Clinical trials: Coronary Bypass
Cardiac Surgery
Thrombin Generation During Cardiopulmonary Bypass With Titrated Versus Conventional Anticoagulation Management.
In this study, the investigators will be comparing anticoagulation for Cardiopulmonary Bypass (CPB) guided by the Hemostasis Management System (HMS Plus) with the current dosing based on weight and ACT measurements.
- Trial name
- THROMBIN (NCT03347201)
- Testing
- HMS Plus
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Coronary Artery Bypass Graft Triple Vessel, Apoptotic DNA Damage
Remote Ischemic Preconditioning of Human Myocardium
The investigators aim to definitively show if human myocardium can be remotely preconditioned. In the writings there are no experiments that would prove that the remote preconditioning protocol effects on the higher protection of…
- Trial name
- NCT01994707
- Testing
- Remote ischemic preconditioning
- Where
- Poland
- Volunteers
- 134 people
- Sponsor
- Medical University of Silesia
Kidney Failure
AKIN Criteria: Acute Kidney Injury After On-Pump Coronary Artery Bypass Graft (CABG)
The purpose of this study is evaluate clinical outcomes and 30-day mortality after on-pump CABG.
- Trial name
- NCT00780845
- Volunteers
- 817 people
- Sponsor
- Hospital de Base
Coronary Artery Disease, Ischemia
Coronary Steal Via Natural Internal Mammary Artery-To-Coronary Artery Bypasses
CORONARY ARTERY DISEASE AND THE BENEFIT OF BYPASSES Despite considerable advances in medicine, cardiovascular diseases remain the number one cause of death globally.
- Trial name
- CIMA (NCT02332564)
- Testing
- Coronary Artery Balloon Occlusion for Determination of Collateral Flow Index
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronary Artery Disease, Ascending Aortic Aneurysm
Coronary Artery Bypass Grafting With Ascending Aortic Replacement
This retrospective study investigates early outcomes after CABG as well as graft patency rate in patients with concomitant AAR. 35 patients undergoing CABG with concomitant AAR (CABG+AAR group) were case-control matched to 35…
- Trial name
- NCT07071857
- Testing
- ECG CT angiography, TTFM, computed tomography of the aorta and/or grafts
- Volunteers
- 70 people
- Sponsor
- Tomsk Cardiology Research Institute
Coronary Bypass Graft Occlusion
Diagnostic and Prognostic Value of Cardiac Biomarkers for Early Coronary Bypass Occlusion in Patients Undergoing Coronary Revascularization
This study is to evaluate the correlation between hs-cTn level as cardiac biomarker for ischemia and early graft occlusion as assessed by CCT in patients undergoing coronary bypass surgery.
- Trial name
- NCT04595630
- Testing
- data collection from the hospital records
- Where
- 3 sites in Croatia, Poland and 1 more
- Volunteers
- 480 people
- Sponsor
- University Hospital, Basel, Switzerland
Coronary Artery Disease With Need for Bypass Surgery, Coronary Artery Disease(CAD)
Postural Mobilization Compared to Noradrenaline Only in Off-Pump CABG Surgery
This interventional prospective randomized study is designed to compare hemodynamic management using postural mobilization (+/- noradrenaline) versus noradrenaline only in patients undergoing open-heart coronary artery bypass…
- Conditions
- Coronary Artery Disease With Need for Bypass Surgery, Coronary Artery Disease(CAD), Coronary Artery Bypass, Off Pump Coronary Artery Bypass Graft
- Trial name
- OPTICAB (NCT07163858)
- Testing
- passive leg raising for hemodynamic management during open-heart coronary bypass grafting, Use of Noradrenaline only in control group
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Infirmerie Protestante de Lyon
Systemic Inflammatory Response Syndrome, Coronary Arteriosclerosis
Cleansing of Suction Blood in Cardiac Surgery for Reduced Inflammatory Response
Cardiac surgery using heart and lung machine produces an inflammatory reaction in the body. This leads in few percent of cases to heart, lung, and kidney disturbances that potentially causes death.
- Trial name
- NCT00159926
- Testing
- Cell saver, No cell saver
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Artery Disease, Delirium
The PATHFINDER Study: A Feasibility Trial
The main purpose of this study is to determine whether a rational strategy of EEG guided multimodal general anesthesia using target specific sedative and analgesics could result in enhanced recovery after anesthesia and surgery…
- Trial name
- PATHFINDER (NCT04016740)
- Testing
- Ropivacaine, Ketamine, Remifentanil
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Beth Israel Deaconess Medical Center
Minimally Invasive Cardiac Surgery
The Quality of Life and Patency Rate After Minimally Invasive Cardiac Surgery
This trial will address essential questions of the efficacy and safety of MICS-CABG in addition to the quality of life and patency rate of the grafts.
- Trial name
- NCT05104320
- Testing
- MICS-CABG, sternotomy CABG
- Volunteers
- 248 people
- Sponsor
- Peking University Third Hospital
Palliation of Congenital Heart Diseases, Cardiopulmonary Bypass
Impact of Chest Wall Mechanics on Lung and Cardiovascular Function During Delayed Sternal Closure
This study aims to describe chest wall mechanics during delayed sternal closure (DSC) in neonates following cardiopulmonary bypass or palliation of congenital heart diseases.
