Clinical trials: Coronavirus (SARS-CoV)
SARS CoV 2 Infection
Effectiveness of COVID-19 Vaccines Against the SARS-COV-2 Delta (B.1.617.2)
Up to now, Corona Virus Disease 2019 (COVID-19) continues to spread rapidly around the world. From the beginning of the epidemic to the present, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has continuously…
- Trial name
- FASTER (NCT05244330)
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
COVID-19, Vaccine Adverse Reaction
Evaluation of the Immunogenicity and Safety BBIBP-CorV Vaccine for COVID-19 in Adults in Guinea
Phase II, non-randomized, open-label, comparative, single center national trial in Guinea, aimed to assess the humoral vaccine immune response induced by BBIBP-CorV vaccine in 200 adults aged between 18 and 45 years or 55 or…
- Conditions
- COVID-19, Vaccine Adverse Reaction, Sars-CoV-2 Infection, Healthy Volunteer
- Trial name
- CovicompareG (NCT05409300)
- Testing
- BBIBP-CorV
- Where
- 2 sites in Guinea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
SARS-CoV 2, COVID-19
Cardiac COVID-19 Health Care Workers
The study will analyze the prevalence of cardiac involvement of health care workers from the University Hospital of Salamanca (HUSA) who have overcome SARS-CoV-2 infection.
- Conditions
- SARS-CoV 2, COVID-19, Coronavirus, Cardiac Magnetic Resonance
- Trial name
- CCC (NCT04413071)
- Testing
- Passed infection of SARS-CoV-2
- Where
- Spain
- Volunteers
- 142 people
- Sponsor
- AORTICA Group
Covid19, SARS-CoV Infection
Host Response Mediators in Coronavirus (COVID-19) Infection - Is There a Protective Effect of Losartan and Other ARBs on Outcomes of Coronavirus Infection?
SARS-CoV-2 is a member of a class of viruses: angiotensin converting enzyme 2 (ACE2)-binding viruses that study calls "ABVs". The World Health Organization (WHO) and others are performing randomized controlled trials (RCTs) of…
- Trial name
- ARBs CORONA II (NCT04606563)
- Testing
- Losartan, Valsartan, Azilsartan
- Where
- 13 sites in Canada, France
- Volunteers
- 341 people
- Sponsor
- University of British Columbia
Respiratory Viral Infection, SARS CoV 2 Infection
Transmission of Respiratory Viruses in Households in The Gambia: a Longitudinal Cohort Study (TransVIR)
Primary endpoints Incidence of symptomatic and asymptomatic infection with SARS-CoV-2 and other respiratory viruses as determined by molecular (e.g.
- Trial name
- TransVIR (NCT05952336)
- Where
- The Gambia
- Volunteers
- 349 people
- Sponsor
- Medical Research Council Unit, The Gambia
Respiratory Failure, SARS-CoV 2
Stress Related Disorders in Family Members of COVID-19 Patients Admitted to the ICU
Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Conditions
- Respiratory Failure, SARS-CoV 2, Corona Virus Infection, Post Intensive Care Unit Syndrome
- Trial name
- NCT04476914
- Where
- 9 sites in United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
SARS-CoV 2, Traumatic Stress Disorder
Consequences of the QUARANTINE Relating to the COvid-19 Epidemic on the Mental Health of the Patients Followed in PSYchiatry
Quarantine related to the Covid-19 pandemic has begun on the 03/17/2020 in France. Quarantine has already be linked to pejorative effects on mental health.
- Trial name
- QUARCOPSY (NCT04405362)
- Sponsor
- University Hospital, Lille
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV 2 Infection), COVID-19
SUNRISE-3: Efficacy and Safety of Bemnifosbuvir in High-Risk Outpatients With COVID-19
The purpose of the study is to evaluate whether bemnifosbuvir (BEM) is effective and safe in adults with COVID-19 who do not need to be in the hospital but who are at high risk for progression to severe disease.
- Trial name
- NCT05629962
- Testing
- Bemnifosbuvir (BEM)
- Where
- 263 sites in United States, Argentina and 17 more
- Volunteers
- 2,285 people
- Sponsor
- Atea Pharmaceuticals, Inc.
Covid-19
Antioxidant Therapy for COVID-19 Study
Finding effective strategies to treat or prevent the novel coronavirus disease that started in 2019 (COVID-19) is a global public health priority.
- Trial name
- GSHSOD-COVID (NCT04466657)
- Testing
- Antioxidation Therapy, Standard of Care
- Where
- 11 sites in Nigeria
- Sponsor
- Obafemi Awolowo University
Covid19
Aggrenox To Treat Acute Covid-19
The purpose of this study is to explore the efficacy of Aggrenox in patients with SARS-CoV-2 infection with symptoms consistent with COVID-19.
