Clinical trials: Coronary Disease
Heart Failure
Heart Failure Events Reduction With Remote Monitoring and eHealth Support Investigator Initiated Trial
The primary objective of the study is to evaluate the efficacy of a telemedicine-based follow-up strategy compared with usual care in the management of patients with chronic heart failure (HF) at high risk of clinical events.
- Trial name
- HERMeS (NCT03663907)
- Testing
- Telemonitoring
- Where
- Spain
- Volunteers
- 510 people
- Sponsor
- Hospital Universitari de Bellvitge
Cardiac Surgical Procedures
Diagnostic Accuracy of Doppler Resistive Indices for Early Diagnosis of Acute Kidney Injury .
To determine if ultrasound measurement of renal and carotid arterial resistive indices are associated with post-cardiac surgery acute kidney injury.
- Trial name
- NCT02580292
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Heart Defects, Congenital
The CHAPTER III Study of Young Adolescents
The CHAPTER III Study (Congenital Heart Adolescents Participating in Transition Evaluation Research) is a cluster randomized controlled trial evaluating the impact of a nurse-led transition intervention in combination with usual…
- Trial name
- NCT02374892
- Testing
- CHAPTER III Study Intervention
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Alberta
Heart Failure, Cognitive Impairment
Mind Your Heart-II
This projects studies the role of mindfulness training (MT) to improve self-care among patients with heart failure and cognitive impairment.
- Trial name
- MYH-II (NCT05431192)
- Testing
- Mindfulness Training + Enhanced Usual Care, Enhanced Usual Care
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- The Miriam Hospital
Cardiovascular Diseases, Heart Diseases
Genetic Analysis of Human Hypertensive End Stage Renal Disease (H-ESRD)
To identify genes causing hypertensive end-stage renal disease (H-ESRD) in high risk African-American populations
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Kidney Failure, Chronic
- Trial name
- NCT00005536
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Failure, Congestive, Dyspnea
The DIAMOND Study: Distensibility Improvement And Remodeling in Diastolic Heart Failure
The purpose of this study is to test the hypothesis that treatment with oral ALT-711 twice daily for 16 weeks will improve aortic distensibility, exercise tolerance, and quality of life in elderly patients with isolated diastolic…
- Conditions
- Heart Failure, Congestive, Dyspnea, Pulmonary Edema
- Trial name
- NCT00043836
- Testing
- ALT-711
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Synvista Therapeutics, Inc
Acute Kidney Injury, Acute Renal Failure
A Comparison of Dilute Versus Concentrated Heparin for CRRT Anticoagulation
Heparin is commonly used for anticoagulation of the extracorporeal circuit during continuous renal replacement therapy (CRRT) but the optimal mode of delivery has not yet been validated.
- Conditions
- Acute Kidney Injury, Acute Renal Failure, Heart Failure
- Trial name
- NCT01318811
- Testing
- Dilute unfractionated heparin, Standard concentration unfractionated heparin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Vanderbilt University
Coronary Artery Disease
Myocardial Stress Perfusion Imaging With Dual Source CT
The investigators propose a novel technique using dual source multidetector computed tomography (DSCT) where information on both coronary anatomy and myocardial perfusion is obtained in a single scan.
- Trial name
- NCT00853671
- Testing
- Adenosine Stress Dual-source CTP
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Myocardial Infarction, Helicobacter Pylori Infection
HELicobacter Pylori Screening to Prevent Gastrointestinal Bleeding in Patients With Acute Myocardial Infarction
Background: Potent antithrombotic therapy has improved prognosis for patients with acute myocardial infarction (MI) significantly, however, at a price of increased bleeding risk. Helicobacter pylori (H.
- Conditions
- Myocardial Infarction, Helicobacter Pylori Infection, GastroIntestinal Bleeding, Cardiovascular Diseases
- Trial name
- HELP-MI (NCT05024864)
- Testing
- Urea breath test (UBT)
- Where
- 35 sites in Sweden
- Volunteers
- 20,000 people
- Sponsor
- Karolinska Institutet
Coronary Artery Disease, Ischemic Mitral Regurgitation
Treatment of Moderate Ischemic Mitral Regurgitation in Patients With Coronary Artery Disease
This study aims to evaluate the effect of angiotensin receptor/neprilysin inhibitors (ARNI) on improving ischemic mitral regurgitation (IMR) in patients with coronary artery disease undergoing isolated coronary artery bypass…
- Conditions
- Coronary Artery Disease, Ischemic Mitral Regurgitation, Angiotensin Receptor/Neprilysin Inhibitor
- Trial name
- NCT06917664
- Testing
- sacubitril/valsartan
- Where
- China
- Volunteers
- 220 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease, Coronary Artery Bypass
Glycemic Control Using Mobile-based Intervention in Patients With Diabetes Undergoing Coronary Artery Bypass to Promote Self-management
The study is a two-arm parallel, randomized clinical trial. The purpose of the study is to evaluate the effectiveness and feasibility of using high-quality medication reminder smartphone application as a tool for secondary…
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass, Diabetes Mellitus
- Trial name
- GUIDEME (NCT04192409)
- Testing
- Smartphone Application
- Where
- China
- Volunteers
- 1,038 people
- Sponsor
- China National Center for Cardiovascular Diseases
Cardiomyopathy
Cardiomyopathy Following Stem Cell Transplantation
This study will examine the incidence of cardiac complications, particularly cardiomyopathy, in patients who have undergone allogeneic (donor) stem cell transplantation at NIH.
