Clinical trials: Coronary Artery Bypass Surgery
Myocardial Injury
Continuous Versus Repetitive Sevoflurane Administration for Preconditioning
Pharmacologic preconditioning by volatile anesthetics may depend on the mode of administration. The researchers hypothesize that a continuous administration in patients scheduled for CABG surgery prebypass will be less effective…
- Trial name
- NCT00569816
- Testing
- Sevoflurane
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Schleswig-Holstein
Ischemic Heart Disease
Stellate Ganglion Block Can Cause Enhanced Recovery After Coronary Arteries Bypass Grafting Surgery
The effects of SGB on the cardiovascular system remain controversial since the cardiac sympathetic nerves pass through the stellate ganglion.
- Trial name
- NCT04439058
- Testing
- ultrasound guided left stellate ganglion block
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- wail abdelaal
Coronary Artery Disease (CAD)
Phase III Study Comparing Two Methods of Cardioplegia in Coronary Artery Bypass Surgery
Comparison of the cardioprotective effects and safety of two cardioplegic solutions (solutions used during a cardiac arrest in the heart surgery) in patients undergoing cardiopulmonary bypass for coronary artery bypass surgery.
- Trial name
- NCT01444235
- Testing
- Custodiol-N, Custodiol
- Where
- 4 sites in Germany
- Volunteers
- 102 people
- Sponsor
- Dr. F. Köhler Chemie GmbH
Coronary Artery Disease
HCR vs. CABG Study
The purpose of the study is to find out if hybrid coronary revascularization (HCR) and coronary artery bypass grafting (CABG) procedure outcomes are similar.
- Trial name
- NCT02892474
- Testing
- Hybrid Coronary Revascularization (HCR), Coronary Artery Bypass Grafting (CABG)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Emory University
Myocardial Ischemia, Hypoxia
The Effect of Mechanical Ventilation on the Occurrence of Myocardial Ischemia: a Pilot Study
The goal of the proposed pilot study is to determine which method can detect myocardial ischemia at the predefined timepoints during endo-CABG.
- Trial name
- VENTMICS (NCT05109715)
- Testing
- Continued ventilation, Discontinued ventilation
- Where
- Belgium
- Volunteers
- 14 people
- Sponsor
- Jessa Hospital
Coronary Artery Disease
Vascular Function on the First Day After Cardiac Surgery
This study examines the flow mediated dilation (FMD) of the brachial artery before and after cardiac surgery. FMD is measured with ultrasound technique.
- Trial name
- NCT02001090
- Where
- Norway
- Volunteers
- 25 people
- Sponsor
- Norwegian University of Science and Technology
Prevention & Control
Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease
The primary objectives of this study are: To determine whether rivaroxaban 2.5 mg twice daily (bid) + aspirin 100 mg once daily (od) compared with aspirin 100 mg od reduces the risk of a composite of myocardial infarction…
- Trial name
- COMPASS (NCT01776424)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Aspirin, Pantoprazole
- Where
- 565 sites in United States, Argentina and 31 more
- Volunteers
- 27,395 people
- Sponsor
- Bayer
Coronary Artery Disease (CAD), Coronary Artery Bypass Graft Surgery (CABG)
Examining the Effects of Video-Assisted Discharge Education After Coronary Artery Bypass Graft Surgery on Patient Satisfaction and Anxiety
This study was conducted to examine the effects of standard and individualized video-assisted discharge education on patient satisfaction and anxiety levels following Coronary Artery Bypass Graft (CABG) surgery.
- Conditions
- Coronary Artery Disease (CAD), Coronary Artery Bypass Graft Surgery (CABG), Postoperative Discharge Education
- Trial name
- NCT07528859
- Testing
- video discharge education, individual video discharge training, discharge education
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Acute Kidney Injury
Effect of Sodium Bicarbonate on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass (OPCAB)
In this single-site, randomized, controlled and double-blind clinical trial, the investigators evaluate the effect of sodium bicarbonate on prevention of acute kidney injury in high risk patients undergoing off pump coronary…
- Trial name
- NCT01840241
- Testing
- sodium bicarbonate, normal saline
- Where
- South Korea
- Volunteers
- 162 people
- Sponsor
- Yonsei University
Coronary Artery Disease
A Prospective Randomized Study for Comparison of Y-Composite Grafts
The purpose of this study is to compare early and 1-year graft patency rates of saphenous vein composite grafts with those of right internal thoracic artery composite graft and mid-term clinical outcomes in patients who undergo…
- Trial name
- SAVERITA (NCT01051986)
- Testing
- saphenous vein composite grafting, right internal thoracic artery composite grafting
- Where
- South Korea
- Volunteers
- 224 people
- Sponsor
- Seoul National University Hospital
Cardiovascular Event, Coronary Artery Bypass Graft
Glycosylated Hemoglobin and Risk of Perioperative Major Cardiovascular Events in Diabetic Patients Undergoing Coronary Bypass Revascularization (HbA1c)
Glycosylated Hemoglobin (HbA1c) is considered as one of the best markers to assess the glycaemia treatment over a period of 3 to 4 months, and is considered as predictive marker for perioperative mortality and morbidity.
