Clinical trials: Coronary Occlusion
Systemic Sclerosis, Cardiac Diseases
Development and Prevention of Severe Heart Disease in Systemic Sclerosis
Systemic sclerosis is an orphan, multiorgan disease affecting the connective tissue of the skin and all internal organs. Cardiac involvement, mainly characterised by small intramyocardial coronary artery involvement and…
- Conditions
- Systemic Sclerosis, Cardiac Diseases, Heart Block, Cardiac Arrhythmia
- Trial name
- NCT01829126
- Where
- 11 sites in France, Germany and 4 more
- Volunteers
- 765 people
- Sponsor
- Gabriele Valentini
Coronary Artery Disease, Percutaneous Coronary Intervention
Study of the Long-term Effects of P2Y12 Inhibitor Monotherapy and Coagulation Markers After Percutaneous Coronary Angioplasty.
Patients who undergo percutaneous coronary intervention (PCI) are commonly treated with antiplatelet therapy to prevent stent thrombosis and recurrence of events.
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Coronary Syndromes, Antiplatelet Therapy
- Trial name
- HI-TECH 2 (NCT07582835)
- Testing
- Clopidogrel, Ticagrelor, Prasugrel
- Where
- Switzerland
- Volunteers
- 355 people
- Sponsor
- Cardiocentro Ticino
Sick Sinus Syndrome
Atrial Synchrony Evaluation of Bachmann Bundle Pacing in Sick Sinus Syndrome
This is a prospective, randomized study to compare the effects of Bachmann bundle pacing (BBP) versus conventional right atrial appendage (RAA) pacing on atrial electromechanical synchrony in patients with sick sinus syndrome…
- Trial name
- NCT07055035
- Testing
- Bachmann Bundle Pacing, Right Atrial Appendage Pacing
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Shiyan City Renmin Hospital
Nerve Block, Coronary Artery Bypass
Comparison of Erector Spinae Plane Block and Transversus Thoracic Muscle Plane Block in Coronary Artery Surgery
The main objective of this study is to evaluate postoperative pain intensity comparatively between erector spinae plane block and transversus thoracic muscle plane block in patients undergoing open coronary artery surgery.
- Conditions
- Nerve Block, Coronary Artery Bypass, Anesthesia and Analgesia
- Trial name
- NCT06709625
- Testing
- Transversus thoracis plane block, Erector spina plane block (ESP)
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people
- Sponsor
- Ankara City Hospital Bilkent
Aortic Stenosis
Transcatheter Heart Valve (THV) Sizing and Leakage After Transcatheter Aortic Valve Implantation (TAVI) Before and After Establishing Routine Preprocedure Multi Slice Computerized Tomography (MSCT) Aortic Assessment. A Retrospective Registry Study
The objective of this study is to evaluate the effect of annular sizing strategy (MDCT versus TEE) in transcatheter aortic valve implantation on the prevalence and severity of paravalvular regurgitation.
- Trial name
- NCT02005640
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Aarhus University Hospital Skejby
Mesenteric Ischemia
Microcirculation During Extracorporeal Circulation
Digestive tract is supposed to be the motor of multiple organ failure. In ICU patients, mesenteric ischemia appears even when macrocirculatory parameters are controlled especially in our experience in patients coming in ICU after…
- Trial name
- CITRON4 (NCT01389947)
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Aortic Stenosis, Gastrointestinal Microbiome
Involvement of the Gut Microbiota in Calcified Aortic Stenosis
Calcific aortic stenosis (CAS) is a disease characterized by progressive calcification of the aortic valve, obstructing the passage of blood from the left ventricle into the general circulation.
- Conditions
- Aortic Stenosis, Gastrointestinal Microbiome, Metabolomics
- Trial name
- Gut-CAS (NCT06021535)
- Testing
- No intervention
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronary Artery Disease
Drug Elution and Distal Protection During Percutaneous Coronary Intervention in ST Elevation Myocardial Infarction
The purpose of this study is to evaluate the clinical, echocardiographic and angiographic outcome of distal protection in the infarct related coronary artery and implantation of drug eluting versus bare metal stents in patients…
- Trial name
- NCT00192868
- Testing
- Distal protection and drug eluting stent
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sarcopenia, Exercise Intolerance
Prehabilitation for Cardiac Surgery in Patients With Reduced Exercise Tolerance
Among patients awaiting cardiac surgery, a significant proportion are patients with severe angina, heart failure (HF) and peripheral atherosclerosis.
- Conditions
- Sarcopenia, Exercise Intolerance, Heart Failure, Peripheral Artery Disease
- Trial name
- NCT04545268
- Testing
- Neuromuscular electrical stimulation (NMES), Transcutaneous electrical stimulation
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Research Institute for Complex Problems of Cardiovascular Diseases, Russia
Coronary Artery Disease
Effect of Olivomed (Olive Extract) on Endothelial, Cardiac and Vascular Function
Olive extracts are considered to have antioxidant properties. The investigators will study the effect of olive extracts containing hydroxytyrosol (HT)-olivomed and combination of Oleuropein (OL), Hydroxytyrosol (HT), Oleocanthal…
- Trial name
- NCT04520126
- Testing
- Olivomed (capsules containing hydroxytyrosol), OlivomedSmart - Capsules containing - combination of Oleuropein (OL), Hydroxytyrosol (HT), Oleocanthal (OC) - (OL:HT:OC 2:1:3), (5 mg HT bid).
