Clinical trials: Coronary Bypass
Cardiac Disease, Cardiac Surgery
Platelet Transfusion During Neonatal Open Heart Surgery
Hypothesis: Dilutional thrombocytopenia after cardiopulmonary bypass (CPB) is universal and administration of donor apheresis platelets just prior to termination of bypass will assist in early correction of coagulopathy, early…
- Conditions
- Cardiac Disease, Cardiac Surgery, Cardiopulmonary Bypass, Platelet Transfusion
- Trial name
- CPB (NCT03045068)
- Testing
- Platelet Transfusion, FFP and Cryoprecipitate, PRBC and cell saver Transfusion
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- The University of Texas Health Science Center, Houston
Supraventricular Tachycardia
Adenosine Versus Verapamil for Management of Supraventricular Tachycardia Post- Coronary Artery Bypass Grafting
This prospective study was conducted in 268 patients aged from 65-70 years posted for coronary artery bypass grafting. Patients were randomly allocated to either adenosine or verapamil(control) groups.
- Trial name
- NCT04203368
- Testing
- adenosine, verapamil
- Where
- Egypt
- Volunteers
- 268 people
- Sponsor
- Ain Shams University
Endothelial Dysfunction, Hemolysis Intravascular
Effects of Nitric Oxide on the Endothelium During Hemolysis.
This study is an ancillary (add-on) study to the clinical trial entitled "Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction", which has Clinical Trials.gov identifier NCT02836899.
- Conditions
- Endothelial Dysfunction, Hemolysis Intravascular, Cardiovascular Diseases, Cardiovascular Risk Factor
- Trial name
- NCT03748082
- Testing
- Nitric Oxide, Reactive Hyperemia Index, Endothelial Cells Collection
- Where
- 2 sites in United States
- Sponsor
- Massachusetts General Hospital
Acute Coronary Syndrome
Bleeding in Patients Undergoing CABG (Coronary Artery Bypass Graft) During Dual Antiplatelet Therapy
The aim of the study is to evaluate surgery-related bleeding and mortality in patients needing acute coronary artery bypass grafting with or without valve replacement during dual antiplatelet therapy with aspirin and a P2Y12…
- Trial name
- NCT02030548
- Where
- Austria
- Volunteers
- 144 people
- Sponsor
- Medical University of Graz
Cardiopulmonary Bypass
Amobarbital and Cardiopulmonary Bypass
Explore the effects of amobarbital on myocardial protection and prognosis in patients undergoing cardiac surgery with cardiopulmonary bypass, investigate the new usage of old drugs, and provide reliable clinical scientific basis…
- Trial name
- NCT06757868
- Testing
- Amobarbital, Midazolam
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Tongji Hospital
Coronary Artery Disease
A Study of Hemopure® to Enhance Tissue Preservation During Cardiopulmonary Bypass Surgery
The purpose of this study is to determine if Hemopure® will enhance tissue preservation during Cardiopulmonary Bypass surgery.
- Trial name
- NCT00301535
- Testing
- HBOC-201 (hemoglobin glutamer-250 bovine)
- Where
- 3 sites in Greece, South Africa and 1 more
- Volunteers
- 60 people
- Sponsor
- Biopure Corporation
Cardiac Surgery Requiring Cardiopulmonary Bypass, Acute Kidney Injury
SIRAKI 02 Posthoc Analysis.
Our randomized controlled trial with 343 patients requiring non emergent cardiac surgery with a prolonged expected cardiopulmonary bypass (CPB) time (>90 minutes) demonstrated that the use of an extracorporeal blood purification…
- Conditions
- Cardiac Surgery Requiring Cardiopulmonary Bypass, Acute Kidney Injury, Chronic Kidney Disease(CKD), Kidney Failure, Acute
- Trial name
- OXI-SAFE-CEC (NCT06781294)
- Testing
- Extracorporeal Cytokine hemadsorption therapy
- Where
- Spain
- Volunteers
- 343 people
- Sponsor
- Hospital Universitari de Bellvitge
Patients Waiting for Elective Coronary Artery Bypass Graft Surgery
Pre-habilitation Program for Elective Coronary Artery Bypass Graft Surgery Patients
Low levels of physical fitness increase the risk of death in patients with cardiovascular disease. Although cardiac rehabilitation programs improve the health of patients after heart surgery, most patients are not referred until…
- Trial name
- NCT01914094
- Testing
- Prehab
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- St. Boniface Hospital
Cardiac Surgery, Protein Metabolomics
Cerebral Monitor Guided Therapy on Cerebral Outcomes After Cardiac Surgery
The purpose of this study is to compare patients' metabolomic profiles who are managed with a brain monitor that measures cerebral oxygen to those who are managed by conventional measures to hopefully decrease postoperative…
- Conditions
- Cardiac Surgery, Protein Metabolomics, Cerebral Function, Cardiopulmonary Bypass
- Trial name
- NCT03316183
- Testing
- Perioperative and postoperative management
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
Coronary Artery Bypass Grafting, Coronary Artery Disease
Melatonin Impact on the Outcomes of Myocardial Ischemia/Reperfusion Injury During Coronary Artery Bypass Grafting Surgery
The ischemia/reperfusion (I/R) injury of the myocardium initiates a variety and complex sets of inflammatory reactions that may both exaggerate local injury as well as provoke injury of distant organ function .
