Clinical trials: Coronary Patient
Heart Failure
Influence of Neurohormonal Blockade on Natriuresis in Heart Failure Patients
Heart failure is a condition that can affect a person's health and daily life. In this study, we aim to investigate how diuretic medications work and how they affect patients with heart failure.
- Trial name
- uGDMT (NCT07781826)
- Testing
- Neurohormonal blockade intensification
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Wroclaw Medical University
Cardiac Disease, Aortic Valve Disease
PREhabilitation in Patients Awaiting Acute Inpatient Cardiac SurgEry
This is a single centre, single arm pilot feasibility study to determine the feasibility and practicality of prehabilitation in acute inpatients waiting for cardiac surgery.
- Conditions
- Cardiac Disease, Aortic Valve Disease, Coronary Artery Disease, Endocarditis
- Trial name
- (PREP-ACE) (NCT06275100)
- Testing
- Prehabilitation
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Hull
Heart Transplantation
A Study of Safety, Tolerability & Efficacy of Certican in de Novo Heart Transplant (Tx) Patients
The study is designed to evaluate whether Neoral dose optimization together with a therapeutic drug monitoring of Certican will prevent renal dysfunction as observed in the pivotal cardiac trial while maintaining the efficacy.
- Trial name
- NCT00098007
- Testing
- Everolimus (Certican)
- Where
- 28 sites in United States, Australia and 6 more
- Volunteers
- 199 people
- Sponsor
- Novartis Pharmaceuticals
Atrial Fibrillation, Deep Vein Thrombosis
Weekly Monitoring Strategy of Capillary INR Versus Monthly Monitoring Strategy of Venous INR in Elderly Patients in a Nursing Home.
This primary care study aims to compare the "time in therapeutic range" (TTR) of two strategies for monitoring the international normalized ratio (INR) over 6 months in nursing homes.
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Stroke
- Trial name
- INR-CAP (NCT05561244)
- Testing
- Weekly monitoring using the capillary International Normalised Ratio strategy
- Where
- 33 sites in France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Myocardial Infarction, Myocardial Infarction, Acute
BIO monitorinG in Patients With Preserved Left ventricUlar Function AfteR Diagnosed Myocardial Infarction
The BIO|GUARD-MI study investigates whether continuous arrhythmia monitoring and the consequent treatment after detected arrhythmias in patients after myocardial infarction with preserved cardiac function, but other risk factors…
- Conditions
- Myocardial Infarction, Myocardial Infarction, Acute, Myocardial Infarction Old
- Trial name
- BIO-GUARD-MI (NCT02341534)
- Testing
- BioMonitor
- Where
- 59 sites in United States, Australia and 12 more
- Volunteers
- 802 people
- Sponsor
- Biotronik SE & Co. KG
Atrial Fibrillation, Aortic Valve Stenosis
WATCH-TAVR, WATCHMAN for Patients With Atrial Fibrillation Undergoing Transcatheter Aortic Valve Replacement
To evaluate the safety and effectiveness of the left atrial appendage occlusion with WATCHMAN Device in prevention of stroke and bleeding in patients with atrial fibrillation (AF) undergoing transcatheter aortic valve replacement…
- Trial name
- NCT03173534
- Testing
- WATCHMAN, TAVR
- Where
- 32 sites in United States
- Volunteers
- 350 people
- Sponsor
- samir kapadia
Atrial Fibrillation
Efficacy and Safety of Azimilide in the Prophylactic Treatment of Patients With Atrial Fibrillation.
Atrial fibrillation (an abnormal rhythm in the upper chamber of the heart) is a common supraventricular arrhythmia (a type of abnormal heart rhythm) for which antiarrhythmic therapy is often prescribed.
- Trial name
- NCT00035464
- Testing
- Azimilide Dihydrochloride
- Where
- 103 sites in United States, Canada
- Volunteers
- 431 people
- Sponsor
- Forest Laboratories
Hematopoietic Stem Cell Transplantation, Cardiotoxicity
Effect of Angiotensin Converting Enzyme and Sacubitril Valsartan in Patients After Bone Marrow Transplantation
The purpose of the present study is to investigate the effect of ACE inhibitors and the sacubitril-valsartan complex in bone marrow transplant patients by assessing cardiovascular and endothelial parameters in order to search for…
- Trial name
- NCT04092309
- Testing
- ACE inhibitor, Sacubitril-Valsartan
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- University of Athens
High-risk Cardiac Patients
Registry Study for the Evaluation of High-risk Cardiac Patients by WILLEM AI-based ECG Platform
The WILLEM Registry is a large-scale, single-group, observational, registry study to collect continuous clinical evidence of Willem in real-world settings.
- Trial name
- WILLEMRegistry (NCT07333547)
- Testing
- Willem AI ECG assessment
- Where
- 5 sites in United States, Ecuador and 1 more
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Idoven 1903 S.L.
