Clinical trials: Coronary Artery Bypass Surgery
Coronary Artery Disease, Coronary Graft Stenosis
Effect of High-Intensity Interval Training Versus Home-Based Rehabilitation Program On Patients Underwent Coronary Artery Bypass Graft Surgery
1. To assess the effect of high-intensity interval training on peak metabolic equivalents in patients with coronary heart disease after the coronary artery bypass grafting surgery. 2.
- Trial name
- NCT07775742
- Testing
- High Intensity Interval Training program, home-based cardiac rehabilitation intervention, no intervention program
- Where
- Saudi Arabia
- Volunteers
- 84 people
- Sponsor
- Kafrelsheikh University
Cardiac Surgery, Heart Surgery
Safety and Performance Evaluation of CPB Venous and Arterial Cannulas
This is a two-phase study evaluating the Eurosets arterial and venous cannulas for use during cardiopulmonary bypass (CPB) procedures. Phase 1 is a pilot study focused on assessing cannula safety.
- Conditions
- Cardiac Surgery, Heart Surgery, Cardiopulmonary Bypass, Coronary Surgery
- Trial name
- NCT07354841
- Testing
- Eurosets Venous and Arterial Cannula, Control Arterial and Venous Cannulas
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Eurosets S.r.l.
Antiplatelet Therapy of Coronary Artery Bypass
A Single-center, Prospective,Randomized Study of Antiplatelet Effects of Ticagrelor Versus Clopidogrel in Patients With Dual Anti-platelet Therapy After Coronary Artery Bypass Grafting
This study is designed to demonstrate that the onset of the antiplatelet effect of 90mg bid dose ticagrelor is more rapid and greater than 75 mg qd dose clopidogrel in patients undergoing CABG surgery.
- Trial name
- ATCCC (NCT02330640)
- Testing
- ticagrelor, clopidogrel, asprin
- Where
- China
- Volunteers
- 137 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Off Pump Coronary Artery Bypass Surgery
Getinge's Beating Heart Product Family Post-Market Clinical Follow-up (PMCF) Study
This observational study aims to collect data on the performance and safety of Getinge's Beating Heart products used during open-heart coronary artery bypass graft surgery.
- Trial name
- NCT07286890
- Testing
- Vacuum Stabilizer System, Vacuum Positioner System, Blower/Mister
- Where
- 7 sites in United States, Germany and 1 more
- Volunteers
- 200 people
- Sponsor
- Maquet Cardiovascular
Microcirculation, Fluid Therapy
Effects of Fluid Therapy on Microcirculatory Reactivity
Through preoperative fluid therapy, to investigate whether it can alleviate the microcirculation dysfunction after induction of anesthesia, and reduce the incidence of perioperative fluid therapy-related complications, thereby…
- Trial name
- NCT04982016
- Testing
- crystal therapy, colloid therapy
- Volunteers
- 126 people
- Sponsor
- Beijing Anzhen Hospital
Erector Spinea Block in Open Heart Surgery
Continuous Erector Spinea Block Versus Intravenous Analgesia in Coronary Bypass Surgery
Adequate postoperative pain relief in patients in cardiac surgery is very essential. multimodal techniques for perioperative pain management post cardiac surgery include intravenous patient controlled analgesia, thoracic epidural…
- Trial name
- NCT03866733
- Testing
- continous erector spinea block, intravenous narcotics
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Postoperative Pain
Pecto-intercostal Fascial Plane Block for Postoperative Analgesia and Recovery Profile After Off-Pump Coronary Artery Bypass Surgery
Moderate to severe postoperative pain is usually encountered after cardiac surgery.Improper postoperative pain control could have multiple hemodynamic hazards in addition to prolonged postoperative ventilatory support and…
- Trial name
- NCT05774249
- Testing
- Ultrasound guided pecto-intercostal Fascial Plane Block using bupivacaine, Ultrasound guided pecto-intercostal Fascial Plane Block using normal saline
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Cardiac Surgical Procedures, Thoracic Surgical Procedures
Pulse Pressure Variation Measured During Valsalva Maneuver to Predict Fluid Responsiveness Under Open-chest Condition
Pulse pressure variation (PPV) is a well-known dynamic preload indicator to predict fluid responsiveness. However, its usefulness in open-chest conditions has been equivocal.
- Conditions
- Cardiac Surgical Procedures, Thoracic Surgical Procedures, Sternotomy
- Trial name
- NCT02457572
- Testing
- Valsalva maneuver, Fluid loading
- Where
- South Korea
- Volunteers
- 55 people
- Sponsor
- Samsung Medical Center
Postoperative Pain
Efficacy of Erector Spinae Plane Block in Caridac Surgery
Introduction: Opioid-based pharmacological treatment is frequently used in the treatment of pain after coronary artery bypass graft (CABG) surgery.
- Trial name
- NCT05312957
- Testing
- erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Coronary Artery Bypass Grafting, Postoperative Recovery
Artificial Intelligence-Supported Individualized Discharge Education After Coronary Artery Bypass Grafting
This randomized controlled trial aims to evaluate the effect of artificial intelligence-supported individualized discharge education on postoperative recovery in patients undergoing coronary artery bypass grafting.
