Clinical trials: Coronary Patient
Stroke, Acute, Stroke
Yield of Implantable Cardiac Monitoring Device in Patients With Acute Ischemic Stroke.
In this prospective cohort study, the investigators aim to investigate the incidence of ICM-detected AF in unselected ischemic stroke patients and its association with anticoagulation initiation and stroke recurrence.
- Conditions
- Stroke, Acute, Stroke, Stroke, Ischemic, Atrial Fibrillation
- Trial name
- NCT05494034
- Testing
- Reveal LINQTM
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- National and Kapodistrian University of Athens
Coronary Artery Disease, Percutaneous Coronary Intervention
Anti-platelet Effect of Berberine in Patients After Percutaneous Coronary Intervention
The APLABE-PCI is a single-center, randomized, open-label, controlled, dose-escalating, parallel-group study, which is designed to assess the anti-platelet effect of berberine in approximately 64 patients receiving aspirin and…
- Trial name
- APLABE-PCI (NCT03378934)
- Testing
- Berberine, Standard treatment, Aspirin
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Peking Union Medical College Hospital
Coronary Artery Disease (CAD)
Impact of CYP2C19 Genotype-guided Clopidogrel and Ticagrelor Treatment on Platelet Function Test and Metabolomics Profile
Several studies have shown that pharmacodynamic (PD) response varies between patients treated with clopidogrel and that individuals with reduced response have an increased risk of recurrent ischemic events, particularly in…
- Trial name
- NCT05516784
- Testing
- Clopidogrel, Ticagrelor
- Where
- Malaysia
- Volunteers
- 80 people
- Sponsor
- Universiti Sains Malaysia
Coronary Artery Disease
STRATEGY for Left Main Coronary Bifurcation Lesion II
In patients with unprotected left main (LM) true bifurcation lesion (cohort A), elective 2-stent strategy is superior to provisional strategy at preventing the occurrence of 12-month target lesion failure after percutaneous…
- Trial name
- STRATEGY-II (NCT01798433)
- Testing
- One stent technique alone, One stent technique + Elective FKB, Provisional approach
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Cancer, Dyspnea, Paroxysmal
Fentanyl Buccal Tablet for the Relief of Episodic Breathlessness in Cancer Patients
"Episodic breathlessness (or dyspnea) is one form of chronic refractory breathlessness characterized by a severe worsening of breathlessness intensity or unpleasantness beyond usual fluctuations in the patient's perception.
- Trial name
- EFFENDYS (NCT04635852)
- Testing
- Fentanyl, Immediate release morphine
- Where
- 3 sites in Germany
- Volunteers
- 10 people
- Sponsor
- University of Cologne
Hypertension, Portal, Cardiomyopathies
Multiparametric Cardio-hepatic MRI in Patients With Noncirrhotic Portal Hypertension
The aim of this study is to use multiparametric MRI to investigate any differences in myocardial structure and function in patients with noncirrhotic portal hypertension compared with a control group with liver cirrhosis.
- Trial name
- NCT05041452
- Testing
- Cardiac magnetic resonance scan
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bonn
Acute Decompensated Heart Failure
Mobile Education System to Improve Disease Knowledge, Self-efficacy and Quality of Life in Patients With Heart Failure
Heart failure (HF) is an incurable and complex disease syndrome with sophisticated disease trajectories. The guideline for HF management suggests that treatment should include adequate education to help patients have better…
- Trial name
- NCT06161649
- Testing
- accepting the operation process of automated intelligent education software system
- Where
- Taiwan
- Volunteers
- 138 people
- Sponsor
- Chang Gung Memorial Hospital
Heterozygous Familial Hypercholesterolemia, Coronary Artery Disease
Efficacy and Safety Study of ISIS 301012 (Mipomersen) as Add-on in Familial Hypercholesterolemic Patients With Coronary Artery Disease
The purpose of this study is to determine whether mipomersen safely and effectively lowers low-density lipoprotein cholesterol (LDL-C) in patients with Heterozygous Familial Hypercholesterolemia (HeFH) and coronary artery disease…
- Trial name
- RADICHOL II (NCT00706849)
- Testing
- mipomersen sodium
- Where
- 48 sites in United States, Canada
- Volunteers
- 124 people
- Sponsor
- Kastle Therapeutics, LLC
Obesity, Heart Failure With Normal Ejection Fraction
Unsaturated Fatty Acids to Improve Cardiorespiratory Fitness in Obesity and HFpEF
This study is designed to evaluate the effects of a diet rich in unsaturated fatty acids (UFA)-also known as 'healthy fats'-in patients with obesity and heart failure with preserved ejection fraction (HFpEF) on dietary…
- Trial name
- UFA-Preserved2 (NCT03966755)
- Testing
- UFA dietary recommendations
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Virginia Commonwealth University
Mitral Valve Insufficiency
High and Intermediate Risk Degenerative Mitral Regurgitation Treatment: A Trial Comparing MitraClip® to Surgical Therapy
The study is comparing MitraClip® to Surgical therapy in high and intermediate risk patients, who should be older than 18 years, and shall evaluate safety and efficacy of MitraClip® vs.
