Clinical trials: Corticosteroid Injection
Kidney Transplantation
Randomized Trial of Induction Therapies in High Immunological Risk Kidney Transplant Recipients
The purpose of this research study is to find out the effects of adding B lymphocyte modulating agents in patients at risk for rejection receiving an anti-rejection (immunosuppressive) regimen of Thymoglobulin® induction with…
- Trial name
- NCT00782821
- Testing
- Rabbit Antithymocyte Globulin, Velcade, Rituxan
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Cincinnati
Congenital Heart Disease, Disorder of Fetus or Newborn
Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass
Although cardiopulmonary bypass (heart-lung machine) is a necessary component of heart surgery, it is not without consequences. Cardiopulmonary bypass initiates a potent inflammatory response secondary to the body's recognition…
- Trial name
- NCT01579513
- Testing
- Methylprednisolone
- Where
- 2 sites in United States
- Volunteers
- 190 people
- Sponsor
- Medical University of South Carolina
Allergic Fungal Rhinosinusitis
Add-on Dupilumab for AFRS as Postoperative Therapy (ADAPT)
The purpose of this study is to find a more effective treatment for allergic fungal rhinosinusitis (AFRS). Most people suffering from nasal polyps have elevated levels of white blood cells called eosinophils that are involved in…
- Trial name
- ADAPT (NCT05545072)
- Testing
- Dupilumab, Intranasal Corticosteroid Sprays (INCS)
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Emory University
Uveitis
Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis
Uveitis is an acute or chronic inflammatory condition of unknown etiology. Although uveitis often responds adequately to topical corticosteroids, there are many patients for which this treatment is either inadequate or not…
- Trial name
- NCT02769702
- Testing
- Acthar
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Washington University School of Medicine
Crohn's Disease
Examining the Long Term Safety, Efficacy, and Corticosteroid-sparing Effect of Certolizumab Pegol in Crohn's Disease
This is an open-label extension study designed to measure the safety, efficacy, and corticosteroid-sparing effect of certolizumab pegol (CDP870) in patients with moderate to severe Crohn's disease previously enrolled in C87059…
- Trial name
- COSPAR II (NCT00356408)
- Testing
- Certolizumab pegol
- Where
- 63 sites in United States, Canada and 1 more
- Volunteers
- 106 people
- Sponsor
- UCB Pharma
Persistent Asthma
Study of Safety of Foradil in Patients With Persistent Asthma
The purpose of this study was to assess whether the risk of serious asthma-related events (asthma-related hospitalizations, asthma related intubations, and asthma related deaths) in adolescents and adults (12 years of age and…
- Trial name
- NCT01845025
- Testing
- Formoterol 12 mcg, Fluticasone propionate 100 mcg, Fluticasone propionate 250 mcg
- Where
- 27 sites in United States
- Volunteers
- 827 people
- Sponsor
- Novartis Pharmaceuticals
Asthma
Phase 3 Study to Evaluate the Efficacy & Safety of Tralokinumab in Adults & Adolescents With OCS Dependent Asthma
A Multicentre, Randomized, Double-blind, Parallel Group, Placebo Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Tralokinumab in Reducing Oral Corticosteroid dependent Asthma.
- Trial name
- TROPOS (NCT02281357)
- Testing
- Tralokinumab
- Where
- 51 sites in United States, Belgium and 5 more
- Volunteers
- 140 people
- Sponsor
- AstraZeneca
Uveitis, Anterior Uveitis
Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients
Uveitis represents a heterogeneous group of diseases that results from ocular inflammatory reaction involving ocular tissue and vasculature. The inflammation usually causes pain, redness, photophobia and blurred vision.
- Conditions
- Uveitis, Anterior Uveitis, Intermediate Uveitis, Posterior Uveitis
- Trial name
- NCT02764697
- Testing
- H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Tampa Bay Uveitis Center, LLC
Asthma
Clinical Study to Evaluate the Efficacy and Safety of VR506 Using a New Inhaler for the Treatment of Asthma
To evaluate the clinical efficacy, safety, tolerability and dose-response relationship, using oral corticosteroid (OCS) modulation, of 3 different doses of VR506 using a twice daily regimen from a new dry powder inhaler (nDPI)…
- Trial name
- NCT01720069
- Testing
- VR506
- Where
- 77 sites in United States, Bulgaria and 6 more
- Volunteers
- 197 people
- Sponsor
- Vectura Limited
Renal Transplantation
Belatacept Early Steroid Withdrawal Trial
The study purpose is to determine the safety and efficacy of a belatacept-based immunosuppressive regimen (calcineurin inhibitor free) with alemtuzumab or rabbit antithymocyte globulin (rATG) induction and early glucocorticoid…
- Trial name
- NCT01729494
- Testing
- Alemtuzumab, rabbit antithymocyte globulin, Belatacept
- Where
- 8 sites in United States
- Volunteers
- 316 people
- Sponsor
- University of Cincinnati
Breast Carcinoma
Fluocinonide Cream in Treating Symptoms of Vaginal Dryness and Painful Sexual Intercourse In Patients With Breast Cancer Undergoing Hormone Therapy
This phase II trial studies how well giving fluocinonide cream works in treating symptoms of vaginal dryness and painful sexual intercourse in patients with breast cancer undergoing hormone therapy.
