Clinical trials: Coronavirus (SARS-CoV)
COVID-19
Incidence of COVID-19 Following Vaccination in Botswana Against SARS CoV 2
The AstraZeneca Study is a single-arm, open-label, interventional, Phase 3b study to determine the incidence of laboratory-confirmed COVID-19 hospitalizations, disease severity, and deaths and attributable adverse events (AEs) in…
- Trial name
- NCT05715944
- Testing
- AZD 1222
- Where
- Botswana
- Volunteers
- 10,888 people, healthy volunteers welcome
- Sponsor
- Botswana Harvard AIDS Institute Partnership
Covid19, SARS-CoV Infection
Can SARS-CoV-2 Viral Load and COVID-19 Disease Severity be Reduced by Resveratrol-assisted Zinc Therapy
Administration of Zinc and resveratrol or double placebo for a period of 5 days and will be monitored for a 14 day period in covid-19 positive patients in an outpatient setting
- Trial name
- Reszinate (NCT04542993)
- Testing
- Zinc Picolinate, Resveratrol
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Swedish Medical Center
Corona Virus Infection, COVID-19
Inhaled NO for the Treatment of COVID-19 Caused by SARS-CoV-2 (US Trial)
The purpose of this open label, randomized, study is to obtain information on the safety and efficacy of 80 ppm Nitric Oxide given in addition to the standard of care of patients with COVID-19 caused by SARS-CoV-2.
- Conditions
- Corona Virus Infection, COVID-19, SARS-CoV 2, Nitric Oxide
- Trial name
- NCT04397692
- Testing
- Nitric Oxide delivered via LungFit™ system
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Beyond Air Inc.
Respiratory Failure, SARS-CoV 2
Stress Related Disorders in Family Members of COVID-19 Patients Admitted to the ICU
Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Conditions
- Respiratory Failure, SARS-CoV 2, Corona Virus Infection, Post Intensive Care Unit Syndrome
- Trial name
- NCT04476914
- Where
- 9 sites in United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
SARS CoV 2 Infection, COVID-19 Breakthrough
SARS-CoV-2 Specific Antibody Responses and Impact for COVID-19 Disease in Ethiopia
In this study we aim to characterize SARS CoV-2 strain specific immune response (SARS-CoV-2 Spike IgG) in health care workers and general populations at the Jimma Medical Center and the St.
- Conditions
- SARS CoV 2 Infection, COVID-19 Breakthrough, COVID-19 Recurrent
- Trial name
- CoVICIS (NCT06435403)
- Where
- 2 sites in Ethiopia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Michael Hoelscher
SARS-CoV 2, Respiratory Distress Syndrome, Adult
Characteristics and Outcomes of Patients With COVID-19 Admitted to the ICU
This is a case series of patients with COVID-19 admitted to the largest university hospital in Sao Paulo, Brazil, during the 2020 COVID-19 pandemic. Data will be collected prospectively and retrospectively.
- Conditions
- SARS-CoV 2, Respiratory Distress Syndrome, Adult, Corona Virus Infection, Critical Illness
- Trial name
- EpiCoV-Brazil (NCT04378582)
- Testing
- risk factors
- Where
- Brazil
- Volunteers
- 1,589 people
- Sponsor
- University of Sao Paulo General Hospital
SARS-CoV Infection, Covid-19
Characterizing the Immune Response and Neuronal Damage in COVID-19
The Investigators plan to study the innate and adaptive immune response, the inflammatory response, and associated complications such as complement activation and neurological damage in SARS-Cov-2 infected individuals.
- Trial name
- NCT04510012
- Testing
- Analysis of cytokine response, innate and adaptive immune response, complement activation, and serum neurofilaments as a marker of neurological damage.
- Where
- Switzerland
- Volunteers
- 88 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Covid19, SARS-CoV 2
Efficacy of Melatonin in the Prophylaxis of Coronavirus Disease 2019 (COVID-19) Among Healthcare Workers.
There is an urgent need to evaluate interventions that can prevent the infection with SARS-CoV 2 of healthcare workers at risk. Melatonin is an inexpensive and safe product with protective effect in both bacterial and viral…
- Conditions
- Covid19, SARS-CoV 2, Coronavirus Infection
- Trial name
- MeCOVID (NCT04353128)
- Testing
- Melatonin 2mg
- Where
- Spain
- Volunteers
- 450 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
SARS CoV 2 Infection, COVID-19
PROSPECTIVE OPEN LABEL CLINICAL TRIAL TO ADMINISTER A BOOSTER DOSE OF PFIZER/BIONTECH OR MODERNA COVID-19 VACCINE IN HIGH-RISK INDIVIDUALS
The recent rise in infections with the Omicron variant of the SARS-CoV-2 is alarming. Equally disconcerting is the fact that individuals who were previously vaccinated (< 6 months) and have co-morbidities that are considered high…
- Trial name
- NCT05279365
- Testing
- Pfizer/BioNTech (BNT162b2), Moderna
- Where
- 4 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- DHR Health Institute for Research and Development
SARS CoV 2 Infection
Effectiveness of COVID-19 Vaccines Against the SARS-COV-2 Delta (B.1.617.2)
Up to now, Corona Virus Disease 2019 (COVID-19) continues to spread rapidly around the world. From the beginning of the epidemic to the present, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has continuously…
- Trial name
- FASTER (NCT05244330)
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Postural Orthostatic Tachycardia Syndrome, Post Acute Sequelae of SARS CoV 2 Infection
NC Testing in LC & POTS
Patients with Postural Orthostatic Tachycardia Syndrome (POTS) and Post-Acute Sequelae of COVID (PASC, or "Long COVID") experience cognitive dysfunction.
