Clinical trials: Coronary Computed Tomographic Angiography
Coronary Artery Disease
CHART Study of Coronary CT Angiography in Coronary Artery Disease
In a cohort of patients referred to coronary computed tomography angiography (CCTA), the investigators aim: 1. To describe the natural history of the coronary atherosclerotic plaque development and progression or regression, as…
- Trial name
- CHART-VISION (NCT05380622)
- Testing
- Coronary CT angiography
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Breast Cancer, Cardiac Toxicity
BreAst Cancer and Cardiotoxicity Induced by RAdioTherapy: the BACCARAT Study
Breast radiotherapy RT used until the 1990s was clearly responsible for increased mortality due to long term cardiac complications.
- Trial name
- BACCARAT (NCT02605512)
- Testing
- Subclinical cardiac lesions and biomarkers
- Where
- France
- Volunteers
- 118 people
- Sponsor
- Sophie JACOB
Coronary Artery Disease, Atherosclerotic Plaque
Changes in Plaque Characteristics After Short-term Statin Therapy as Assessed With Coronary CT
INTENSE Trial is a prospective, double-blind, randomized, placebo-controlled, single-center study with two arms (40 mg intensified statin therapy vs matching placebo for rosuvastatin) among statin-naive patients referred to…
- Conditions
- Coronary Artery Disease, Atherosclerotic Plaque, Coronary Computed Tomography Angiography, Statin Therapy
- Trial name
- INTENSE (NCT06603363)
- Testing
- Rosuvastatin 40mg, Coronary Computed Tomography Angiography (Coronary CTA), Blood test
- Where
- Hungary
- Volunteers
- 140 people
- Sponsor
- Prof. Maurovich-Horvat Pál
Coronary Artery Disease, Angina Pectoris
Study Comparing CT Scan and Stress Test in Diagnosing Coronary Artery Disease in Patients Hospitalized for Chest Pain
The purpose of this study is to determine whether coronary artery CT scanning or nuclear stress testing is better at diagnosing chest pain patients with coronary artery disease to select appropriate candidates for coronary…
- Conditions
- Coronary Artery Disease, Angina Pectoris, Unstable Angina, Acute Coronary Syndrome
- Trial name
- PROSPECT (NCT00705458)
- Testing
- Coronary Computed Tomography Angiography, Stress Nuclear Myocardial Perfusion Imaging
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Montefiore Medical Center
Chest Pain, Angina
Stress Echocardiography and Heart Computed Tomography (CT) Scan in Emergency Department Patients With Chest Pain
The purpose of this study is to determine whether stress echocardiography or computed tomography (CT) of the heart is better at diagnosing emergency room chest pain patients to select appropriate candidates for hospitalization…
- Conditions
- Chest Pain, Angina, Angina Pectoris, Coronary Artery Disease
- Trial name
- NCT01384448
- Testing
- Stress Echocardiography, Coronary CT Angiography
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Montefiore Medical Center
Cardiovascular Diseases (CVD), Coronary Artery Disease
wCAR-Austria: A Women-Specific Score to Assess Cardiovascular Risk in Women Aged 40 to 65
The wCAR-Austria Study is a multicentre, prospective, interventional study evaluating a novel women-specific cardiovascular risk score (wCAR) in 800 women aged 40-65 years across Austria.
- Conditions
- Cardiovascular Diseases (CVD), Coronary Artery Disease, Atheroscleroses
- Trial name
- wCAR-Austria (NCT07849127)
- Testing
- Arm 1: wCAR-CARE - Precision Prevention (Arm A), Guideline-directed standard of care
- Where
- Austria
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Women's Heart Austria
Coronary Artery Disease
Impact of Coronary CT Angiography, Physiologic Assessment and Pharmacotherapy on the Clinical Outcomes
The investigators aim to investigate the prognostic implication of stenosis and plaque features on coronary CT angiography (CCTA), physiologic assessment, and pharmacotherapy after invasive coronary angiography.
- Trial name
- PRIME-CT (NCT04547231)
- Testing
- Fractional flow reserve, Coronary CT angiography
- Where
- South Korea
- Volunteers
- 992 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease
Coronary CT Angiography as the Primary Initial Method of Evaluating Patients With Subacute Chest Pain (CT PRIME)
This study is designed to evaluate a new approach to the diagnosis of chronic or sub-acute chest pain patients in the out-patient setting.
- Trial name
- CTPRIME (NCT00584337)
- Where
- United States
- Sponsor
- Corewell Health East
Coronary Artery Disease, Atheroscleroses
Drug-Eluting Balloon Treatment vs. Guideline-Directed Medical Therapy for the Treatment of Lipid-Rich Plaques
The goal of this clinical trial is to find out whether treating vulnerable plaques in the coronary arteries with a drug-coated balloon can make them less dangerous than using standard medication alone.
