Clinical trials: Coronary Atherosclerosis
Acute Coronary Syndromes (ACS), Sleep Quality
Eye-Ear Sleep Band for Sleep Quality in Coronary Care Unit
Sleep disturbances are common in patients admitted to the coronary care unit (CCU), where continuous light, noise, and monitoring equipment disrupt normal sleep.
- Conditions
- Acute Coronary Syndromes (ACS), Sleep Quality, Sleep Deprivation
- Trial name
- EESQ-CCU (NCT07490743)
- Testing
- Eye-Ear Sleep Band, Standard CCU Care
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Koç University
Coronary Artery Disease, Inflammatory Response
Efficacy of Dexamethasone to Improve Clinical Outcomes in Coronary Artery Bypass Patients
This is a single-center, double-blind, randomized controlled clinical trial comparing four groups: placebo conventional coronary artery bypass graft (CCABG) group, dexamethasone CCABG group, placebo off-pump coronary artery…
- Trial name
- NCT05487508
- Testing
- Dexamethasone, Normal saline
- Where
- Indonesia
- Volunteers
- 120 people
- Sponsor
- Universitas Indonesia
Diabetes Mellitus
Sex Differences in the Risk of Cardiovascular Diseases Associated With Diabetes
To evaluate the risk of cardiovascular events associated with medication use for controlling blood glucose, blood pressure and cholesterol levels in men and women with diabetes treated in primary care
- Trial name
- NCT02542774
- Testing
- No intervention is given.
- Where
- United Kingdom
- Volunteers
- 80,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Myocardial Infarction, Arrhythmia, Ventricular
MASTER II - Microvolt T Wave Alternans Testing for Risk Stratification of Post MI Patients
The purpose of the study is to determine the usefulness of Microvolt T Wave Alternans (MTWA) testing of patients that have had a heart attack and have decreased pumping ability of the lower chamber of their heart.
- Conditions
- Myocardial Infarction, Arrhythmia, Ventricular, Ischemic Cardiomyopathy
- Trial name
- NCT00305214
- Testing
- T Wave Alternans Test
- Where
- 47 sites in United States
- Volunteers
- 405 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Depression, Coronary Artery Disease (CAD)
A Trial of Inflammatory Markers, Depressive Symptoms, and Heart Disease
The purpose of this study is to examine the relationship between depressive symptoms and markers of inflammation, two predictors of heart disease.
- Conditions
- Depression, Coronary Artery Disease (CAD), Acute Coronary Syndrome (ACS)
- Trial name
- CHIME (NCT00208117)
- Testing
- Sertraline (Zoloft), Simvastatin (Zocor)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Coronary Artery Disease
Inflammation and Coronary Endothelial Function
The investigators are studying whether anti-inflammatory agents can improve abnormal coronary artery function in patients with coronary artery disease (CAD) and abnormal coronary artery endothelial function.
- Trial name
- NCT02366091
- Testing
- Methotrexate, Colchicine
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Johns Hopkins University
Coronary Artery Disease
Drug-Coated Balloon in Combination With New Generation Drug-Eluting Stent in the Treatment of Long Diffuse Coronary Artery Disease
An observational study to evaluate safety and efficacy of the hybrid approach DES/DCB in the treatment of long diffuse de novo coronary artery disease
- Trial name
- HYPER II (NCT05650450)
- Testing
- DES+DCB
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Coronary Artery Disease
Exercise-induced High-sensitivity Troponin Levels as a Predictor for Obstructive Coronary Artery Disease
1. To compare hs-TnT levels after a cardiac stress test in patients with vs. patients without CAD 2. To assess the level of post-exercise hs-TnT predicting CAD (using ROC-analysis) 3.
- Trial name
- EUROCAD (NCT02626806)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Acute Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction
Proteomic Profiling of Coronary Thrombus in Acute Myocardial Infarction
ST-elevation myocardial infarction (STEMI) is mostly caused by the rupture or the erosion of a vulnerable atherosclerotic plaque, initiating with intraluminal thrombosis and resulting in total occlusion of the coronary artery.
- Trial name
- NCT03731884
- Testing
- Time from the onset of symptoms to PCI
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- G. d'Annunzio University
CaIMR, Prognosis
The Usefulness of CaIMR in Patients With STEMI
The coronary artery system is composed of three different types of blood vessels, namely epicardial arteries, arterioles and capillaries.
- Conditions
- CaIMR, Prognosis, ST-segment Elevation Myocardial Infarction
- Trial name
- NCT04984915
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Zhongnan Hospital
Cardiovascular Diseases
Atorvastatin Versus Simvastatin In The Prevention Of Coronary Heart Disease (CHD) In Patients With Known CHD
To investigate whether a long-term strategy to lower LDL cholesterol with atorvastatin as much as possible will improve prognosis in CHD patients compared with a strategy reflecting current best clinical practice with simvastatin.
