Clinical trials: Coronary Artery Bypass Surgery
Coronary Artery Disease, Angina Pectoris
Patient-Reported Preferences Affecting Revascularization Decisions
Selection of a treatment strategy for patients with symptoms due to coronary artery disease requires consideration of patient preferences.
- Trial name
- PREPARED (NCT02272062)
- Testing
- Decision-making tool for coronary artery disease treatment
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- Duke University
Thoracic Surgery, Postoperative Period
Efficacy of Triburter on Respiratory Muscle Function in Patients After CABG in Cardiac Rehabilitation Phase II
Post-surgery patients have muscle impairments, especially in the respiratory muscles, because the anesthesia, surgical incision, mechanical ventilation, pain, and prolonged postures, affect the mechanical condition of respiratory…
- Conditions
- Thoracic Surgery, Postoperative Period, Weakness, Muscle
- Trial name
- NCT05496049
- Testing
- Triburter, Incentive spirometry
- Where
- Colombia
- Volunteers
- 30 people
- Sponsor
- Fundación Cardiovascular de Colombia
Coronary Artery Disease
Initial Evaluation of Vascudyne Coronary Artery Bypass Conduit
The Vascudyne Coronary Artery Bypass Study (VCAB-1) is an initial safety and feasibility study of the Vascudyne, Inc. Coronary Artery Bypass Conduit (CAB A) for bypass of stenosed native coronary arteries in patients undergoing…
- Trial name
- VCAB-1 (NCT06434935)
- Testing
- CABA
- Where
- Paraguay
- Volunteers
- 5 people
- Sponsor
- Vascudyne, Inc.
Cardiac Surgery
Cardioprotective Effects of Endogenous Erythropoietin in Patients Undergoing Coronary Artery Bypass Surgery
Several studies have highlighted the cardioprotective effects of acute normovolemic hemodilution during cardiac surgery. The aim of our study is to show that an increase in endogenous erythropoietin (EPO) might explain the…
- Trial name
- NCT00854217
- Testing
- acute normovolemic hemodilution
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Chronic Coronary Occlusion, Unprotected Left Main Coronary Artery Disease
EXCEL Clinical Trial
To establish the safety and efficacy of the commercially approved XIENCE Family Stent System (inclusive of XIENCE PRIME, XIENCE V, XIENCE Xpedition and XIENCE PRO [for use outside the United States [OUS] only]) in subjects with…
- Conditions
- Chronic Coronary Occlusion, Unprotected Left Main Coronary Artery Disease, Stent Thrombosis, Vascular Disease
- Trial name
- EXCEL (NCT01205776)
- Testing
- Percutaneous Coronary Intervention, CABG
- Where
- United States
- Volunteers
- 1,905 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Bypass Grafting, Preoperative Anxiety
Nurse Navigation Programs Affect to Anxiety, Perception of Quality Nursing Care and Stress Hormone Levels
This study aims to evaluate the effect of a nurse-led preoperative navigation program on preoperative anxiety, perceived quality of perioperative nursing care, and serum cortisol levels in patients undergoing coronary artery…
- Trial name
- NCT07528989
- Testing
- Nursing navigation program
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Uludag University
Coronary Arteriosclerosis
Epicardial Echocardiography of Coronary Anastomoses Using the Echoclip Device
The aim of this study is to evaluate whether use of the echoclip device (an ultrasound transducer positioning device which can stabilize the involved part of the myocardium on the beating heart) facilitates imaging of coronary…
- Trial name
- NCT02919124
- Testing
- Echoclip
- Where
- Denmark
- Volunteers
- 56 people
- Sponsor
- Aalborg University Hospital
Leg Wound Complication After No-Touch Harvestingof Veins
Proximal Versus Distal Segments of No-Touch Saphenous Vein Grafts
The optimum segment of No-Touch veins for bypassing is still undefined. The purpose of this study is to assess the incidence of leg wound complication after No-Touch harvesting of proximal segment of saphenous veins compared to…
- Trial name
- NCT04284956
- Testing
- Proximal and distal segment of saphenous vein harvested by No-Touch technique
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China National Center for Cardiovascular Diseases
Cardiac Surgery, Coronary Artery Disease
Enhanced Recovery After Cardiac Surgery
Enhanced Recovery Protocols (ERPs or bundles) have been established in many surgical specialties (such as colon cancer and orthopaedic joint surgeries) for several years in hospitals worldwide.
