Clinical trials: Coronary Stent Implantation
Coronary Artery Disease
A Randomized Controlled Comparison Between One Versus More Than Six Months of Dual Antiplatelet Therapy After Biolimus A9-eluting Stent Implantation
DES are preferred over BMS for most patients, however prolonged dual antiplatelet therapy is required for patients treated with DES for prevention of late or very late stent thrombosis. which increases a risk of major bleeding.
- Trial name
- NCT02513810
- Testing
- BioFreedom with 1 month DAPT, BioMatrix or Ultimaster with 6 to 12 months DAPT
- Where
- South Korea
- Volunteers
- 3,020 people
- Sponsor
- Yonsei University
Ischaemic Heart Disease
Sirolimus Eluting Stents in Complex Coronary Lesions (SCANDSTENT)
The purpose of this study is to evaluate the clinical and angiographic outcome of implantation of stents eluting or not eluting Sirolimus in patients with complex coronary artery lesions suitable for percutaneous coronary…
- Trial name
- NCT00151658
- Testing
- Coronary Drug Eluting Stents for PCI
- Where
- Denmark
- Volunteers
- 322 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome
Starring Optical Coherence Tomography During Percutaneous Coronary Intervention Guidance
The starring optical coherence tomography during percutaneous coronary intervention guidance (OCT-AGEM) registry aims to evaluate the clinical impact of intra-procedural optical coherence tomography (OCT) in coronary…
- Conditions
- Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome, MINOCA, INOCA (Ischemia With Non Obstructive Coronary Artery Disease)
- Trial name
- OCT-AGEM (NCT07182799)
- Testing
- Plaque vulnerability assessment, Stent implantation optimization
- Where
- Italy
- Volunteers
- 3,200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Coronary Heart Disease
Relation Among Shear Stress Distribution, Stent Design, and Subsequent Vessel Healing After Drug-eluting Stent Implantation (SHEAR DES)
The purpose of this study is to evaluate the differences of wall shear stress distribution among different types of drug-eluting stents and its impact on vessel healing evaluated by intravascular optical coherence tomography…
- Trial name
- NCT01942044
- Testing
- Promus element, Xience prime, and Nobori
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Kobe University
Acute Coronary Syndrome
Prasugrel Versus Clopidogrel to TREAT High Platelet Reactivity
MAIN AIM: To compare the pharmacological potency of administering adjusted 600 mg clopidogrel loading doses and 60 mg prasugrel in patients with high on-clopidogrel platelet reactivity (HPR) after PCI.
- Trial name
- TREAT-HPR (NCT01493999)
- Testing
- Clopidogrel reloading, Prasugrel
- Where
- Hungary
- Volunteers
- 147 people
- Sponsor
- University of Pecs
Coronary Artery Disease (CAD)
Testing Platelet Reactivity In Patients Undergoing Elective Stent Placement on Clopidogrel to Guide Alternative Therapy With Prasugrel (TRIGGER-PCI)
To determine the efficacy of prasugrel versus clopidogrel for the reduction of adverse cardiovascular outcomes in patients with high platelet reactivity on clopidogrel after successful implantation of coronary drug-eluting…
- Trial name
- TRIGGER-PCI (NCT00910299)
- Testing
- Prasugrel, Clopidogrel
- Where
- 27 sites in United States, Germany
- Volunteers
- 423 people
- Sponsor
- Eli Lilly and Company
Coronary Artery Disease, Stent Restenosis
Matrix Metalloproteinases Expression in the Neointimal Hyperplasia Induced by Drug Eluting Stent (DES) Implantation
If intimal growth is such that the initial lumen is narrowed significantly, distal blood flow is restricted and chronic tissue ischemia results.
- Trial name
- NCT03375528
- Testing
- DES implantation
- Volunteers
- 50 people
- Sponsor
- Dankook University
CHD - Coronary Heart Disease, Angina, Stable
Coronary Microcirculatory and Bioresorbable Vascular Scaffolds
Angina and heart attacks are caused by narrowings in the coronary arteries (blood vessels) supplying the heart. These narrowings can be opened using a balloon and stent (angioplasty).
- Conditions
- CHD - Coronary Heart Disease, Angina, Stable, Myocardial Ischemia
- Trial name
- EMPIRE-BVS (NCT03076476)
- Testing
- Bioresorbable Vascular Scaffolds (BVS), Drug-Eluting Stent (DES) - slow, Drug-Eluting Stent (DES) - standard(std)
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Coronary Artery Disease
Prevention of Restenosis After Genous Stent Implantation Using a Paclitaxel Eluting Balloon in Coronary Arteries
Percutaneous coronary intervention with stent implantation is limited on the one hand by restenosis due to smooth muscle cell proliferation and on the other hand by stent thrombosis due to incomplete or not sufficient enough…
- Trial name
- NCT00732953
- Testing
- Genous stent implantation with paclitaxel-eluting balloon dilation, Genous stent implantation
- Where
- 3 sites in Germany
- Volunteers
- 120 people
- Sponsor
- University of Ulm
Coronary Artery Disease
Evaluation of Outcomes of EES Implantation for Unprotected Left Main Coronary Artery Stenosis (PRE-COMBAT 2)
This study is a multicenter, open label, prospective, single arm trial Single arm group; following angiography, eligible patients with unprotected LMCA stenosis >50% by visual estimation, which is equally treatable by the both…
- Trial name
- NCT01348022
- Where
- 21 sites in South Korea
- Volunteers
- 397 people
- Sponsor
- Seung-Jung Park
Coronary Disease
Platelet Reactivity After Cessation of Clopid in the Setting of Coronary Stent Implantation I: PRACTICE I
Single center randomized parallel group study to determine if: 1. there is a temporary increase in platelet reactivity after abrupt discontinuation of clopidogrel due to a potential rebound phenomenon. 2.
