Clinical trials: Corticosteroids
Chronic Obstructive Pulmonary Disease
A Study to Assess the Pharmacokinetics and Safety of Budesonide, Glycopyrronium, & Formoterol (BGF) Metered Dose Inhaler (MDI) With a Next-Generation Propellant (NGP) With a Spacer, BGF MDI Hydrofluoroalkane (HFA) With a Spacer, as Well as BGF MDI NGP Without a Spacer
This study aims to assess the effect on total systemic exposure and to characterize exposure BGF MDI HFO with a spacer compared to without a spacer; also, to demonstrate that total systemic exposure of BGF when administered as…
- Trial name
- NCT06297668
- Testing
- Treatment A: BGF MDI HFA, Treatment B: BGF MDI HFO, Treatment C: BGF MDI HFO
- Where
- Germany
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Adhesive Capsulitis
Formal Physical Therapy (PT) vs. Home PT for Adhesive Capsulitis
This study aims to evaluate physical therapy (standard of care) and home exercise vs. home exercise alone for the treatment of adhesive capsulitis.
- Trial name
- NCT03049787
- Testing
- Home Exercise Protocol, Physical Therapy Protocol
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Medical Center
Primary Hyperaldosteronism, Aldosterone-Producing Adenoma
[18F]AlF-NOTA-pentixather PET/CT in Patients With Suspected Primary Hyperaldosteronism
The study was proposed to include 20 patients with clinical suspicion of primary aldosteronism for [18F]AlF-NOTA-pentixather PET/CT imaging and to analyze the specificity and sensitivity of [18F]AlF-NOTA-pentixather PET/CT for…
- Trial name
- NCT05815069
- Testing
- [18F]AlF-NOTA-pentixather PET/CT
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Chronic Obstructive Pulmonary Disease
Effects of Inhaled Corticosteroids in the Systemic Inflammation Induced by Exercise in Patients With COPD
Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary and systemic inflammation. The effect of inhaled corticosteroids (IC) on inflammation in COPD is controversial.
- Trial name
- NCT02209974
- Testing
- Fluticasone
- Where
- Spain
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Hospital Son Llatzer
Tooth Impaction | {Tooth} | Dental, Corticosteroid
Comparison of the Effects of Protocols Applied After Surgical Extraction of Impacted Mandibular Third Molars
Following the surgical extraction of the most commonly impacted mandibular third molars, the first group was planned to receive methylprednisolone, the second group hyaluronic acid, the third group ozone therapy, the fourth group…
- Conditions
- Tooth Impaction | {Tooth} | Dental, Corticosteroid, Hyaluronic Acid, Ozone
- Trial name
- NCT06900907
- Testing
- Diode laser, Hyaluronic acid, Ozone
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Batman University
Oral Pyogenic Granuloma
Corticosteroid Intralesional Injection as an Alternative Treatment in Oral Pyogenic Granuloma in the Esthetic Zone.
Gingival Pyogenic granuloma in the esthetic zone represents an esthetic problem. While surgical treatment may not give the premium esthetic demands, corticosteroid may acheive this balance.
- Trial name
- NCT05534334
- Testing
- Solu-Cortef
- Where
- 2 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Rotator Cuff Tear, Rotator Cuff Tendinitis
Autologous Adult Adipose-Derived Regenerative Cell Injection Into Chronic Partial-Thickness Rotator Cuff Tears
The purpose of this investigation is to evaluate the safety and superior effectiveness in functional improvement in patients with partial-thickness rotator cuff tears (PTRCTs) after the administration of a single injection of…
- Trial name
- NCT03752827
- Testing
- Adipose Derived Regenerative Cells, Corticosteroid
- Where
- 14 sites in United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- InGeneron, Inc.
Postoperative Pain, Symptomatic Irreversible Pulpitis
Effect of Apical Patency and Local Corticosteroid on Pain and Neuropeptides Release in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial
The goal of this randomized clinical trial is to learn the effect of using local corticosteroids and maintaining apical patency in reducing post-preparation pain in patients with acute irreversible pulpitis in molar teeth.
- Trial name
- NCT06457828
- Testing
- Non-corticosteroid injection, Corticosteroid injection
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Osteoarthritis
Ultrasound (US)-Guided Versus Sham Ultrasound Corticosteroid (CS) Knee Injections
To determine if ultrasound-guided knee steroid injections are more effective than sham ultrasound knee steroid injections for the treatment of osteoarthritis.
- Trial name
- NCT01032720
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- VA Connecticut Healthcare System
Healthy Volunteers
A Study to Compare the Pharmacokinetics of Budesonide and Albuterol Delivered by PT027 Compared With PT007 and PT008 Administered Separately.
This is a Phase 1 study to compare the pharmacokinetics of budesonide and albuterol delivered by PT027 compared with PT007 and PT008 administered separately.
