Clinical trials: Coronary Atheroma
Type 2 Diabetes Mellitus, Coronary Artery Disease
Aspirin Dosing in Diabetic Patients
Since diabetic platelets are characterized by an enhanced turnover rate, it may be hypothesized that an increase in the frequency, rather than the dose, of drug administration may be a more effective strategy to inhibit platelet…
- Trial name
- NCT01201785
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Coronary Artery Disease
Portuguese Study on The Evaluation of FFR Guided Treatment of Coronary Disease
Functional evaluation of coronary lesions, through the evaluation of fractional flow reserve (FFR) with pressure-wire in patients with coronary artery disease (CAD) was evaluated in a randomised trial - the FAME trial - where it…
- Trial name
- POST-IT (NCT01835808)
- Testing
- Fractional flow reserve (St. Jude Medical pressure-wire)
- Where
- Portugal
- Volunteers
- 918 people
- Sponsor
- Portuguese Society of Cardiology
Coronary Artery Disease
Routine Angiography Follow-Up After Percutaneous Coronary Intervention in High-Risk Patients
Comparison of clinical outcomes between routine angiography follow-up and routine clinical follow-up after percutaneous coronary intervention in high-risk patients.
- Trial name
- NCT05923489
- Testing
- Routine Angiography Follow-up, Routine Clinical Follow-up
- Where
- China
- Volunteers
- 2,618 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Coronary Artery Disease, Stenosis
Clinical Usefulness of Fractional Flow Reserve Measurement for Significant Stenosis in Proximal Coronary Artery
Fractional flow reserve (FFR) is a pressure-wire-based index that is used during coronary angiography to assess the potential of a coronary stenosis to induce myocardial ischemia.
- Trial name
- NCT02475291
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- Yonsei University
HR Vaiability, Aerobic Physical Fitness,Blood Pressure, Blood Sugar Level, Blood HDL, LDL
Aerobic Exercise Training & the Autonomic System In Patients After Myocardial Infarction or Stroke
The purpose of this study is to examine the effect of Aerobic Physical Activity on the function of the Autonomic System in patients after Myocardial Infarction or Stroke.
- Trial name
- NCT00259948
- Testing
- Aerobic exercise training
- Where
- Israel
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Angioplasty, Transluminal, Percutaneous Coronary, Coronary Arteriosclerosis
ECLIPSE Feasibility Trial (Ensure's Vascular Closure Device Speeds Hemostasis Trial) EU
To assess the safety and feasibility of the 7F Ensure Medical Vascular Closure Devices to facilitate hemostasis in patients undergoing diagnostic or interventional procedures.
- Trial name
- ECLIPSE (NCT00574691)
- Testing
- 7F Ensure Medical Vascular Closure Device
- Where
- Germany
- Volunteers
- 93 people
- Sponsor
- Cordis US Corp.
Healthy, Diabetes Type 2
Assessment of Three Instruments for the Non-invasive Measurement of Arterial Stiffness.
The ASI Non-Invasive Arterial Stiffness Screening Device (ASI Device) is an investigational device under development for the non-invasive assessment of arterial stiffness.
- Conditions
- Healthy, Diabetes Type 2, Obesity, Coronary Artery Disease
- Trial name
- ASI-2012 (NCT01722474)
- Testing
- ASI Device
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Myocardial Infarction, Diastolic Dysfunction
Angiotensin-Neprilysin Inhibition in Diastolic Dysfunction After AMI
This study examines the effect of Entresto on central hemodynamic parameters during exercise in patients with diastolic dysfunction following acute myocardial infarction.
- Trial name
- ARNiAMI (NCT04149990)
- Testing
- Entresto Pill
- Where
- 2 sites in Denmark
- Volunteers
- 51 people
- Sponsor
- Jacob Moller
Coronary Artery Diseases
BIOFLOW-III UK Satellite Registry Orsiro Stent System
Clinical evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES). 500 subjects will be enrolled in this registry.
- Trial name
- NCT02257710
- Testing
- Orsiro
- Where
- 4 sites in United Kingdom
- Volunteers
- 500 people
- Sponsor
- Biotronik UK Ltd.
Coronary Artery Disease, Acute Coronary Syndrome
PET/CT for the Quantification of Atherosclerotic Plaque Inflammation
This is a single-centre prospective trial with 140 patients employing [18F]-fluorodeoxyglucose positron emission computed tomography (FDG PET/CT) and advance motion correction and image fusion algorithms to create motion frozen…
- Trial name
- QAEK (NCT01553513)
- Testing
- [18F]-FDG positron emission computed tomography, Invasive coronary angiography, Intravascular ultrasound and virtual histology
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Myocardial Infarction
Cangrelor in Acute Myocardial Infarction: Effectiveness and Outcomes Registry
The purpose of this registry is to address optimal platelet inhibition during the early management of MI patients prior to coronary angiography or CABG.
