Clinical trials: Coronary Bifurcations
Coronary Artery Disease, Coronary Artery Disease (Left Main)
µQFR for Branch Stenosis After Single Stent in Bifurcation Lesions
Murray-law based single-view quantitative flow ratio (µQFR) has been recommended for guiding percutaneous coronary intervention (PCI) in selective patients.
- Conditions
- Coronary Artery Disease, Coronary Artery Disease (Left Main), Obstructive Coronary Artery Disease, Stent Implantation
- Trial name
- NCT07116083
- Where
- China
- Volunteers
- 290 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Artery Disease
BiOSS LIM C vs 2nd Generation DES in Non-LM Bifurcations
Coronary bifurcations are encountered in about 15 - 20% of percutaneous coronary interventions (PCI). They are considered technically challenging and associated with worse clinical outcomes than non-bifurcation lesions.
- Trial name
- POLBOS 3 (NCT03548272)
- Testing
- Percutaneous Coronary Intervention with stent implantation
- Where
- Poland
- Volunteers
- 518 people
- Sponsor
- Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland
Coronary Artery Disease
Nordic Bifurcation Study. How to Use Drug Eluting Stents (DES) in Bifurcation Lesions?
How to use drug eluting stents (DES) in bifurcation lesions. A strategy of routine stenting of both main vessel and side branch versus a strategy of routine main vessel stenting and optional treatment of side branch.
- Trial name
- BIFI (NCT00376571)
- Testing
- Percutaneous coronary intervention
- Where
- Denmark
- Volunteers
- 413 people
- Sponsor
- Aarhus University Hospital Skejby
Coronary Artery Disease
The COMPLETE Treatment of Bifurcation With Two-stent Techniques: Randomized Comparison of Crush Versus Culotte Technique
In this COMPLETE randomized trial, using the contemporary second-generation drug-eluting stent, we aimed to test whether the crush technique is superior to the culotte technique for the treatment of bifurcation lesions in terms…
- Trial name
- COMPLETE (NCT05488665)
- Testing
- Crush technique, Culotte technique
- Where
- South Korea
- Volunteers
- 512 people
- Sponsor
- Yonsei University
Coronary Artery Disease
Balloon-Stent Kissing Technique Versus Jailed Wire Technique for the Coronary Bifurcation Lesions
To compare the immediate and long-term clinical outcomes between Balloon-Stent Kissing Technique (BSKT) and Jailed Wire Technique (JWT) for the interventional treatment of coronary bifurcation lesions.
- Trial name
- NCT03429634
- Testing
- Balloon-Stent Kissing technique, Jailed Wire technique
- Where
- China
- Volunteers
- 89 people
- Sponsor
- Dalian University
Coronary Disease
Clinical Trial on Safety and Efficacy of Drug-coated Balloon in Treatment of Coronary Bifurcation Lesions
The objective of this study is to evaluate the safety and efficacy of paclitaxel-coated balloon in treatment of coronary bifurcation lesions.
- Trial name
- BJDCB-BIF (NCT03223974)
- Testing
- Paclitaxel DCB, DES
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing Hospital
Coronary Artery Disease, Coronary Bifurcation Lesion
Bifurcation PCI With a Hybrid Strategy With Drug Eluting Balloons Versus a Stepwise Provisional Two-stent Strategy
The optimal treatment of coronary bifurcation lesions is complex and remains subject of current research. There is ongoing debate about the optimal strategy for bifurcations with upfront two-stent strategy or provisional…
- Trial name
- Hybrid DEB (NCT05731687)
- Testing
- Hybrid DEB approach with drug-eluting balloon, Two-stent strategy
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Cathreine BV
Coronary Bifurcation Lesion, Coronary Artery Disease (CAD)
Crossover vs Accurate Ostial PCI for Medina 0.0.1 and 0.1.0 Left Main Bifurcation Lesions
Coronary artery disease is a leading cause of mortality and morbidity globally. The left coronary artery system is critically important due to its supply of a large area of myocardium.
- Conditions
- Coronary Bifurcation Lesion, Coronary Artery Disease (CAD), Left Main Coronary Artery Stenosis
- Trial name
- NCT07596706
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- Istanbul Mehmet Akif Ersoy Educational and Training Hospital
Coronary Artery Disease, Bifurcation Lesion
Using 3D Imaging to Optimize Bifurcation Stenting
The primary purpose of this study is to determine whether bifurcation stenting guided by on-line three-dimensional optical frequency domain imaging (3D-OFDI) is superior to that with angiographic guidance by measuring incomplete…
- Trial name
- NCT02972489
- Testing
- 3D OFDI guidance arm, Angio guidance arm
- Where
- 2 sites in Japan, Netherlands
- Volunteers
- 106 people
- Sponsor
- Increase Co., Ltd.
Coronary Artery Disease
DK Nano-Culotte Stenting For Coronary Bifurcation Lesion
True coronary bifurcation lesions are still great of interest due to their complex anatomy, uncertainty of optimal stenting strategy and increased adverse cardiovascular outcomes.