- Conditions
- Cardiac Surgery, Coronary Artery Disease, Aortic Valve Disease, Mitral Valve Disease
- Trial name
- ERAS (NCT03859102)
- Testing
- Pre-operative Carbohydrate PreLoad drink, Oral Gabapentin pre-op, Oral Lansoprazole pre-op
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- James Cook University Hospital
Coronary Artery Disease
MOTIV Study- Effect of Antidepressive Treatment by Escitalopram in Patients Undergoing Coronary Artery Bypass Grafting
The purpose of this study is to determine the effect of an antidepressive medication (Escitalopram), started preoperatively and given during 6 months, on 6-month and 1 year post-operative morbidity and mortality after coronary…
- Trial name
- NCT00243477
- Testing
- Escitalopram
- Where
- France
- Volunteers
- 368 people
- Sponsor
- Hopital Jean Minjoz
Coronary Arterial Disease (CAD), Coronary Artery Bypass Graft (CABG)
Comparison of Oxygen Reserve Index and Spirometry in Predicting Respiratory Complications After Coronary Artery Bypass Surgery
Coronary artery disease (CAD) is one of the most common cardiac conditions, primarily caused by atherosclerosis. Studies have shown that environmental factors such as lifestyle, diet, genetics, and air pollution contribute to the…
- Conditions
- Coronary Arterial Disease (CAD), Coronary Artery Bypass Graft (CABG), Postoperative Pulmonary Complication
- Trial name
- NCT07063277
- Testing
- Preoperative Evaluation with ORI and Spirometry
- Where
- Turkey (Türkiye)
- Volunteers
- 142 people
- Sponsor
- Ankara Bilkent Sehir Hastanesi
Glycemic Control
Aggressive Versus Moderate Glycemic Control in Diabetic Coronary Bypass Patients
entGlycemic control has been found to improve clinical outcomes following Coronary Bypass Surgery. This study tests the hypothesis that obtaining tighter glycemic control(80-120mg/dl) as opposed to more moderate control…
- Trial name
- NCT00576394
- Testing
- IV Insulin drip, Insulin
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- American Heart Association
Heart Diseases, Coronary Artery Disease
Intraoperative Echocardiography in Low-Risk CABG Surgery
This goal of this study is to better understand when and where intraoperative transesophageal echocardiography (TEE) should (or should not) be used during coronary artery bypass graft (CABG) surgeries.
- Conditions
- Heart Diseases, Coronary Artery Disease, Chest Pain, Stenosis Coronary
- Trial name
- NCT06154265
- Testing
- TEE probe
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Hemorrhage
Tranexamic Acid, Hemorrhage and Transfusions After Combined Aortic Valve Replacement and Coronary Artery Bypass Surgery.
In this study we will investigate whether tranexamic acid given as an intravenous bolus injection before start of surgery, followed by a continuous infusion during surgery reduces, perioperative hemostatic activation, and…
- Trial name
- NCT00375466
- Testing
- Tranexamic acid
- Where
- Norway
- Volunteers
- 63 people
- Sponsor
- St. Olavs Hospital
Acute Coronary Syndrome
Effect of Glucose-insulin-potassium Solution on Myocardial Protection During Off-pump Coronary Bypass Surgery in Patients With Acute Coronary Syndrome
Patients undergoing multivessel off-pump coronary bypass surgery (OPCAB) inevitably experience cumulative ischemia-reperfusion injury at myocardium.
- Trial name
- NCT01384656
- Testing
- GIK solution
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Yonsei University
Coronary Artery Bypass Graft
Effect of Deep Breathing Exercises on Post Operative Sleep Duration
This study will provide the evidence that during the postoperative period deep breathing exercise combined with physical training can positively influence the sleep duration and quality.
- Trial name
- NCT05058222
- Testing
- Deep Breathing Exercise after every 3hrs, each session consists of 10 deep breaths Exercise, Deep Breathing Exercise after every 3hrs, each session consist of 30 deep breaths Exercise
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Riphah International University
Excessive Amount of Blood / Fluid Transfusion
Blood Transfusions in Coronary Artery Bypass Surgery
The hemolytic product free-hemoglobin (fHb) reduces nitric oxide (NO) bioavailability. The present study aims to establish whether transfusions of stored allogenic blood or intraoperative autologous salvaged blood result in…
- Trial name
- NCT02953951
- Testing
- blood transfusion
- Where
- Italy
- Volunteers
- 95 people
- Sponsor
- Universita di Verona
Complication of CABG
Effects of Cardiac Rehabilitation on Postoperatory of Coronary Artery Bypass Graft.
Randomized Clinical Trial to evaluate the use of different techniques of physical therapy on recovery of functional capacity, pulmonary function and respiratory muscle strength in the period of hospital stay after coronary artery…
- Trial name
- NCT01410253
- Testing
- Combination of four techniques of physiotherapy, Combination of three techniques of physiotherapy, Combination of two techniques of physiotherapy
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Blood Loss, Surgical
Efficacy Study of Recombinant Protein (Ecallantide) to Reduce Blood Loss During Primary Coronary Bypass Grafting or Valve Repair/Replacement
The primary objective of this study was to assess the efficacy and safety of 2 dose levels of ecallantide versus placebo in reducing blood loss following cardiopulmonary bypass (CPB), as measured by chest tube drainage during the…
- Trial name
- NCT00448864
- Testing
- Ecallantide
- Where
- 15 sites in United States
- Volunteers
- 75 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Increased Drug Resistance
Prevalence and Level of Thienopyridine Resistance Seen in a Contemporary Percutaneous Coronary Intervention or Coronary Artery Bypass Graft Population
The primary objective of this prospective clinical registry is to determine the prevalence and level of thienopyridine resistance seen in a population undergoing contemporary percutaneous coronary intervention (PCI) or coronary…
- Trial name
- VASP (NCT01408927)
- Testing
- Thienopyridine resistance testing, Aspirin resistance testing, Genetic polymorphism assessment
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Medstar Health Research Institute
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