Clinical trials: Corticosteroids
Postoperative Pain, Symptomatic Irreversible Pulpitis
Effect of Apical Patency and Local Corticosteroid on Pain and Neuropeptides Release in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial
The goal of this randomized clinical trial is to learn the effect of using local corticosteroids and maintaining apical patency in reducing post-preparation pain in patients with acute irreversible pulpitis in molar teeth.
- Trial name
- NCT06457828
- Testing
- Non-corticosteroid injection, Corticosteroid injection
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Cutaneous Atrophy Due to Corticosteroids
Interest of Topical Spironolactone's Administration to Prevent Corticoid-induced Epidermal Atrophy
The purpose of this study is to determine whether spironolactone could significantly reduce cutaneous atrophy due to corticosteroids.
- Trial name
- SPIREPI (NCT01407471)
- Testing
- Clobetasol + Spironolactone
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy
A Bronchoscopy Study to Assess the Effects of Inhaled Corticosteroids on Adult Healthy Volunteers
This is a randomized, single-blind, controlled, single centre bronchoscopy study designed to assess the effects of fluticasone propionate on airway gene expression and cellularity in healthy adult controls without asthma.
- Trial name
- NCT02476825
- Testing
- Fluticasone propionate, Accuhaler
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Asthma
Novel Method for Removal of Orally Deposited Inhaled Fluticasone Propionate
This study is to find out if an Extra Virgin Olive-Oil-based Water (EVOOW) mix, removes more Fluticasone Propionate (FP) from the mouth than Water alone.
- Trial name
- EVOOW (NCT07664527)
- Testing
- Fluticasone Propionate, Water Mouthwash, EVOOW Mouthwash
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Knee Osteoarthritis
Efficacy of Micro-fragmented Adipose Tissue Injection for Knee Osteoarthritis.
Knee osteoarthritis (OA) causes patients considerable joint pain and leads to instability, reduced range of motion, and functional limitations.
- Trial name
- NCT03379168
- Testing
- Microfragmented Adipose Tissue (Lipogems), Corticosteroid injection, Saline
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Dustin L. Richter, MD
Twin Pregnancy, Antepartum Condition or Complication
Effects of ACS in Twin With LPB: Study Protocol for a RCT
This study will be the first study that evaluates the effectiveness of antenatal corticosteroid (ACS) in late preterm twin neonates.
- Trial name
- NCT03547791
- Testing
- Betamethason Sodium Phosphate, Normal saline
- Where
- South Korea
- Volunteers
- 848 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Allergic Rhinitis
The Efficacy Of Rhinophototherapy Compared To Intranasal Corticosteroids On The Nasal Mucosa
The aim of this study to compare the efficacy of Rhinophototherapy to Intranasal Corticosteroids on the the nasal mucosa of allergic rhinitis patients.
- Trial name
- NCT05919316
- Testing
- Rhinophototherapy, Nasonex Nasal Spray
- Where
- Malaysia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Physical Activity
Effects of Hyaluronic Acid vs. Hyaluronic Acid on Knee Osteoarthritis
Using double blind, randomized controlled design to study the immediate, short-term and intermediate-term therapeutic effects of ultrasound guided hyaluronic acid injection and hyaluronic acid combined corticosteroid injection to…
- Trial name
- NCT02625727
- Testing
- hyaluronic acid, hyaluronic acid combined corticosteroid
- Where
- Taiwan
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Chronic Obstructive Pulmonary Disease
An Investigation of the Mechanism of Action of Seretide in Chronic Obstructive Pulmonary Disease
This study is investigating the possible mechanisms of action of an inhaled treatment (Seretide), currently used worldwide in millions of patients with COPD (Chronic Obstructive Pulmonary Disease) and how it improves the symptoms…
- Trial name
- IMAS (NCT00974805)
- Testing
- Seretide 500 Accuhaler
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Pregnant Women
Corticosteroid Therapy on Glucose Control in Pregnant Women With Diabetes
Preterm birth occurs in 25% of women with insulin requiring diabetes in pregnancy. The administration of corticosteroid therapy to accelerate fetal lung maturation is indicated in women at risk for preterm birth.
