Clinical trials: Coronary Physiology
Open Heart Surgery, Cardiovascular Disease
The Effect of Neurophysiological Facilitation Techniques on Health Parameters in Early Stages After Open Heart Surgery
In this study, researchers aimed to investigate effects of neurophysiological facilitation on functional capacity and respiratory parameters of patients who underwent open heart surgery.
- Conditions
- Open Heart Surgery, Cardiovascular Disease, Physiotherapy
- Trial name
- NCT06551714
- Testing
- Phase 1 cardiac rehabilitation, Neurophysiological facilitation techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Dogus Universitesi
Transthyretin Amyloid Cardiopathy, Mitochondrial Pathology
The Effect of Trimetazidine on Mitochondrial Function, Myocardial Performance, and Invasive Hemodynamics in Patients Diagnosed With Wild-Type Transthyretin Cardiac Amyloidosis
Wild-type transthyretin cardiac amyloidosis (ATTRwt) is a deposition disorder in which one of the proteins of the body misfolds and accumulates at various places in the body, including the heart, leading to both mechanical and…
- Trial name
- CACTuS - TMZ (NCT05633563)
- Testing
- Trimetazidine
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Steen Hvitfeldt Poulsen
Heart Failure, Type2diabetes
Mitochondrial Substrate Utilization in the Diabetic Human Heart
Diabetes can lead to heart failure independently, but the underlying causes remain incompletely understood. The main aim of this study is to identify differential regulation of mitochondrial substrate utilization and complex…
- Conditions
- Heart Failure, Type2diabetes, Insulin Resistance, Mitochondrial Diseases
- Trial name
- NCT05958706
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Pulmonary Hypertension, Valvular Heart Disease
Evaluating Right Ventricular (RV) Size and Function Using the Upper Valley RV Algorithm and Novel Imaging Modalities
The primary purpose of this study is to evaluate the diagnostic performance of three methods for measuring right ventricular size and function including the Philips Novel RV quantification technologies (RV Heart Model volumetric…
- Conditions
- Pulmonary Hypertension, Valvular Heart Disease, Congenital Heart Disease, Congestive Heart Failure
- Trial name
- UVRV (NCT03935178)
- Testing
- Measuring Right Ventricular Size and Function
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Platelet Function Tests, Thrombin Generation Tests
Point-of-care Assessment of Thrombin Generation and Platelet Function in Children Requiring Cardiopulmonary Bypass
Coagulopathy after cardiopulmonary bypass (CPB) is associated with increased morbidity and mortality. Clot formation and clot stability are important factors in coagulation and hemostasis.
- Conditions
- Platelet Function Tests, Thrombin Generation Tests, Perioperative Coagulopathy
- Trial name
- NCT02833025
- Testing
- Thrombin generation and Platelet Function Testing
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- The Hospital for Sick Children
Coronary Artery Disease (CAD), Obstructive Coronary Artery Disease
Comprehensive Invasive Physiological Evaluation of Obstructive Coronary Artery Disease
The goal of this clinical trial is to test whether adding coronary function testing and starting targeted medical treatment for identified vasomotor disorders will also improve angina symptoms and quality of life in patients with…
- Conditions
- Coronary Artery Disease (CAD), Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction (CMD), Vasospasm, Coronary
- Trial name
- NCT07449052
- Testing
- Coronary function testing, Percutaneous coronary intervention
- Volunteers
- 450 people
- Sponsor
- UMC Utrecht
Liver Disease, Cardiovascular Disease
Liver Function Measured by HepQuant-SHUNT in the Prediction of Outcomes in Patients With Heart Disease
Background: It is still difficult to predict the outcome in patients requiring Fontan Revisions and in those who have evidence of congestive hepatopathy and probable cirrhosis requiring major cardiac surgery including heart…
- Trial name
- NCT02506335
- Testing
- Cholate testing
- Volunteers
- 14 people
- Sponsor
- Northwestern University
Healthy
Estrogen Alternatives Study
Healthy postmenopausal women not currently taking hormone replacement or hormone modulating therapy take a 3-month course of estradiol/raloxifene/placebo to evaluate the effects of each on vascular function, as indicated by PET…
- Trial name
- NCT00108238
- Testing
- Estradiol followed by progesterone, Raloxifene
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Liver Cirrhosis
Prospective Analysis Of Cardiac Function In Cirrhotic Patients By Echocardiography And Its Correlation With Events
The cardiac abnormalities in patients with cirrhosis are already reported from the 50's, in studies of patients with alcoholic cirrhosis.
- Trial name
- NCT01433848
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Rio de Janeiro State University
Neurovascular Coupling Mechanism and Cognitive Function
Study on the Neurovascular Coupling Function in Patients Undergoing Cardiac Surgery
Existing researches show that brain is an organ highly dependent on continuous blood supply. Energy and oxygen required for normal physiological activities in the brain are stably maintained by a neurovascular regulatory…
- Trial name
- NCT02977455
- Volunteers
- 30 people
- Sponsor
- Xiangya Hospital of Central South University
Obstructive Pulmonary Function, Restrictive Pulmonary Function
Study to Compare the Pharmacokinetics and Pharmacodynamics of ASA Powder for Oral Inhalation With Non-enteric-coated Chewable Aspirin in Adult Subjects With Obstructive or Restrictive Pulmonary Function
The goal of this clinical trial is to compare the pharmacokinetics (PK) pharmacodynamics (PD), safety and tolerability of acetylsalicylic acid powder for oral inhalation (I-ASA) with non-enteric-coated chewable aspirin (C-ASA) in…
- Trial name
- NCT05625347
- Testing
- single dose (100 mg) of ASA, single dose (162 mg) of non-enteric-coated chewable aspirin tablets
- Where
- 4 sites in United States
- Volunteers
- 4 people
- Sponsor
- Vectura, Inc.
Cardiac Surgical Procedures
The Impact of Storage Techniques on Platelets Number and Function After Acute Normovolemic Hemodilution (ANH)
Acute normovolemic hemodilution (ANH) is part of our current protocol to decrease post-operative bleeding and homologous blood transfusions post cardiopulmonary bypass.
- Trial name
- NCT02060838
- Testing
- Acute normovolemic hemodilution (ANH)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Aymen N Naguib
Breast Cancer
Protection of Cardiovascular Function With Crocin in BrEast Cancer Patients Undergoing Radiotherapy and Chemotherapy
The potential cardiovascular toxicity of tumor treatment and its resulting cardiovascular events have gradually become an important health risk for tumor survivors.
- Trial name
- ProtECtion (NCT05504148)
- Testing
- crocin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Qilu Hospital of Shandong University
Hypoplastic Left Heart Syndrome, Obstructive Sleep Apnea Syndrome
Sleep Disordered Breathing in Children With Single Ventricle Physiology
This is an exploratory study designed to evaluate the incidence of, and to quantify sleep disordered breathing following stage I Norwood reconstructive surgery. Sleep disordered breathing will be correlated with: 1.
- Conditions
- Hypoplastic Left Heart Syndrome, Obstructive Sleep Apnea Syndrome, Single Ventricle Physiology
- Trial name
- NCT00156455
- Where
- United States
- Sponsor
- University of Rochester
Heart Failure, Depression
Vascular Effects of Sertraline in Heart Failure
To determine the effects of chronic sertraline treatment on brachial artery flow-mediated dilation in patients with chronic heart failure and depression
- Trial name
- NCT00585455
- Testing
- sertraline
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Yale University
PET / CT, Coronary Microvascular Disease
The Value of PET Quantitative Analysis of Coronary Physiology in Coronary Microvascular Disease
With the aging of the population and the acceleration of urbanization process, the number of cardiovascular diseases in China continues to increase, with one in five adults suffering from cardiovascular disease.
- Trial name
- NCT04005963
- Testing
- 13N-NH3 PET cardiac blood flow perfusion rest and load imaging
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Heart Arrest, Ventricular Fibrillation
Observational and Diagnostical Study on Transient Allostatic Responses of Thyroid Function After Cardiopulmonary Resuscitation
Time-limited adaptive responses of thyroid function are common in the critically ill. About 70% of all patients treated on intensive care units develop a so-called non-thyroidal illness syndrome (NTIS) or TACITUS (thyroid…
- Conditions
- Heart Arrest, Ventricular Fibrillation, Ventricular Flutter, Ventricular Tachycardia
- Trial name
- Thyro-CPR (NCT04392258)
- Testing
- TSH determination, FT4 determination, FT3 determination
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Ruhr University of Bochum
Tricuspid Regurgitation, Tricuspid Valve Insufficiency
Evaluation of the Impact of Interventional Treatments for Symptomatic, Severe Tricuspid Valve Insufficiency on Renal Integrity and Function, as Well as on Physical Function and Activity in Older Adults.
The hypothesis is that renal function will improve following tricuspid valve intervention. A reduction in renal biomarkers is also expected.
- Conditions
- Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Cardio-Renal Syndrome, Frailty
- Trial name
- TriRenGe (NCT07464106)
- Testing
- Transcatheter edge-to-edge repair (TEER)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Robert Bosch Medical Center
Atrial Fibrillation
Renal Function and Hemolysis After Pulsed-field Ablation for Atrial Fibrillation
The aim of the project is to assess hemolysis and renal function after catheter ablation for atrial fibrillation using pulsed-field energy.
- Trial name
- NCT06198933
- Testing
- Pulsed-field ablation
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Charles University, Czech Republic
Acute Decompensated Heart Failure
Dopamine in Acute Decompensated Heart Failure II
The aim of this study is to compare the effects of 1) high-dose furosemide, 2) low-dose furosemide, and 3) low-dose furosemide combined with low-dose dopamine on diuresis, clinical status, renal function, electrolyte balance…
- Trial name
- DAD-HF II (NCT01060293)
- Testing
- High-dose furosemide, Low-dose furosemide, Low-dose furosemide combined with low-dose dopamine
- Where
- 6 sites in United States, Greece
- Volunteers
- 161 people
- Sponsor
- Larissa University Hospital
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