Clinical trials: Coronary Bypass
Coronary Artery Bypass
Systematic Assessment of Competitive Flow in Coronary Artery Bypass Grafts by Wave Intensity Analysis
Narrowing of the arteries that supply blood to the heart can lead to heart attacks and death. One way of treating this is to use artery and vein grafts from other parts of the body to bypass the narrowing.
- Trial name
- NCT01118468
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Imperial College London
Fluid Therapy, Coronary Artery Bypass Surgery Patients
Evaluation of Fluid Responsiveness With Recruitment Maneuver After Sternotomy in Coronary Artery Bypass Surgery
Assuming that the basic reliability of dynamic indices will increase with the application of functional hemodynamic tests after sternotomy and protective lung ventilation in patients undergoing elective coronary artery bypass…
- Conditions
- Fluid Therapy, Coronary Artery Bypass Surgery Patients, Lung Recruitment Maneuver
- Trial name
- fluidresponse (NCT06249568)
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ankara City Hospital Bilkent
Coronary Artery Bypass Grafting Surgery
Study of the Therapeutic Effects of Intercessory Prayer (STEP)
Intercessory prayer is widely believed to influence recovery from illness, but claims of benefits are not supported by well-controlled clinical trials.
- Trial name
- NCT00179491
- Testing
- Intercessory Prayer
- Volunteers
- 1,802 people
- Sponsor
- Beth Israel Deaconess Medical Center
Cardiac Surgery, Coronary Artery Bypass Grafting
Safety, Tolerability and Pharmacodynamics of AP214 Acetate in Patients Undergoing Cardiac Surgery
The purpose of the present research study is to investigate for the first time, the safety and tolerability of infusion doses of AP214 in subjects having heart surgery such as coronary bypass graft and/or valve repair or…
- Conditions
- Cardiac Surgery, Coronary Artery Bypass Grafting, Valve Surgery, Kidney Injury
- Trial name
- NCT00628264
- Testing
- AP214
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Action Pharma A/S
Coronary Artery Disease, Systemic Inflammation
MIECC vs Conventional Cardiopulmonary Bypass and Systemic Inflammation in CABG
This prospective observational study evaluates the effects of minimally invasive extracorporeal circulation (MIECC) and conventional cardiopulmonary bypass on systemic inflammatory response in patients undergoing coronary artery…
- Trial name
- MIECC-CABG (NCT07823400)
- Testing
- Minimally Invasive Extracorporeal Circulation, Conventional Cardiopulmonary Bypass
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Levosimendan, Cardiac Surgery
Interest of Levosimendan Preconditioning for Cardiac Surgery Under CEC in Heart Failure Patients With Impaired Ejection Fraction
Levosimendan, a drug with inotropic, vasodilatory and myocardial protective properties, has been proposed for the prevention and treatment of postoperative low cardiac output syndrome in cardiac surgery.
- Conditions
- Levosimendan, Cardiac Surgery, Heart Failure With Reduced Ejection Fraction
- Trial name
- LevoCV (NCT06021587)
- Testing
- Levosimendan, No Levosimendan
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
Pain, Anxiety
Effect of Reflexology Massage on Pain and Anxiety.
Aim: The aim of this study is to examine the effects of reflexology hand massage group and placebo group on pain and anxiety in patients undergoing coronary artery bypass graft surgery.
- Trial name
- NCT05428644
- Testing
- massage therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Dokuz Eylul University
Brain Natriuretic Peptide, Coronary Artery Bypass Graft Surgery
Desflurane,Brain Natriuretic Peptide and Cardiac Surgery
During coronary artery bypass grafting (CABG) operations with cardiopulmonary bypass (CPB), the use of desflurane continuously or intermittently may have effects on serum brain natriuretic peptide (BNP) levels.
- Conditions
- Brain Natriuretic Peptide, Coronary Artery Bypass Graft Surgery, Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- NCT04238806
- Testing
- Desflurane Inhalational agent
- Volunteers
- 151 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Coronary Artery Occlusive Dissease
Effect of Preoperative Oral Carbohydrates on Postoperative Insulin Resistance in Patients Undergoing OPCAB(Off- Pump Coronary Artery Bypass Surgery)
Surgical stress creates a state of insulin resistance which has been related to increased postoperative complications. Fasting before surgery induces a catabolic state that contributes to the development of insulin resistance.
- Trial name
- NCT02330263
- Testing
- carbohydrate beverage
- Where
- South Korea
- Volunteers
- 57 people
- Sponsor
- Yonsei University
Pulmonary Function, Coronary Artery Disease
Additional Effects of Ujjayi Pranayama
Studying the impact of Ujjayi pranayama on post-Coronary Artery Bypass Grafting (CABG) patients has the potential to positively influence healthcare.
