Clinical trials: Coronary Bypass
Congenital Heart Disease, Mechanical Ventilation Complication
Mechanical Ventilation During Cardiopulmonary Bypass
The study is about a protocol of protective mechanical ventilation during cardiopulmonary bypass used during cardiosurgery for the correction of congenital heart diseases, to evaluate what's the best for the lungs
- Conditions
- Congenital Heart Disease, Mechanical Ventilation Complication, Cardiopulmonary Bypass
- Trial name
- VENICE (NCT03629574)
- Testing
- Ventilation during cardiopulmonary bypass
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera di Padova
Muscle Wasting
Effects of Functional Electrical Stimulation in Patients Undergoing Coronary Artery Bypass Grafting Surgery
Even with major advances in clinical therapy and percutaneous interventions, coronary artery bypass grafting (CABG) is the most common cardiac surgery performed worldwide and is an effective treatment in reducing symptoms and…
- Trial name
- NCT03560713
- Testing
- Functional Electrical Stimulation (FES)
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Universidade Federal de Santa Maria
CABG, Cardiac Anesthesia
Impact of the Cardiopulmonary Bypass and Cross-Clamp Time Ratio on Postoperative Outcomes in Open Heart Surgery: A Prospective Observational Analysis
This study aims to investigate the relationship between the ratio of cardiopulmonary bypass (CPB) time to cross-clamp (CC) time and postoperative complications in open heart surgery.
- Conditions
- CABG, Cardiac Anesthesia, Cardiac Surgery Prognosis, Bypass Complication
- Trial name
- NCT06873620
- Where
- Turkey (Türkiye)
- Volunteers
- 348 people
- Sponsor
- Ahmet Yuksek
Graft Patency, Coronary Artery Bypass Grafting Surgery
ThrombElastoGraphic Haemostatic Status and Antiplatelet Therapy After Coronary Artery Bypass Graft Surgery
The purpose of this study is to determine whether adding clopidogrel to aspirin after coronary bypass operation (CABG) improves graft patency, in patients that have preoperatively increased platelet activity(hypercoagulable) and…
- Conditions
- Graft Patency, Coronary Artery Bypass Grafting Surgery, Hypercoagulability, Thrombosis
- Trial name
- TEG-CABG (NCT01046942)
- Testing
- Clopidogrel+acetylsalicylic acid, acetylsalicylic acid
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Systemic Inflammatory Response Syndrome (SIRS), Leukocyte Disorders
Effects of Cardiopulmonary Bypass (CPB)-Leukocyte Filtration on Interleukins Serum Levels and Pulmonary Function
To test the hypothesis that leukocyte filtering during cardiopulmonary bypass (CPB) might reduce the inflammatory response and protect the lungs against the acute injury
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Leukocyte Disorders, Complications Due to Coronary Artery Bypass Graft
- Trial name
- PulmFunction (NCT01469676)
- Testing
- Filtering group LG-6, Pall Biomedical Products
- Volunteers
- 22 people
- Sponsor
- University of Sao Paulo
Coronary Artery Disease (CAD)
Epicardial Delivery of XC001 Gene Therapy to Promote Angiogenesis in CAD Patients Undergoing Treatment With CABG
This is a 26-week (with a 26-week extension) multicenter, randomized, double-blind, placebo-controlled Phase 2 study of XC001 versus placebo.
- Trial name
- EXACT-CABG (NCT07118449)
- Testing
- XC001
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- XyloCor Therapeutics, Inc.
Coronary Artery Disease, Aspirin
Effect of Preoperative Aspirin in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
Effect of Preoperative Aspirin in patients undergoing Off-pump Coronary Artery Bypass Grafting. A double-blind, placebo-controlled, randomized trial.
- Trial name
- NCT03049085
- Testing
- Aspirin, vitamin C
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- Medinet Heart Centre
Atrial Fibrillation
READ-POAF Pilot Studies Postoperative Atrial Fibrillation After Cardiac Surgery
Postoperative atrial fibrillation after coronary artery bypass grafting will be monitored up to 1 year after the procedure by implanting a Reveal XT internal loop recorder two weeks before the surgery.
- Trial name
- NCT01530750
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Coronary Artery Occlusive Disease
Effect of Intraoperative Iloprost Inhalant on Hemodynamic Stability in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery
Considering that the cause of hemodynamic instability during OPCAB is closely related to right ventricular dysfunction with pulmonary artery hypertension, the use of inhaled iloprost (a selective pulmonary vasodilator) in…
- Trial name
- NCT04598191
- Testing
- Iloprost, Control (Normal saline)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Coronary Artery Bypass, Off-Pump
Cell Savers and Blood Quality
Cell savers are routinely used in our hospital during off-pump coronary artery bypass grafting to retrieve and wash blood that is lost during the operation.