- Trial name
- IDEAL (NCT00159835)
- Testing
- atorvastatin, simvastatin
- Where
- 194 sites in Denmark, Finland and 4 more
- Volunteers
- 8,600 people
- Sponsor
- Pfizer
Coronary Artery Disease, Type 2 Diabetes
Empagliflozin Versus Vildagliptin in CAD Patients With T2DM
We compared the cardioprotective effects of empagliflozin, an SGLT2 inhibitor, with those of vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, focusing on various inflammatory biomarkers lipid profile, and cardiac…
- Trial name
- NCT06313008
- Testing
- Empagliflozin 10 MG, Vildagliptin 50 MG
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Damanhour University
Platelet Aggregation, Platelet Transcriptome
Pharmacogenomics of Antiplatelet Response - I
This clinical trial is examining the role of genetic polymorphism on the effect of clopidogrel (with or without aspirin) on platelet response in persons at high-risk for myocardial infarction or stroke due to family history of…
- Conditions
- Platelet Aggregation, Platelet Transcriptome, Coronary Artery Disease
- Trial name
- PARes-I (NCT01815008)
- Testing
- Clopidogrel, Aspirin
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Johns Hopkins University
Coronary Artery Disease, Heart Diseases
Randomization of Single vs Multiple Arterial Grafts
The primary hypothesis of ROMA is that in patients undergoing primary isolated non-emergent coronary artery bypass surgery (CABG), the use of two or more arterial grafts compared to a single arterial graft is associated with a…
- Trial name
- ROMA (NCT03217006)
- Testing
- Single arterial graft, Multiple arterial grafting
- Where
- 59 sites in United States, Austria and 15 more
- Volunteers
- 4,300 people
- Sponsor
- Weill Medical College of Cornell University
Acute Coronary Syndrome
Effect of Pentoxifylline on Endothelial Dysfunction in Patients With Acute Coronary Syndrome
This study aims to investigate the effect of pentoxifylline administration on the status of endothelial function and oxidative stress biomarkers in patients with Acute Coronary Syndrome (ACS).
- Trial name
- NCT04367935
- Testing
- Pentoxifylline
- Where
- Egypt
- Volunteers
- 43 people
- Sponsor
- Ain Shams University
Coronary Artery Disease
CONTRAST (Can cONTrast Injection Better Approximate FFR compAred to Pure reSTing Physiology?)
The purpose of this study is to determine the diagnostic performances of iodine contrast medium and resting conditions to predict fractional flow reserve (FFR). Reference FFR will be measured using standard adenosine.
- Trial name
- CONTRAST (NCT02184117)
- Testing
- Adenosine, Contrast Media, Resting conditions
- Where
- 11 sites in United States, Belgium and 7 more
- Volunteers
- 763 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cardiovascular Diseases, Heart Diseases
Compliance in the Physicians' Health Study
To evaluate the relationships of compliance in taking aspirin or aspirin placebo with the risk of major cardiovascular endpoints, using data collected in the Physicians' Health Study.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Myocardial Infarction
- Trial name
- NCT00005404
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
HFrEF - Heart Failure With Reduced Ejection Fraction, Myocardial Infarction (MI)
Vericiguat for Heart Failure With Reduced Ejection Fraction After Myocardial Infarction
The effects of vericiguat on cardiac remodeling in patients with chronic stable heart failure after myocardial infarction have not been reported.
- Trial name
- HFrEF (NCT06717204)
- Testing
- Vericiguat Oral Tablet [Verquvo], Prescription Drugs
- Where
- 3 sites in China
- Volunteers
- 210 people
- Sponsor
- Qilu Hospital of Shandong University
Coronary Artery Disease, Optical Coherence Tomography
Effect of PCSK9 Inhibitors on Coronary Atherosclerotic Plaques Derived From Optical Coherence Tomography
The presence of coronary atherosclerotic vulnerable plaque significantly impacts the clinical outcomes of patients diagnosed with coronary artery disease (CAD).
- Trial name
- NCT06520904
- Testing
- PCSK9 inhibitor, Statin
- Where
- China
- Volunteers
- 396 people
- Sponsor
- First Affiliated Hospital of Xinjiang Medical University
Coronary Heart Disease
Questionnaires Assessing the Quality of Life of Patients Treated for Coronary Heart Disease
Cardiovascular disease remains the leading cause of death in Europe and worldwide. In 2014, they led to more than 4 million deaths in Europe, and coronary heart disease alone accounts for nearly 1.8 million deaths, or 20% of all…
- Trial name
- NCT03904589
- Testing
- Quality of Life assessment
- Where
- Belgium
- Volunteers
- 201 people
- Sponsor
- José Castro
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