Clinical trials: Coronary Artery Spasm
Coronary Vasospasm
Effect of Glucose on Ocular Blood Flow
The primary objective is to assess the effect of glucose on retinal vascular diameter in otherwise healthy vasospastic subjects compared to non-vasospastic controls.
- Trial name
- NCT00350129
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Radial Artery Occlusion, Radial Artery Spasm
Radial Access Data in Vascular Interventions Registry
The RADIUS study is a prospective observational registry designed to collect real-world data regarding radial and ulnar artery access in percutaneous vascular interventions.
- Conditions
- Radial Artery Occlusion, Radial Artery Spasm, Vascular Access Complications, Coronary Artery Disease
- Trial name
- RADIUS (NCT07614386)
- Testing
- Radial and Ulnar Artery Access
- Where
- Turkey (Türkiye)
- Volunteers
- 20,000 people
- Sponsor
- Mersin Medicalpark Hastanesi
Radial Artery Spasm, Angina
Topical Nitroglycerine Treatment for Radial Artery Spasm Prevention
The primary objective of the study is to determine the role of transdermal vasodilators as an adjunct to parenteral vasodilators in reducing radial artery spasm, improving patient comfort, and post procedure radial artery patency…
- Conditions
- Radial Artery Spasm, Angina, Coronary Artery Disease
- Trial name
- TNT-RASP (NCT02832115)
- Testing
- Topical Nitroglycerine, Topical Lidocaine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Aultman Health Foundation
Coronary Vasospasm, Cardiac Death
Coronary Spasm Presenting Aborted Sudden Cardiac Death, the Multicenter Registry
The purpose of this study is to evaluate the natural course of coronary spasm patients presenting aborted sudden cardiac death and analyze risk factors.
- Trial name
- NCT02298543
- Testing
- coronary spasm
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seung-Jung Park
Coronary Vasospasm
The Effect of Nebivolol in Hypertensive Patients With Coronary Arterial Spasm
The correlation between endothelial dysfunction and the risk of coronary heart disease is well known through previous studies. The degradation of the function of nitric oxide acting on the endothelium of blood vessels is mainly…
- Trial name
- NCT03930433
- Testing
- Nebivolol, Diltiazem, Nebivolol+Diltiazem
- Where
- South Korea
- Volunteers
- 51 people
- Sponsor
- Korea University Anam Hospital
Internal Mammary Artery Syndrome, Vasodilation
Effect of Topically-applied Milrinone or Nitroglycerin on Internal Mammary Artery Free Flow
Forty-six consecutive patients undergoing elective primary coronary artery bypass grafting were enrolled. After the left IMA was harvested, free flow was measured under controlled hemodynamic conditions before any intervention…
- Trial name
- NCT06301880
- Testing
- The topical application of a vasodilator on the LIMA graft
- Where
- Syria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Damascus University
Coronary Spasm
Efficacy of Endothelin Receptor Antagonism in Coronary Artery Spasm
The goal of this randomized clinical trial is to assess if adjunctive bosentan therapy, in comparison to placebo, can reduce the rate of epicardial vasospasm at follow-up spasm provocation CFT (fuCFT) in patients with previously…
- Trial name
- EDIT-CAS (NCT06432452)
- Testing
- Endothelin Receptor Antagonist
- Where
- 4 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Sleep Apnea, Obstructive, Hypoxia
"Reversibility of Cardiovascular Injury With CPAP Use: Mechanisms Involved"
The purpose of this study is to determine the factors that are associated with improved cardiovascular function with the use of CPAP therapy on subjects diagnosed with moderate to severe obstructive sleep apnea.
- Conditions
- Sleep Apnea, Obstructive, Hypoxia, Hypercapnia, Sleep Disorders
- Trial name
- NCT01317329
- Testing
- Clinically prescribed CPAP therapy
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Wisconsin, Madison
Coronary Vasospasm, Coronary Microvascular Dysfunction
The NetherLands Registry of Invasive Coronary Vasomotor Function Testing (NL-CFT)
The goal of this registry is to collect data on patients referred for clinically indicated coronary vasomotor function test (CFT) and answer different questions on prevalence, safety and outcomes. The registry is observational.
- Conditions
- Coronary Vasospasm, Coronary Microvascular Dysfunction, Non-Obstructive Coronary Atherosclerosis
- Trial name
- NL-CFT (NCT06083155)
- Testing
- Coronary Function Test, Patient questionnaires
- Where
- 15 sites in Netherlands
- Volunteers
- 2,000 people
- Sponsor
- Radboud University Medical Center
Healthy
Determination of Variances in Exhaled Nitric Oxide Output in Normal Healthy Male Volunteers Consuming High and Low Nitrate/Nitrite Diets
This study will determine whether and how nitrites and nitrates in the diet affect the level of nitric oxide gas that is breathed out in air.