- Trial name
- NCT00673543
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Macular Edema, Uveitis
PeriOcular and INTravitreal Corticosteroids for Uveitic Macular Edema Trial
To evaluate the relative efficacy of three commonly utilized regional corticosteroids for the regional treatment of uveitic macular edema: periocular triamcinolone acetonide; intravitreal triamcinolone acetonide; intravitreal…
- Trial name
- POINT (NCT02374060)
- Testing
- Periocular triamcinolone 40 mg, Intravitreal triamcinolone 4 mg, Dexamethasone intravitreal implant
- Where
- 26 sites in United States, Australia and 2 more
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- JHSPH Center for Clinical Trials
Atopic Dermatitis
Clinical vs. Anecdotal Evidence - Pediatric Atopic Dermatitis
In dermatology, topical anti-inflammatory medications, such as corticosteroids, are the mainstay treatment of managing patients with atopic dermatitis.
- Trial name
- NCT03559075
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Asthma
The Effect of Long Term Inhaled Corticosteroids on the Risk of Cardiovascular Morbidities
Cardiovascular disease is a major cause of morbidity and mortality worldwide. It is the second leading cause of death in Hong Kong. The disease burden is huge and effective control measures should target at prevention level.
- Trial name
- NCT00959257
- Where
- 4 sites in Hong Kong
- Volunteers
- 1,394 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
COPD
Investigation on the Role of Corticosteroids and Beta-Agonists on Cytokine Production in COPD Patients
Research on the synergistic effect of corticosteroids and beta-agonists on the cytokine production in COPD patients. Blood will be obtained from healthy volunteers and COPD patients and blood monocytes will be stimulated to…
- Trial name
- NCT00263380
- Where
- 2 sites in Netherlands
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- St. Antonius Hospital
Primary Hyperaldosteronism, Aldosterone-Producing Adenoma
[18F]AlF-NOTA-pentixather PET/CT in Patients With Suspected Primary Hyperaldosteronism
The study was proposed to include 20 patients with clinical suspicion of primary aldosteronism for [18F]AlF-NOTA-pentixather PET/CT imaging and to analyze the specificity and sensitivity of [18F]AlF-NOTA-pentixather PET/CT for…
- Trial name
- NCT05815069
- Testing
- [18F]AlF-NOTA-pentixather PET/CT
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Oral Health, Molar, Third
Comparing Pain and Swelling After Surgical Extraction of Mandibular Third Molar in Dexamethasone Injection and Without Corticosteroid Methods
In some cases, impacted wisdom teeth should be extracted. Surgical extraction of these impacted third molars may provide special complication as pain, swelling, and trismus.
- Trial name
- NCT01896427
- Testing
- 21-benzyloxy-9alpha-fluoro-16alpha-methylpregna-1,4-dien-11beta,17alpha-diol-3,20-dione
- Where
- Iran
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Mohammad Javad Shirani
Hypertrophic Scars
Treatment of Hypertrophic Scars Using Fractional Laser and Fractional Laser-assisted Topical Corticosteroid Delivery
The objective of this study is to evaluate the efficacy and safety of using ablative fractional laser- assisted topical corticosteroid delivery for the treatment of hypertrophic scar.
- Trial name
- NCT02487212
- Testing
- 0.05% Clobetasol propionate, Petrolatum gel, Fractional Erbium:Yag (2,940-nm) laser
- Where
- Thailand
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Tonsillectomy
Postoperative Oral Corticosteroids Following Tonsillectomy
Tonsillectomy is one of the most common surgical procedures in the United States, and post-operative pain management is a challenge for otolaryngologists.
- Trial name
- NCT03352115
- Testing
- Prednisolone
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Tennis Elbow, Epicondylitis, Lateral Humeral
A Randomized Control Trial to Evaluate the Efficacy of Autologous Blood Injection Versus Local Corticosteroid Injection for Treatment of Lateral Epicondylitis
Lateral epicondylitis, is a common problem encountered in the orthopaedic practice. Histopathological reports have shown that lateral epicondylitis is not an inflammatory process but a degenerative condition termed 'tendinosis'.
- Trial name
- NCT00947765
- Testing
- Autologous blood injection, Local corticosteroid injection
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dojode, Chetan M., MBBS, MS
Chronic Obstructive Pulmonary Disease
Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of AZD8871 in Healthy Subjects
AZD8871 is a new chemical entity possessing long-acting effect in a single molecule which presents a novel treatment approach to chronic obstructive pulmonary disease [COPD] and potentially also asthma (in combination with an…
- Trial name
- NCT02814656
- Testing
- AZD8871
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AstraZeneca