Clinical trials: Coronary Bypass
On-pump Cardiac Surgery, High Risk for Bleeding
COmbined pLaTelet and eRythrocyte AutotransfusioN During Cardiac surgEry (COLTRANE) Trial
Despite significant advances in patient blood management, cardiac surgery remains a surgical procedure at high risk for bleeding.
- Conditions
- On-pump Cardiac Surgery, High Risk for Bleeding, Autotransfusion
- Trial name
- COLTRANE (NCT06425614)
- Testing
- Autotransfusion
- Where
- 10 sites in France
- Volunteers
- 570 people
- Sponsor
- University Hospital, Bordeaux
Cardiac Surgery, Cardiopulmonary Bypass
Norepinephrine Infusion During Cardiopulmonary Bypass
The primary objective is to test the efficacy and safety of the accuracy of continuous intravenous infusion of norepinephrine during cardiopulmonary bypass (CPB) on the prevention of hyperlactatemia after cardiac surgery.
- Trial name
- Norcal (NCT04312971)
- Testing
- Norepinephrine, Increase infusion rate, Decrease infusion rate
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Acute Kidney Injury (AKI), Chronic Kidney Disease (CKD)
Assessment of Plasma and NGAL for the Early Prediction of Acute Kidney Injury After Cardiac Surgery in Adults Study
The study aims to recruit 156 (54 Acute Kidney Injury (AKI);102 non-AKI) patients undergoing Cardio pulmonary bypass (CPB) surgery, including those with Chronic Kidney Disease (CKD) and multiple co-morbidities.
- Conditions
- Acute Kidney Injury (AKI), Chronic Kidney Disease (CKD), End Stage Renal Disease (ESRD), Estimated Glomerular Filtration Rate (eGFR)
- Trial name
- NGAL (NCT02733328)
- Testing
- CPB Surgery
- Where
- United Kingdom
- Volunteers
- 405 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Myocardial Protection
Myocardial Biopsy in Congenital Cardiac Surgery
Despite major advances in the technical aspects of surgical repair of congenital heart diseases, perioperative myocardial damage with low cardiac output remains the most common cause of morbidity and death after repair of…
- Trial name
- NCT03595111
- Testing
- myocardial biopsy
- Volunteers
- 60 people
- Sponsor
- Assiut University
Coronary Artery Stenosis, Coronary Artery Bypass Graft Surgery
Steroid-induced Reduction of Surgical Stress Study
The stress response as induced by myocardial cellular damage during cardiac surgery may lead to myocardial stunning and apoptosis, and could therefore impair postoperative patient recovery.
- Trial name
- STRESS (NCT00807521)
- Testing
- Dexamethasone
- Where
- Netherlands
- Sponsor
- Amsterdam UMC, location VUmc
Cardiopulmonary Bypass
Validation of Near Infrared Spectroscopy (NIRS) During Heart-Lung Bypass in Children
Non-invasive assessment of blood flow to organs has long challenged clinicians. Recently, near infrared spectroscopy (NIRS) has been recognized as a methodology that may achieve this goal.
- Trial name
- NIRS (NCT00745394)
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Congenital Heart Disease, Postoperative Pulmonary Complications
Perioperative Lidocaine for Lung Protection in Infants Undergoing Cardiac Surgery
Cardiopulmonary bypass-associated pulmonary injury is a common complication after infant cardiac surgery and may contribute to impaired oxygenation, prolonged mechanical ventilation, and longer intensive care stay.
- Conditions
- Congenital Heart Disease, Postoperative Pulmonary Complications, Acute Lung Injury
- Trial name
- PLICS (NCT07499154)
- Testing
- Lidocaine %2 ampoule, Normal Saline (0.9% NaCl)
- Where
- China
- Volunteers
- 320 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Post Operative Arrythmia
Impact of Ligament of Marshall Resection on Atrial Fibrillation Occurrence in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Controlled Trial
Background: 20-40% of patients with ischemic heart disease managed with coronary artery bypass grafting (CABG) surgeries face the risk of postoperative atrial fibrillation (POAF), which is a known hazardous outcome.
- Trial name
- NCT07492901
- Testing
- A standard on-pump coronary artery bypass grafting (ON-CAB), adjunctive LoM resection
- Where
- 2 sites in Egypt
- Volunteers
- 220 people
- Sponsor
- Kasr El Aini Hospital
Atelectasis, Postoperative
Single-step vs Stepwise Lung Recruitment Maneuvers After Cardiopulmonary Bypass
This prospective randomized controlled trial aims to compare the hemodynamic and pulmonary effects of single-step and stepwise lung recruitment maneuvers in adult patients undergoing elective cardiac surgery with cardiopulmonary…
- Trial name
- NCT07432477
- Testing
- Single Step Lung Recruitment Maneuver, Stepwise Lung Recruitment Maneuver
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Ondokuz Mayıs University
Coronary Arteriosclerosis, Coronary Artery Bypass Graft
Stem Cell Therapy as Adjunct to Revascularization
The purpose of this study is to determine whether it is safe to receive an injection of your own bone marrow adult stem cells (autologous BM-MNC) to your heart wall during coronary artery bypass graft (CABG).