- Trial name
- NCT01422408
- Testing
- Fluocinonide Cream, Management of Therapy Complications, Questionnaire Administration
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- OHSU Knight Cancer Institute
Endocrine System Diseases
Prevention of Growth Retardation by Early Treatment With Growth Hormone (GH) in Children With CJA Treated by Corticosteroid Therapy
To evaluate the effect of increasing the growth hormone dose on the statural response To assess the value of early treatment during the course of arthritic disease by comparing the height acquired in the medium term by children…
- Trial name
- NCT00174291
- Testing
- Somatropin
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Pfizer
Dysphagia After Anterior Cervical Decompression and Fusion of the Spine
Effect of Intravenous Corticosteroid Injections on Dysphagia After Cervical Spine Surgery
This is a randomized, double-blind, placebo-controlled study to examine the effect of local intravenous steroids following anterior cervical spine surgery on the development of dysphagia in patients.
- Trial name
- NCT02266797
- Testing
- Dexamethasone, Saline
- Where
- 3 sites in United States
- Volunteers
- 4 people
- Sponsor
- NYU Langone Health
Kidney Transplant Recipients
Evaluate Effects and Safety of Pre-load Myfortic® in Transplant Patients
This study is specifically designed to determine whether the initiation of Myfortic 2 weeks prior to transplantation will enhance the therapeutic efficacy of Simulect induction therapy in low to moderate risk patients.
- Trial name
- NCT01336296
- Testing
- mycophenolic acid
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Cincinnati
Asthma
Evaluating Long Acting Beta Agonists Used to Treat Asthma Among Those With Either Arg/Arg or Gly/Gly Genotypes
The investigators are conducting a study of asthma patients who use fluticasone with salmeterol (Advair) or any other combination of an inhaled corticosteroid (ICS) and a long acting beta agonist (LABA) to manage their asthma…
- Trial name
- ARGARG (NCT00521222)
- Testing
- Fluticasone with salmeterol, Fluticasone HFA, Ipratropium HFA
- Where
- 3 sites in United States
- Volunteers
- 90 people
- Sponsor
- Columbia University
Osteoarthritis of the Knee
Study of FX006 in Patients With Osteoarthritis of the Knee
The purpose of this study was to evaluate the safety, efficacy and pharmacokinetics of FX006 in patients with osteoarthritis of the knee.
- Trial name
- NCT01487161
- Testing
- FX006, TCA IR
- Where
- 21 sites in United States, Australia and 1 more
- Volunteers
- 229 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Trigger Finger
Differential Efficacy of Corticosteroid Solutions for Non-Operative Treatment of Digit Flexor Tenosynovitis
Trigger finger is a common cause of hand pain and dysfunction. Its due to chronic inflammation of the flexor tendon that leads to a pulley system mismatch.
- Trial name
- NCT04002037
- Testing
- Triamcinolone Acetonide 40mg/mL, Triamcinolone Acetonide 10mg/mL, Dexamethasone 4 mg/ml
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- University of Missouri-Columbia
Sacro-Iliac Spondylosis
Particulate Corticosteroid Versus Non-particulate Corticosteroid for Sacroiliac Joint Injection
Comparing two different corticosteroids (dexamethasone and triamcinolone) for use in sacroiliac joint injections
- Trial name
- NCT03166761
- Testing
- Dexamethasone, Triamcinolone Acetonide
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Vanderbilt University Medical Center
Pelvic Girdle Pain
Ultrasound Guided Posterior Sacroiliac Ligament Corticosteroid Injection in Pregnancy-Related Pelvic Girdle Pain
The purpose of this study is to see if pelvic girdle pain can be more effectively treated with the use of injectable anti-inflammatory medication plus physical therapy compared with physical therapy and a saline injection.
- Trial name
- NCT02044991
- Testing
- Corticosteroid
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Loyola University
Post Surgical Ocular Inflammation and Pain
Safety and Efficacy of KPI-121 in Subjects With Postsurgical Inflammation and Pain
The primary objective of the study is to investigate the efficacy and safety of KPI-121 1.0% ophthalmic suspension compared to placebo in subjects who have undergone cataract surgery.
- Trial name
- NCT02793817
- Testing
- KPI-121 1% Ophthalmic Suspension dosed BID, Vehicle of KPI-121 Ophthalmic Suspension dosed BID
- Where
- 35 sites in United States
- Volunteers
- 520 people
- Sponsor
- Kala Pharmaceuticals, Inc.