- Trial name
- NCT05406284
- Testing
- double kissing nano culotte stenting
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Istanbul Mehmet Akif Ersoy Educational and Training Hospital
Coronary Artery Disease
IVUS-guided DK Crush Stenting Technique for Patients With Complex Bifurcation Lesions
This study is designed to investigate whether IVUS-guided DK crush stenting technique compared to angiography-guided DK crush after the indexed procedure will lead to lower rates of the composite endpoint of target vessel failure…
- Trial name
- DKCRUSH-VIII (NCT03770650)
- Testing
- Stenting
- Where
- China
- Volunteers
- 556 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Ischemic Heart Disease
Comparison Between Everolimus-eluting Stent (EES) and Sirolimus-eluting Stent (SES) in the Bifurcation Lesion
In study-1, the purpose of this study is to compare the long-term outcome of provisional stenting between EES and SES deployment.
- Trial name
- J-REVERSE (NCT01266239)
- Testing
- kissing balloon inflation, EES vs. SES
- Where
- 5 sites in Japan
- Volunteers
- 300 people
- Sponsor
- Shin Yukuhashi Hospital
Coronary Artery Disease
Double Rewire Versus Double Kissing Crush Stenting Technique in Left Main Bifurcation Lesions
The DR vs DK trial is designed to elucidate the benefits of Double Rewire crush technique (DR-Crush) over Double Kissing Crush (DK-Crush) technique in patients with Unprotected Left Main Bifurcation lesions (ULMb).
- Trial name
- DR vs DK crush (NCT05258318)
- Testing
- DK crush, DR crush
- Sponsor
- Fundación EPIC
Coronary Artery Disease, Ischemic Heart Disease
Comparison of PROVISIONal 1-stent Strategy with DEB Versus Planned 2-stent Strategy in Coronary Bifurcation Lesions.
[The Purpose of the Clinical Study] The purpose of this randomized comparison study is to compare the 1-stent strategy with a drug-eluting balloon and the 2-stent strategy in patients with non-LM coronary true-bifurcation…
- Trial name
- PROVISIONDEB (NCT06002932)
- Testing
- Procedure: planed 2-stent strategy, Procedure: provisional 1-stent plus DEB strategy
- Where
- South Korea
- Volunteers
- 750 people
- Sponsor
- Saint Vincent's Hospital, Korea
Coronary Artery Disease, Coronary Artery Disease (Left Main)
Optimization of Complex Percutaneous Coronary Intervention With Liberal Use of Intracoronary Imaging Versus Contemporary Practice
Coronary artery disease remains a leading cause of mortality worldwide and is commonly treated with percutaneous coronary intervention (PCI). Typically, PCI is guided by invasive coronary angiography (ICA).
- Conditions
- Coronary Artery Disease, Coronary Artery Disease (Left Main), Chronic Total Occlusion (CTO), Bifurcation Coronary Artery Disease
- Trial name
- OPTIMIZE-PCI 2 (NCT07114393)
- Testing
- Liberal use of intracoronary imaging during complex PCI
- Where
- Netherlands
- Volunteers
- 11,092 people
- Sponsor
- Cathreine BV
Coronary Disease
Safety and Efficacy Study of the Nile PAX Drug-Eluting Coronary Bifurcation Stent
The purpose of this trial is to assess the safety and efficacy of the Nile PAX® Drug Eluting Coronary Bifurcation Stent System for the treatment of single de novo bifurcation lesions in native coronary arteries with a main branch…
- Trial name
- BIPAX (NCT01308229)
- Testing
- Nile PAX® paclitaxel-eluting coronary stent
- Where
- 10 sites in Brazil, Bulgaria and 5 more
- Volunteers
- 102 people
- Sponsor
- MINVASYS
Coronary Artery Disease
Trans-Radial Coronary Interventions Using A Sheathless Guiding Catheter
Background: The transradial approach is increasingly used in percutaneous coronary intervention (PCI) because of lower major access site complications, lower bleeding risk and earlier patient mobilization.
- Trial name
- Sheathless-TRI (NCT01327365)
- Testing
- trans-radial PCI (TRI)
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- University Hospital, Geneva
Percutaneous Coronary Intervention
The Safety and Efficacy of DIOR Balloon in Coronary Bifurcation Lesions
To evaluate the safety and effectiveness of paclitaxel-eluting coronary artery balloon dilation catheter (DIOR) in revascularization of coronary bifurcation lesions compared with paclitaxel-eluting balloon (Bingo), and to provide…
- Trial name
- BEYOND-II (NCT03820622)
- Testing
- Paclitaxel-Eluting Coronary Balloon Dilation Catheter (DIOR), Paclitaxel-Eluting Balloon (Bingo)
- Where
- 13 sites in China
- Volunteers
- 220 people
- Sponsor
- CCRF Inc., Beijing, China
Unprotected Left Main Coronary Artery Disease
Comparison of HYBRID Versus Two-Stent Strategies in Unprotected True Left MAIN Bifurcation
The number of deaths from heart disease is rising globally, particularly in developing countries. This condition involves the narrowing of arteries that supply blood to the heart.
- Trial name
- HYBRID MAIN (NCT07159737)
- Testing
- Two-stent strategy, Hybrid Strategy
- Volunteers
- 800 people
- Sponsor
- Hospital Sultanah Bahiyah
Coronary Artery Disease, Coronary Bifurcation Lesions
Progress Bifurcation Global Registry
Coronary bifurcation lesions are lesions (or blockages) that occur at or near the intersection of a major coronary artery and one of the arteries' side branches.
- Trial name
- NCT05100992
- Testing
- Percutaneous Coronary Interbention
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- Minneapolis Heart Institute Foundation