- Conditions
- Coronary Arteriosclerosis, Coronary Artery Bypass Graft, Myocardial Revascularization
- Trial name
- STAR (NCT00463853)
- Testing
- Autologous stem cell therapy, CABG, CMRI
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Heart Diseases, Coronary Disease
Effects of Respiratory Muscle Training on Postoperative Pulmonary Complications of Cardiac Surgery
This study will evaluate the profilatic effects of inspiratory muscle training (IMT) on functional capacity, respiratory muscle strength, postoperative pulmonary complications and days of hospitalization (PPC) in patients…
- Conditions
- Heart Diseases, Coronary Disease, Cardiovascular Diseases, Coronary Artery Occlusion
- Trial name
- NCT03094923
- Testing
- Inspiratory Muscle Training
- Volunteers
- 32 people
- Sponsor
- University of the State of Santa Catarina
Coronary Artery Disease
Pexelizumab in Patients Undergoing Coronary Artery Bypass Grafting With Cardiopulmonary Bypass (PRIMO-CABG II)
During a heart bypass procedure, a substance called "complement" is activated by the body. This "complement activation" causes an inflammatory response that can lead to side affects such as chest pain, heart attacks, stroke…
- Trial name
- NCT00088179
- Testing
- pexelizumab in conjunction with CABG
- Where
- 188 sites in United States, France and 2 more
- Volunteers
- 4,000 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Anticoagulation, Coronary Endarterectomy
Antithrombotic Therapy After Coronary Artery Bypass Grafting Combined With Coronary Endarterectomy
Coronary endarterectomy (CE) combined with coronary artery bypass grafting (CABG) can be the final option for achieving complete revascularization in diffuse coronary artery disease patients.
- Trial name
- NCT05782270
- Testing
- Warfarin, DAPT, CE+CABG
- Where
- China
- Volunteers
- 202 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Myocardial Infarction, Coronary Artery Disease
Use of Intra-aortic Balloon Pump Before Surgery for Acute Myocardial Infarction
The optimal timing of surgery in patients with acute myocardial infarction (AMI) and the utilization of preoperative intra-aortic balloon pumps (IABP) in these patients are subjects of ongoing discussion and disagreement.
- Conditions
- Acute Myocardial Infarction, Coronary Artery Disease, Coronary Bypass Graft Stenosis of Autologous Vessel, Troponin
- Trial name
- NCT06468982
- Testing
- Intra-aortic Balloon Pump
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 156 people
- Sponsor
- Ataturk University
Acute Kidney Injury, Osmolality Disturbance
Hyperosmolality and Acute Kidney Injury After Cardiac Surgery
The goal of this randomized controlled trial is to test if a hyperosmolar prime solution used for cardiopulmonary bypass increases the risk for acute postoperative kidney injury.
- Conditions
- Acute Kidney Injury, Osmolality Disturbance, Cardiopulmonary Bypass
- Trial name
- NCT05914896
- Testing
- HighOsmo
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Umeå University
Valvular Disease
Impact of Cardiopulmonary Bypass Time on Gastrointestinal Complications
This retrospective study investigates the relationship between cardiopulmonary bypass (CPB) duration and the incidence of gastrointestinal complications (GICs) in patients undergoing heart valve replacement.
- Trial name
- NCT06697405
- Testing
- Prolonged ≥ 120 minutes
- Where
- China
- Volunteers
- 1,444 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Cardiovascular Disease
Phase II Study To Evaluate The Safety and Efficacy of Hemoglobin Raffimer in Patients Undergoing First Time CABG Surgery
To evaluate the efficacy of Hemolink™ in combination with Intraoperative Autologous Donation (IAD) versus control (IAD alone) in facilitating avoidance of allogeneic RBC transfusion during and following primary CABG surgery
- Trial name
- NCT00038454
- Testing
- Hemolink (hemoglobin raffimer IV solution)
- Where
- 28 sites in United States, Canada and 1 more
- Volunteers
- 180 people
- Sponsor
- Hemosol
Arteriosclerosis of Coronary Artery Bypass Graft
Graft Patency Outcomes in Patients Undergoing Coronary Artery Bypass Grafting Via Minimally Invasive Coronary Surgery
This clinical study has been developed to evaluate the clinical outcomes in patients undergoing coronary artery bypass grafting via Minimally Invasive Coronary Surgery (MICS); a minimally invasive coronary bypass procedure that…
- Trial name
- MICS (NCT01334866)
- Testing
- Minimally invasive coronary artery bypass graft surgery
- Where
- 2 sites in United States, Canada
- Volunteers
- 91 people
- Sponsor
- Medtronic Cardiovascular
Acquired Bleeding Disorder, Cardiac Surgery Requiring Cardiopulmonary Bypass
Multi-national Study Investigating the Effect and Safety of rFXIII on Transfusion Needs in Patients Undergoing Heart Surgery
This trial is conducted in Canada, Asia, Europe and USA. The aim of this clinical trial is to investigate the effect and safety of rFXIII on transfusion needs in patients undergoing heart surgery.
- Trial name
- NCT00914589
- Testing
- catridecacog
- Where
- 32 sites in United States, Canada and 8 more
- Volunteers
- 479 people
- Sponsor
- Novo Nordisk A/S
CAD, Atheroscleroses, Coronary
Comprehensive Computed Tomography Guidance of Coronary Bypass Graft Surgery
Apply CT angiography, CT perfusion imaging and advanced image processing techniques to improve revascularization decision-making and surgical strategies in patients undergoing coronary artery bypass graft surgery.
- Conditions
- CAD, Atheroscleroses, Coronary, Computed Tomography, Coronary Artery Bypass
- Trial name
- NCT03894423
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Stanford University
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