Clinical trials: Corticosteroids
Neuroendocrine Carcinomas, Neuroendocrine Tumors
A First-in-Human Phase I Trial With Antibody Drug Conjugate ADCT-701 in Neuroendocrine Tumors, Carcinomas and Malignant Peripheral Nerve Sheath Tumors
Background: Neuroendocrine neoplasms (NENs) are rare cancers in the gastrointestinal tract, pancreas, lungs, adrenal glands, and other areas of the body.
- Conditions
- Neuroendocrine Carcinomas, Neuroendocrine Tumors, Carcinoma, Neuroendocrine, Carcinoma, Adrenocortical
- Trial name
- NCT06041516
- Testing
- ADCT-701
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Cancer Institute (NCI)
Graft-versus-host Disease (GVHD)
Study of Itacitinib in Combination With Corticosteroids for the Treatment of Acute GVHD
To determine if Itacitinib in combination with corticosteroids is safe and tolerable in patients with Grade IIB-IVD acute graft-versus-host disease (GVHD).
- Trial name
- NCT02614612
- Testing
- Itacitinib (200 mg), Itacitinib (300 mg), prednisone or methylprednisolone (corticosteroids)
- Where
- 23 sites in United States
- Volunteers
- 31 people
- Sponsor
- Incyte Corporation
Knee Osteoarthritis (Knee OA)
Randomized Controlled Study Evaluating Genicular Artery Embolization Against Intra-Articular Corticosteroid Knee Injection for Osteoarthritic Knee Pain
Multi-center, prospective, randomized trial of GAE using Nexsphere-F against steroid injection
- Trial name
- RESORB (NCT06872567)
- Testing
- genicular artery embolization, Corticosteroid Injection
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- North American Science Associates Ltd.
Asthma
Benralizumab Airway Remodeling Study in Severe Eosinophilic Asthmatics
The purpose of the study is to evaluate effect of benralizumab on structural and lung function changes in severe eosinophilic asthmatics.
- Trial name
- CHINOOK (NCT03953300)
- Testing
- Benralizumab
- Where
- 35 sites in United States, Canada and 3 more
- Volunteers
- 75 people
- Sponsor
- AstraZeneca
Adrenocortical Carcinoma, Gastrointestinal Carcinoid Tumor
Seneca Valley Virus-001 and Cyclophosphamide in Treating Young Patients With Relapsed or Refractory Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features
RATIONALE: Seneca Valley virus-001 may be able to kill certain kinds of tumor cells without damaging normal cells. Adding low dose cyclophosphamide (in part B of study) may help to kill even more tumor cells.
- Conditions
- Adrenocortical Carcinoma, Gastrointestinal Carcinoid Tumor, Kidney Cancer, Neuroblastoma
- Trial name
- NCT01048892
- Testing
- Seneca Valley virus-001, cyclophosphamide, laboratory biomarker analysis
- Where
- 18 sites in United States
- Volunteers
- 22 people
- Sponsor
- Children's Oncology Group
Oral Lichen Planus
Effect of Oral Zinc Supplementation as an Adjuvant to Topical Corticosteroid in Oral Lichen Planus Patients
Lichen planus is an auto-immune, chronic inflammatory disease that affects mucosal and cutaneous tissue. Erosive and atrophic oral lichen planus (OLP) are difficult to manage because patients present with symptoms ranging from…
- Trial name
- NCT04278599
- Testing
- Oral Zinc supplementation
- Where
- India
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Neoplasms
A Study of the Safety and Effects of ADH-1 Given Intravenously as a Single Agent
N-cadherin, a protein involved in blood vessel cell binding, is increased as cancer progresses, and is on the surface of many tumor cells. ADH-1 blocks N-cadherin.
- Trial name
- NCT00264433
- Testing
- ADH -1 (Exherin™)
- Where
- 11 sites in United States, Canada
- Sponsor
- Adherex Technologies, Inc.
Covid-19
Clinical Outcome of Patients With COVID-19 Pneumonia Treated With Corticosteroids and Colchicine
Cross sectional study of 301 adult patients with Covid-19 Pneumonia treated with corticosteroid and/or colchicine
- Trial name
- NCT04654416
- Testing
- Corticosteroid with or without colchicine
- Where
- Colombia
- Volunteers
- 301 people
- Sponsor
- Clínica Medellín - Grupo Quirónsalud
Vulvar Lichen Sclerosus
To Compare Inflammatory Biomarkers Before and After Treatment With Clobetasol or Fractional CO2 Laser, in Women With Histologically Confirmed Vulvar Lichen Sclerosus, Without Prior Corticosteroid Treatment.
