Clinical trials: Coronary Bypass
Kidney Failure, Acute
Evaluation of Neutrophil Gelatinase-associated Lipocalin (NGAL) in Early and Evolving Acute Kidney Injury
Some patients who undergo cardiovascular surgery requiring cardiopulmonary bypass will develop a kidney injury following their surgery.
- Trial name
- EVOLVE (NCT00445809)
- Where
- 11 sites in United States, Canada
- Volunteers
- 355 people
- Sponsor
- Abbott RDx Cardiometabolic
Mitral Regurgitation, Coronary Artery Disease
Randomised Ischaemic Mitral Evaluation (RIME) Trial
The study is a randomised controlled trial comparing two treatment strategies for patients with moderate functional ischaemic mitral regurgitation undergoing coronary artery bypass grafting (CABG).
- Trial name
- RIME (NCT00413998)
- Testing
- CABG + Mitral valve annuloplasty, CABG
- Where
- 9 sites in Poland, United Kingdom
- Volunteers
- 73 people
- Sponsor
- Imperial College London
Cardiac Surgical Procedures, Cardiopulmonary Bypass
Steroids In caRdiac Surgery Trial (SIRS Trial)
SIRS trial is a large simple study in which high-risk patients undergoing cardiac surgery requiring the use of cardiopulmonary bypass (CPB) are randomly allocated to receive a pulse dose of Methylprednisolone or a matching…
- Conditions
- Cardiac Surgical Procedures, Cardiopulmonary Bypass, Systemic Inflammatory Response Syndrome
- Trial name
- NCT00427388
- Testing
- Methylprednisolone
- Where
- Canada
- Volunteers
- 7,507 people
- Sponsor
- Population Health Research Institute
Cardiopulmonary Bypass, Cardiac Surgery
Integration of Minimal Invasive Cardiopulmonary Bypass System and the Research of Its Blood Compatibility
Research objective: (1) To develop a minimally invasive extracorporeal circulation integrated system, and to form a new product package, the package of the system should include the extracorporeal circulation off-set supplies for…
- Trial name
- IMICPBS (NCT04476342)
- Testing
- minimal invasive cardiopulmonary bypass (MICPB) system
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Coronary Syndrome
Ticagrelor and ASA vs. ASA Only After Isolated Coronary Artery Bypass Grafting in Patients With Acute Coronary Syndrome
The study is a Randomised Registry-based Clinical Trial (RRCT) to assess whether dual antiplatelet therapy with ticagrelor and ASA compared to ASA alone improves outcome after isolated CABG in patients with acute coronary…
- Trial name
- TACSI (NCT03560310)
- Testing
- Ticagrelor 90mg twice daily and ASA 75-100 mg daily, ASA 75-160 mg daily
- Where
- 22 sites in Denmark, Finland and 3 more
- Volunteers
- 2,201 people
- Sponsor
- Vastra Gotaland Region
Atrial Fibrillation, Obesity and Obesity-related Medical Conditions
Metabolic Surgery for Atrial Fibrillation Elimination
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. It is estimated that between 3 and 6 million Americans are currently living with AF, while 12 million people in the United States will have AF in 2030.
- Trial name
- METSAFE (NCT07027969)
- Testing
- Roux-en-Y Gastric Bypass or Sleeve Gastrectomy, Anti-Obesity Medication (AOM) treatment
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ali Aminian
Hemostasis
In Vivo Effects of Fibrinogen Concentrate (FC) Versus Cryoprecipitate on the Neonatal Fibrin Network Structure After Cardiopulmonary Bypass (CPB)
This primary aim of this study is to compare the in vivo effects of fibrinogen concentrate and cryoprecipitate on the neonatal fibrin network after surgery with cardiopulmonary bypass to develop effective and safe strategies for…
- Trial name
- NCT03932240
- Testing
- Fibrinogen Concentrate (FC), Cryoprecipitate
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Emory University
Cardiovascular Diseases
Development of a Method for Converting Visual Analogue Scale (VAS) Scores for Pain and Mobility to EQ-5D Answers
The objective of this study is to investigate how mobility and pain scores, measured on a Visual Analogue Scale (VAS), correspond to patients' EuroQol-5Dimensions-3Levels (EQ-5D-3L) answers on pain and mobility.
- Trial name
- NCT01424683
- Where
- Denmark
- Volunteers
- 217 people
- Sponsor
- Lars Oddershede
Anesthesia, Hypothermia
Examine the Effects of Maintaining Body Core Temperature During CABGs
Although data on cardioprotective effects (as profile of troponin I)of perioperative maintenance of normothermia during CABGs are already known, little is known about the effects of maintaining normothermia on clinical outcomes…
- Conditions
- Anesthesia, Hypothermia, Coronary Artery Bypass Grafting
- Trial name
- NCT00791050
- Testing
- Allon Thermowrap. MTRE Advanced Technologies Ltd.
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Centro Cardiologico Monzino
Post Operative Care After Cardiac Surgery With Cardio Pulmonary Bypass
Bio Impedance Electrical Analysis to Predict Outcome After Cardiac Surgery
Phase angle determined by bioelectrical impedance analysis is a strong prognostic factor in several medical areas as clinical nutrition, nephrology, infectious disease, oncology.
