Clinical trials: Coronary Physiology
Septic Shock, Cardiomyopathy
Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic Shock
The aim of this study is to investigate the effects milrinon and levosimandan on n heart function in septic cardiomyopathy and how norepinephrine affects the left and right ventricular function in patients with septick shock…
- Trial name
- SCLM (NCT02640846)
- Testing
- Norepinephrine, Milrinone, Levosimendan
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Sahlgrenska University Hospital
Healthy Subjects
A Study in Healthy Subjects to Investigate Whether Administration of Clazosentan Can Affect Normal Heart Function
The study will investigate whether administration of clazosentan can affect normal heart function in healthy subjects
- Trial name
- NCT03657446
- Testing
- Clazosentan, Moxifloxacin
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Coronary Artery Disease, Postprandial Hyperglycemia
Vitamin D Supplementation in CAD and Postchallenge Hyperglycemia
The main aim of the investigation is to clarify, whether vitamin D supplementation in coronary artery disease patients with vitamin D deficiency and postchallenge hyperglycemia has an impact on endothelial dysfunction and…
- Conditions
- Coronary Artery Disease, Postprandial Hyperglycemia, Vitamin D Deficiency
- Trial name
- NCT01183442
- Testing
- vitamin D
- Where
- Austria
- Volunteers
- 22 people
- Sponsor
- Medical University of Graz
Stenosis, Aortic
Omics in Valvular Disease
The aim of our study is to investigate the effects of impaired left ventricular remodeling on the short- and long-term prognosis in AS partecipants undergoing extracorporeal circulation during valve repair surgery and in…
- Trial name
- OVERLOAD (NCT05768594)
- Testing
- Blood sample
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Coronary Artery Disease
Symptom Management Intervention in Elderly Coronary Artery Bypass Patients
The major purpose of this experimental study is to test the effects of the symptom management home care nursing intervention (SMHCNI) on recovery outcomes of elderly CABG patients, using a randomized, two group (n=284) repeated…
- Trial name
- NCT00572988
- Volunteers
- 232 people
- Sponsor
- University of Nebraska
Coronary Heart Disease
Glycocalyx and Oxidative Stress in Endothelial Function (Part 2)
The primary research objective of the project is to determine the role of eGC in microvascular reactivity in patients with coronary heart disease (CHD) before and after bypass grafting (cross-sectional study 2).The main objective…
- Trial name
- GlikoOxEND (NCT07451873)
- Where
- Croatia
- Volunteers
- 35 people
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Postoperative Delirium (POD)
The Study of Postoperative Delirium and Glymphatic System Function in Cardiac Surgery
Postoperative delirium after cardiac surgery is an acute cerebral dysfunction characterized by inattention, impaired consciousness, and cognitive and orientation disturbances.
- Trial name
- Delirium (NCT06901479)
- Testing
- Blood was drawn for proteomics testing and Magnetic Resonance Imaging.
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Hypovolemic Shock, Cardiogenic Shock
Renal Resistive Index in Patients With Shock
This study consists of two substudies. The first substudy: 'Renal resistive index in critically ill patients with cardiogenic and septic shock' Design: cross-sectional observational Aim of this project is: 1.
- Conditions
- Hypovolemic Shock, Cardiogenic Shock, Septic Shock, Kidney Failure, Acute
- Trial name
- NCT02558166
- Where
- Netherlands
- Volunteers
- 92 people
- Sponsor
- Amsterdam UMC, location VUmc
Coronary Arteriosclerosis, Acute Coronary Syndrome
GRAVITAS: Gauging Responsiveness With A VerifyNow Assay-Impact On Thrombosis And Safety
The objective of the GRAVITAS trial is to determine whether tailored anti-platelet therapy using the Accumetrics VerifyNow P2Y12 assay reduces major adverse cardiovascular events after drug-eluting stent implantation.
- Trial name
- GRAVITAS (NCT00645918)
- Testing
- clopidogrel
- Where
- 82 sites in United States, Canada
- Volunteers
- 2,800 people
- Sponsor
- Accumetrics, Inc.
Hypertrophic Cardiomyopathy, Heart Diseases
Comparison of the Effects of Inspiratory Muscle Training and Baduanjin Exercises in Hypertrophic Cardiomyopathy Patients
The study aims to compare the effects of inspiratory muscle training and Baduanjin exercises on pulmonary function, exercise capacity, and quality of life in patients with hypertrophic cardiomyopathy.
