Clinical trials: Coronary Calcification
Coronary Artery Calcification, Arterial Stiffness
The InterVitaminK Trial - Effects of Vitamin K Supplementation on Cardiovascular, Metabolic, and Bone Health
The purpose of this study is to examine the effect of menaquinone-7 (MK-7) supplementation on cardiovascular, metabolic, and bone health.
- Trial name
- InterVitaminK (NCT05259046)
- Testing
- Menaquinone-7 (MK-7) tablet (333 µg)
- Where
- Denmark
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Aortic Valve Stenosis, Aortic Valve Calcification
SLOW-Slower Progress of caLcificatiOn With Vitamin K2
A randomized 12-month trial will include two groups of 100 individuals aged over 50 years, with asymptomatic mild to moderate Aortic valve stenosis (AVA > 1 cm2, Vmax < 4 m/s).
- Conditions
- Aortic Valve Stenosis, Aortic Valve Calcification, Mitral Annular Calcification, Mitral Valve Calcification
- Trial name
- NCT04429035
- Testing
- Vitamin K2
- Where
- 2 sites in Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Renal Dialysis, Cardiovascular Diseases
Vascular Calcification, Inflammation and Coronary Flow Velocity in Hemodialysis Patients
The aim of this cross-sectional study is to determine the correlation of coronary artery calcification as measured by electron-beam computerized tomography and coronary flow reserve measured by trans-thoracic Doppler…
- Conditions
- Renal Dialysis, Cardiovascular Diseases, Atherosclerosis, Inflammation
- Trial name
- NCT00921089
- Where
- Turkey (Türkiye)
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Coronary Artery Calcification
The Effects and Safety of Low Calcium Dialysis on Coronary Artery Calcification in Maintenance Hemodialysis Patients
This study aim to observe the preventive effect and the long term safety of low calcium dialysis on coronary artery calcification in Maintenance hemodialysis (MHD) patients.
- Trial name
- NCT02498457
- Testing
- low calcium dialysis
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Cardiovascular Disease (CVD)
Cardiovascular Risk Assessment and Coronary Calcium Score in Thai MASLD Patients
Metabolic dysfunction-associated steatotic liver disease (MASLD) is common in Thailand and is strongly linked to metabolic risk factors such as obesity, diabetes, hypertension, and dyslipidemia.
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Cardiovascular Disease (CVD), Coronary Artery Calcification
- Trial name
- MASLD-CAC (NCT07865936)
- Where
- Thailand
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Watcharasak Chotiyaputta
Kidney Disease, Chronic, Heart Failure
New Heart Failure Biomarkers in Early Stage Chronic Kidney Disease-Mineral and Bone Disorder
the objective of this study is to : -Determinate wether the circulating levels of iFGF23 and klotho can be a predictor biomarker of HF in patients with CKD-MBD.
- Trial name
- CKD-MBD-HF (NCT03307707)
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Pr. Semir Nouira
Coronary Artery Disease (CAD), Coronary Artery Calcification
Screening for Coronary Artery Disease USing Primary Evaluation With Coronary CTA in Aviation Medicine (SUSPECT)
SUSPECT is a prospective, single-center, cohort study of 250 military aircrew at the Center for Man in Aviation, Royal Netherlands Air Force.
- Conditions
- Coronary Artery Disease (CAD), Coronary Artery Calcification, Occupational Diseases, Aviator's; Disease
- Trial name
- SUSPECT (NCT05508893)
- Testing
- CT Angiography, Exercise stress test
- Where
- 2 sites in Netherlands
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Chronic Kidney Disease, Renal Osteodystrophy
Serum Sclerostin Levels, Cardiovascular Parameters and Carpal Tunnel Syndrome in Maintenance Hemodialysis Patients
Sclerostin, the product of the SOST gene, located on chromosome 17, locus q11.2 in humans, was originally believed to be a non-classical Bone morphogenetic protein (BMP) antagonist.Sclerostin was recently identified as a…
- Conditions
- Chronic Kidney Disease, Renal Osteodystrophy, Left Ventricular Hypertrophy
- Trial name
- NCT01382966
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- RFM Renal Treatment Services
Atherosclerosis, Cardiovascular Disease
A Prospective Study on Predictive Value of Non-Invasive Atherosclerotic Measurements in Elderly Chinese
The purpose of this study is to determine whether non-invasive atherosclerotic measurements (baPWV, IMT, FMD, CACS, ABI) are valuable predictors for cardiovascular events in elderly.