- Trial name
- CAMEO (NCT04076813)
- Where
- 11 sites in United States
- Volunteers
- 5,050 people
- Sponsor
- Chiesi USA, Inc.
Coronary Artery Disease (CAD), Bypass, Cardiopulmonary
Multivessel Minimally Invasive Coronary Bypass Grafting as HYBRID Revascularization Versus Conventional Off-pump Coronary Artery Bypass Grafting
The MICRA-HYBRID trial is a prospective, multicenter, randomized controlled study comparing multivessel hybrid coronary revascularization (HCR) as minimally invasive arterial bypass grafting to left-sided coronary targets (LAD…
- Conditions
- Coronary Artery Disease (CAD), Bypass, Cardiopulmonary, Minimally Invasive Coronary Revascularization Surgery, Off-pump Coronary Artery Bypass
- Trial name
- MICRA-HYBRID (NCT07314138)
- Testing
- Multivessel Hybrid Coronary Revascularization, Off-pump coronary arterial bypass grafting (OPCAB)
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Myocardial Infarction (MI)
Can Wearable Technology be Used to Predict Exercise Intensity
There is a knowledge gap in the literature around using watts to measure exercise intensity in walking and running, this is largely due to new technological developments.
- Trial name
- (CWTPEI) (NCT06871943)
- Testing
- Incremental Shuttle Walk Tests
- Volunteers
- 24 people
- Sponsor
- Keele University
Coronary Artery Disease, Coronary Restenosis
Absorb BVS vs. Drug Coated Balloon for Treatment Of ISR
AbsorbISR is a randomized, controlled trial, single center, prospective, not blinded to evaluate two strategies of in stent restenosis treatment: Implantation of drug eluting bioresorbable stent scaffold Absorb® vs.
- Trial name
- AbsorbISR (NCT02474485)
- Testing
- BVS Absorb implantation., DEB Sequent Please inflation., Control coronary angiography.
- Where
- Switzerland
- Volunteers
- 53 people
- Sponsor
- SIS Medical AG
Cardiovascular Diseases, Heart Diseases
Social Support and CHD Risk Factors--A Community Study
To examine the mechanism through which social support affects morbidity and mortality from coronary heart disease.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- NCT00005343
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Coronary Syndrome
Identification of Clopidogrel CYP2C19 Metabolizer and Thienopyridine Treatment After an Acute Coronary Syndrome
To demonstrate that a strategy of fast genetic testing performed in outpatient clinic allows to select adequately one of the 2 antiplatelet treatments approved in the same indication (ACS with PCI - prasugrel 10mg MD or…
- Trial name
- GAMMA (NCT01390974)
- Where
- France
- Volunteers
- 270 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ST Elevation Acute Myocardial Infarction
Cyclosporine and Prognosis in Acute Myocardial Infarction (MI) Patients
Infarct size is a major determinant of prognosis after Acute Myocardial Infarction (AMI). The investigators recently reported that cyclosporine A, when administered immediately prior to percutaneous coronary intervention (PCI)…
- Trial name
- CIRCUS (NCT01502774)
- Testing
- Injection of Cyclosporin, Echocardiography
- Where
- 45 sites in Belgium, France and 1 more
- Volunteers
- 970 people
- Sponsor
- Hospices Civils de Lyon
Coronary Artery Disease
Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation
Narrowing of coronary arteries interferes with blood flow and can cause chest pain. But patients may have more than one narrowing and studies have shown that not all narrowings need to be treated.
- Trial name
- DEFINE-FLAIR (NCT02053038)
- Testing
- iFR, FFR
- Where
- 50 sites in United States, Australia and 15 more
- Volunteers
- 2,500 people
- Sponsor
- Imperial College London
Coronary Artery Disease, Myocardial Ischemia
Regadenoson Combined With Symptom-Limited Exercise in Patients Undergoing Myocardial Perfusion Imaging
Not infrequently, a physician is faced with uncertainty regarding the ability of a patient to perform adequate exercise in the noninvasive evaluation of known or suspected coronary artery disease (CAD) by the use of radionuclide…
- Trial name
- NCT01021618
- Testing
- Regadenoson, Symptom-limited exercise
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Hartford Hospital
Myocardial Infarction, Myocardial Ischemia
18F-fluorocholine PET-MR Imaging of Coronary Plaque Vulnerability
This study is designed as a prospective observational feasibility study. The investigators will study whether vulnerable plaques on OCT (fibrous cap ≤ 70 μm) show a locally increased uptake of 18F-choline on PET-MRI compared to…
- Conditions
- Myocardial Infarction, Myocardial Ischemia, Atherosclerosis, Coronary Artery Disease
- Trial name
- NCT03252990
- Testing
- PET-MRI, Optical Coherence Tomography
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center