Clinical trials: Coronary Artery Vasospasm
Coronary Vasospasm
Effect of Glucose on Ocular Blood Flow
The primary objective is to assess the effect of glucose on retinal vascular diameter in otherwise healthy vasospastic subjects compared to non-vasospastic controls.
- Trial name
- NCT00350129
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Coronary Artery Spasm, Hypertension
The Prevalence of Coronary Spasm in Hypertensive Patients Treated With Antihypertensive Medication
Autonomic nerve function is involved in both blood pressure (BP) regulation and the pathogenesis of coronary artery spasm(CAS), but few studies have been published about the relationship between CAS and effect of BP lowering…
- Trial name
- NCT01882790
- Where
- 3 sites in South Korea
- Volunteers
- 1,933 people
- Sponsor
- Korea University
Variant Angina
ANti-Oxidant in Variant Angina (ANOVA) Trial
Purpose Objectives 1. To evaluate the anti-oxidant effect of long-term Vitamin C+E therapy on coronary vasospasm improvement. 2. To evaluate the anti-oxidant effect of long-term statin therapy on coronary vasospasm improvement.
- Trial name
- NCT03228238
- Testing
- Vitamin C and Vitamin E, Statin, Standard medication for variant angina
- Where
- South Korea
- Volunteers
- 320 people
- Sponsor
- Seoul National University Hospital
Spasm
Noninvasive Cardiac Imaging in Vasospastic Angina Korean Registry (NAVIGATOR)
With regard to the characteristics of spasm segment, had been clearly described by other invasive imaging methods including intravascular ultrasound and optical coherence tomography.
- Trial name
- NAVIGATOR (NCT03570671)
- Testing
- Spasm positive, Spasm negative
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Dong-A University
Microvascular Angina, Microvascular Coronary Artery Disease
EUROpean Coronary microCirculatory Resistance and Absolute Flow Trial
Rationale: coronary microvascular disease is a relatively 'new' entity within the field of cardiology. The investigators are able to investigate the microcirculation by measurements performed in the catheterization laboratory.
- Conditions
- Microvascular Angina, Microvascular Coronary Artery Disease, Coronary Vasospasm, Microvascular Resistance
- Trial name
- EURO-ccraft (NCT04598308)
- Testing
- absolute flow and resistance measurements
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Angina Pectoris, Variant
Efficacy Study of Atorvastatin to Treat Variant Angina
The objective of this study is to evaluate effect of statin treatment for vasospastic angina.
- Trial name
- ESAVA (NCT00620204)
- Testing
- atorvastatin
- Where
- South Korea
- Volunteers
- 136 people
- Sponsor
- Samsung Medical Center
Angina Pectoris, Variant, Sudden Cardiac Death
Implantable Cardioverter Defibrillator Versus Optimal Medical Therapy In Patients With Variant Angina Manifesting as Aborted Sudden Cardiac Death
The purpose of this study is to determine whether ICD(Implantable Cardioverter Defibrillator) implantation on the top of optimal medical therapy in patients with variant angina manifesting as aborted sudden cardiac death reduces…
- Trial name
- VARIANT ICD (NCT02845531)
- Testing
- Implantable Cardioverter Defibrillator, Optimal Medical Therapy
- Where
- 26 sites in South Korea
- Volunteers
- 140 people
- Sponsor
- Kee-joon Choi
Coronary Artery Disease, Ischemic Heart Disease (IHD)
Gangwon PCI Prospective Registry
This prospective, multicenter registry will consecutively enroll patients of all ages undergoing percutaneous coronary intervention (PCI) at four university hospitals in Gangwon Province, Republic of Korea.
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease (IHD), Unstable Angina (UA), Non-ST Elevated Myocardial Infarction
- Trial name
- GWPCI (NCT02038127)
- Testing
- Percutaneous Coronary Intervention (PCI)
- Where
- 4 sites in South Korea
- Volunteers
- 10,000 people
- Sponsor
- Yonsei University
Coronary Atherosclerosis, Endothelial Dysfunction
Lp-PLA2 and Coronary Atherosclerosis in Humans
The majority of the acute coronary events are caused by coronary artery segments with minimal luminal disease, but with potentially significant vascular wall inflammation and oxidative stress leading to plaque vulnerability.
- Trial name
- AIM 1 and II (NCT01557088)
- Testing
- Blood sampling from the Coronary Sinus and Aorta, Intravascular Ultrasound of the coronary artery.
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- Mayo Clinic
Angina, Stable, Coronary Vasospasm
CORonary MICrovascular Angina (CorMicA)
Angina is form of chest pain that is due to a lack of blood to the heart muscle. Angina is commonly triggered by stress and exertion, and is a common health problem worldwide.
- Conditions
- Angina, Stable, Coronary Vasospasm, Coronary Circulation, Coronary Syndrome
- Trial name
- CorMicA (NCT03193294)
- Testing
- Stratified medicine involving a diagnostic intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 151 people
- Sponsor
- NHS National Waiting Times Centre Board
Coronary Artery Disease
Uric Acid Levels and Endothelial Functions
Uric acid is a risk factor for coronary artery disease (CED) in postmenopausal women but the association with inflammation and coronary microvascular endothelial dysfunction is not well-defined.