- Trial name
- NCT06490250
- Testing
- Inspiratory Muscle Training, Baduanjin Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Istanbul University - Cerrahpasa
Perinatal HIV Infection, Cardiac Fibrosis
Immune Correlates of Cardiac Structure and Function
The purpose of this study is to determine the occurrence of scarring of the heart (cardiac fibrosis) and inflammation in those with perinatally acquired Human Immunodeficiency Virus (HIV) infection compared to people not infected…
- Conditions
- Perinatal HIV Infection, Cardiac Fibrosis, Cardiac Inflammation
- Trial name
- NCT05328713
- Testing
- Cardiac MRI
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Atrial Fibrillation
Left Atrial Function After Pulsed Field Ablation of Atrial Fibrillation
Introduction: Pulsed field ablation (PFA) has emerged in routine clinical practice as a new promising technology in catheter-based treatment of atrial fibrillation (AF).
- Trial name
- NCT06478342
- Testing
- ablation
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Heart Failure
The Role of Nuclear Imaging in Heart Failure
Heart failure is a clinical syndrome of exercise intolerance and/or congestion. The potential roles of myocardial perfusion and metabolic abnormalities in subjects with cardiovascular risks, metabolic disease and heart failure…
- Trial name
- NCT02697669
- Testing
- 18F-FDG PET
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Far Eastern Memorial Hospital
Liver Fat, Cardiac Function
Short-term Fat Overfeeding on the Effects of Liver Metabolism
Despite work showing the overconsumption of saturated fatty acids (SFA) to be metabolically deleterious, debate continues about whether there is a link between SFA and cardiovascular disease risk.
- Conditions
- Liver Fat, Cardiac Function, Lipid Disorder, Adiposity
- Trial name
- FOS (NCT05962190)
- Testing
- Diet
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Postoperative Neuromuscular Block
Sugammadex and Heart Failure
Although anticholinesterase reversal agents have been used in combination with anticholinergic drugs for over half a century, it has been suggested that they should be used with caution in patients with underlying cardiovascular…
- Trial name
- NCT01509651
- Testing
- Sugammadex
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- Onze Lieve Vrouw Hospital
Chronic Heart Failure, Central Sleep Apnea
Effect of Adaptive Servoventilation on Cardiac Function in Chronic Heart Failure and Cheyne-Stokes Respiration
Sleep disordered breathing is common in patients with chronic heart failure. Adaptive servoventilation is a novel method of treatment central sleep apnoea, especially associated with Cheyne-Stokes-respiration.
- Conditions
- Chronic Heart Failure, Central Sleep Apnea, Cheyne-Stokes Respiration
- Trial name
- NCT01212705
- Testing
- Adaptive servoventilation
- Where
- Poland
- Sponsor
- Military Institute od Medicine National Research Institute
Acute on Chronic Systolic Congestive Heart Failure, Cardiorenal Syndrome
Feasibility of the SCD in Cardiorenal Syndrome Patients Awaiting LVAD
Cardiovascular disease is the leading cause of mortality in the US, accounting for 45% of all deaths. Chronic Heart Failure (CHF) is now understood to be a multi-system disease process involving not only the cardiovascular system…
- Trial name
- NEUTRALIZE-CRS (NCT03836482)
- Testing
- Selective Cytopheretic Device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- SeaStar Medical
Cardiac Remodeling, Ventricular, Right Ventricular Hypertrophy
Longitudinal Analysis of Right Ventricular Remodeling in Response to Prolonged Strength Training Using 3D-echocardiography
Right ventricular (RV) physiological remodeling in response to prolonged strength exercise remains poorly studied. This prospective, non-randomized, single-center study, proposes to follow 24 healthy sedentary volunteers who will…
- Trial name
- FORCE-VD (NCT04187170)
- Testing
- Strength physical training
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Right Ventricular Dysfunction, Pneumonectomy; Status
Right Ventricle Function After Major Right Lung Resection
Major lung resection is associated with high post-operative morbidity and mortality and significant long-term decreased functional capacity, especially due to cardiorespiratory complications.
- Trial name
- RIVER (NCT04167241)
- Testing
- Echocardiography
- Volunteers
- 50 people
- Sponsor
- Humanitas Clinical and Research Center
Diabetes Mellitus, Type 2, Obesity, Abdominal
Ghrelin and Diastolic Heart Function
In type 2 diabetes mellitus (T2DM) and obese patients the adipose tissue could over-express cytokines, sirtuin-1 (SIRT1), and microRNAs (miRs) implied in the regulation of left ventricle (LV) diastolic function (LV-DF).
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Abdominal, Diastolic Dysfunction
- Trial name
- NCT05988346
- Testing
- abdominal plastic intervention
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Campania Luigi Vanvitelli
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