- Trial name
- NCT02046824
- Testing
- Xtra®, Sorin cellsaver, C.A.T.S.®, Fresenius cellsaver, CardioPAT®, Haemonetics, cellsaver
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- University Medical Center Groningen
Coronary Artery Disease
Effectiveness of Early Cardiac Rehabilitation
The goal of this experimental study is to compare the effects of early (2nd week) cardiac rehabilitation applied in addition to usual care on functional capacity, quality of life, frailty and body composition in patients…
- Trial name
- NCT06116773
- Testing
- Training, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University - Cerrahpasa
Rheumatic Heart Disease, Cardiopulmonary Bypass
Thymosin α1 Use in Rheumatic Heart Disease Patients Undergoing Cardiac Surgery on Cardiopulmonary Bypass
Rheumatic heart disease usually accompanied by weakened immune function. And the cardiopulmonary bypass further aggravating the decline of immune function.
- Conditions
- Rheumatic Heart Disease, Cardiopulmonary Bypass, Immunotherapy
- Trial name
- NCT05487469
- Testing
- Thymosin Alpha1, Blank Control
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanjing Medical University
Coronary Artery Disease
Propofol or Midazolam for Sedation and Early Extubation Following Coronary Artery Bypass Graft Surgery
Propofol and midazolam are used frequently as sedating agents among patients who undergo coronary artery bypass graft surgery but no study in Pakistan has been done to compare their effectiveness aiming early extubation.
- Trial name
- NCT05290324
- Testing
- Midazolam
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Chaudhry Pervaiz Elahi Institute of Cardiology
Coronary Artery Disease
Symptom Management Intervention in Elderly Coronary Artery Bypass Patients
The major purpose of this experimental study is to test the effects of the symptom management home care nursing intervention (SMHCNI) on recovery outcomes of elderly CABG patients, using a randomized, two group (n=284) repeated…
- Trial name
- NCT00572988
- Volunteers
- 232 people
- Sponsor
- University of Nebraska
Cardiac Surgery, Coronary Artery Bypass Grafting
Oscillating Positive Expiratory Pressure (OPEP) Therapy in High Risk Patients Following Cardiac Surgery
Respiratory dysfunction following cardiac surgery is well documented and due in part to the location of the incision and nature of the surgery.
- Conditions
- Cardiac Surgery, Coronary Artery Bypass Grafting, Chronic Obstructive Pulmonary Disease (COPD), Older Adults
- Trial name
- NCT02732574
- Testing
- Oscilatory Positive Expiratory Pressure (OPEP) device
- Where
- Canada
- Volunteers
- 162 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Postoperative; Dysfunction Following Cardiac Surgery
Cerebral Energy State in Cardiac Surgery
Impaired cerebral function remains an important complication of cardiopulmonary bypass (CPB) during cardiac surgery. The aim of the present study is to investigate whether the lactate to pyruvate (LP) ratio obtained by…
- Trial name
- NCT02846818
- Testing
- Microdialysis
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Odense University Hospital
Coronary Artery Disease, Cardiac Rehabilitation
Home-based Transitional Telerehabilitation in Cardiac Recovery
The main aim is to determine the impact of home video-based cardiac rehabilitation program on elderly patients' health-related quality of life and therapeutic self-care post-coronary revascularization
- Trial name
- NCT06192290
- Testing
- Home-based transitional Cardiac Telerehabilitation
- Where
- Egypt
- Volunteers
- 118 people
- Sponsor
- Mansoura University
Elective Off-pump Coronary Artery Bypass Grafting
Relation Between Mixed Venous Oxygen Saturation and Cerebral Oxygen Saturation Measured by Absolute and Relative Near-infrared Spectroscopy During Off-pump Coronary Artery Bypass Grafting.
In this clinical study the investigators compared mixed venous oxygen saturation (SmvO2) with relative and absolute cerebral oxygen saturation (rScO2) measurements.
- Trial name
- NCT01673841
- Testing
- Relative and absolute cerebral oxygen saturation (rScO2) measurements.
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- University Hospital, Ghent
Kidney Failure, Acute
Fenoldopam in Pediatric Cardiac Surgery
The purpose of this study is to determine whether fenoldopam infusion during cardiopulmonary bypass in young children with congenital heart disease is able to reduce indicators of acute kidney injury (biomarkers reduction…
- Trial name
- NCT00982527
- Testing
- Fenoldopam
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Complications Due to Coronary Artery Bypass Graft, Coronary Artery Disease
Neurological Complications Comparing Endoscopically vs. Open Harvest of the Radial Artery
Coronary artery bypass grafting (CABG) using the radial artery (RA) has since the nineties gone through a revival. The initially reported worse outcome in RA graft patients compared to patients grafted with the saphenous vein…
- Conditions
- Complications Due to Coronary Artery Bypass Graft, Coronary Artery Disease, Myocardial Ischemia, Coronary Disease
- Trial name
- NEO (NCT01848886)
- Testing
- Endoscopic radial artery harvest, Open radial artery harvest, Mammarioradial graft (Y-graft)
- Where
- Denmark
- Volunteers
- 301 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
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