- Trial name
- NCT00352209
- Where
- 2 sites in United States
- Sponsor
- National Institutes of Health Clinical Center (CC)
Heart Failure, Diastolic
Diuretics and Dopamine in Heart Failure With Preserved Ejection Fraction
Heart Failure with preserved Ejection Fraction (HFPEF) accounts for 40-50% of all heart failure patients with a frequency of hospital admissions for acute decompensation and short and long term mortality similar to patients with…
- Trial name
- ROPA-DOP (NCT01901809)
- Testing
- Furosemide, Dopamine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Johns Hopkins University
Chronic Heart Failure, Nutrition
Nutritional Interventions in Chronic Heart Failure
This study recruited patients diagnosed with heart failure by cardiologists and cardiac outpatients whose cardiac functions were graded from 1 to 4 according to the New York Heart Association as the study participants.
- Trial name
- NCT03845309
- Testing
- Self-Care Behavior
- Where
- Taiwan
- Volunteers
- 95 people
- Sponsor
- National Taiwan University Hospital
Coronary Artery Disease
A Study of Diabetic Patients With De Novo Native Coronary Artery Lesions
The main objective of this study is to assess the safety and effectiveness of the CYPHER sirolimus-eluting stent in maintaining minimum lumen diameter in de novo native coronary artery lesions as compared to the uncoated Bx…
- Trial name
- SCORPIUS (NCT00495898)
- Testing
- CYPHER sirolimus-eluting stent, uncoated Bx VELOCITY balloon-expandable stent
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Cordis US Corp.
Atrial Fibrillation
INtra-procedural ultraSound Imaging During Pulmonary Veins Isolation
One of the biggest limitations of the currently used percutaneous techniques for Pulmonary Vein Isolation (PVI) in the setting of atrial fibrillation ablation is the lack of real-time information about the left atrial (LA) wall…
- Trial name
- INSIDEPVs (NCT03372798)
- Testing
- ICE/IVUS imaging during atrial fibrillation ablation
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Oxford University Hospitals NHS Trust
Stent Restenosis, Coronary Artery Disease
Effect of Exercise Training in Coronary Artery Disease Patients After Stenting
To determine the effects of exercise training on ankle-brachial index and Quality of Life in coronary artery disease patients after stenting.
- Trial name
- NCT05315193
- Testing
- Structured In-patient and Home plan, Conventional Therapy
- Where
- Pakistan
- Volunteers
- 73 people
- Sponsor
- Riphah International University
Heart Failure With Reduced Ejection Fraction (HFrEF), Low T3 Syndrome
Developing Oral LT3 Therapy for Heart Failure - HFrEF
Investigation of the safety, feasibility, and preliminary efficacy of thyroid hormone therapy with Liothyronine (LT3) in individuals with heart failure with reduced ejection fraction (HFrEF) and low triiodothyronine (T3) syndrome…
- Trial name
- DOT3HF-HFrEF (NCT04112316)
- Testing
- Liothyronine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Pennsylvania
Cardiovascular Diseases
Effect of Trimetazidine During the Primary PCI on Cardiac Function in Patients With ST-elevation Myocardial Infarction
Giving preoperative loading dose of 60mg of trimetazidine can safely and effectively reduce the PCI-related myocardial damage for the patients undergoing selective PCI.
- Trial name
- NCT02826616
- Testing
- Trimetazidine
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Chinese PLA General Hospital
Aortic Valve Stenosis
Impact of Postdilatation With the InterValve V8 Aortic Valvuloplasty Balloon Following TAVI Procedure
This study is designed to monitor the safety and performance of the V8 balloon when used as a postdilatation balloon in self-expanding Transcatheter Aortic Valve Implantation (TAVI) device procedures.
- Trial name
- PostCorE (NCT02472106)
- Testing
- Post-dilatation
- Volunteers
- 9 people
- Sponsor
- InterValve, Inc.