- Trial name
- NCT07780994
- Testing
- Artificial Intelligence-Supported Individualized Discharge Education, Standard Discharge Education
- Volunteers
- 80 people
- Sponsor
- Izmir Katip Celebi University
Colchicine, Inflammation in Cardiac Surgery
Colchicine's Effect on Inflammatory Markers
This study wants to see if the medicine colchicine can help lower inflammation and reduce the chance of developing an irregular heartbeat (atrial fibrillation) after heart bypass surgery.
- Conditions
- Colchicine, Inflammation in Cardiac Surgery, Post Operative Atrial Fibrillation, Inflammatory Markers
- Trial name
- NCT07287345
- Testing
- Colchicine (Colcrys®)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ayesha Ather
CAD, Arrhythmia Ventricular
Adding Lidocaine to Custodiol Mixture
The Bretschneider solution, also known as Custodiol, has been widely used in open-heart surgery requiring cardiopulmonary bypass (CPB) since its introduction in 1970.
- Trial name
- NCT07205757
- Testing
- Lidocaine Hydrochloride, Custodiol Solution
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Fayoum University Hospital
Off Pump Coronary Artery Bypass Surgery
Heparin Resistance: Predictors and Outcomes
The investigators evaluated clinical impact of reduced heparin responsiveness (HRreduced) on the incidence of perioperative myocardial infarction (MI) and restenosis at 6 months after off-pump coronary artery bypass graft surgery…
- Trial name
- NCT01044888
- Testing
- Heparin
- Where
- South Korea
- Volunteers
- 199 people
- Sponsor
- Yonsei University
Coronary Artery Bypass Grafting
The Effect of Intranasally Administered Nitroglycerin on Hemodynamic Response to Laryngoscopy and Intubation Among Patients Undergoing Coronary Artery Bypass Grafting (CABG) Surgery
Numerous preventive medications have been used to lessen the cardiovascular response to laryngoscopy and intubation. Though some advantages have been noted, most of these treatments have not been found to be completely…
- Trial name
- NCT06637956
- Testing
- Nitroglycerin (NTG)
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- Muhammad Aamir Latif
Selenium Level
Effect of Heart-lung-machine on Selenium Status of Cardiac Surgical Patients Undergoing Coronary Bypass Surgery
Since selenium has demonstrated significant characteristics for a series of biochemical processes, for antioxidant activity and immune stimulation, this observational study should represent the effect of heart-lung-machine on…
- Trial name
- SEOPCAB (NCT01409057)
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- RWTH Aachen University
Anesthesia
Anesthesia and Lymphocytes Apoptosis
Most researches revealed that volatile anesthetic sevoflurane has a more marked cardioprotective effect against ischemia compared with intravenous agent propofol.However, propofol has been suggested to be more benefit for…
- Trial name
- OPCAB (NCT01461551)
- Testing
- Sevoflurane, Propofol, combine of sevoflurane and propofol
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Ruijin Hospital
Ischaemic Heart Disease
SheppHeartCABG - Phase One Rehabilitation After Coronary Artery Bypass Grafting
Background: Patients undergoing coronary artery bypass graft surgery often experience a range of problems and symptoms related to the procedure and the underlying heart disease.These problems include anxiety and depressive…
- Trial name
- SheppHeart (NCT02290262)
- Testing
- Comprehensive phase one rehabilitation
- Where
- Denmark
- Volunteers
- 326 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Artery Disease, Left Ventricular Cardiac Dysfunction
Clinical Outcome of Coronary Artery Bypass Graft Surgery Versus Percutaneous Coronary Intervention in Patients With Severe Left Ventricular Disfunction (CROWN)
The objective of this study is to evaluate the best treatment strategy in patients with critical coronary artery disease and severe left ventricular dysfunction.
- Trial name
- CROWN (NCT07817524)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Coronary Artery Disease, Valvular Heart Disease
Strategies for Revascularization in Patients Undergoing Heart Valve Surgery With Concomitant Coronary Artery Disease
The purpose of this study is to determine whether, in patients undergoing elective valvular heart surgery, revascularization of concomitant coronary artery disease (CAD) guided by FFR (Fractional flow reserve) would be superior…
- Trial name
- SAVE-IT (NCT02173860)
- Testing
- FFR-guided surgical revascularization, Angio-guided surgical revascularization
- Where
- Portugal
- Volunteers
- 502 people
- Sponsor
- Portuguese Society of Cardiology
Advanced Heart Failure, Ischemic Heart Failure
HiCM-188 Cell Therapy in Adults With Advanced Heart Failure Undergoing Heart Bypass Surgery
This clinical study will evaluate the safety and tolerability of HiCM-188, an investigational allogeneic induced pluripotent stem cell (iPSC)-derived cardiomyocyte therapy, in adults with advanced heart failure who are undergoing…
- Trial name
- NCT07646210
- Testing
- HiCM-188 Cells
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- HELP Therapeutics Co., Ltd.
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