- Trial name
- NCT06663800
- Testing
- Ujjayi Paranayama, Standard Protocol
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Coronary Artery Bypass Graft Surgery, Myocardial Ischemia
A Safety and Efficacy Study to Confirm the Cardioprotective Effects of MC-1 in Patients Undergoing High-Risk CABG
The purpose of this study is to determine the effect of MC-1 on the combined incidence of cardiovascular death and nonfatal myocardial infarction (MI) up to and including 30 days following coronary artery bypass graft (CABG)…
- Conditions
- Coronary Artery Bypass Graft Surgery, Myocardial Ischemia, Reperfusion Injury
- Trial name
- NCT00402506
- Testing
- (MC-1) Pyridoxal 5'-phosphate
- Where
- 2 sites in United States, Canada
- Volunteers
- 3,000 people
- Sponsor
- Medicure
Patients Undergoing Cardiac Surgery, Patients With Coronary Artery Bypass Surgery With CEC
Ability of Pupillometry to Reduce Sufentanil Consumption in Planned Cardiac Surgery: Randomized, Controlled, Single-center Clinical Superiority Trial
The objective of general anesthesia is to obtain a loss of consciousness, stillness, and sufficient analgesia to allow surgery. Thus, general anesthesia has two components: hypnosis and analgesia.
- Trial name
- PUCCAR (NCT03864016)
- Testing
- Induction and maintenance of anesthesia, Adaptation of sufentanil doses according to the usual protocol, Adjustment of sufentanil doses according to pupillometry
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Obesity, Morbid
ECG Triggered Dual Source CT for Non-invasive Pre-operative Cardiac Imaging in Morbid Obese Patients
Coronary arterial disease is a risk factor for bariatric surgery and might be a predictor for later major adverse coronary events.
- Trial name
- NCT02802579
- Testing
- standard protocol, enhanced protocol, enhanced obesity protocol
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- Cantonal Hospital of St. Gallen
Cardiac Surgery
Effects of Extra Corporeal Circuit Prime on Electrolytes Balance and Clinical Outcome Following Cardiac Surgery
About 6000 heart operations are performed in Sweden every year. A heart-lung machine is used almost exclusively in all heart operations. This machine fills the role of heart and lungs during surgery while the heart is stopped.
- Trial name
- Prime (NCT03302286)
- Testing
- Heart-lung machine primining solution which includes Mannitol, Heart-lung machine primining solution which does not include Mannitol
- Where
- Sweden
- Volunteers
- 110 people
- Sponsor
- Region Skane
Cardiac Surgery
HLA-DR Expression in Neonates After Cardiac Surgery Under Cardiopulmonary Bypass
The purpose of this study is to determine how monocyte HLA-DR and other markers of immune function change with time in neonates who underwent cardiac surgery with cardiopulmonary bypasss.
- Trial name
- IMMUNOPED (NCT03309839)
- Testing
- Blood collection
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Nantes University Hospital
Elective Cardiac Surgery
CytoSorb® Reduction of FREee Hemoglobin/Acute Kidney Injury (AKI) During Cardiac Surgery
Prospective, multi-center, randomized, blinded, pivotal clinical study. Subjects will be randomized in a 1:1 ratio to either standard of care (SOC) alone or standard of care plus treatment with the CytoSorb® device.
- Trial name
- REFRESH II-AKI (NCT03384875)
- Testing
- CytoSorb
- Where
- 20 sites in United States
- Volunteers
- 186 people
- Sponsor
- CytoSorbents, Inc
Kidney Failure, Acute, Oxidative Stress Induction
N-acetylcysteine to Prevent Renal Failure
The purpose of this study is to determine the possible effect nephroprotective of N-acetylcysteine in patients with chronic kidney disease undergoing elective coronary artery bypass grafting by serial evaluation of renal function…
- Trial name
- NCT01359722
- Testing
- N-acetylcysteine, Control
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Instituto do Coracao
Tetralogy of Fallot
Reoxygenation for Cyanotic Pediatric CHD
Evidence is emerging that those patients with cyanotic pathologies may be more vulnerable to end-organ injury during and after surgery than those patients without, because of compromised cardiopulmonary performances or the…
- Trial name
- Reoxygenation (NCT03568357)
- Testing
- Reoxygenation
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Nanjing Medical University
Lactic Acidosis, Blood Glucose, High
Nitroglycerin Infusion During Cardiac Surgery
Hypothermic cardiopulmonary bypass results in peripheral vasoconstriction and heparin trapping. Hypoperfusion and ischemic-reperfusion injury are associated with systemic inflammatory response, while insufficient and delayed…
- Trial name
- NCT01901419
- Testing
- Nitroglycerin infusion
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Pain
Pain Prevention and Treatment Through the Enhancement of the Anti-nociceptive Component of Pain Modulation Profiles
To utilize the plasticity of the central pain pathways in order to (i) shift individuals with a pro-nociceptive pain modulation profile towards an anti-nociceptive one, and (ii) assess its relevance in minimizing pain-derived…
- Trial name
- NCT02020122
- Testing
- Duloxetine, Pregabalin
- Where
- Israel
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus