Clinical trials: Cortical Excitability
Cerebrovascular Accident
Preliminary Study of Transcranial Magnetic Stimulation for Stroke Rehabilitation
This is a preliminary study to evaluate the possible use of transcranial magnetic stimulation (TMS), together with exercise, for rehabilitation of chronic stroke patients.
- Trial name
- NCT00050128
- Testing
- rTMS, Magstim
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy
Effect of Hypnosis on Motor Cortex Excitability
This study is intended to investigate neurophysiological mechanisms of hypnosis using transcranial magnetic stimulation (TMS) and assessment of motor cortex excitability in healthy volunteers under hypnosis.
- Trial name
- NCT00416247
- Testing
- Hypnosis
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Attention Deficit Disorder With Hyperactivity
Cortical Excitability: Phenotype and Biomarker in Attention-deficit, Hyperactivity Disorder (ADHD) Therapy
The purpose of this study is to find out if children with attention-deficit, hyperactivity disorder (ADHD) have a difference in how their brain cells "fire" or react.
- Trial name
- NCT01330693
- Testing
- Atomoxetine, Sugar Pill
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Cincinnati
Major Depression
Antidepressant Effect of Theta-Burst rTMS
The aim of this study is to evaluate the safety and efficacy of theta-burst rTMS in patients with major depression. Patients will be randomized to receive ether left-sided intermittent theta-burst rTMS or rigt-sided continuous…
- Trial name
- NCT00515658
- Testing
- theta-burst rTMS
- Where
- Israel
- Sponsor
- Rambam Health Care Campus
Migraine, Chronic Headache
Does Topiramate Adjust the Excitability of the Brain in Migraine Sufferers?
The purpose of the study is to determine by the use of non-invasive magnetic stimulation if the medication Topiramate adjusts the excitability of the migraine sufferer's brain.
- Trial name
- NCT00286923
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Emerald City Headache Organization
Migraine Disorders
Effects of the Visual Stimulation on the Motor and Visual Cortex in Migraneurs With and Without Aura
The aim of this study is to investigate the motor and visual cortex excitability in response to visual stimulation of migraineurs with and without aura compared to healthy individuals.
- Trial name
- NCT02564822
- Testing
- Visual Stimulation
- Where
- Brazil
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Cortical Excitability, Multiple Sclerosis
Effect of Galvanic Vestibular Stimulation on Cortical Excitability and Hand Dexterity in Multiple Sclerosis Patients
This study will be conducted to investigate the following: 1. The impact of implementing GVS in MS rehabilitation on cortical excitability. 2. The influence of GVS on upper limb function in patients diagnosed with MS.
- Trial name
- GVS on MS (NCT06195644)
- Testing
- Galvanic vestibular stimulation, MovAlyzeR® software from Neuroscript, BODYFIT Mini Portable Pedal Home Exerciser (cyclic ergometer)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Shoulder Impingement Syndrome, Chronic Pain
Sensorimotor Cortex Excitability in Shoulder Impingement Syndrome
Shoulder pain is a common musculoskeletal system complaint, accounting for 7-34% of patients in the clinic. The most common shoulder problem is subacromial impingement syndrome (SIS).
- Conditions
- Shoulder Impingement Syndrome, Chronic Pain, Transcranial Magnetic Stimulation, Electroencephalography
- Trial name
- NCT05627986
- Testing
- No intervention
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Healthy Volunteers (HV), Transcranial Photobiomodulation
Frequency-Dependent Effects of Transcranial Photobiomodulation With Same Peak Irradiance on Cortical Excitability and Fine Motor Performance
This study investigates the frequency-dependent neuromodulatory effects of transcranial photobiomodulation (tPBM) over the primary motor cortex (M1) on cortical excitability and fine motor performance in healthy young adults.
- Conditions
- Healthy Volunteers (HV), Transcranial Photobiomodulation, Cortical Excitability
- Trial name
- NCT07752602
- Testing
- Transcranial Photobiomodulation
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Focal Epilepsy
Cortical Excitability Assessment Using Paired Pulses
The identification of the epileptogenic zone (EZ) during pharmacoresistant focal epilepsy presurgical assessment frequently requires intracranial recordings like stereo-electroencephalography (SEEG).
- Trial name
- PP (NCT02245061)
- Testing
- paired pulses cortical electrical stimulation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Dementia
Comparative Study Between Alzheimer's and Multi-infarct Dementia
Dementia is a neurological disease that causes cognitive and behavioral impairments that could ultimately interfere with the ability to function at work or to do the usual daily activities.
- Trial name
- NCT05781139
- Testing
- levels of Neurofilaments (NfL) in serum
- Where
- Egypt
- Volunteers
- 76 people
- Sponsor
- Assiut University
Adrenergic Beta-2 Agonist Effect, Albuterol Effect
Beta2-mimetic and Central Nervous System
Beta2-mimetics such as Salbutamol have been shown to have ergogenic effects. Acute and chronic inhaled or oral doses of Salbutamol have been shown to increase whole body exercise and muscle performances.
- Trial name
- BETACTIV (NCT02925130)
- Testing
- Salbutamol
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Obsessive Compulsive Disorder, Healthy
Cortical Excitability in Obsessive-Compulsive and Related Disorders
This study will use transcranial magnetic stimulation (TMS) to study the function of the cerebral cortex (outer layer of the brain) in people with obsessive compulsive disorder (OCD) and related disorders.
- Trial name
- NCT00029068
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Dravet Syndrome
Transcranial Magnetic Stimulation to Measure Cortical Excitability in Dravet Syndrome
Dravet syndrome (DS) is an epileptic encephalopathy caused by pathogenic variants in the SCN1A gene resulting in medically refractory epilepsy and psychomotor delays.
- Trial name
- NCT04614506
- Testing
- Transcranial Magnetic Stimulation (TMS), Electroencephalogram (EEG)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Boston Children's Hospital
Healthy
Effects of GABA Modulator AZD7325 on Cortical Excitability
GABA (gamma-aminobutyric acid) is the main inhibitory compound in the human brain. Drugs that enhance its effects by binding on GABA receptors (e.g., benzodiazepines) are used to treat various diseases such as epilepsy, insomnia…
- Trial name
- NCT02135198
- Testing
- 2 mg AZD7325, 10 mg AZD7325
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University College, London
Healthy Volunteers
Cortical Excitability Using Transcranial Magnetic Stimulation and Neuronavigation Device
This study has two main goals : to investigate the impact of aging on cortical excitability (CE) to investigate the impact of "state dependency" on CE, using a cognitive task and an emotional one.
- Trial name
- RC-TMS (NCT02596789)
- Testing
- TMS "Magpro®, Magventure Inc" device
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Healthy Male Volunteers
Effects of Lacosamide on Human Motor Cortex Excitability: a Transcranial Magnetic Stimulation Study
This study has been designed to explore dose-depended effects of lacosamide (LCM) on motor cortex excitability with TMS in a randomized, double-blind, placebo-controlled crossover trial in young healthy human subjects, and to…
- Trial name
- NCT01382017
- Testing
- Lacosamide, Carbamazepine
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Kiel
Movement Disorder, Healthy
Brain Excitability During Self-Paced Voluntary Movements
This study will use transcranial magnetic stimulation to examine how the brain controls movement by sending messages to the spinal cord and muscles and what goes wrong with this process in disease.
- Trial name
- NCT00017966
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Young Adults
Cortical Excitability and Typing Performance After Action Observation and Motor Execution
Goal: This study will aim to investigate the effects of different motor stimulation strategies-motor execution (ME) and action observation (AO)-on cortical excitability and typing performance in healthy individuals.
- Trial name
- NCT07009561
- Testing
- Motor Execution Typing Task, Action Observation of Typing Task
- Where
- United Arab Emirates
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sharjah
Healthy
Effect of Talampanel (an AMPA Receptor Blocker) on Brain Activity
This study will use transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to test the safety of an experimental anti-epileptic drug called Talampanel and learn how it affects brain activity.
- Trial name
- NCT00057460
- Testing
- Talampanel
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)