- Trial name
- BiPOCS (NCT05229159)
- Testing
- Bioelectrical impedance analysis
- Where
- France
- Volunteers
- 220 people
- Sponsor
- Hospices Civils de Lyon
Mitral Valvular Heart Disease
Comparison of 6% Hydroxyethyl Starch 130/0.4 With 5% Albumin as Priming Solution for Cardiopulmonary Bypass
Comparison of 6% hydroxyethyl starch 130/0.4 with 5% albumin as priming solution for cardiopulmonary bypass
- Trial name
- NCT00978588
- Testing
- 6% hydroxyethyl starch 130/0.4 and 5% albumin
- Volunteers
- 36 people
- Sponsor
- Yonsei University
Coronary Artery Bypass Grafting (CABG) Surgery
Improving Adherence to Medication After Coronary Artery Bypass Surgery (CABG) in Older Adults
Coronary artery bypass grafting (CABG) surgery is often performed in elderly patients, but non-adherence to post-CABG guideline medications is a common and serious clinical concern in this age group.
- Trial name
- NCT02109523
- Testing
- Motivational Interviewing (MI, volitional intervention, Routine discharge counseling
- Where
- 13 sites in Iran
- Volunteers
- 288 people
- Sponsor
- Qazvin University Of Medical Sciences
Carotid Endarterectomy, Coronary Artery Bypass Grafting
Multidisciplinary CAE and CABG Surgery to Optimize the Management of High-risk Patients During the Perioperative Period
This project uses concurrent CEA+CABG combined surgery on high-risk patients with severe carotid artery stenosis and severe coronary artery stenosis.
- Trial name
- NCT04960488
- Testing
- carotid endarterectomy and coronary artery bypass grafting
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University Third Hospital
Cardiopulmonary Bypass, Coronary Artery Bypass
GLS in Difficult CPB Weaning
The goal of this observational study is to learn whether global longitudinal strain (GLS), measured by echocardiography, can predict difficulty separating from cardiopulmonary bypass (CPB) in adults undergoing elective cardiac…
- Conditions
- Cardiopulmonary Bypass, Coronary Artery Bypass, Heart Valve Diseases, Echocardiography
- Trial name
- NCT07390903
- Testing
- Myocardial strain imaging
- Where
- 2 sites in Italy, Turkey (Türkiye)
- Volunteers
- 213 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Coronary Artery Disease, Stable Coronary Artery Disease
Cardiovascular Events Related to Treated Coronary Arteries in Stable Multivessel CAD
This retrospective cohort study evaluates cardiovascular events directly related to treated coronary arteries in patients with stable multivessel coronary artery disease.
- Conditions
- Coronary Artery Disease, Stable Coronary Artery Disease, Multivessel Coronary Artery Disease, Myocardial Ischemia
- Trial name
- NCT07362108
- Testing
- Coronary Artery Bypass Grafting, Percutaneous Coronary Intervention, Optimized Medical Therapy
- Volunteers
- 1,695 people
- Sponsor
- Instituto do Coracao
Postoperative Pain, ICU Hospitalization
The Effect of Parasternal Block on Postoperative Pain in Patients Undergoing Coronary Artery Bypass Graft Surgery
Objective: This study aims to investigate the effects of intraoperative parasternal block on postoperative analgesia in patients undergoing elective coronary artery bypass graft surgery.
- Conditions
- Postoperative Pain, ICU Hospitalization, Extubation Time
- Trial name
- NCT06893601
- Testing
- Parasternal block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Aydin Adnan Menderes University
Cardiac Disease, Surgery-Complications
One-year Patency Comparison Between Radial Artery and No-touch Saphenous Vein Grafts in Women Undergoing Isolated CABG
The use of a graft from the left internal thoracic artery to the left anterior descending artery has become the gold standard for the indication of coronary artery bypass grafting.
- Conditions
- Cardiac Disease, Surgery-Complications, Graft Failure
- Trial name
- QUEEN (NCT06179329)
- Testing
- Coronary artery bypass graft
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- University of Sao Paulo General Hospital
Ischemia/Reperfusion Injury After Neonatal Cardiac Surgery, Inflammatory Reaction After Neonatal Cardiac Surgery
Efficacy of Nitric Oxide Administration in Attenuating Ischemia/Reperfusion Injury During Neonatal Cardiopulmonary Bypass
Around 7500 neonates born yearly in the United States have complex congenital heart disease that require surgical repair in the first few days of life.
- Trial name
- NCT02151877
- Testing
- Inhaled Nitric Oxide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wake Forest University Health Sciences
CoaguChek® XS System, Coagulation Function
Diagnostic Accuracy Study of a Point-of-Care Test for Coagulation Function
Intraoperative coagulopathies in complex procedures are common. For the diagnosis and adequate therapy, laboratory tests are necessary, which can delay the patient's therapy.
- Trial name
- NCT06037720
- Testing
- Coaguchek testing
- Volunteers
- 50 people
- Sponsor
- Hospital de Base
Cardiopulmonary Bypass
Cefazolin Dosing in Children Undergoing Cardiac Surgery With Cardiopulmonary Bypass
Pharmacokinetics of cefazolin in children undergoing cardiac surgery.
- Trial name
- CEFA (NCT02749981)
- Testing
- blood and tissue sampling
- Volunteers
- 56 people
- Sponsor
- University Hospital, Ghent
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