- Trial name
- NCT00027157
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Radial Artery Spasm
Nitrate Use to Obtain Radial Spasm Embarrassment (NURSE - TTS Trial)
Transradial cardiac catheterization and percutaneous coronary intervention are increasingly being performed worldwide in elective and emergency procedures, with many centres adopting the transradial route as their first choice of…
- Trial name
- NURSE-TTS (NCT04766151)
- Testing
- Transdermal glyceryl trinitrate 10mg patches
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- 424 General Military Hospital
Coronary Disease, Verapamil Toxicity
Is Verapamil In TransRadial Interventions OmittabLe?
Background Verapamil is traditionally applied prophylactically in transradial procedures to prevent radial artery spasm. However, verapamil may have side effects and is contraindicated in some clinical settings.
- Trial name
- VITRIOL (NCT01402427)
- Testing
- Verapamil
- Where
- Hungary
- Volunteers
- 591 people
- Sponsor
- State Health Center, Hungary
Coronary Vasospasm, Microvascular Angina
Abnormal Coronary Vasomotion in Patients With Suspected Coronary Artery Disease (CAD)
In patients with chest pain and/or shortness of breath coronary artery disease (CAD) is suspected depending on the pattern of symptoms and the electrocardiogram (ECG).
- Conditions
- Coronary Vasospasm, Microvascular Angina, Coronary Artery Disease
- Trial name
- ACOVA (NCT00921856)
- Testing
- Intracoronary acetylcholine provocation test
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Peter Ong, MD
Coronary Artery Disease
Uric Acid Levels and Endothelial Functions
Uric acid is a risk factor for coronary artery disease (CED) in postmenopausal women but the association with inflammation and coronary microvascular endothelial dysfunction is not well-defined.
- Trial name
- NCT02862522
- Testing
- Questionnaire of overall health
- Where
- United States
- Volunteers
- 229 people
- Sponsor
- Mayo Clinic
Angina, Stable, Coronary Vasospasm
CORonary MICrovascular Angina (CorMicA)
Angina is form of chest pain that is due to a lack of blood to the heart muscle. Angina is commonly triggered by stress and exertion, and is a common health problem worldwide.
- Conditions
- Angina, Stable, Coronary Vasospasm, Coronary Circulation, Coronary Syndrome
- Trial name
- CorMicA (NCT03193294)
- Testing
- Stratified medicine involving a diagnostic intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 151 people
- Sponsor
- NHS National Waiting Times Centre Board
Coronary Artery Disease (CAD), Obstructive Coronary Artery Disease
Comprehensive Invasive Physiological Evaluation of Obstructive Coronary Artery Disease
The goal of this clinical trial is to test whether adding coronary function testing and starting targeted medical treatment for identified vasomotor disorders will also improve angina symptoms and quality of life in patients with…
- Conditions
- Coronary Artery Disease (CAD), Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction (CMD), Vasospasm, Coronary
- Trial name
- NCT07449052
- Testing
- Coronary function testing, Percutaneous coronary intervention
- Volunteers
- 450 people
- Sponsor
- UMC Utrecht
Coronary Artery Spasm, Autonomic Dysfunction
The Effect of Autonomic Function on Coronary Vasomotion
Autonomic nerve function is involved in both blood pressure (BP) regulation and the pathogenesis of coronary artery spasm (CAS), but few studies have been published about the relationship between CAS and BP, with the exception of…
- Trial name
- NCT01877993
- Where
- 3 sites in South Korea
- Volunteers
- 2,169 people
- Sponsor
- Korea University
Coronary Arterial Disease (CAD), Radial Artery Spasm
Impact of Preprocedural Stress Ball Use on Radial Artery Outcomes in Elective Coronary Angiography
This randomized, double-blind, controlled trial aims to evaluate the effect of preprocedural hand exercise using a stress ball on the incidence of radial artery spasm and other vascular complications in patients undergoing…
- Conditions
- Coronary Arterial Disease (CAD), Radial Artery Spasm, Radial Artery Occlusion, Transradial Angiogram
- Trial name
- SPARROW (NCT07087522)
- Testing
- Stress Ball Use
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Sakarya University
Myocardial Infarction With Non-Obstructive Coronary Arteries
Prognostic Value of Precision Medicine in Patients With MINOCA (PROMISE Trial).
The aim of our study is to evaluate if the use of a precision-medicine approach with a specific therapy tailored on the underlying pathogenic mechanism will improve the quality-of-life in MINOCA patients.
- Trial name
- PROMISE (NCT05122780)
- Testing
- Coronary angiography, OCT imaging, Percutaneous coronary intervention (PCI):
- Where
- 3 sites in Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Coronary Atherosclerosis, Endothelial Dysfunction
Assessment of Coronary Plaque Composition
The investigators' hypothesis is that local activation of the endogenous Lipoprotein-associated phospholipase A2 (Lp-PLA2) plays an integral role in early atherosclerosis, and contributes to the mechanism of coronary endothelial…
- Conditions
- Coronary Atherosclerosis, Endothelial Dysfunction, Coronary Small Vessel Disease
- Trial name
- NCT01581632
- Testing
- LipiScan/LipiScan IVUS
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Mayo Clinic