- Trial name
- NCT03772223
- Testing
- Treatment A (Budesonide/Albuterol Sulfate metered dose inhaler), Treatment B (Budesonide metered dose inhaler), Treatment C (Albuterol Sulfate metered dose inhaler)
- Where
- United Kingdom
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Asthma
Approach to Predict Steroid Sensitivity in Patients With Asthma
Inhaled corticosteroids are widely used as the primary therapy for asthma, which affects approximately 20 million people in the United States.
- Trial name
- NCT00811278
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Severe Acute Alcoholic Hepatitis, Alcohol
Intestinal Microbiota Profiling in Severe Acute Alcoholic Hepatitis Patients
In humans, alcohol-related dysbiosis exists with a decrease in bacteroides. This dysbiosis is responsible for the breakdown of the intestinal barrier by a decrease in the synthesis of protective mucus, and some proteins involved…
- Conditions
- Severe Acute Alcoholic Hepatitis, Alcohol, Intestinal Microbiota, Corticosteroids
- Trial name
- HepathAlc-IM (NCT06159244)
- Testing
- stool withdrawal
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Atopic Dermatitis
Clinical vs. Anecdotal Evidence - Pediatric Atopic Dermatitis
In dermatology, topical anti-inflammatory medications, such as corticosteroids, are the mainstay treatment of managing patients with atopic dermatitis.
- Trial name
- NCT03559075
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Psoriasis
Conditioning, the Placebo Effect, and Psoriasis
This study uses the psychological principle known as classical conditioning to try to improve the standard treatment of psoriasis.
- Trial name
- NCT00005922
- Testing
- Partial schedule of pharmacotherapeutic reinforcement, Dose control for Arm B, Standard pharmacotherapeutic protocol
- Where
- 2 sites in United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Facet Joint Pain, Arthropathy
Effect of Post-Radiofrequency Corticosteroid Injection on the Incidence of Post-Neurotomy Neuritis
The purpose of this study is to compare the incidence of post-neurotomy neuritis (PNN) in adult patients undergoing radiofrequency neurotomy (RFN) for spine facet and sacroiliac joint pain, comparing those who receive a local…
- Conditions
- Facet Joint Pain, Arthropathy, Sacroiliac Joint Dysfunction, Post-neurotomy Neuritis
- Trial name
- PNN (NCT07839195)
- Testing
- Dexamethasone, Normal Saline, Bupivacaine
- Where
- Thailand
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Siriraj Hospital
Symptomatic Irreversible Pulpitis (SIP)
Impact of Intracanal Cryotherapy and Corticosteroids on Post Endodontic Pain
The aim of the study: is to evaluate efficiency of using either intracanal corticosteroids or intracanal cryotherapy as a final flush irrigation on post endodontic pain in lower molar teeth with symptomatic irreversible pulpitis.
- Trial name
- NCT07676396
- Testing
- dexamethasone, Cold Saline, cold sodium hypochlorite
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- October 6 University
Asthma
Investigating The Pharmacokinetics Of An Inhaled Dose Of A New Corticosteroid In Patients With Impaired Liver Function
The proposed study is designed to investigate the pharmacokinetics, pharmacodynamics (as measured by serum cortisol) and safety of GW685698X in subjects with moderate hepatic impairment and in healthy subjects following a single…
- Trial name
- NCT00419237
- Testing
- GW685698X
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Primary Gonarthrosis
The Efficacy of Intra-articular Triamcinolone Acetonide 5mg vs. 10 mg vs. 40 mg in Patients With Knee Osteoarthritis
Osteoarthritis of the knee is a common problem that is increasing in prevalence as the population ages. In a knee with osteoarthritis, there is variable damage to the articular cartilage and underlying bone that can cause varying…
- Trial name
- NCT05806021
- Testing
- Triamcinolone Acetonide
- Where
- Canada
- Volunteers
- 327 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Vasoconstriction
Evaluation of the Vasoconstriction Properties of MC2-01 Cream
The objective of this trial is to compare the vasoconstriction potential
- Trial name
- NCT03758365
- Testing
- MC2-01 Cream, Clobetasol Propionate 0.05% Lotion, Betamethasone Dipropionate 0.05% Cream
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- MC2 Therapeutics
Full Thickness Rotator Cuff Tear, Rotator Cuff Tendinitis
Effectiveness of Corticosteroid vs. Ketorolac Shoulder Injections: A Prospective Double-Blinded Randomized Trial
The purpose of this study is to compare the functional outcomes of patients with shoulder pathology treated with either ketorolac or corticosteroid injections, in a randomized double-blinded study.
- Trial name
- NCT04115644
- Testing
- Ketorolac, Kenalog
- Where
- 2 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Michael Khazzam