Clinical trials: Coronary Patient
Atrial Fibrillation, Persistent
Subxyphoid Hybrid MAZE Registry for Patients With Persistent Atrial Fibrillation
Minimally invasive surgical procedures have been advocated as an alternative to catheter ablation for the treatment of persistent atrial fibrillation.
- Trial name
- SubXMAZE (NCT04148625)
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Cardiopulmonary Failure
Evaluation of Ultrasound of the Heart in Patients With Low Blood Pressure
Hypothesis: Goal-directed echocardiography by trained critical care physicians is equivalent to that of echocardiography technicians/cardiologists for the purpose of determining etiology (reason) of cardiopulmonary failure.
- Trial name
- NCT01723176
- Testing
- Echocardiography
- Where
- United States
- Sponsor
- Northwell Health
Coronary Heart Disease (CHD), CHD Risk-Equivalent Disease
Study to Assess the Tolerability and Efficacy of Anacetrapib in Patients With Coronary Heart Disease (CHD) or CHD Risk-Equivalent Disease (MK-0859-019)
This study will evaluate the efficacy of anacetrapib (100 mg) for 24 weeks relative to placebo, on plasma concentrations of Low Density Lipoprotein Cholesterol and assess the safety and tolerability of anacetrapib (100 mg) in…
- Trial name
- DEFINE (NCT00685776)
- Testing
- anacetrapib
- Volunteers
- 1,623 people
- Sponsor
- Merck Sharp & Dohme LLC
Breast Cancer
A Study of Cardiac Safety in Patients With HER2 Positive Early Breast Cancer Treated With Herceptin
This is a single cohort observational safety study. All patients will be treated and monitored according to the local clinical practice.
- Trial name
- NCT01152606
- Testing
- trastuzumab [Herceptin]
- Where
- 205 sites in Austria, Belgium and 7 more
- Volunteers
- 3,942 people
- Sponsor
- Hoffmann-La Roche
Tachycardia, Atrial Fibrillation
Observation of Clinical Routine Care for Patients With BIOTRONIK Implantable Cardiac Monitors (ICMs)
This registry is performed for the long-term assessment of outcome, performance and residual safety aspects of the BIOMONITOR III and possible successors in a real-life clinical set-up.
- Conditions
- Tachycardia, Atrial Fibrillation, Syncope, Bradycardia
- Trial name
- BIOSTREAM-ICM (NCT04075084)
- Where
- 31 sites in Australia, Czechia and 7 more
- Volunteers
- 1,400 people
- Sponsor
- Biotronik SE & Co. KG
Cardiac Surgery
Patient Perspectives on Advance Care Planning Discussions Prior to Cardiac Surgery
The purpose of this study is to explore patient perspectives on Advance Care Planning (ACP) prior to cardiac surgery, including perceptions of benefits, drawbacks, and barriers to ACP.
- Trial name
- NCT04796233
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Major Depressive Disorder, Coronary Artery Disease
Vortioxetine in Patients With Major Depressive Disorder and Coronary Artery Disease
This is a preliminary, open-label, clinical trial designed to assess the efficacy, safety, and tolerability of vortioxetine for the treatment of major depressive disorder in patients with coronary artery disease.
- Trial name
- NCT02454426
- Testing
- Vortioxetine
- Where
- United States
- Sponsor
- Thomas Jefferson University
Stable Angina Pectoris, Ad Hoc Percutaneous Coronary Intervention
Doubling the Maintenance Dose of Clopidogrel in Patients With High On-Clopidogrel Platelet Reactivity
The purpose of the study is to determine whether administration of 150 mg clopidogrel is effective in reducing the one-year incidence of thromboischemic events in patients with high on-clopidogrel platelet reactivity compared to…
- Trial name
- DOSER (NCT00638326)
- Testing
- clopidogrel
- Where
- Hungary
- Volunteers
- 500 people
- Sponsor
- University of Pecs
Hypertension, Left Ventricular Diastolic Dysfunction
Sacubitril/Valsartan Versus Valsartan Alone on Left Atrial Volume Index in Hypertensive Patients
Hypertension is a leading global risk factor for cardiovascular disease and is frequently associated with left atrial and ventricular remodeling, leading to subclinical diastolic dysfunction[cite: 2].
- Conditions
- Hypertension, Left Ventricular Diastolic Dysfunction, Essential (Primary) Hypertension
- Trial name
- NCT07853625
- Testing
- Sacubitril / Valsartan, Valsartan
- Volunteers
- 102 people
- Sponsor
- University of Health Sciences Lahore
Hyponatremia
Retrospective Analysis of ECG Changes and Arrhythmias in Patients With Profound Hyponatremia
The primary objective of this retrospective study is to determine the impact of hyponatremia on quantitative measurements and characteristics of the ECG.
- Trial name
- NCT07255833
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- University of Cologne
Atrial Fibrillation (AF), Catheter Ablation
PROMBot-HSM-FA: Protocol for a Feasibility Study of a Chatbot Platform to Collect Patient-reported Outcomes After AF Ablation
The goal of this clinical trial is to learn if using a WhatsApp-based chatbot called PROMBot-FA can help people recover after atrial fibrillation ablation.