- Trial name
- HiRiDe (NCT02534155)
- Testing
- MitraClip®, Mitral valve Surgery
- Where
- 12 sites in Germany, Italy and 1 more
- Volunteers
- 294 people
- Sponsor
- University of Zurich
Myocardial Infarction, Angioplasty, Transluminal, Percutaneous Coronary
Strategies of Revascularization in Patients With ST-segment Elevation Myocardial Infarction (STEMI) and Multivessel Disease
Multivessel disease has been reported to occur between 40 and 60% of patients with ST-segment elevation myocardial infarction (STEMI) and has been associated to a worse prognosis.
- Conditions
- Myocardial Infarction, Angioplasty, Transluminal, Percutaneous Coronary, Echocardiography, Stress
- Trial name
- CROSS-AMI (NCT01179126)
- Testing
- complete multivessel revascularization, stress echocardiography and revascularization if required
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Complexo Hospitalario Universitario de A Coruña
Heart Transplant Failure
Pilot Study: Interest of Belatacept as a Non-nephrotoxic Immunosuppressive Treatment in Cardiac Transplant Patients at Risk of Chronic Renal Failure (BELACOEUR)
Heart transplantation (TC) is the standard treatment for terminal heart failure. Chronic kidney disease (CKD) is a common complication responsible for increased mortality and morbidity.
- Trial name
- BELACOEUR (NCT04180085)
- Testing
- Belatacept Injection
- Where
- 4 sites in France
- Volunteers
- 25 people
- Sponsor
- Nantes University Hospital
Adult Patients Undergoing CABG
Effect of Preoperative Stellate Ganglion Block on Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting
The primary objective of this study is to determine the feasibility of preoperative stellate ganglion block in reducing the incidence of postoperative atrial fibrillation in patients undergoing CABG.
- Trial name
- NCT07271615
- Testing
- Stellate Ganglion Block
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Coronary Artery Disease, Exercise Addiction
Aerobic Exercise on Ventilatory Efficiency in CAD Patients
The purpose of the present study was to test the hypothesis that patients with coronary artery disease with lower aerobic fitness exhibit greater responsiveness on improving ventilatory efficiency after aerobic exercise training.
- Conditions
- Coronary Artery Disease, Exercise Addiction, Complication, Cardio-respiratory
- Trial name
- NCT02106533
- Testing
- Aerobic exercise training
- Volunteers
- 123 people
- Sponsor
- Hospital TotalCor
Coronary Artery Disease, Anesthesia
Myocardial Strain Analysis in Anaesthetized Coronary Artery Disease Patients During Hyperoxia and Normoxaemia
The purpose of this study is to investigate the impact of supraphysiologic oxygen (hyperoxia) on myocardial function in anaesthetized patients with coronary artery disease.
- Trial name
- Strecho-O₂ (NCT04424433)
- Testing
- Oxygen
- Where
- Switzerland
- Volunteers
- 106 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diabetes Mellitus, Atrial Fibrillation
Dapagliflozin in Patients With Atrial Fibrillation (DAPA-AF)
The study will investigate the effect of Dapagliflozin on atrial fibrillation (AF) burden. AF burden will be defined as the percent of time spent in AF over a 2-week period, assessed by noninvasive continuous heart rhythm…
- Trial name
- NCT05174052
- Testing
- Dapagliflozin 10Mg Tab
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Oklahoma
Tricuspid Regurgitation
TRILUMINATE Pivotal Trial
The primary objective of this trial is to demonstrate the safety and effectiveness of the TriClip device in improving clinical outcomes in symptomatic patients with severe tricuspid regurgitation (TR), who are at intermediate or…
- Trial name
- NCT03904147
- Testing
- TriClipTM Device
- Where
- 76 sites in United States, Canada and 3 more
- Volunteers
- 572 people
- Sponsor
- Abbott Medical Devices
SIRS, Cytokine Storm
Cytokine Hemoadsorption in ECMO Patients
Cytokine hemoadsorption is a novel therapy used to improve outcome in critically ill patients with a dysregulated cytokine response and hemodynamic instability.
- Conditions
- SIRS, Cytokine Storm, Cardiogenic Shock, Cardiac Arrest
- Trial name
- NCT04901338
- Where
- Slovenia
- Volunteers
- 25 people
- Sponsor
- University Medical Centre Ljubljana
STEMI
Intensive Statin Treatment for STEMI Patients Undergoing Primary PCI
This is a retrospective, randomized, parallel, open-labeled, controlled study to find out whether STEMI patients undergoing emergency PCI can benefit from intensive atorvastatin treatment compared with routine treatment.
- Trial name
- NCT01033058
- Testing
- atorvastatin
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Chao Yang Hospital
Ischemic Heart Disease, ST-segment Elevation Myocardial Infarction
Late Reperfusion With Percutaneous Coronary Intervention in Patients With ST-segment Elevation Myocardial Infarction
Although recommended therapy for patients with ST-segment elevation myocardial infarction is primary PCI, it remains unestablished whether patients with a symptom duration of more 12 hours benefit from acute revascularisation.
- Trial name
- LATE-MI (NCT02445885)
- Testing
- PCI
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Thomas Engstrom
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