Clinical trials: Coronary Physiology
Patients Who Are Scheduled to Undergo a PCI (Percutaneous Coronary Intervention) for CTO (Chronic Total Occlusion)
TIcaGrEloR and ABSORB Bioresorbable Vascular Scaffold Implantation for Recovery of Vascular Function After Successful Chronic Total Occlusion Recanalization
The study is a single-centre, randomized, active controlled, open label clinical trial. The primary hypothesis is that ticagrelor will show superiority over clopidogrel immediately after CTO-PCI (chronic total occlusion …
- Trial name
- TIGER-BVS (NCT02211066)
- Testing
- Clopidogrel, Ticagrelor
- Where
- 2 sites in Spain
- Volunteers
- 59 people
- Sponsor
- Hospital Clinic of Barcelona
Right Coronary Artery Occlusion
Right Ventricular Function Change After PCI to Right Coronary Artery
Proximal RCA occlusions were very often found among men with fatal pre-hospital MI; whereas left-sided coronary occlusions were significantly more frequent in hospital-admitted survivors of MI.
- Trial name
- NCT03543345
- Testing
- echocardiography study
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Duchenne Muscular Dystrophy, Cardiomyopathies
The Preventive Efficacy of Carvedilol on Cardiac Dysfunction in Duchenne Muscular Dystrophy
Purpose This cardiac dysfunction in patients with Duchenne muscular dystrophy is associated with minor cardiac damage as indicated by elevation of plasma cardiac troponin I (cTnI).
- Trial name
- NCT00606775
- Testing
- Carvedilol
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Suzuka Hospital
Recovery of Function, Postoperative Period
Early Heart Rate Variability and Sleep and Quality of Recovery After Cesarean Delivery
This prospective single-center observational cohort study investigates whether objectively measured early postoperative heart rate variability (HRV) and sleep parameters are associated with patient-reported quality of recovery…
- Conditions
- Recovery of Function, Postoperative Period, Cesarean Section
- Trial name
- Otonom-CS (NCT07897331)
- Testing
- Wearable-derived heart rate variability and sleep monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Buca Seyfi Demirsoy State Hospital
Atherosclerosis
ELITE: Early Versus Late Intervention Trial With Estradiol
The purpose of this study is to examine the effects of oral 17B-estradiol (estrogen) on the progression of early (subclinical) atherosclerosis and cognitive decline in healthy postmenopausal women.
- Trial name
- NCT00114517
- Testing
- 17B-estradiol
- Where
- United States
- Volunteers
- 643 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Atherosclerosis, Diabetes
Quantitative Assessment and Characterization of Microvascular Function Using Diffuse Optical Tomography
Atherosclerosis is accompanied by microvascular dysfunction (an impairment of blood vessels to dilate or constrict in response to demand).
- Conditions
- Atherosclerosis, Diabetes, Coronary Artery Disease
- Trial name
- DOT (NCT03411213)
- Testing
- diffuse optical tomography
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Cardiovascular Disease
Monocentric Registry to Investigate the Role of Platelet Function, Platelet Genetics, Proteomics and Metabonomics in Heart Disease
Molecular targets on platelets are pivotal for the development of new pharmacological substrates for platelet inhibition and to better understand the impact of platelet-mediated inflammatory processes for the progression of heart…
- Trial name
- TuePIC (NCT01417884)
- Where
- Germany
- Volunteers
- 3,000 people
- Sponsor
- University Hospital Tuebingen
Complex Congenital Heart Disease
Preliminary Efficacy of a Remote Cardiac Rehabilitation Program in Pediatric Patients With Complex Congenital Heart Disease
This study aims to evaluate the preliminary efficacy of a 12-week community-based remote cardiac rehabilitation program on cardiopulmonary function and quality of life in pediatric patients (aged 8 to 18 years) with complex…
- Trial name
- NCT07572435
- Testing
- Community-Based Remote Cardiac Rehabilitation Program, standard of care
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Seoul National University Hospital
Fatigue, Tachycardia
Effect of Caffeine on Heart Function
The primary objective of this study is to assess the effect of an energy drink on ventricular repolarization as measured by the interval between the cardiac Q wave and the cardiac T wave (QT interval)obtained from the body…
- Trial name
- NCT02401776
- Testing
- Monster Energy Drink, Coffee
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Congestive Heart Failure
Irbesartan in Heart Failure With Preserved Systolic Function (I-Preserve)
The purpose of this clinical research study is to learn if Irbesartan is superior to placebo in reducing mortality and cardiovascular morbidity in subjects with heart failure with preserved systolic function.