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- University of Athens
Coronary Artery Disease
Effects of Guiding Catheter on FFR and NHPR for the Assessment of Coronary Artery Stenoses (Disengage@Rest)
The DISENGAGE@rest study is a prospective registry carried out at Federico II University of Naples with the aim to evaluate the influence of the guiding catheter engagement within the coronary ostium on both FFR and…
- Trial name
- Disengage@Rest (NCT04975425)
- Testing
- Fractional Flow Reserve
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Federico II University
Atrioventricular Block, Left Bundle Branch Area Pacing
Left Bundle Branch Area Pacing in AVB Patients
Right ventricular pacing (RVP) causes left ventricular mechanical dyssynchrony by inducing electrical interventricular and intraventricular dyssynchrony.
- Trial name
- NCT03851315
- Testing
- permanent left bundle branch area pacing
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fu Wai Hospital, Beijing, China
Coronary Artery Disease
68Ga-NODAGA-RGD PET in Patients With an Occluded Coronary Artery
Background: In patients with coronary artery disease, acute or chronic coronary artery occlusion is associated with various degrees of ischemic myocardial injury and left ventricle dysfunction.
- Trial name
- RGDHeart (NCT04871217)
- Testing
- 68Ga-NODAGA-RGD PET-imaging
- Where
- 3 sites in Finland, Netherlands and 1 more
- Volunteers
- 60 people
- Sponsor
- Turku University Hospital
Aortic Stenosis
A Comparison of Advanced Imaging Techniques in Aortic Stenosis
In patients with aortic stenosis the valve through which blood is pumped out of the main heart chamber is narrowed. This results in heart muscle working harder to open the valve so blood can circulate around the body.
- Trial name
- AIm-AS (NCT01775215)
- Testing
- Cardiac I123-MIBG Scintigraphy, Cardiac MRI, Stress and rest Echocardiogram
- Where
- United Kingdom
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Healthy Volunteers, Heart Failure
Water- and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung Disease
The purpose of the study is to determine whether the excretion of renal water- and salt-channels in the urine reflects the handling of water and salt in the kidneys, and whether the excretion can be used to monitor and/or predict…
- Conditions
- Healthy Volunteers, Heart Failure, Aortic Stenosis, Ischemic Heart Disease
- Trial name
- NCT00830726
- Testing
- Pharmacologic and mechanical heart failure treatment, Aortic valve replacement, Revascularisation in Acute Coronary Syndrome
- Where
- Denmark
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kolding Sygehus
Coronary Occlusion, Thrombosis (Stent Thrombosis)
XIENCE V Everolimus Eluting Coronary Stent System (EECSS) China: Post-Approval Randomized Control Trial (RCT)
This is a prospective, randomized, active-controlled, open label, parallel two-arm, multi-center, post-approval study descriptively comparing the XIENCE V EECSS to the CYPHER SELECT PLUS Sirolimus-Eluting Coronary Stent System…
- Conditions
- Coronary Occlusion, Thrombosis (Stent Thrombosis), Vascular Disease, Myocardial Ischemia
- Trial name
- NCT01178268
- Testing
- XIENCE V EECSS, CYPHER SELECT PLUS SECSS
- Where
- 2 sites in China
- Volunteers
- 546 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Disease
CO2 as a Stress Agent for Perfusion Imaging
Myocardial perfusion imaging (MPI) is a nuclear scan using a radioisotope to see blood flow to the muscles of the heart when the heart is at rest and when it is under stress.
- Trial name
- CO2 STRESS (NCT02043535)
- Testing
- Delivery of precise levels of carbon dioxide with the RA-MR™ Virtual Sequential Gas Delivery System., Delivery of rubidium radioisotope (Rb-82) using the automated pump/elution system
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Aortic Stenosis, Gender
TAVI and Gender Outcomes Aortic Stenosis Undergoing Transfemoral Transcatheter Aortic Valve Implantation.
Severe aortic stenosis (AS) is the commonest form of valvular abnormality in the developed world and transcatheter aortic valve implantation (TAVI) is now widely practiced as in many cases is the preferred treatment option over…
- Conditions
- Aortic Stenosis, Gender, Surgery
- Trial name
- NCT04915976
- Volunteers
- 14,086 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Atrial Fibrillation, Stroke
Hemostatic Activity Following LAAO
The primary objective of this study is to prospectively investigate hemostatic activity following transcatheter left atrial appendage occlusion (LAAO).
- Trial name
- NCT05011981
- Testing
- Left Atrial Appendage Occlusion
- Where
- Denmark
- Volunteers
- 135 people
- Sponsor
- University of Aarhus
Aortic Valve Stenosis, Aortic Valve Disease
Anticoagulation for Aortic Bioprosthesis (ANTIPRO)
This study evaluates the clinical and hemodynamic outcome in patients after aortic valve replacement. Half of the patients will receive warfarin + aspirin and the other half will receive only aspirin.
- Conditions
- Aortic Valve Stenosis, Aortic Valve Disease, Aortic Valve Insufficiency, Aortic Valve Regurgitation
- Trial name
- NCT03807921
- Testing
- Warfarin, Aspirin
- Where
- 2 sites in Uruguay
- Volunteers
- 140 people
- Sponsor
- Instituto Nacional de Cirugia Cardiaca, Uruguay