- Trial name
- PRACTICE I (NCT00684359)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medstar Health Research Institute
Coronary Artery Disease
Duration of Clopidogrel Therapy After Drug-Eluting Stent (DES-LATE)
This is randomized-controlled trial to evaluate the difference of composite of cardiac death, myocardial infarction, or Stroke between the dual antiplatelet therapy group and the aspirin monotherapy group after 1-year of…
- Trial name
- DES-LATE (NCT01186146)
- Testing
- Aspirin monotherapy, Aspirin,Clopidogrel
- Where
- 19 sites in South Korea
- Volunteers
- 5,000 people
- Sponsor
- Seung-Jung Park
Coronary Artery Disease, Percutaneous Coronary Intervention
Ethnic Differences and the Ischemia/Bleeding Risk of DAPT Duration
this study is an individual patient level meta-analysis of randomized clinical trials, to evaluate the influence of ethnicity, to study whether the relative tradeoff between ischemia and bleeding is distinct by ethnicity.
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Dual Antiplatelet Therapy
- Trial name
- NCT03338335
- Testing
- prolonged DAPT
- Where
- South Korea
- Volunteers
- 16,000 people
- Sponsor
- Seoul National University Hospital
Stable Coronary Artery Disease
Computed Tomography Coronary Angiography Before Stent Implantation
The purpose of the study is to determine whether results of the computed tomography coronary angiography may be helpful in planning and performing percutaneous angioplasty in patients with stable angina pectoris.
- Trial name
- NCT01205425
- Testing
- PCI on the basis of coronary angiography, CT guided PCI
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Major Adverse Cardiovascular and Cerebrovascular Events (MACCE)
Observational Prospective Study OPTIMA II - Follow-up
The current follow-up study was planned to reveal the rates of Major Adverse Cardiovascular and Cerebrovascular Events (MACCE) during 4-year follow-up in patients participated in OPTIMA study.
- Trial name
- OPTIMAII (NCT02099565)
- Where
- Russia
- Volunteers
- 572 people
- Sponsor
- AstraZeneca
Coronary Artery Disease, Myocardial Ischemia
Primary FIbrinolysis and Secondary STenting Versus immEdiate Stenting in ST-segment Elevation Myocardial Infarction
This prospective, multicenter, randomized, controlled, open-label clinical study has a target enrollment of 240 subjects. It will explore whether STEMI patients transferred to a PCI center following thrombolytic therapy and…
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Acute Coronary Syndrome, Heart Diseases
- Trial name
- FISSTEMI (NCT04663932)
- Testing
- immediate stenting group(one-step strategy), deferred stenting group (two-step strategy)
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Harbin Medical University
Coronary Artery Disease
TAXUS IV-SR: Treatment of De Novo Coronary Disease Using a Single Paclitaxel-Eluting Stent
The ultimate goal of a paclitaxel eluting stent system (TAXUS stent) is to prevent restenosis by blunting the initial response to stent implant injury and sustaining the arrested response until vascular healing has taken place.
- Trial name
- NCT00292474
- Testing
- percutaneous coronary intervention
- Where
- United States
- Volunteers
- 1,326 people
- Sponsor
- Boston Scientific Corporation
Acute Myocardial Infarction, Coronary Syndrome
Antiplatelet Therapy Following Stent Implantation
Coronary artery stents, particularly drug-eluting stents (DES), are used in the majority of patients who undergo percutaneous coronary intervention (PCI) to improve symptoms in patients with obstructive coronary artery disease.
- Conditions
- Acute Myocardial Infarction, Coronary Syndrome, Angina, Unstable
- Trial name
- Anti-Clot (NCT02051361)
- Where
- Greece
- Volunteers
- 900 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Coronary Artery Disease
Comparison Between P2Y12 Antagonist Monotherapy and Dual Antiplatelet Therapy After DES
To compare the efficacy and safety of clopidogrel monotherapy versus aspirin plus P2Y12 antagonist following 3-month of DAPT in patients undergoing PCI with DES.
- Trial name
- SMART-CHOICE (NCT02079194)
- Testing
- P2Y12 antagonist monotherapy, aspirin plus P2Y12 antagonist
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease, Coronary Disease
Late Stent Strut Apposition and Coverage After Drug-Eluting Stent Implantation by OCT in Patients With AMI
The purpose of this study is to evaluate the incidence of late incomplete stent apposition (ISA) and un-coverage by optical coherence tomography (OCT) following everolimus-eluting stent (EES) with bioabsorbable polymer (SYNERGY™…
- Conditions
- Coronary Artery Disease, Coronary Disease, Myocardial Ischemia, Arterial Occlusive Diseases
- Trial name
- NCT02770651
- Testing
- Everolimus-Eluting stent, Zotarolimus-Eluting stent
- Where
- South Korea
- Volunteers
- 69 people
- Sponsor
- Keimyung University Dongsan Medical Center