- Conditions
- Cardiovascular Event, Coronary Artery Bypass Graft, Diabetes Mellitus
- Trial name
- NCT03590223
- Testing
- Coronary Bypass Revascularization
- Where
- Switzerland
- Volunteers
- 589 people
- Sponsor
- University Hospital, Basel, Switzerland
Coronary Artery Bypass Surgery, Coronary Heart Disease
Clinical Study to Evaluate Nesiritide in Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery A014 / NAPA
The purpose of this study is to assess the effects of nesiritide compared to placebo when given with standard of care therapies, on kidney function, heart function and the need of other treatments in heart failure patients…
- Conditions
- Coronary Artery Bypass Surgery, Coronary Heart Disease, Coronary Artery Bypass Grafting, Cardiopulmonary Bypass
- Trial name
- NCT00653042
- Testing
- Nesiritide
- Volunteers
- 305 people
- Sponsor
- Scios, Inc.
Ischemic Heart Disease
Optimum Platelet Inhibition After Coronary Bypass Surgery
To investigate the effect of different dosages of aspirin on platelet aggregation and to determine the possible mechanisms of aspirin resistance, we intend to compare the effects of low, medium dose aspirin with clopidogrel (an…
- Trial name
- NCT00262275
- Testing
- Aspirin, Clopidogrel
- Where
- United Kingdom
- Sponsor
- Papworth Hospital NHS Foundation Trust
Respiratory, Postoperative Pain
The Effect of Pranayama on Pain and Respiration After Coronary Bypass Surgery
After CABG surgery, patients tend to breathe superficially because they experience pain while breathing. By restricting deep inspiration and cough; There is a decrease in lung tidal volume, vital capacity, and functional residual…
- Conditions
- Respiratory, Postoperative Pain, Nursing
- Trial name
- NCT06485531
- Testing
- Pranamaya, Pursed Lips Breathing
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Atrial Fibrillation New Onset
Combined Use of Dexmedetomidine and Hydrocortisone to Prevent New Onset AF After CABG Surgery
Atrial fibrillation (AF) occurs in 20% to 40% of patients after Coronary artery bypass grafting (CABG) and is associated with numerous detrimental sequelae.
- Trial name
- NCT05674253
- Testing
- Dexmedetomidine + Hydrocortisone
- Where
- Egypt
- Volunteers
- 248 people
- Sponsor
- Ain Shams University
Neurological Injury, Stroke
Carbon Dioxide Surgical Field Flooding and Aortic No-touch Off-pump Coronary Artery Bypass Grafting to Reduce Neurological Injuries After Surgical Coronary Revascularization (CANON): a Randomised, Controlled, Investigator and Patient Blinded Single Center Superiority Trial With Three Parallel Arms.
The objective of this study is to investigate the value of employing the aortic no-touch off-pump coronary artery bypass technique and the practice of carbon dioxide surgical field flooding for the prevention of type 1 and 2…
- Conditions
- Neurological Injury, Stroke, Postoperative Cognitive Dysfunction, Postoperative Delirium
- Trial name
- CANON (NCT03074604)
- Testing
- aortic no-touch OPCABG, OPCABG with partial clamp applying carbon dioxide, OPCABG with partial clamp
- Where
- Poland
- Volunteers
- 192 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Coronary Atherosclerotic Heart Disease
Relationship Between Apelin and New-onset Atrial Fibrillation After Coronary Artery Bypass Grafting
To investigate whether apelin can be used as an indicator to predict postoperative atrial fibrillation in patients with coronary atherosclerotic heart disease, and to provide an objective basis for the clinical selection of a…
- Trial name
- NCT02807532
- Testing
- atrial fibrillation, non-atrial fibrillation
- Volunteers
- 120 people
- Sponsor
- General Hospital of Shenyang Military Region
Coronary Artery Bypass
Enhancing Care Study in Patients After CABG
Review the data of patients who underwent coronary artery bypass grafting (CABG) at the National Center for Cardiovascular Disease, Fuwai Hospital from January 2013 to June 2023 including medical history, head CT scan, and…
- Trial name
- OptiCABG (NCT06488352)
- Where
- China
- Volunteers
- 40,000 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Unstable Angina, Coronary Artery Bypass Graft
Comparison Between Lidocaine, Dexmedetomidine, and Their Combined Infusion in Subjects Undergoing Coronary Artery Bypass Graft
The aim of the present study is to compare the antiarrhythmic and myocardial protective effect between lidocaine, dexmedetomidine, and their combined infusion in subjects undergoing coronary artery bypass graft.
- Conditions
- Unstable Angina, Coronary Artery Bypass Graft, Dexmedetomidine, Lidocaine
- Trial name
- NCT01688648
- Testing
- Lidocaine infusion, Dexmedetomidine infusion
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease
Topical Vancomycin in Prevention of Methicillin-Resistant Staphylococcal Related Mediastinitis in Patients Receiving Coronary Artery Bypass Graft
Sternal or mediastinal infections after heart operation occurs infrequently but carries a high cost in money, morbidity, and mortality.
- Trial name
- NCT00711685
- Testing
- coronary artery bypass grafting via midline sternotomy
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Far Eastern Memorial Hospital
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