Clinical trials: Coronary Artery Bypass Surgery
Coronary Artery Bypass, Myocardial Reperfusion Injur
Remote Ischemic Conditioning to Attenuate Myocardial Death and Improve Operative Outcome.
This study evaluates the addition of remote ischemic preconditioning and postconditioning to standard myocardial protection protocol in patients submitted to off - pump coronary artery bypass grafting in a prospective, 1:1…
- Conditions
- Coronary Artery Bypass, Myocardial Reperfusion Injur, Ischemic Preconditioning, Myocardial, Ischemic Postconditioning
- Trial name
- RICARDO (NCT03363958)
- Testing
- Remote Ischemic Preconditioning with Postconditioning
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Medinet Heart Centre
Heart Failure Due to Coronary Artery Disease
Optimizing Strategy of Coronary Revascularization in Patients With Multivessel Lesions Combined Heart Failure
As the end stage of almost all cardiovascular diseases, heart failure has become an increasingly common cause of cardiovascular morbidity and mortality worldwide.
- Trial name
- OSCRM-HF (NCT02775578)
- Testing
- Coronary Artery Bypass Grafting, Percutaneous Coronary Intervention, Hybrid Coronary Revascularization
- Where
- China
- Volunteers
- 525 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Hemodynamic Instability
Compare Hemodynamic Parameters of Propofol and Sevoflurane During CPB Time in Undergoing CABG to Avoid Lactate Level
Hemodynamic parameters and lactate level will be on CBP during CABG surgery patients.
- Trial name
- NCT05004545
- Testing
- Propofol
- Where
- Pakistan
- Volunteers
- 126 people
- Sponsor
- Chaudhry Pervaiz Elahi Institute of Cardiology
Coronary Artery Disease (CAD), Coronary Artery Bypass Graft Surgery(CABG)
A Clinical Trial To Investigate The Effect Of EA-230 On Hospital Length Of Stay In Patients With Coronary Artery Disease (CAD) Undergoing Coronary Artery Bypass Grafting (CABG) Surgery.
EA-230 is a new therapy that may help people recover faster and have fewer problems after bypass surgery. In an earlier clinical trial, participants who received EA-230 during Coronary Artery Bypass surgery stayed in the…
- Trial name
- EasyBoost (NCT07357675)
- Testing
- EA-230 90mg/kg/hour
- Where
- 6 sites in United States, Belgium and 2 more
- Volunteers
- 300 people
- Sponsor
- EBI Anti Sepsis BV
Coronary Artery Bypass, Off-Pump, Intraoperative Hypotension
Intraoperative Hypotension and Acute Kidney Injury After Off-pump Coronary Artery Bypass Grafting Surgery
Acute renal injury (AKI) is a common complication after cardiac surgery and is associated with worse outcomes. Hypotension is an important risk factor for the development of AKI after noncardiac surgery.
- Conditions
- Coronary Artery Bypass, Off-Pump, Intraoperative Hypotension, Acute Kidney Injury
- Trial name
- NCT03889730
- Where
- China
- Volunteers
- 821 people
- Sponsor
- Peking University First Hospital
Off Pump Coronary Artery Bypass Surgery
Tranexamic Acid in Off-pump Coronary Surgery
The aim of this prospective, randomized, double-blinded, placebo-controlled study was to evaluate the effects of tranexamic acid, a synthetic antifibrinolytic drug, on the postoperative bleeding and transfusion requirements in…
- Trial name
- TAOPCAB (NCT01064167)
- Testing
- Tranexamic Acid
- Where
- China
- Volunteers
- 231 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Cardiovascular, Coronary Artery Bypass
A Single-centre Study Comparing a Non-invasive Lactate Sensor to Standard Invasive Measurements in Patients Undergoing Coronary Artery Bypass Surgery.
The main goal of this study is to see how well a non-invasive lactate sensor measures lactate levels compared to standard blood tests.
- Conditions
- Cardiovascular, Coronary Artery Bypass, Valve Replacement
- Trial name
- CONTINUUM L (NCT06597253)
- Testing
- Lactate sensor
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Queen Mary University of London
Cardiac Disease, Surgery-Complications
One-year Patency Comparison Between Radial Artery and No-touch Saphenous Vein Grafts in Women Undergoing Isolated CABG
The use of a graft from the left internal thoracic artery to the left anterior descending artery has become the gold standard for the indication of coronary artery bypass grafting.
- Conditions
- Cardiac Disease, Surgery-Complications, Graft Failure
- Trial name
- QUEEN (NCT06179329)
- Testing
- Coronary artery bypass graft
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- University of Sao Paulo General Hospital
Coronary Artery Disease
Comparison of Two Methods of Strain by Perioperative Transesophageal Echo in CABG : An Observational Study
There is an increasing need for diagnostic modalities able to objectively quantify myocardial function. Quantification of regional myocardial function with ultrasound is challenging on its own.