- Trial name
- ATTAC-19 (NCT04410328)
- Testing
- Dipyridamole ER 200mg/ Aspirin 25mg orally/enterally AND Standard of care, Standard of care
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Rutgers, The State University of New Jersey
Long COVID-19 Syndrome, COVID 19
Evaluating the Impact of a Functional and Cognitive Strategy in Patients With Long Covid-19
This study aims to evaluate the impact of a functional and cognitive rehabilitation strategy compared to evidence-based informational messages, on functional capacity, cognitive abilities, quality of life, and disease progression…
- Conditions
- Long COVID-19 Syndrome, COVID 19, Noncommunicable Disease, Hypertension
- Trial name
- NCT06871293
- Testing
- Functional and cognitive rehabilitation strategy, Evidence-Based Informational Support
- Where
- Colombia
- Volunteers
- 374 people
- Sponsor
- Fundación Cardioinfantil Instituto de Cardiología
SARS CoV 2 Infection, Cancer
Mortality of Cancer Surgery During SARS CoV2 Pandemic
The impact of cancer surgery during covid epidemic is not clear. The published reports show contradictory findings that extend from no change in mortality to increased mortality, further no data on exposure and outcome of health…
- Trial name
- NCT05240378
- Testing
- Surgery
- Where
- India
- Volunteers
- 1,576 people
- Sponsor
- Banaras Hindu University
Corona Virus Infection, Acute Respiratory Distress Syndrome
Losartan for Patients With COVID-19 Requiring Hospitalization
This is a multi-center, double-blinded study of COVID-19 infected patients requiring inpatient hospital admission randomized 1:1 to daily Losartan or placebo for 7 days or hospital discharge.
- Conditions
- Corona Virus Infection, Acute Respiratory Distress Syndrome, SARS-CoV Infection
- Trial name
- NCT04312009
- Testing
- Losartan
- Where
- 13 sites in United States
- Volunteers
- 205 people
- Sponsor
- University of Minnesota
Coronavirus, COVID-19
Cytokine Adsorption in Severe COVID-19 Pneumonia Requiring Extracorporeal Membrane Oxygenation
In December 2019 in the city of Wuhan in China, a series of patients with unclear pneumonia was noticed, some of whom have died of it.
- Conditions
- Coronavirus, COVID-19, SARS-CoV Infection, Respiratory Failure
- Trial name
- CYCOV (NCT04324528)
- Testing
- vv-ECMO + cytokine adsorption (Cytosorb adsorber), vv-ECMO only (no cytokine adsorption)
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Dr. Alexander Supady
COVID-19, SARS-CoV 2
PROSAIC-19 - Prospective Longitudinal Assessment in a COVID-19 Infected Cohort
DESIGN Longitudinal prospective observational multicentre study. Primary objective: Understand the immune mechanisms driving COVID-19 disease in patients with a history of lung disease
- Conditions
- COVID-19, SARS-CoV 2, ARDS, Human, Immune System Disorder
- Trial name
- PROSAIC-19 (NCT04444609)
- Testing
- Blood tests sputum, nasal lavage and brushing
- Where
- United Kingdom
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Severe Acute Respiratory Syndrome Coronavirus 2, SARS-CoV 2
Antibody Seroprevalence and Rate of Asymptomatic Infections With SARS-CoV-2 in Austrian Hospital Personnel.
Context: On March 11, the World Health Organization (WHO) announced the current corona virus disease 2019 (COVID-19) outbreak as a pandemic.
- Conditions
- Severe Acute Respiratory Syndrome Coronavirus 2, SARS-CoV 2, Coronavirus Infection, Covid19
- Trial name
- NCT04354779
- Testing
- a specifically designed self-administered questionnaire
- Where
- Austria
- Volunteers
- 3,301 people, healthy volunteers welcome
- Sponsor
- AUVA
COVID-19, Coronavirus
Will Hydroxychloroquine Impede or Prevent COVID-19
This is a prospective, multi-site study designed to evaluate whether the use of hydroxychloroquine in healthcare workers (HCW), Nursing Home Workers (NHW), first responders (FR), and Detroit Department of Transportation bus…
- Conditions
- COVID-19, Coronavirus, Coronavirus Infections, SARS-CoV 2
- Trial name
- WHIP COVID-19 (NCT04341441)
- Testing
- Hydroxychloroquine - Daily Dosing, Hydroxychloroquine - Weekly Dosing, Monitoring Visit - Baseline
- Where
- United States
- Volunteers
- 624 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Covid-19 Prevention
A Study of Ad26.COV2.S in Adults (COVID-19)
The purpose of the study is to assess the safety, reactogenicity, and immunogenicity of Ad26.COV2.S at 2 dose levels, administered intramuscularly (IM) as a single-dose or 2-dose schedule, with a single booster vaccination…
- Trial name
- NCT04436276
- Testing
- Ad26.COV2.S
- Where
- 12 sites in United States, Belgium
- Volunteers
- 1,085 people, healthy volunteers welcome
- Sponsor
- Janssen Vaccines & Prevention B.V.
Covid19, BCG Vaccination Reaction
Clinical Trial Evaluating the Effect of BCG Vaccination on the Incidence and Severity of SARS-CoV-2 Infections Among Healthcare Professionals During the COVID-19 Pandemic in Poland
Countries that have not carried out universal mass vaccination against tuberculosis (BCG) have been shown to have higher incidence and death rates due to COVID-19 than countries with mass, long-term BCG immunization programmes.
- Conditions
- Covid19, BCG Vaccination Reaction, SARS-CoV Infection
- Trial name
- NCT04648800
- Testing
- BCG-10 vaccine, 0.9% saline
- Where
- 6 sites in Poland
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Hanna Czajka
Subacute Thyroiditis, SARS CoV 2 Infection
Subacute Thyroiditis in the SARS-CoV-2 Era
Many cases of subacute thyroiditis (SAT) have been described related to SARS-CoV-2 infection, but no prospective data about follow-up is known.
- Conditions
- Subacute Thyroiditis, SARS CoV 2 Infection, Thyrotoxicosis
- Trial name
- SAT-COVID-19 (NCT06391515)
- Testing
- Blood sample, CRF, thyroid ultrasound
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- University of Modena and Reggio Emilia