- Conditions
- Coronary Artery Disease, Atheroscleroses, Cardiovascular Disease, Vulnerable Coronary Plaques
- Trial name
- DELETE-LRP (NCT07107971)
- Testing
- Paclitaxel-eluting balloon
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
FFR-CT, CT Angiography
Spectral and Ultra High Resolution CT Systems for Non-Invasive Detection of Myocardial Ischemia: Stress CT Perfusion VS. FFR-CT
Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Coronary Computed Tomography angiography (CCTA) gained a pivotal clinical role for excellent sensitivity in rule-out CAD, but has limited…
- Conditions
- FFR-CT, CT Angiography, CT Perfusion, Coronary Arterial Disease (CAD)
- Trial name
- SURE-CT (NCT07544277)
- Where
- 2 sites in Italy
- Volunteers
- 142 people
- Sponsor
- IRCCS San Raffaele
Kidney Transplant Recipient
Clinical Significance of 64-slice Multidetector Coronary CT Angiography to Evaluate the Prevalence and Severity of Coronary Artery Disease in Renal Transplant Recipients
The aim of this study is to evaluate the clinical usefulness of 64-slice multidetector coronary CT angiography (MDCTA) in renal transplant recipients who had no previous coronary artery disease (CAD).
- Trial name
- NCT01753505
- Testing
- 64-slice Multidetector coronary CT angiography
- Where
- South Korea
- Volunteers
- 93 people
- Sponsor
- Yonsei University
Cardiac Arrest (CA), Myocardial Infarction (MI)
Diagnostic Accuracy of ECG-less Gated Cardiac CT in Resuscitated Cardiac Arrest Survivors Without ST Elevation Myocardial Infarction
In a significant portion of patients surviving a cardiac arrest, the event is caused by a myocardial infarction (a narrowing or blockage of one or more blood vessels that supply blood to the heart, the coronary arteries).
- Trial name
- OPEN CCTArrest (NCT07388342)
- Testing
- ECG-less gated cardiac CT
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitair Ziekenhuis Brussel
Coronary Artery Disease
Relationship Between Coronary CT Angiography Findings and Prognosis Of Patients Undergoing PCI
Researchers at Cerrahpaşa Medical School in Istanbul are studying how a heart imaging test called coronary CT angiography can help improve care for people with coronary artery disease.
- Trial name
- NCT07051473
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Coronary Artery Disease
Coronary MDCTA With Iopamidol Injection 370
Determine the validity and compare the visualization of arterial segments obtained with 3 doses of iopamidol to determine dose for further investigation in future trials.
- Trial name
- NCT00558792
- Testing
- Isovue 370, 70 mL, Isovue 370, 80 mL, Isovue 370, 90 mL
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Bracco Diagnostics, Inc
Hypertension
The COlchicine HypERtENsion Trial
The purpose of this study to investigate the effects of colchicine on measures of vascular and cardiac function in patients with hypertension.
- Trial name
- COHERENT (NCT04916522)
- Testing
- Colchicine
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Herlev and Gentofte Hospital
Coronary Artery Disease, Coronary Disease
Prospective Multicenter Registry On Radiation Dose Estimates Of Cardiac CT Angiography in Daily Practice in 2017 (PROTECTION VI)
Background: CCTA is a common way to evaluate coronary artery disease. It stands for coronary computed tomography angiography. It uses scanning to look at the arteries that supply blood to the heart.
- Conditions
- Coronary Artery Disease, Coronary Disease, Myocardial Ischemia, Arterial Occlusive Diseases
- Trial name
- NCT03253692
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Coronary Syndrome, Coronary Artery Disease
Feasibility of a Deep Learning-based Algorithm for Non-invasive Assessment of Vulnerable Coronary Plaque
The primary objective of this study is to assess the accuracy in terms of sensitivity, specificity, negative and positive predicted values of the DL-based algorithm with respect to correct identification of the plaque and…
- Conditions
- Chronic Coronary Syndrome, Coronary Artery Disease, Stable Angina, Acute Coronary Syndrome
- Trial name
- FOCUS DL (NCT06186336)
- Testing
- Deep Learning-based Vulnerable Plaque Detection and Assessment Tool
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- GE Healthcare
Coronary Artery Disease, Coronary Atheroscleroses
Risk Evaluation by COronary Imaging and Artificial intelliGence Based fuNctIonal analyZing tEchniques - IV
This study is a single-center, prospective cohort study. The study is designed to identify novel circulating biomarkers for early prediction of high-risk coronary plaques.
- Conditions
- Coronary Artery Disease, Coronary Atheroscleroses, Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome
- Trial name
- RECOGNIZE-IV (NCT06793787)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Ruijin Hospital
Coronary Heart Disease
Analysis of Coronary CT Angiography to Identify Patients With Significant Coronary Artery Stenosis
The investigators propose to develop a computational framework involving a novel automatic image segmentation algorithm based on CTA images, an artery model reconstruction algorithm for stenosis detection, and quantification of…
- Trial name
- CTAAnalyzer (NCT02791113)
- Testing
- Fractional Flow Reserve (FFR) Measurement
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- National Heart Centre Singapore
Coronary Artery Disease (CAD), Coronary Artery Calcification
Screening for Coronary Artery Disease USing Primary Evaluation With Coronary CTA in Aviation Medicine (SUSPECT)
SUSPECT is a prospective, single-center, cohort study of 250 military aircrew at the Center for Man in Aviation, Royal Netherlands Air Force.
- Conditions
- Coronary Artery Disease (CAD), Coronary Artery Calcification, Occupational Diseases, Aviator's; Disease
- Trial name
- SUSPECT (NCT05508893)
- Testing
- CT Angiography, Exercise stress test
- Where
- 2 sites in Netherlands
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht