Clinical trials: Coronary Bypass
Congenital Heart Disease
Platelets or Fibrinogen as First-line Treatment for Bleeding During Pedatric Heart Surgery
The study aims to test whether platelet transfusion or fibrinogen concentrate is the most effective treatment of intraoperative bleeding, when performing open heart surgery with cardiopulmonary bypass on children with congenital…
- Trial name
- NCT04807621
- Testing
- Platelet transfusion, Fibrinogen concentrate
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Sahlgrenska University Hospital
Ischaemic Heart Disease
Trial of Rehabilitation in Phase 1 After Coronary Artery Bypass Grafting
Patients undergoing coronary artery bypass graft surgery often experience a range of problems and symptoms related to the procedure and the underlying heart disease.
- Trial name
- SheppHeart (NCT01941355)
- Testing
- Exercise training component, Psycho-educative component
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
A Total of 234 Patients With Acute Coronary Syndrome Who Will Undergo OPCAB.
Impact of High-dose Pretreatment of Rosuvastatin in Patients With Acute Coronary Syndrome Following Off-pump Coronary Artery Bypass: Results From the HIROP-ACS (HIgh-dose Pretreatment of Rosuvastatin During Off-Pump Coronary Bypass in Acute Coronary Syndrome) Study
Periprocedural treatment with high-dose statins is known to have cardioprotective and pleiotropic effects, such as anti-thrombotic and anti-inflammatory actions.
- Trial name
- NCT01971606
- Testing
- Rosuvastatin
- Where
- South Korea
- Volunteers
- 234 people
- Sponsor
- Yonsei University
Acute Kidney Injury, Congenital Heart Disease
Nitric Oxide During Cardiopulmonary Bypass in Neonates to Reduce Risk of Acute Kidney Injury
Acute kidney injury following cardiac surgery for congenital heart defects in children is a major cause of both short- and long-term morbidity and mortality, affecting up to 60% of high risk patients.
- Trial name
- NCT04259684
- Testing
- gases Nitric Oxide (gNO)
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cardiovascular Diseases
Application of Exercises Based on the Pilates in Coronary Artery Bypass Grafting
The major cause of mortality worldwide is due to cardiovascular diseases. A way to treat these diseases is coronary artery bypass grafting, one of the most common surgical procedures in the world.
- Trial name
- NCT02109055
- Testing
- Pilates, Conventional Physiotherapy
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Intracranial Embolism and Thrombosis, Postoperative Complications
TCD Detection of Gas and Solid Micro-Emboli in Patients Undergoing Coronary Artery Bypass Grafting (CABG): The Influence of Proximal Anastomosis Technique
The purpose of this study is to test the hypothesis that using three different techniques to anastomose coronary grafts to the aorta: partial occlusion, single cross clamp, or using the Heartstring anastomotic device, will change…
- Trial name
- NCT00294814
- Testing
- Proximal anastomosis using Heartstring anastomotic device
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rambam Health Care Campus
Coronary Disease
Long-term Remote Ischemic Preconditioning Improves Myocardial Perfusion and Prognosis of Patients After CABG
Remote Ischemic preconditioning (RIPC) has been reported to improve myocardial microcirculation, promote collateral circulation recruitment, and improve myocardial perfusion in patients.Two large randomized controlled trials…
- Trial name
- L-RIPC-CABG (NCT04779008)
- Testing
- remote ischemic preconditioning （RIPC）
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Angina Pectoris
Evaluation of Graft Material in Coronary Artery Bypass Grafting (CABG)
The aim of the study is to evaluate the patency in different kinds of vessels used as graft material in coronary artery bypass grafting.
- Trial name
- NCT01310725
- Testing
- Coronary artery bypass grafting
- Where
- Sweden
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Cardioplegia Solution Adverse Reaction
Histidine-Tryptophan-Ketoglutarate Solution Versus Blood Cardioplegia in CABG
Background: In cardiac surgery, myocardial protection is mandatory during cross clamp time followed by reperfusion. Use of cardioplegic solutions preserves myocardial energy stores, hindering electrolyte disturbances and acidosis…
- Trial name
- NCT04203680
- Testing
- HTK cardioplegic solution, blood cardioplegia
- Where
- 2 sites in Egypt
- Volunteers
- 320 people
- Sponsor
- Ain Shams University
Ischaemic Heart Disease, Contrast-induced Nephropathy
Randomised Controlled Trial to Assess Whether Computed Tomography Cardiac Angiography Can Improve Invasive Coronary Angiography in Bypass Surgery Patients
A large number of patients with symptomatic ischaemic heart disease undergo coronary artery bypass grafting (CABG) to alleviate their symptoms and improve prognosis.
- Trial name
- BYPASS-CTCA (NCT03736018)
- Testing
- CTCA
- Where
- United Kingdom
- Volunteers
- 688 people
- Sponsor
- Queen Mary University of London
Delirium
Delirium Reduction by Volatile Anesthesia in Cardiac Surgery
Parallel group, prospective, randomized, controlled, single-blinded trial. The aim of our study is to test the hypothesis that volatile anesthesia would reduce the incidence of early postoperative delirium in patients undergoing…
- Trial name
- DELICATE (NCT03729011)
- Testing
- Volatile agent, Propofol
- Where
- 5 sites in Russia
- Volunteers
- 405 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Sudden Cardiac Death, Ventricular Fibrillation
LifeVest Post-CABG Registry
This is a multi-center prospective registry of patients with an ejection fraction (EF) ≤ 35% following coronary artery bypass graft (CABG) surgery in order to test the hypothesis that wearable defibrillators (WD) will decrease…
- Conditions
- Sudden Cardiac Death, Ventricular Fibrillation, Ventricular Tachycardia, Ventricular Dysfunction
- Trial name
- NCT01448005
- Testing
- wearable defibrillator (LifeVest)
- Where
- 5 sites in United States
- Volunteers
- 69 people
- Sponsor
- Zoll Medical Corporation
Hyperglycemia
Sitagliptin for Hyperglycemia in Patients With T2DM Undergoing Cardiac Surgery
The purpose of this study is to determine whether treatment with sitagliptin reduces the frequency and severity of high blood sugar (hyperglycemia) after cardiac surgery and to determine whether treatment with sitagliptin is…
- Trial name
- SITA-CABGDM (NCT02556918)
- Testing
- Sitagliptin, Regular Human Insulin, Insulin glargine
- Where
- 3 sites in United States
- Volunteers
- 202 people
- Sponsor
- Emory University
Coronary Artery Disease
Saphenous Vein as Y-composite Versus Aortocoronary Conduit for CABG
Left internal thoracic artery (LITA) has been acknowledged as the first graft of choice for coronary artery bypass grafting (CABG).
- Trial name
- CONFIG2 (NCT05704296)
- Testing
- Y-composite grafting, Aortocoronary grafting
- Where
- South Korea
- Volunteers
- 290 people
- Sponsor
- Ho Young Hwang
Coronary Arterial Disease (CAD), Fraility
Correlation of Euroscore-II, STS Risk Scoring Systems and Frailty Tests with Cardiac Histopathological Findings in Coronary Bypass Surgery
Various risk classification systems are used to predict postoperative mortality and morbidity development in cardiac surgery. Risk calculation with these systems is a guide in determining preoperative strategies, performing cost…
- Conditions
- Coronary Arterial Disease (CAD), Fraility, Histopathology, Cardiac Risk Factors
- Trial name
- NCT06784609
- Testing
- Coronary Artery Bypass Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Postoperative Delirium, Postoperative Stroke
Postoperative Stroke and Epiaortic Ultrasound in CABG
This study aims to investigate the incidence of postoperative stroke and neurocognitive impairment in patients undergoing coronary artery bypass grafting (CABG), with or without the use of epi-aortic ultrasound (EAU).
- Trial name
- EAU and POCD (NCT07101393)
- Testing
- Intraoperative Epiaortic Ultrasound (EAU)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Ataturk University
Pulmonary Hypertension
Iloprost-Study: Comparison of Nitric Oxide to Iloprost (Ventavis) for Treatment of Pulmonary Hypertension in Children After Cardiopulmonary Bypass Surgery
Inhaled nitrous oxide (iNO) will be compared to aerosolized iloprost (ILO) in pediatric patients after cardiac surgery with pulmonary hypertension.
- Trial name
- NCT00235521
- Testing
- aerosolized iloprost
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Heidelberg University
Coronary Surgery With Cardiopulmonary Bypass
Effects of a Goal-directed Hemodynamic Therapy Driven by ECOM on Morbidity and Mortality After Cardiac Surgery?
Goal-directed hemodynamic and fluid optimizations are shown to be a key factor of the medical care during anesthesia.According to medical literature, goal-directed fluid and hemodynamic optimizations are more efficient when based…
- Trial name
- ECOMIII (NCT01535716)
- Testing
- hemodynamic optimization strategy driven by the ECOM, standard management strategy
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Caen
Heart Disease
Impact of Preoperative FFR on Arterial Bypass Graft Functionality
This study was designed to evaluate the correlation between pre-operative FFR and the functionality of arterial bypass grafts six months after coronary artery bypass grafting.
- Trial name
- IMPAG (NCT02527044)
- Testing
- Fractional Flow Reserve (FFR)
- Where
- 2 sites in Belgium, Canada
- Volunteers
- 120 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Coronary Artery Bypass, Epidural Anesthesia
Comparison of Ropivacaine and Levobupivacaine in High Thoracic Epidural Anesthesia
In High Thoracic Epidural Anesthesia (HTEA) the use of a local anesthetic (LA) with low cardiac toxicity is crucial as myocardial contractility is often already seriously impaired.
- Trial name
- NCT00552864
- Testing
- Ropivacaine, Levobupivacaine
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- Centro Cardiologico Monzino
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