferential strain with the echocardiographic parameters of left ventricular function and the degree of actual hemodynamic deterioration in patients…
- Trial name
- NCT01840969
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Yonsei University
Post Opeative Pulmonary Complication
The Effect of Acapella and Incentive Spirometry on Blood Gases and Peak Expiratory Flow Rate After Coronary Artery Bypass Graft.
The goal of this clinical trial is to learn if whether the Acapella and Incentive Spirometry have effect on Blood Gas and Peak Expiratory Flow Rate among patients undergoing Coronary Artery Bypass Graft Surgery.
- Trial name
- NCT07337746
- Testing
- Incentive Spirometry therapy, Acapella therapy
- Where
- 2 sites in Iraq
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Postoperative Cognitive Dysfunction
Correlation Between Markers of Neuronal Injury and Cognitive Dysfunction After Coronary Artery Bypass Surgery
This study aims to evaluate the possible Correlation Between Serum Levels of Markers of Neuronal Injury and Cognitive Dysfunction after Coronary Artery Bypass Surgery.
- Trial name
- NCT01550159
- Where
- Brazil
- Volunteers
- 88 people
- Sponsor
- Maria José Carvalho Carmona
Immunosuppression
Improvement of Postoperative Immunosuppression in Patients Receiving Coronary Artery Bypass Grafting by TEAS
The coronary artery bypass grafting (CABG) is a surgery to relieve angina and reduce mortality of coronary heart disease. However, the patient is more prone to have immunosuppression after the surgery, causing secondary…
- Trial name
- NCT02933996
- Testing
- TEAS+GA group
- Where
- China
- Volunteers
- 88 people
- Sponsor
- ShuGuang Hospital
Atrial Fibrillation
The Value of add-on Arrhythmia Surgery in Patients With Atrial Fibrillation Undergoing Cardiac Surgery
The hypothesis being studied is that add-on arrhythmia surgery in patients with atrial fibrillation (AF) undergoing valvular or coronary surgery improves quality of life, is cost-effective, reduces perioperative and long-term…
- Trial name
- NCT01019759
- Testing
- pulmonary vein isolation
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Maastricht University Medical Center
Coronary Artery Bypass
One-lung Ventilation During Internal Thoracic Artery Grafting in Cardiac Surgery
Coronary artery bypass grafting is a current cardiac surgery. Internal thoracic artery is usually taking to restore coronary revascularization, and its dissection can lead to accidental or voluntary pleural effusions.
- Trial name
- VUPPAM (NCT02823054)
- Testing
- EZ-Blocker
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Airway Ultrasound, Airway Edema
Cuff Pressure and Airway Edema in CABG With CPB
This study investigates how endotracheal tube (ETT) cuff pressure management during cardiopulmonary bypass (CPB) in coronary artery bypass grafting (CABG) affects upper airway edema.
- Conditions
- Airway Ultrasound, Airway Edema, Endotracheal Tube
- Trial name
- NCT07148024
- Testing
- ETT cuff pressure 0 mmHg, ETT cuff pressure 20-30 mmHg
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Engin Çetin
Coronary Graft Patency
Aspirin and Plavix Following Coronary Artery Bypass Grafting
The design of the study will be randomized, double blind trial, which will examine the effects of addition of clopidogrel to current guideline recommended background therapy on lowering the incidence of graft stenosis after…
- Trial name
- ASAP-CABG (NCT01158703)
- Testing
- clopidogrel, sugar pill, Aspirin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ahmad Slim
Three Vessel Coronary Disease
Long-Term Outcomes in Patients With Three-Vessel Disease
The long-term outcome of coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), and medical therapy (MT) alone for triple-vessel disease (TVD) patients is controversial.
- Trial name
- NCT05007054
- Testing
- PCI or CABG
- Where
- China
- Volunteers
- 4,300 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Coronary Artery Disease, Complication of Coronary Artery Bypass Graft
Negative Pressure Dressing After Saphenous Vein Harvest
This study will test the effectiveness of negative pressure wound therapy (using the VAC Prevena device, KCI Canada Inc.) applied to the saphenous vein harvest site after Coronary Artery Bypass Grafting (CABG).
- Conditions
- Coronary Artery Disease, Complication of Coronary Artery Bypass Graft, Wound Complication
- Trial name
- NCT01698372
- Testing
- Prevena device (Group A)
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of Calgary
Coronary Heart Disease
Efficacy and Safety of Aspirin Therapy With CABG
evaluate the safety of preoperative aspirin therapy when performing bypass surgery in conditions of artificial blood circulation
- Trial name
- NCT02942680
- Testing
- acetylsalicylic acid started for 24 hours before surgery, acetylsalicylic acid stayed for 5 days before surgery
- Where
- Russia
- Volunteers
- 350 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Coronary Artery Bypass Grafting, Postoperative Atrial Fibrilation
Apixaban Versus Warfarin for the Management of Post-operative Atrial Fibrillation
In this open-label, prospective, randomized pilot study, patients who develop atrial fibrillation after isolated coronary artery bypass grafting surgery will be identified.
- Conditions
- Coronary Artery Bypass Grafting, Postoperative Atrial Fibrilation, Stroke, Systemic Embolism
- Trial name
- NCT02889562
- Testing
- Apixaban, Warfarin
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Sanford Health
Cardiac Surgical Procedures, Coronary Artery Bypass
Treatment With 5-AminoLEvuliNic Acid Before Cardiac Surgery
TALEN is a prospective randomised double-blind placebo-controlled phase 2 study of 5-Aminolevulinic Acid with Sodium Ferrous Citrate (5-ALA-SFC) in adult patients undergoing cardiac surgery on cardiopulmonary bypass (CPB).
- Conditions
- Cardiac Surgical Procedures, Coronary Artery Bypass, Aortic Valve Disease, Mitral Valve Disease
- Trial name
- TALEN (NCT07027670)
- Testing
- 5-Aminolevulinic Acid hydrochloride (5-ALA), Sodium ferrous citrate (SFC)
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- University of Oxford
Videolaryngoscopy
Laryngoscopy and Coronary Artery Bypass Graft Surgery
In this prospective, randomized, controlled trial, the purpose is to compare Macintosh laryngoscope, EzVision® video laryngoscope, McGrath® video laryngoscope and Storz® video laryngoscope in terms of hemodynamic response…
- Trial name
- VL (NCT06349005)
- Testing
- Tracheal intubation using Storz VL, Tracheal intubation using Macintosh laryngoscopy, Tracheal intubation using MacGrath VL
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Konya Meram State Hospital
Acute Kidney Injury
Arterial Stiffness and AKI Post-CABG
Acute Kidney Injury is a condition where your kidneys suddenly stop working properly and usually occurs if you are already unwell with an illness and can happen after having surgery.
- Trial name
- Heart-AKI (NCT02364427)
- Testing
- Arterial stiffness - Vicorder to measure pulse wave velocity
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- King's College Hospital NHS Trust
Ischemic Heart Disease
Pulse Pressure Variation (PPV) to Predict Fluid Responsiveness During Cardiac Displacement in Patients Undergoing Off-pump Coronary Artery Bypass Surgery (OPCAB)
Pulse pressure variation (PPV) known as a dynamic preload index is increasingly being used for guide of fluid management under various clinical situations.
- Trial name
- NCT01041742
- Testing
- fluid loading
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Seoul National University Hospital
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