- Trial name
- NCT01208116
- Testing
- Cardiovascular events
- Where
- China
- Volunteers
- 1,290 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases
Immunomodulatory Effects of PCSK9 Inhibition
Cardiovascular disease (CVD) represents the leading cause of death worldwide. While medications, such as statins, significantly reduce atherosclerotic CVD (ASCVD) risk by lowering low density lipoprotein levels, they may also…
- Conditions
- Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases, Atherosclerosis, Arterial Inflammation
- Trial name
- INSPIRAR (NCT05720156)
- Testing
- 99mTc-tilmanocept SPECT/CT scanning
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Atherosclerosis, Atheroscleroses, Coronary
Detection of Coronary Artery Calcifications by Whole Blood Transcriptome Analyzed by Artificial InTelligence Algorithms
The goal of this observational study is to determine the diagnostic accuracy of peripheral whole blood transcriptomes analyzed by an artificial intelligence algorithm to detect the presence and extent of coronary calcification in…
- Conditions
- Atherosclerosis, Atheroscleroses, Coronary, Atherosclerotic Plaque
- Trial name
- CAC-TRAIT (NCT05619042)
- Where
- Argentina
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Santiago Gabriel Miriuka
Diabetes, Coronary Artery Calcification
A Study Comparing Skin Fluorescence to Coronary Artery Calcification
This study examines the relationship between the SCOUT DM device and coronary artery calcification as determined by rapid computed tomography in patients at risk for coronary heart disease.
- Trial name
- CACS (NCT00895427)
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- VeraLight, Inc.
Aortic Valve Disease, Aortic Valve Stenosis
Evaluation of the Inflammatory Response in Post-operated Aortic Valve Replacement Patients.
Background Calcification of the aortic valve affects more than 26% of adult patients over 65 years of age and is the main indication for valve replacement in the United States of America.
- Conditions
- Aortic Valve Disease, Aortic Valve Stenosis, Aortic Valve Calcification, Prosthetic Valve Malfunction
- Trial name
- NCT04557345
- Testing
- Determination of cytokines, Two-dimensional transthoracic echocardiogram
- Where
- Mexico
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Aortic Valve Disease, Aortic Valve Stenosis
Myeloid Cells in Aortic Valve Stenosis
Investigators plan to characterize systemic inflammation and circulating immune cells in participants with moderate and severe calcific aortic valve disease and matched healthy controls.
- Trial name
- MIRACLE (NCT04717219)
- Testing
- Blood drawing
- Where
- 3 sites in Netherlands
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Aging
Effect of Two Years of Resistance Training on Health Status in Postmenopausal Women: Longitudinal Study Active Aging.
Aging is a natural process of the life cycle that can result in morphological, neuromuscular, metabolic, physiological, cognitive and behavioral changes that can compromise quality of life, autonomy, self-esteem, health and life…
- Trial name
- NCT06621368
- Testing
- Exercise, Control-no treatment
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Londrina
Chronic Kidney Disease
CRICKET Study, Coronary Calcium Scores in Patients With Chronic Kidney Disease
Patients with Chronic Kidney Disease (CKD) have been shown to have high coronary calcium scores (CAC), but the temporal association between Glomerular Filtration Rate, CVD risk factors and CAC has not been described.
- Trial name
- NCT00142636
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Cardiovascular Diseases, Heart Diseases
Coronary Artery Calcification in Type 1 Diabetes
To investigate the occurrence and associated risk factors for subclinical heart disease in persons with insulin-dependent diabetes mellitus (IDDM).
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Diabetes Mellitus
- Trial name
- NCT00005754
- Volunteers
- 1,420 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Depression, Major Depressive Disorder
Associations Between Depression and Cardiovascular Disease - a Study of Patients With Late Onset Depression
Studies show that depression is a risk factor for the development of coronary artery disease (CAD). Furthermore there is an increased occurrence of depression in patients with CAD.
- Conditions
- Depression, Major Depressive Disorder, Cardiovascular Disease, Coronary Artery Disease
- Trial name
- NCT00818506
- Where
- Denmark
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Calcific Aortic Stenosis, Calcific Aortic Stenosis - Bicuspid Valve
Identification of Genetic Causes of Calcific Aortic Valve Disease
This study aims to identify the molecular genetic causes of the variability in development of calcific aortic valve disease in bicuspid and tricuspid aortic valves and their associated aortic dilation.
- Conditions
- Calcific Aortic Stenosis, Calcific Aortic Stenosis - Bicuspid Valve, Aortic Valve Disease, Aortic Valve Calcification
- Trial name
- NCT04149600
- Testing
- Patients scheduled to undergo aortic valve replacement or aortic surgery at BIDMC will be approached for participation in this study.
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Cardiovascular Diseases, Heart Diseases
Ventricular Size and Value Calcification Measures by Computed Tomography - Ancillary to MESA
To rescan 6,700 subjects in the MESA study to obtain computed tomography measures of calcification.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Coronary Arteriosclerosis
- Trial name
- NCT00065780
- Volunteers
- 6,814 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center