Clinical trials: Coronary Atherosclerosis
Coronary Artery Disease
Pharmacodynamic Effects of Dabigatran in Patients on Dual Antiplatelet Therapy
Dual antiplatelet therapy consisting of aspirin and clopidogrel is the cornerstone of treatment for prevention of atherothrombotic events in patients with coronary artery disease (CAD) undergoing percutaneous coronary…
- Trial name
- NCT01852162
- Testing
- Dabigatran
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Florida
Ischemic Heart Disease
A Clinical Trial on No-touch Vein Graft (NT-graft) in Coronary Surgery
The primary objective in this study is to investigate if vein grafts harvested and implanted with the non-touch technique are superior to conventional vein graft technique with respect to mid-term patency, in patients undergoing…
- Trial name
- SWEDEGRAFT (NCT03501303)
- Testing
- No touch technique, Control technique
- Where
- 9 sites in Denmark, Sweden
- Volunteers
- 902 people
- Sponsor
- Uppsala University
Coronary Artery Disease
Remote Ischemic Postconditioning During Percutaneous Coronary Interventions
Angioplasty is a commonly performed procedure for treating blockage of the blood vessels in the heart. Although this procedure is usually successful, it is often accompanied by a small degree of damage to the heart (i.e., small…
- Trial name
- RIP-PCI (NCT00970827)
- Testing
- remote ischemic postconditioning
- Where
- Canada
- Volunteers
- 360 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Acute ST Segment Elevation Myocardial Infarction, Acute Myocardial Infarction
FLOW Evaluation to Guide Revascularization in Multi-vessel ST-elevation Myocardial Infarction
Although current guidelines recommend fractional flow reserve (FFR) to identify haemodynamically relevant coronary lesion(s) in stable patients when evidence of ischaemia is not available (Class I, Level of Evidence: A), no…
- Conditions
- Acute ST Segment Elevation Myocardial Infarction, Acute Myocardial Infarction, Multi Vessel Coronary Artery Disease
- Trial name
- FLOWER-MI (NCT02943954)
- Testing
- Angiography guided PCI, Fractional Flow Reserve (FFR)
- Where
- France
- Volunteers
- 1,170 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myocardial Infarction
Development and Validation of a Multimodal Artificial Intelligence Model for Early Prediction of Acute Myocardial Infarction
Acute myocardial infarction (AMI) remains a leading cause of mortality worldwide. Although early revascularization has markedly improved short-term outcomes, the incidence of major adverse cardiovascular events after the index…
- Trial name
- NCT07457320
- Testing
- Percutaneous coronary intervention
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Coronary Artery Disease, Coronary Artery Stenosis
Absorb IV Randomized Controlled Trial
ABSORB IV is a prospective, randomized (1:1, Absorb BVS to XIENCE), single-blind, multi-center study, registering approximately 2610 subjects from approximately 140 sites in the United States and outside the United States.
- Conditions
- Coronary Artery Disease, Coronary Artery Stenosis, Coronary Disease, Coronary Stenosis
- Trial name
- NCT02173379
- Testing
- Absorb BVS, XIENCE
- Where
- 120 sites in United States, Australia and 3 more
- Volunteers
- 2,604 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Disease
Switching From DAPT to Dual Pathway Inhibition With Low-dose Rivaroxaban in Adjunct to Aspirin in Patients With Coronary Artery Disease
Recent studies indicate that anti-factor-Xa inhibition with low-dose rivaroxaban may have a role in the reduction of ischemic recurrences in patients with atherosclerotic disease manifestations.
- Trial name
- SWAP-AC (NCT04006288)
- Testing
- Clopidogrel, Prasugrel, ticagrelor
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Florida
Coronary Artery Disease, Ischemic Heart Disease
Graft Patency of QFR-guided Versus Angio-guided Coronary Artery Bypass Grafting
Coronary artery bypass grafting(CABG) is the golden standard for severe coronary artery disease(CAD), the current surgery strategy is mainly based on coronary angiography(CAG), but many trials of PCI have shown that visually…
- Trial name
- NCT03770520
- Testing
- QFR-guided CABG, Angio-guided CABG
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease Acute Coronary Syndrome Myocardial Ischemia Plaque Characterization
The AIPLAQUE Study: An Artificial Intelligence-based Prospective Study to Analyze PLAQUE Using CCTA
This trial is a single-center, prospective, observational clinical study. All patients who have at least one coronary artery stenosis of 30%-90% in diameter ≥ 2mm confirmed by CCTA, and who are scheduled to undergo clinically…
- Trial name
- NCT05750082
- Testing
- CCTA CT-FR CAG OCT
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Harbin Medical University
Ischemic Heart Disease, Cardiac Valve Disease
Passive Leg Raising Test to Predict Hypotension During Induction of Anesthesia in Patients Undergoing Cardiac Surgery
Hypotension frequently occurs during anesthesia induction. Preload decrease by anesthetics was often considered as one of main causes for this hypotension. However, the studies on this topic have been lacking.
- Trial name
- NCT01144546
- Testing
- passive leg raising (45 degree leg elevation for 1-2 min)
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease, Chest Pain
Effects of Heart Imaging Radiation on DNA Double-Stranded Breaks in Blood Lymphocytes and Hair Follicle Cells
Purpose 1. To investigate the effects of cardiac imaging radiation on the induction of DNA double-strand breaks by enumerating gamma-H2AX foci in blood lymphocytes and plucked hair follicle cells. 2.