- Trial name
- NCT05552586
- Testing
- Melatonin
- Volunteers
- 22 people
- Sponsor
- Ain Shams University
Coronary Artery Disease, Coronary Disease
The INVADER™ Percutaneous Transluminal Coronary Angioplasty (PTCA) Post Market Clinical Follow-up (PMCF) Study
The aim of the present observational study is to collect clinical data on the non-implantable medical device INVADER™ PTCA in the daily use in an unselected population.
- Conditions
- Coronary Artery Disease, Coronary Disease, Vascular Diseases
- Trial name
- NCT05904951
- Testing
- INVADER™ PTCA Balloon Dilatation Catheter
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Alvimedica
Percutaneous Coronary Intervention, Myocardial Infarction
Exercise Prescription in Cardiac Rehabilitation
Cardiac Rehabilitation (CR) is an effective exercise-based lifestyle therapy for patients with cardiac disease. There are two common methods of exercise prescription, an effort based exercise prescription and target heart rate…
- Conditions
- Percutaneous Coronary Intervention, Myocardial Infarction, Coronary Artery Bypass Graft
- Trial name
- NCT03925493
- Testing
- Graded Exercise Stress test (GXT) with Target Heart Rate Range, Heart rate monitors
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Baystate Medical Center
Postoperative Delirium
Biochemical Predictors of Delirium in Cardiac Surgery
Delirium is a common neurologic complication after cardiac surgery occuring in 30-50% of patients. The occurence of this complication is associated with worse outcomes, including prolonged length of stay in the ICU and hospital…
- Trial name
- NCT03931499
- Testing
- Metabolomic analysis
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Elective Coronary Artery Bypass Graft Surgery
Colchicine in Coronary Artery Bypass Graft (CABG)
There is evidence that inflammatory processes may play a key role during surgical myocardial reperfusion. The hypothesis of this study is that colchicine, an anti-inflammatory agent, may lead to reduction in periprocedural…
- Trial name
- NCT02122484
- Testing
- Colchicine
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- G.Gennimatas General Hospital
Depression, Coronary Disease
Treatment of Depression After Coronary Bypass Surgery
This randomized controlled trial will test the efficacy of (1) cognitive behavior therapy and (2) supportive stress management as treatments for depression in people who have recently undergone coronary artery bypass graft…
- Trial name
- NCT00042198
- Testing
- Cognitive behavior therapy, Supportive Stress Management
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Washington University School of Medicine
Coronary Artery Disease, Acute Coronary Syndromes
CRAGS (Coronary aRtery diseAse in younG adultS)
Young patients requiring myocardial revascularization are generally considered at low operative risk, but data on their immediate and late outcome are scarce.
- Conditions
- Coronary Artery Disease, Acute Coronary Syndromes, Young Patient, Percutaneous Coronary Intervention
- Trial name
- CRAGS (NCT01838746)
- Where
- 9 sites in Finland, Iceland and 2 more
- Volunteers
- 2,000 people
- Sponsor
- University of Turku
Hypotension, Poor Peripheral Perfusion
Effect of Vasopressin on Tissue Oxygen Saturation in Cardiac Surgery Patients During Cardiopulmonary Bypass
The objective of this research is to compare the effect of a low dose Vasopressin infusion or placebo during cardiopulmonary bypass on vasopressor requirements, hemodynamics and tissue oxygen saturation and its recovery using…
- Trial name
- NCT01532505
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Mohamed Ismail
Coronary Artery Bypass Surgery
A Comparison of Etomidate and Ketamine for Anesthesia Induction in Coronary Artery Bypass Graft Surgery
The aim of this study is to determine whether ketamine is an acceptable alternative to etomidate for anesthesia induction in coronary artery bypass graft surgery in terms of hemodynamic stability and also to compare these agents…
- Trial name
- NCT01386229
- Testing
- Ketamine, Etomidate
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Baskent University
Congenital Heart Disease, Open Heart Surgery
Localized Evidence of Cytokine Adsorption Therapy During Pediatric Cardiac Surgery: A Single Center Randomized Controlled Trial (LEAT)
The Localized Evidence of Cytokine Adsorption Therapy (LEAT) study is a prospective, randomized controlled trial conducted at the Institut Jantung Negara in Malaysia.
- Conditions
- Congenital Heart Disease, Open Heart Surgery, Cardiopulmonary Bypass, Endocarditis Acute and Subacute
- Trial name
- LEAT (NCT07771491)
- Testing
- Hemoadsorption (Jafron HA-60/HA380)
- Volunteers
- 120 people
- Sponsor
- Norfaniza Zabidi
Coronary Artery Disease, Atrial Fibrillation
A Study Of Stellate Ganglion Blockade With Liposomal Bupivacaine In Preventing Atrial Fibrillation After Isolated Coronary Artery Bypass Grafting Surgery
The purpose of this study is assess the incidence of postoperative atrial fibrillation (POAF) within one week of surgery in patients who receive pre-surgical stellate ganglion blockade with liposomal bupivacaine, compared to…
- Trial name
- NCT07570940
- Testing
- Liposomal bupivacaine
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Mayo Clinic
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