- Trial name
- NCT00095238
- Testing
- Irbesartan
- Where
- 229 sites in United States, Argentina and 23 more
- Volunteers
- 4,128 people
- Sponsor
- Bristol-Myers Squibb
Child Development
The Role of Motion in Infants' Ability to Categorize
This study is concerned with psychological and physiological development in infants. Specifically, researchers are interested in when and how babies are able to group similar objects, like animals or vehicles, into the same…
- Trial name
- NCT00362076
- Where
- United States
- Volunteers
- 941 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Coronary Disease, Heart Diseases
Myocardial Contrast Echocardiography (MCE) to Check for Living and Working Heart Muscle
Coronary artery disease (CAD) can cause poor blood flow and supply to the heart muscle. It can result in irreversible damage to the heart muscle and poor function.
- Trial name
- NCT00001891
- Testing
- Myocardial contrast echocardiography, Dobutamine echocardiography
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
Precision Therapy in Complex High-risk Coronary Artery Disease
This is a prospective registry to enroll complex high-risk coronary heart disease patients. The purpose of this study is to compare intracoronary physiology and imaging-guided intervention strategy and angiography-guided…
- Trial name
- PTCA (NCT04444960)
- Testing
- percutaneous coronary intervention
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Menopausal Women
Study of Early Hormone Replacement Therapy on Risk Factors for Sudden Cardiac Death
As an ancillary study to the KEEPS study (see ClinicalTrials.gov Identifier: NCT00154180), the primary purpose is to measure effects of estrogen vs.
- Trial name
- KEEPS (NCT00580775)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Yale University
Lung Cancer, Ventricular Failure, Right
Right Side of Heart Function After Lung Surgery
The purpose of this study is explore the impact of lung cancer surgery on the function of the right side of the heart.
- Trial name
- NCT01892800
- Testing
- Lung resection
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- University of Glasgow
Heart Failure, Chronic Systolic Heart Failure
SCD for CRS in Congestive Heart Failure (CHF) (No Left Ventricular Assist Device)
The purpose of this clinical trial is to see if a new device (SCD) is safe and if it can reduce damage to the kidney enough to allow medications to work to improve heart and kidney function for use in patients that have moderate…
- Conditions
- Heart Failure, Chronic Systolic Heart Failure, Renal Failure, Cardiorenal Syndrome
- Trial name
- NCT04589065
- Testing
- Selective Cytopheretic Device
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Lenar Yessayan
Cardiomyopathy
Speckle Tracking in Pediatric Patients
An echocardiogram, also called a cardiac ultrasound or echo, is a medical test that takes pictures of the heart using sound waves. It shows images of the structures of the heart without using radiation.
- Trial name
- NCT00489957
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Emory University
Heart Arrest, Out-Of-Hospital, Computed Tomography
Head Computed Tomography for Predicting Neurological Outcome After Cardiac Arrest
The European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) joint guidelines for post-resuscitation care recommend a multimodal approach to prognostication of neurological outcome.
- Conditions
- Heart Arrest, Out-Of-Hospital, Computed Tomography, Unconsciousness, Neurologic Deficits
- Trial name
- NCT03913065
- Testing
- CT
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Lund University
Myocardial Infarction, Iron-deficiency
An Open Study on the Efficacy of Iron Therapy Using iv Iron Relative to Oral Iron for Increasing LV Systolic Function
The OPERA-MI trial evaluates the effect of i.v. ferric carboxymaltose compared to the effect of oral iron, on left ventricular systolic function.
- Trial name
- OPERA-MI (NCT05309499)
- Testing
- ferric carboxymaltose, ferrous sulphate
- Where
- Russia
- Volunteers
- 298 people
- Sponsor
- Kazan State Medical University
Quality of Life, Pacemaker Ddd Permanent
Clinical Benefit of Rigourous AV Delay Optimization in Patients With a Dual Chamber Pacemaker
Though AV optimization has become a cornerstone in optimization of patients with a cardiac resynchronization therapy (CRT) device, surprisingly the use of AV optimization in patients with a dual chamber (bicameral (BIC))…
- Conditions
- Quality of Life, Pacemaker Ddd Permanent, Atrial Dysfunction
- Trial name
- CBRAVO (NCT01998256)
- Testing
- AV optimization
- Where
- Belgium
- Volunteers
- 28 people
- Sponsor
- Jessa Hospital
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