- Conditions
- Palliation of Congenital Heart Diseases, Cardiopulmonary Bypass, Chest Wall Mechanics, Neonatal Delayed Sternal Closure
- Trial name
- NCT05257525
- Testing
- Esophageal manometry catheter at various PEEP levels and tidal volumes
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- The Hospital for Sick Children
Children With Heart Defects
Heparin Responses in Pediatric Patients Undergoing Cardiopulmonary Bypass.
Heparin is an anticoagulant or "blood thinner". Heparin is always given to patients undergoing open-heart surgery to prevent blood from clotting when a patient is placed on the heart-lung machine.
- Trial name
- NCT00166140
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Emory University
Hemodynamic Instability, Vasoplegic Syndrome
Hemodynamic Instability Prevented With Polaramine® Infusion Before Extracorporeal Circulation
This single-institution randomized controlled trial prospective will enrolled 48 patients scheduled for an aortic valve replacement.
- Trial name
- HIPPIE (NCT02675374)
- Testing
- dexchlorpheniramine (Polaramine®) injection
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Bordeaux
Coronary Artery Disease, Myocardial Infarction
Impact of a Corrie Cardiac Rehabilitation Program
In this randomized clinical trial, the researchers are investigating whether a multi-component virtual/hybrid cardiac rehabilitation program will improve functional status, cholesterol level, overall cardiovascular health…
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Myocardial Ischemia, Coronary Artery Occlusion
- Trial name
- mTECH-Rehab (NCT05238103)
- Testing
- Corrie Hybrid Cardiac Rehabilitation Program
- Where
- United States
- Volunteers
- 259 people
- Sponsor
- Johns Hopkins University
Coronary Artery Bypass Grafting, Mortality
CASUS vs. APACHE II in Predicting Mortality After Coronary Artery Bypass Grafting
The study seeks to determine the value of CASUS in predicting mortality as compared with APACHE II scoring system among patients undergoing coronary artery bypass grafting.
- Trial name
- CASUS (NCT05026437)
- Testing
- Cardiac surgery score and APACHE II scoring
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 204 people
- Sponsor
- Antalya Training and Research Hospital
Multiple Organ Dysfunction With Severe Endotoxemia
Efficacy and Safety of Hemoperfusion With Polymyxin B in Septic Shock Associated With Severe Endotoxemia in Cardiac Surgery Patients (РМХ vs SS)
Sepsis is a state of multiple organ dysfunction caused by a generalized immune-inflammatory response of the body to an infectious agent, with pronounced heterogeneity and interchangeability of clinical and laboratory…
- Trial name
- РМХ vs SS (NCT04920565)
- Testing
- hemoperfusion with polymyxin B
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Acute Lung Injury
L-citrulline for Prevention of Sequelae of Acute Lung Injury in Pediatrics Undergoing Cardiopulmonary Bypass for Heart Defects
The purpose of this study is to determine whether L-citrulline is effective and safe in the prevention of clinical sequelae of Acute Lung Injury in pediatric subjects undergoing surgery for congenital heart defects.
- Trial name
- NCT02891837
- Testing
- L-citrulline
- Where
- 29 sites in United States, Austria and 2 more
- Volunteers
- 189 people
- Sponsor
- Asklepion Pharmaceuticals, LLC
Open Heart Surgery, Cardiopulmonary Bypass
Evaluation of Optic Nerve Sheath Diameter Changes During Cardiopulmonary Bypass in Open Heart Surgery
During cardiopulmonary bypass (CPB) in open-heart surgery, direct measurement of intracranial pressure is not feasible. Evaluation of the optic nerve sheath diameter (ONSD) by ultrasonography is considered a reliable method for…
- Conditions
- Open Heart Surgery, Cardiopulmonary Bypass, Intracranial Pressure, Optic Nerve Sheath Diameter
- Trial name
- NCT07253922
- Testing
- Ultrasonography of the Optic Nerve Sheath
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Medipol University
Coronary Artery Bypass Graft
Prospective Data Analysis of a Quality Improvement Initiative in High Risk Cardiac Surgery Patients
This project is designed to assess the impact of implementing a hemodynamic optimization protocol, utilizing flow guided parameters that is provided by technology from Edwards Lifesciences, for patients undergoing high risk…
- Trial name
- NCT04458701
- Testing
- Hemodynamic monitoring
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- Loma Linda University
Anxiety, Discharge Readiness
The Effect of Nurse-led Video-assisted Discharge Training on Anxiety and Readiness for Discharge After Coronary Artery Bypass Graft Surgery
This clinical trial aims to evaluate the effect of nurse-led video-assisted discharge education on discharge readiness and anxiety in patients undergoing coronary artery bypass graft surgery.
- Conditions
- Anxiety, Discharge Readiness, Nursing, Training
- Trial name
- NCT06806631
- Testing
- Video assisted discharge training
- Where
- Turkey (Türkiye)
- Volunteers
- 89 people
- Sponsor
- Uskudar University
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