Clinical trials: Coronary Physiology
ST Elevation Myocardial Infarction
Coronary Physiology Testing in Acute Coronary Syndromes
This is an interventional, prospective, multicenter study (5 IRCCS hospitals belonging to the Italian Cardiology Network) in patients with STEMI treated with successful primary PCI to assess the ability of coronary physiology…
- Trial name
- CoPhyTea (NCT04677257)
- Testing
- PCI, invasive coronary physiology and CMR
- Where
- 5 sites in Italy
- Volunteers
- 130 people
- Sponsor
- IRCCS San Raffaele
Heart Failure With Reduced Ejection Fraction
Effects of Preferential Left Ventricular Pacing on Ventriculoarterial Coupling and Clinical Course of Heart Failure
Randomized trial of adult patients to study the effects of preferential left ventricular pacing on ventriculoarterial coupling of both systemic and pulmonary circulation, indices of systolic and diastolic function of both…
- Trial name
- READAPT (NCT04420065)
- Testing
- Preferential left ventricular pacing, Biventricular pacing
- Where
- Greece
- Volunteers
- 220 people
- Sponsor
- National and Kapodistrian University of Athens
Myocardial Infarction, Inflammation
Simvastatin Effect on Inflammation and Endothelial Function After Myocardial Infarction
During myocardial infarction, inflammatory response may negatively influence ventricle wall remodeling as well as endothelium-dependent vasomotor function in the coronary and systemic arterial systems.
- Conditions
- Myocardial Infarction, Inflammation, Endothelial Dysfunction
- Trial name
- NCT00906451
- Testing
- Simvastatin
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- Brasilia Heart Study Group
Myocardial Infarction, Percutaneous Coronary Intervention
Escalating Clopidogrel by Involving a Genetic Strategy - Thrombolysis In Myocardial Infarction 56
To determine whether higher as compared with lower maintenance doses of clopidogrel can adequately improve the degree of platelet inhibition in carriers of a reduced-function CYP2C19 allele.
- Trial name
- ELEVATE (NCT01235351)
- Testing
- Clopidogrel
- Where
- United States
- Volunteers
- 335 people
- Sponsor
- The TIMI Study Group
Cardiac Disorder
Microcirculation in Cardiac Surgery
The purpose of this study is to determine whether cardiopulmonary bypass affects mesenteric microcirculatory function, using sublingual evaluation, in cardiac surgery.
- Trial name
- MICROCARD (NCT01330745)
- Testing
- sublingual microcirculatory evaluation
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Rouen
Atrial Fibrillation, Thrombotic Risk
Regulation of Platelet Function in Older Patients With Atrial Fibrillation
The goal of this observational study is to learn about the effects of antiplatelet drugs on patients over the age of 80 with atrial fibrillation.
- Trial name
- NCT07724301
- Volunteers
- 50 people
- Sponsor
- University of Michigan
Mitral Regurgitation, Mitral Stenosis
Mild ANH on Pre-bypass Coagulation Function During Cardiac Surgery
The impact of acute normovolemic hemodilution (ANH) using hydroxyethyl starch before initiating cardiopulmonary bypass (CPB) on whole blood viscoelastic profile after CPB has not been well established.
- Conditions
- Mitral Regurgitation, Mitral Stenosis, Tricuspid Regurgitation
- Trial name
- NCT06664320
- Testing
- Acute normovolemic hemodilution (ANH), hydroxyethyl starch (HES 130/0.6)
- Where
- 2 sites in South Korea
- Volunteers
- 70 people
- Sponsor
- Konkuk University Medical Center
Cardiovascular Risk Factors
A Study of Different Types of Fatty Acid on Risk Factors for Heart Disease
Experimental elevation of non-esterified fatty acids (NEFA) impairs endothelial function and insulin sensitivity but the impact of NEFA composition is unknown.
- Trial name
- eFAIRE (NCT01351324)
- Testing
- Absence or presence of fish oil
- Where
- United Kingdom
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Reading
Menopause Related Conditions
Quercetin for Cardio-Skeletal Muscle Health and Estrogen Deficiency
Double blind randomized controlled parallel pilot trial of Quercetin vs placebo oral administration in 24 postmenopausal women. The study team will conduct a feasibility pilot in preparation for a larger efficacy trial that will…
- Trial name
- QUICKENED (NCT04258410)
- Testing
- Quercetin
- Sponsor
- Wake Forest University Health Sciences
Coronary Artery Disease
A Pharmacodynamic Study Comparing Prasugrel Versus Ticagrelor in Patients Undergoing PCI With CYP2C19 Loss-of-function:
Numerous studies have shown that pharmacodynamics (PD) response profiles vary among clopidogrel treated patients and that individuals with reduced response have an increased risk of recurrent ischemic events.
- Trial name
- NCT02065479
- Testing
- Prasugrel, Ticagrelor
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Florida
Chronic Heart Failure, Hyperuricemia
Allopurinol in Chronic Heart Failure
The purpose of this study is to discover whether the inhibition of the xanthine oxidase with allopurinol leads to a reduction of the production of oxygen free radicals in patients with CHF and thereby improves characteristics of…
- Trial name
- NCT00997542
- Testing
- Allopurinol
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- National Heart and Lung Institute
Congestive Heart Failure, Ventricular Function, Left
Validation of the Gated Blood Pool SPECT: ERNA vs 3D Echo
This research study is designed to evaluate the accuracy of the techniques that are used to analyze heart function. The main purpose of this study is to analyze and compare three different methods of assessment of regional and…
- Trial name
- NCT00576186
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Coronary Artery Disease
Effect of 6R-BH4 Treatment in Coronary Artery Disease (OXBIO Study)
The purpose of this study is to determine the effect of 6R-BH4 on vascular function in patients with coronary artery disease. We hypothesize that 6R-BH4 will improve vascular function in these patients.
- Trial name
- NCT00423280
- Testing
- 6R-BH4
- Where
- United Kingdom
- Volunteers
- 66 people
- Sponsor
- University of Oxford
Preeclampsia, Severe Preeclampsia
Diastolic Dysfunction 2025
This is a prospective observational study conducted at the Maternity and Neonatology Center of Tunis to evaluate cardiac diastolic function in women with preeclampsia compared with normotensive pregnant women.
- Trial name
- NCT07190846
- Testing
- No Intervention (Observational Echocardiographic Evaluation)
- Where
- Tunisia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Atrial Fibrillation, Neuropsychology
Silent Cerebrovascular Lesion and Cognitive Decline Prevention by Cholesterol Lowering in Elderly AF Patients
In elderly patients with atrial fibrillation (AF) the presence of silent brain infarcts and neurocognitive deficit is high despite adequate treatment with oral anticoagulation.
- Conditions
- Atrial Fibrillation, Neuropsychology, Magnetic Resonance Imaging, Inflammation
- Trial name
- SPACE (NCT00449410)
- Testing
- Atorvastatin, ezetimibe
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- Radboud University Medical Center
Acute Coronary Syndrome, ST Segment Elevation Myocardial Infarction
MAGnesium-based Bioresorbable Scaffold in ST Segment Elevation Myocardial Infarction
This is a prospective, randomized, active control, single-blind, non-inferiority, multicenter clinical trial. 148 subjects will be registered at up to 10 Spanish sites. Subjects will be followed for 5 years.
- Conditions
- Acute Coronary Syndrome, ST Segment Elevation Myocardial Infarction, Stent
- Trial name
- MAGSTEMI (NCT03234348)
- Testing
- Percutaneous coronary intervention
- Where
- 11 sites in Spain
- Volunteers
- 151 people
- Sponsor
- Hospital Clinic of Barcelona
Coronary Heart Disease (CHD), Heart Failure
Community Exercise Treating Effect on Cardiopulmonary Disease Patients
The goal of this clinical trial is to learn if community-based exercise training can benefit patients aged 18 to 85 with diminished cardiovascular and pulmonary function.
- Conditions
- Coronary Heart Disease (CHD), Heart Failure, Cardiomyopathy, COPD
- Trial name
- NCT07154355
- Testing
- community-based exercise training
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Guangdong Provincial People's Hospital
Chronic Kidney Diseases
Influence of Exercise in Patients With Chronic Kidney Disease During Hemodialysis
Introduction: Chronic Renal Failure affects a large part of the world population, being characterized by irreversible renal tissue damage, resulting in systemic disturbances that negatively affect the patient's life.
- Trial name
- NCT03556540
- Testing
- physical exercise
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Metodista de Piracicaba
Coronary Artery Disease
Adiponectin and Circulating Progenitor Cells (CPC) Function
Adiponectin and exercise training contribute to the maintenance of a normal vascular tone by influencing vascular NO bioavailability and concentration and function of endothelial progenitor cells.
- Trial name
- NCT01272674
- Testing
- exercise training
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Parkinson Disease
Effect of Vitamin D3 Supplementation on Cardiac Autonomic Nerve Function in Male Parkinson's Disease Patients With Hypovitaminosis D
The goal of this clinical trial is to see the effect of vitamin D3 supplementation on cardiac autonomic nerve function in male Parkinson's disease patients with hypovitaminosis D Main questions it aims to answer are: 1.
- Trial name
- NCT07084597
- Testing
- Vitamin D
- Where
- Bangladesh
- Volunteers
- 15 people
- Sponsor
- Bangladesh Medical University
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