- Trial name
- NCT02862522
- Testing
- Questionnaire of overall health
- Where
- United States
- Volunteers
- 229 people
- Sponsor
- Mayo Clinic
Endothelial Dysfunction, Atherosclerosis
Blood Markers for Inflammation and Coronary Artery Vasoreactivity Testing in Patients With Chest Pain and Normal Coronary Arteries
The investigators are hoping to discover the cause of chest pain in patients with a normal coronary arteriogram. For patients with chest pain coronary angiography is the standard method by which the blood vessels of the heart can…
- Conditions
- Endothelial Dysfunction, Atherosclerosis, Inflammation, Myocardial Ischemia
- Trial name
- ACOVA (NCT01162824)
- Testing
- Acetylcholine, Adenosine
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- St George's Healthcare NHS Trust
Coronary Vasospasm
The Effect of Nebivolol in Hypertensive Patients With Coronary Arterial Spasm
The correlation between endothelial dysfunction and the risk of coronary heart disease is well known through previous studies. The degradation of the function of nitric oxide acting on the endothelium of blood vessels is mainly…
- Trial name
- NCT03930433
- Testing
- Nebivolol, Diltiazem, Nebivolol+Diltiazem
- Where
- South Korea
- Volunteers
- 51 people
- Sponsor
- Korea University Anam Hospital
Angina Pectoris, Variant
BVS Implantation in Patients With Variant Angina and MODerate Coronary Artery Disease
The purpose of this study is to determine whether BVS(Bioresorbable Vascular Scaffold) implantation with optimal medical therapy can improve the outcome of patients with variant angina and moderate coronary artery disease.
- Trial name
- BIVA-pilot (NCT02932553)
- Testing
- BVS+OMT
- Where
- South Korea
- Sponsor
- Seung-Jung Park
ANOCA, ANOCA - Angina With Non-obstructive Coronary Arteries
Comprehensive Coronary Physiology in Patients With Angina With Nonobstructive Coronary Arteries - Czech Republic
Coronary artery disease (CAD) is a leading cause of morbidity and mortality. While cardiologists have been focused on discrete, visible stenoses of coronary arteries, there is increasing awareness of the importance of…
- Conditions
- ANOCA, ANOCA - Angina With Non-obstructive Coronary Arteries, MINOCA, Microvascular Dysfunction
- Trial name
- CoroPhys-CZ (NCT07103317)
- Where
- Czechia
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Motol
Myocardial Ischemia, Non-Obstructive Coronary Atherosclerosis
Myocardial Ischemia Without Obstructive Coronary Stenoses
Coronary-related myocardial ischemia can result from obstructive epicardial stenosis or non-obstructive causes including coronary microcirculatory dysfunction and vasomotor disorders.
- Conditions
- Myocardial Ischemia, Non-Obstructive Coronary Atherosclerosis, Microvascular Coronary Artery Disease, Vasospastic Angina
- Trial name
- NCT04827498
- Testing
- Invasive coronary endothelium-dependent and non-endothelium-dependent physiological assessment
- Where
- Spain
- Volunteers
- 600 people
- Sponsor
- Hospital San Carlos, Madrid
Angina Pectoris, Variant, Angina Pectoris; Spasm-Induced
ReACHallenge Trial: Acetylcholine Rechallenge After Pretreatment With Vasoactive Drugs
The goal of this clinical trial is to assess the feasibility and clinical value of acetylcholine (ACH) rechallenge after intracoronary verapamil +- nitroglycerine in a patient cohort with angina and non-obstructive coronary…
- Conditions
- Angina Pectoris, Variant, Angina Pectoris; Spasm-Induced, Angina Pectoris With Normal Coronary Arteriogram
- Trial name
- ReACHallenge (NCT05618132)
- Testing
- Acetylcholine rechallenge
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University Hospital, Antwerp
Variant Angina
Evaluate the Efficacy and Safety of Pletaal (Cilostazol) in Subjects With Vasospastic Angina
The objective of this study is to investigate the efficacy and safety of Pletaal (Cilostazol) in comparison with placebo for 4 weeks in vasospastic angina patients who have an insufficient response to Amlodipine (Calcium channel…
- Trial name
- STELLA (NCT01444885)
- Where
- 10 sites in South Korea
- Volunteers
- 50 people
- Sponsor
- Korea Otsuka Pharmaceutical Co., Ltd.
Chronic Coronary Syndrome, Coronary Artery Disease
Advanced Invasive Diagnosis for Patients With Chronic Coronary Syndromes Undergoing Coronary ANGIOgraphy (AID-ANGIO)
AID-ANGIO is an observational, prospective, single arm, longitudinal study. Its objective is to investigate the diagnostic yield of the systematic use of a diagnostic strategy hierarchically addressing both obstructive and…
- Conditions
- Chronic Coronary Syndrome, Coronary Artery Disease, Microvascular Angina, Coronary Vasospasm
- Trial name
- AID-ANGIO (NCT05635994)
- Testing
- AID strategy
- Where
- 4 sites in Spain
- Volunteers
- 260 people
- Sponsor
- Hospital San Carlos, Madrid
Variant Angina
Cardioneuroablation for Variant Angina
Variant angina, also known as vasospastic angina, is a form of chest pain caused by temporary spasms of the coronary arteries, which reduce blood flow to the heart.
- Trial name
- NCT06992830
- Testing
- cardioneuroablation
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Zhibing Lu