- Trial name
- NCT05914649
- Testing
- IV normal saline (999 mL infusion), IV normal saline (50 mL infusion)
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Calgary
COVID 19
Colostrum From MERS-CoV Seropositive Camels for SARS-CoV-2 Infection - a Placebo-controlled Randomized Trial.
The study aims to study the efficacy of colostrum from MERS-CoV-positive camels applied as a nasal spray to COVID-19 patients for treatment and prevention of SARS-CoV-2 infection.
- Trial name
- NCT06857318
- Testing
- Colostrum Nasal Spray, Water for injection
- Where
- Israel
- Volunteers
- 43 people
- Sponsor
- Hadassah Medical Organization
Covid19, Sars-cov 2
Fase I Clinical Trial on NK Cells for COVID-19
Coronavirus Disease 2019 (COVID-19) is spreading worldwide and has become a public health emergency of major international concern. Currently, no specific drugs or vaccines are available.
- Trial name
- NCT04634370
- Testing
- Natural Killer Cells infusion
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
COVID-19
Seroprevalence of Covid-19 in the Staff of the University Hospitals of Strasbourg
The Grand Est region is one of the most affected regions in France during the first wave of the COVID-19 epidemic. A significant increase in the number of patients hospitalized for SARS-CoV 2 infection at the University Hospitals…
- Trial name
- SeroPrevHUS (NCT05652582)
- Where
- France
- Volunteers
- 5,694 people
- Sponsor
- University Hospital, Strasbourg, France
SARS-CoV Infection, Covid19
Can the Electronic Nose Smell COVID-19?
Infection with SARS-CoV-2 causes Corona Virus Disease (COVID-19). The most standard diagnostic method is reverse transcription-polymerase chain reaction (RT-PCR) on a nasopharyngeal and/or an oropharyngeal swab.
- Trial name
- NCT04475562
- Testing
- Aeonose
- Where
- Netherlands
- Volunteers
- 219 people
- Sponsor
- Maastricht University Medical Center
COVID, Covid-19
Trial of Combination Therapy to Treat COVID-19 Infection
In this trial patients will be treated with either a combination of therapies to treat COVID-19 or a placebo. Treatment will last 10 days, and patients will be followed for 6 months.
- Conditions
- COVID, Covid-19, Corona Virus Infection, Coronavirus Infection
- Trial name
- NCT04482686
- Testing
- Ivermectin, Doxycycline Hcl, Zinc
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- ProgenaBiome
SARS-CoV2 Infection
Expanded Access Treatment Protocol: Remdesivir (RDV; GS-5734) for the Treatment of SARS-CoV2 (CoV) Infection (COVID-19)
The primary objective of this study is to provide expanded access of remdesivir (RDV) for the treatment of severe acute respiratory syndrome coronavirus (SARS-CoV2) infection.
- Trial name
- NCT04323761
- Testing
- Remdesivir
- Where
- 272 sites in United States, Australia and 25 more
- Sponsor
- Gilead Sciences
COVID-19, Long COVID
Effectiveness of Transcranial Direct Current in Patients With Persistent COVID-19 With Headaches and Chronic Pain.
This study aims to verify the efficacy/effectiveness of treatment with transcranial direct current stimulation (TDCS) in patients with Long Covid who experience headaches, migraines, and chronic pain, such as arthralgia and…
- Conditions
- COVID-19, Long COVID, Long Covid19, SARS CoV 2 Infection
- Trial name
- NCT05780450
- Testing
- Transcranial Direct Current Therapy (tDCS)
- Where
- 2 sites in Spain
- Volunteers
- 87 people
- Sponsor
- Fundación Universidad Católica de Valencia San Vicente Mártir
COVID-19, SARS-CoV 2
Clinical Scores for Outcome Prediction in Patients With Severe COVID-19 Pneumonia Requiring ECMO
The prognosis of patients with severe COVID-19 disease, whose lungs are so severely diseased that they need to be supported by veno-venous ECMO (extracorporeal membrane oxygenation), is difficult to assess so far.
- Conditions
- COVID-19, SARS-CoV 2, Extracorporeal Membrane Oxygenation, ARDS
- Trial name
- NCT04405973
- Testing
- vv-ECMO
- Where
- Germany
- Volunteers
- 133 people
- Sponsor
- Dr. Alexander Supady
COVID-19, SARS-CoV 2
Antiseptic Mouthwash / Pre-Procedural Rinse on SARS-CoV-2 Load (COVID-19)
In this pilot trial, 150 confirmed COVID-19 individuals will be randomly assigned to 1 of 5 groups: distilled water, CloSYS Ultra Sensitive Rinse (Rowpar Pharmaceutical Inc., USA), Oral-B Mouth Sore (Oral-B, USA), Crest…
- Conditions
- COVID-19, SARS-CoV 2, Severe Acute Respiratory Syndrome Coronavirus 2, Virus Disease
- Trial name
- AMPoL (NCT04409873)
- Testing
- Oral-B Mouth Sore mouthwash, Crest Pro-Health Multi-Protection mouthwash, CloSYS Ultra Sensitive Rinse mouthwash
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of California, San Francisco