Heart Failure, ESKD
Study of Diastolic Dysfunction in ESKD in Hemodialysis Patient
To Asses the prevalence , pattern , and severity of diastolic dysfunction in patients ESKD undergoing regular dialysis and to investigate its correlation with clinical parameters dialysis-related factors and echocardiographic…
- Conditions
- Heart Failure, ESKD, Hemodialysis Patients
- Trial name
- NCT07180888
- Testing
- Echocardiography, Echocardiographic assessment of diastolic dysfunction
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Acute Heart Failure
Effect of Short-term Prednisone Therapy on C-reactive Protein in Patients With Acute Heart Failure
This is a multicenter, parallel-group, randomized, open-label, controlled trial. Patients with a diagnosis of acute heart failure (AHF) in the emergency department (ED) or after emergency presentation to hospital will be screened…
- Trial name
- CORTAHF (NCT05916586)
- Testing
- Prednisone
- Where
- 3 sites in Armenia
- Volunteers
- 101 people
- Sponsor
- Heart Initiative
Angina Pectoris
Evaluation of Succinate Metoprolol on Heart Rate in the Stable Angina Patients
The purpose of this study is to evaluate the effects of Succinate Metoprolol(Betaloc ZOK®) (95 - 190 mg) on heart rate in the Stable angina patients.
- Trial name
- NCT01213173
- Testing
- Succinate Metoprolol (Betaloc ZOK®)
- Where
- 10 sites in China
- Volunteers
- 251 people
- Sponsor
- AstraZeneca
Schizophrenia, Schizoaffective Disorder
The Effects of tDCS on Auditory Hallucination, Insight, Neurocognitive Function and HRV in Patients With Schizophrenia
The study aimed to investigate whether transcranial direct current stimulation could modify auditory hallucination, insight, neurocognitive function, heart rate variability, psychosocial functioning and quality of life in…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Auditory Hallucination, Verbal, Neurocognitive Dysfunction
- Trial name
- NCT03388554
- Testing
- tDCS
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Coronary Artery Disease
Advanced NanoTherapies Dual-API DCB to Treat De-Novo Lesions in Patients With Symptomatic Coronary Artery Disease
This prospective, single-arm, multi-center, safety and feasibility first-in-human study will evaluate the safety and feasibility of the SirPlux Duo™ Dual-API Coated PTCA Balloon Catheter to treat de-novo lesions between ≥2.0 and…
- Trial name
- ADVANCE-DCB (NCT05521542)
- Testing
- SirPlux Duo™ Dual-API Coated PTCA Balloon Catheter
- Where
- 5 sites in Australia, Dominican Republic and 1 more
- Volunteers
- 28 people
- Sponsor
- Advanced NanoTherapies
Coronary Artery Disease, Arrhythmia
Effect of Supplemental Intake of Omega-3 Polyunsaturated Fatty Acids on the Rate and Complexity of Spontaneously Occurring Ventricular and Supraventricular Arrhythmias in Patients With Implantable Cardioverter Defibrillator (ICD) - A Randomized Clinical Trial
We hypothesize that oral supplementation with omega-3 PUFA will decrease occurrence of arrhythmic events among post-MI, ICD recipients.
- Trial name
- NCT00290056
- Testing
- Eicosapentanoic acid (EPA) and Docosahexanoic acid (DHA).
- Where
- 2 sites in Israel
- Volunteers
- 105 people
- Sponsor
- Sheba Medical Center
Coronary Artery Occlusive Disease(CAOD)
The Effect of Balanced Crystalloid Versus 5% Albumin on Endothelial Glycocalyx Degradation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery
It is being revealed that the more severe the damage of the endothelial glycocalyx (EG) layer, the more likely it is that the prognosis of the patients is poor.
- Trial name
- NCT03699462
- Testing
- Plasma solution-A injection, 5% Albumin
- Where
- South Korea
- Volunteers
- 106 people
- Sponsor
- Yonsei University
Heart Failure
A Trial to Study Neladenoson Bialanate Over 20 Weeks in Patients With Chronic Heart Failure With Reduced Ejection Fraction
The objective of the study is to find the optimal dose of once daily oral neladenoson bialanate (BAY 1067197) when given in addition to standard therapy for heart failure with reduced ejection fraction (HFrEF).
- Trial name
- PANTHEON (NCT02992288)
- Testing
- Neladenoson bialanate (BAY1067197)
- Where
- 75 sites in United States, Belgium and 9 more
- Volunteers
- 427 people
- Sponsor
- Bayer
Eisenmenger Syndrome
Transcatheter Valve Implantation in Patients With Dysfunctional Left and Right Sided Heart Valves
A growing body of data, suggests that transcatheter valves are effective when implanted in other locations (mitral, aortic, tricuspid) and in high pressure environments.
- Trial name
- NCT02119442
- Testing
- Transcather Valve Implantation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of California, Los Angeles
Chagas Cardiomyopathy, Chronic Heart Failure
Chagas Cardiomyopathy Bisoprolol Intervention Study: Charity
Chagas disease (CD) is the major cause of disability secondary to tropical diseases in young adults from Latin America. In this region 20 million people are currently infected by T. cruzi, the etiologic agent for CD.
- Trial name
- NCT00323973
- Testing
- Bisoprolol
- Where
- Colombia
- Volunteers
- 500 people
- Sponsor
- Fundación Cardiovascular de Colombia
Patient Outcome Assessment
Effect of Perioperative Dexmedetomidine Administration on Outcome in Cardiac Surgery Patients
Investigation of effect of perioperative Dexmedetomedine administration on mortality, length of ICU and hospital stay, delirium onset, major adverse cardiac and cerebrovascular events, acute kidney injury in cardiac surgery…
- Trial name
- NCT03091166
- Testing
- Dexmedetomidine
- Where
- Russia
- Volunteers
- 169 people
- Sponsor
- Moscow Regional Research and Clinical Institute (MONIKI)
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