- Trial name
- NCT02617888
- Testing
- CCTA ~ BREAST SHIELDS
- Volunteers
- 228 people
- Sponsor
- Walter Reed National Military Medical Center
Coronary Artery Disease
Study of the Safety and Efficacy of Apadenoson for Detection of Myocardial Perfusion Defects Using SPECT MPI
The purpose of this study is to see whether apadenoson is as effective as adenosine when used as a pharmacological stress agent in myocardial SPECT-Imaging to detect defects in the supply of blood to the heart muscle (myocardial…
- Trial name
- ASPECT (NCT00990327)
- Testing
- Apadenoson SPECT-MPI, Adenosine SPECT-MPI
- Where
- 122 sites in United States, Brazil
- Volunteers
- 863 people
- Sponsor
- Forest Laboratories
Acute Coronary Syndrome
A Web-Based Tailored Nursing Intervention to Increase Walking in Patients After an Acute Coronary Syndrome
Acute coronary syndromes (ACS) are one of the leading causes of coronary artery disease mortality, and among the top reasons for health care utilization in Canada.
- Trial name
- NCT02617641
- Testing
- TAVIEenM@RCHE, Publicly available websites
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Montreal Heart Institute
ST Elevation (STEMI) Myocardial Infarction of Other Sites, Repolarization Indices
Relation of Total Ischemic Time to Repolarization Indices and Their Impact on Outcomes Among STEMI Patients Undergoing Primary PCI
1. Evaluate The impact of early versus late presentation on electrocardiographic ventricular repolarization indices. 2. To assess the association between repolarization indices among early, late presentation in relation to…
- Conditions
- ST Elevation (STEMI) Myocardial Infarction of Other Sites, Repolarization Indices, Total Ischemic Time, Primary Percutaneous Coronary Intervention
- Trial name
- NCT07175259
- Testing
- Echocardiography
- Volunteers
- 500 people
- Sponsor
- Assiut University
Stable Angina
Efficacy and Safety of Monocordil Manufactured by Laboratórios Baldacci
Phase III clinical study for the evaluation of clinic and cardiologic effects of isosorbide mononitrate from the incidence of events (angina episodes). This is an open, comparative, monocentric trial.
- Trial name
- NCT02152579
- Testing
- Isosorbide-5-mononitrate
- Where
- Brazil
- Volunteers
- 86 people
- Sponsor
- Laboratórios Baldacci S.A
Coronary Artery Disease
Relation Between Lymphocyte-to-C-Reactive Protein Ratio and Coronary Artery Disease Complexity
Aim(s) of the Research : 1. To assess the relationship between the lymphocyte-to-CRP ratio and CAD complexity as assessed by Syntax score in both emergency (STEMI patients undergoing PPCI) and elective settings (patients…
- Trial name
- NCT06958562
- Testing
- No intervention administered. Standard care will be provided. Blood samples for lymphocyte count and CRP will be collected, and Syntax score will be calculated from angiography.
- Volunteers
- 600 people
- Sponsor
- Assiut University
Coronary Disease
"L-Sandwich" Strategy in the True Coronary Bifurcation Lesions
The treatment of coronary bifurcation lesions continue to remain challenges. Due to the complexity of the anatomical structure and the limitations of imaging, there are poor attachment and under-expansion of the stent at the…
- Trial name
- L-Sandwich (NCT04753827)
- Testing
- Drug eluting stent, Durg coated balloon
- Where
- China
- Volunteers
- 107 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
ST Segment Elevation Myocardial Infarction
ST Segment Resolution After Primary Percutaneous Coronary Intervention.
To compare the ST segment resolution after primary percutaneous coronary intervention (PPCI) with and without thrombus aspiration in patients with ST segment elevation myocardial infarction as ST segment resolution is the best…
- Trial name
- STresolution (NCT03895983)
- Testing
- Percutaneous primary coronary intervention
- Volunteers
- 270 people
- Sponsor
- Assiut University
Coronary Artery Diseases, Multivessel Coronary Artery Disease
SYNTAX III REVOLUTION Trial: A Randomized Study Investigating the Use of CT Scan and Angiography of the Heart to Help the Doctors Decide Which Method is the Best to Improve Blood Supply to the Heart in Patients With Complex Coronary Artery Disease
The SYNTAX III Revolution trial is a randomized diagnostic research study that investigates the use of CT scan and angiogram of the heart to help doctors decide which method is the best to improve blood supply to the heart in…
- Conditions
- Coronary Artery Diseases, Multivessel Coronary Artery Disease, Heart Diseases, Cardiovascular Diseases
- Trial name
- SYNTAX III (NCT02813473)
- Testing
- Coronary Angiography, Computed Tomography (CT) scan
- Where
- 6 sites in Belgium, France and 3 more
- Volunteers
- 223 people
- Sponsor
- ECRI bv
Acute Coronary Syndrome
Clinical Study on the Intervention of Xuesaitong Soft Capsules in Post-Intervention Patients with Acute Coronary Syndrome and Clinical Research Protocol
To assess the effects of Xuesaitong soft capsules on platelet function, clinical efficacy, prognosis, and safety in the treatment of acute coronary syndrome, 400 patients with acute coronary syndrome who underwent PCI were…
- Trial name
- NCT06845254
- Testing
- Xuesaitong soft capsule (main ingredient is Panax notoginseng saponins)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
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