- Trial name
- Strain (NCT02692131)
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Coronary Artery
Combination Effects of High-dose Statin and Trimetazidine on Patients With Aspirin Mono Antiplatelet Therapy 12-months After Coronary Artery Bypass Surgery
Trimetazidine is a metabolic agent without any negative inotropic or vasodilatory properties. In addition, previous reports showed that trimetazidine was effective in reducing intracoronary platelet aggregation and preventing…
- Trial name
- NCT01857921
- Testing
- Pravastatin 20mg/day for 12 months after randomization, Atorvastatin 40 mg and trimetazidine MR 70 mg/day for 12 months after randomization
- Where
- South Korea
- Volunteers
- 290 people
- Sponsor
- Yonsei University
Nerve Block, Coronary Artery Bypass
Comparison of Erector Spinae Plane Block and Transversus Thoracic Muscle Plane Block in Coronary Artery Surgery
The main objective of this study is to evaluate postoperative pain intensity comparatively between erector spinae plane block and transversus thoracic muscle plane block in patients undergoing open coronary artery surgery.
- Conditions
- Nerve Block, Coronary Artery Bypass, Anesthesia and Analgesia
- Trial name
- NCT06709625
- Testing
- Transversus thoracis plane block, Erector spina plane block (ESP)
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people
- Sponsor
- Ankara City Hospital Bilkent
Coronary Artery Bypass Grafting, Open Heart Surgery
Assessment of Platelet Function in Patients Undergoing Open Heart Surgery
The purpose of this external evaluation is to assess the system functionality and analytical performance of the Saturn Investigational Instrument (next generation VerifyNow instrument) and associated cartridge currently under…
- Conditions
- Coronary Artery Bypass Grafting, Open Heart Surgery, Aortic Surgery or Redo Surgery, On-pump Double or Triple Valve Procedures
- Trial name
- Saturn (NCT05441358)
- Testing
- Open Heart Surgery
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- LifeBridge Health
Right Ventricular Dysfunction, Stroke Volume Index
Relationship Between Strain and Stroke Volume in Cardiac Surgery
Patients undergoing coronary artery bypass grafting up tp 30% will develop postoperative right ventricle dysfunction. Its imperative for the physician to fully understand the severity of this complication in order to perform an…
- Conditions
- Right Ventricular Dysfunction, Stroke Volume Index, Longitudinal Heart Strain
- Trial name
- NCT04694378
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Tufts Medical Center
Incentive Spirometry, Oxygen Saturation
The Effects Incentive Spirometry Use in Coronary Artery Bypass Surgery
Background: Incentive spirometry is used in addition to care, especially in reducing pulmonary complications after surgery. Complications in the cardiovascular and pulmonary systems can basically be determined by blood values and…
- Trial name
- NCT05192785
- Testing
- Incentive Spirometry Group
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Moderate Ischemic Mitral Regurgitation
Surgical Strategies in Moderate Ischemic Mitral Insufficiency in Patients Undergoing Coronary Artery Bypass Graft
Ischemic mitral regurgitation (IMR) is a common complication of myocardial infarction, with a reported prevalence of 13-59%. Approximately one-third of these patients have at least moderate MR .
- Trial name
- NCT04279678
- Testing
- Mitral valve repair
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Coronary Artery Bypass Graft Surgery (CABG), Pain
Effect of Swedish Hand Massage on Pain in Patients Undergoing CABG Surgery
Coronary Artery Bypass Grafting (CABG) surgery is performed commonly today. Heart surgery performed on more than two million individuals every year leads patients experience severe postoperative pain for causes such as cutting of…
- Conditions
- Coronary Artery Bypass Graft Surgery (CABG), Pain, Pain Management, Nursing
- Trial name
- NCT06688617
- Testing
- Swedish Hand Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul University - Cerrahpasa
Atrial Fibrillation, Atrial Flutter
Response to RSD1235 Compared to Placebo in Subjects With Atrial Arrhythmia After Heart Surgery
The purpose of this study is to demonstrate the safety and efficacy of RSD1235 compared to placebo in the conversion of atrial arrhythmia to sinus rhythm in subjects following valvular and/or coronary artery bypass graft surgery.
- Trial name
- NCT00125320
- Testing
- RSD1235
- Where
- 22 sites in United States, Argentina and 4 more
- Volunteers
- 190 people
- Sponsor
- Astellas Pharma Inc
Coronary Disease, Aortic Valve Stenosis
Quantitative Measurement of Myocardial Perfusion by Cardiac CT in Patients
It is a common understanding that patients with coronary heart disease are suffering, among others, from reduced myocardial perfusion.
- Trial name
- CCT/MPERF (NCT02361996)
- Where
- 3 sites in Austria, Russia and 1 more
- Volunteers
- 690 people
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Cardiac Disease, Coronary Artery Bypass
Distraction Therapy Using Virtual Reality in Cardiac Rehabilitation
The European Society of Cardiology has been putting forward the need for new adjuncts or models that optimise outcomes from CR programmes.
- Trial name
- NCT06898827
- Testing
- IVR using the Morpheus Programme, Cardiac Rehabilitation control group
- Where
- Malta
- Volunteers
- 20 people
- Sponsor
- University of Malta
Coronary Artery Disease
Continued Ventilation During Cardiopulmonary Bypass
Cardiopulmonary bypass (CPB) is well known to induce a strong anti-inflammatory response. The investigators examined whether continued mechanical ventilation during CPB alters systemic immune activation.
- Trial name
- NCT01627756
- Testing
- Lung Ventilation, Non-ventilated Group
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
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