- Trial name
- PROMBot-HSM-FA (NCT07237178)
- Testing
- PROMBot-FA Chatbot-Supported Follow-Up, Standard Care (in control arm)
- Volunteers
- 76 people
- Sponsor
- Ana Rita Londral, PhD
Fragility
Investigation of a Link Between Heart Rate Variability and Frailty in Geriatric Patients
The aim of this study is the evaluation of differences in heart rate variability (both time- and frequency-domain) [a]: between frail and non-frail patients and [b] at the beginning and end of a geriatric therapy which included…
- Trial name
- NCT03585985
- Testing
- Standard patient monitor, Photoplethysmographie-Imaging (PPGI) + Infrared thermography (IRT)
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Coronary Disease, Myocardial Infarction
Effects of High-dose n-3 Fatty Acids on Clinical Outcome and Serum Lipids - Omacor Following Acute Myocardial Infarction
The object of this study was to evaluate the effect of a high-dose ethylester concentrate of of n-3 fatty acids administered early after an acute myocardial infarction on subsequent cardiac events and serum lipids.The second…
- Trial name
- OFAMI (NCT01422317)
- Testing
- EPA / DHA / Alpha-Tocopherol, Corn Oil / Alpha-Tocopherol (4 mg)
- Where
- Norway
- Volunteers
- 300 people
- Sponsor
- Helse Stavanger HF
Breast Cancer
Assessment of Ability of Breath Hold for Left-sided Breast Cancer Radiation Therapy to Reduce Side Effects to Heart
The purpose of this research study is to demonstrate that Deep Inspiration Breath Hold (DIBH), the technique used at the University of North Carolina (UNC) for left-side breast cancer radiation therapy, can reduce side effects to…
- Trial name
- NCT01849614
- Testing
- Cardiac SPECT perfusion scan
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Coronary Artery Disease, Chest Pain
Coronary Obstruction Detection by Molecular Personalized Gene Expression (Corus CAD or ASGES)
To validate the use of Corus CAD (Age/Sex/Gene Expression score - ASGES) blood assay in subjects who are referred for the work-up of coronary artery disease.
- Conditions
- Coronary Artery Disease, Chest Pain, Cardiovascular Diseases, Coronary Heart Disease
- Trial name
- COMPASS (NCT01117506)
- Testing
- Corus CAD (ASGES)
- Where
- 7 sites in United States
- Volunteers
- 581 people
- Sponsor
- CardioDx
Atrial Fibrillation, Persistent
Cyroablation for Pulmonary Vein Isolation Alone in Patients With Early Persistent AF Assessed by Continuous Monitoring
This study aimed to evaluate the efficacy of Cryoablation in patients with early persistent atrial fibrillation as a first index procedure using continuous cardiac rhythm monitoring.
- Trial name
- COOL-PER (NCT05507749)
- Testing
- cryoballoon ablation, implantable loop recorder insertion
- Where
- South Korea
- Volunteers
- 130 people
- Sponsor
- Seoul National University Hospital
Anesthesia
Impact of Immediate Versus Delayed Tracheal Extubation on Length of ICU Stay of Cardiac Surgical Patients
Ultra-fast track anaesthesia (UFTA) aims at immediate extubation of cardiac surgical patients at the end of the operation. This study compares the effect of UFTA versus continued postoperative mechanical ventilation on the ICU…
- Trial name
- NCT02491749
- Testing
- Ultra Fast-Track Anesthesia
- Volunteers
- 52 people
- Sponsor
- Cairo University
Acute Coronary Syndrome
Statin Contrast Induced Nephropathy Prevention
This open-label study, prospective, randomized trial evaluating the acute (in-hospital) pleiotropic and clinical effects of a hydrophilic statin (rosuvastatin) in patients with acute coronary syndrome
- Trial name
- PRATO-ACS (NCT01185938)
- Testing
- Rosuvastatin
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Centro Cardiopatici Toscani
Tako-Tsubo Cardiomyopathy, Stress-induced Cardiomyopathy
The TAKO-TSUBO And Cancer Registry
Prospective, multicenter, observational registry collecting data from subjects with Tako-Tsubo (stress-induced) cardiomyopathy (TTC).
- Conditions
- Tako-Tsubo Cardiomyopathy, Stress-induced Cardiomyopathy, Acute Coronary Syndrome
- Trial name
- TTAC (NCT01944826)
- Testing
- Registry of patients with Tako-Tsubo cardiomyopathy
- Where
- Germany
- Volunteers
- 800 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Coronary Artery Disease
Angiogenesis Using VEGF-A165/bFGF Plasmid Delivered Percutaneously in No-option CAD Patients; a Controlled Trial
Achieving therapeutic angiogenesis with gene therapy using a plasmid coding human VEGF-A165/bFGF injected into ischemic myocardium of refractory coronary artery disease patients, employing a percutaneous catheter-based technique…
- Trial name
- VIF-CAD (NCT00620217)
- Where
- Poland
- Volunteers
- 52 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
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