The present study is a Clinical trial that compares clobetasol ointment versus Fractional CO2 laser for vulvar lichen sclerosus (VLE) treatment confirmed by histology, with no previous treatment.
- Trial name
- LASER (NCT07240519)
- Testing
- Fractional microablative CO2 Laser
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Postoperative Pain, Symptomatic Irreversible Pulpitis
Effect of Apical Patency and Local Corticosteroid on Pain and Neuropeptides Release in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial
The goal of this randomized clinical trial is to learn the effect of using local corticosteroids and maintaining apical patency in reducing post-preparation pain in patients with acute irreversible pulpitis in molar teeth.
- Trial name
- NCT06457828
- Testing
- Non-corticosteroid injection, Corticosteroid injection
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Asthma
Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids
This is a dose-range finding, double-blind, placebo-controlled, phase IIb study designed to assess efficacy and safety of tozorakimab administered subcutaneously in adult participants with uncontrolled asthma receiving…
- Trial name
- Umbriel (NCT06932263)
- Testing
- Tozorakimab
- Where
- 223 sites in United States, Argentina and 19 more
- Volunteers
- 540 people
- Sponsor
- AstraZeneca
Kidney Transplantation
MMF, Daclizumab and Corticosteroids as Mainstay Immunosuppression in Renal Transplant Patients
To determine the renal function, as expressed by the glomerular filtration rate at 12 months, in renal transplant recipients receiving mycophenolate mofetil, daclizumab, and corticosteroids as mainstay immunosuppression in…
- Trial name
- NCT00231764
- Testing
- daclizumab
- Volunteers
- 1,760 people
- Sponsor
- Ekberg, Henrik, M.D.
Arthropathy of Knee
How Many Dexamethasone Doses Should Be Given Perioperatively?
The purpose of this study is to determine the most efficient and safest dexamethasone dose given perioperatively during total knee arthroplasty that reduces postoperative option consumption and pain, improves postoperative nausea…
- Trial name
- DEXA_PERIOP (NCT06715709)
- Testing
- Dexamethasone IV, Dexamethasone IV+Oral, Dexamethasone IV+Oral 2 Day
- Where
- United States
- Volunteers
- 339 people
- Sponsor
- Mayo Clinic
Asthma, Osteoporosis, Osteopenia
Long-term Effect of Steroid on Metabolic Diseases in Asthmatics
The goal of this retrospective/observational study is to compare the clinical outcomes between the high-cumulative-dose group and the low- cumulative-dose group of oral/inhaled corticosteroid in the long-term management of asthma…
- Conditions
- Asthma, Osteoporosis, Osteopenia, Osteoporosis Risk, Osteoporotic Fractures
- Trial name
- NCT06279078
- Testing
- Corticosteroid
- Where
- South Korea
- Volunteers
- 19,968 people
- Sponsor
- Ajou University School of Medicine
Adrenocortical Carcinoma
Cabozantinib in Advanced Adrenocortical Carcinoma
Adrenocortical carcinoma is an orphan malignant disease that has a dismal prognosis in advanced stages. Mitotane is the only approved treatment but is limited by severe toxicity.
- Trial name
- CaboACC (NCT03612232)
- Testing
- Cabozantinib-s-malate
- Where
- 2 sites in Germany
- Volunteers
- 37 people
- Sponsor
- Wuerzburg University Hospital
Cushing Syndrome, Aldosteronism
China Adrenal Disease Registry
Epidemiologic studies have revealed a tremendous increase in the prevalence of adrenal associated disease and related mortality worldwide.
- Conditions
- Cushing Syndrome, Aldosteronism, Hypoadrenalism, Congenital Adrenal Hyperplasia
- Trial name
- CASE (NCT04890444)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Crohn's Disease
Corticosteroids With Vedolizumab in Crohn's Disease
Use of co-induction with corticosteroid therapies may accelerate the remission rate when used with vedolizumab. Further, this may lead to higher rates of response and remission at week 10 than would be seen with vedolizumab…
- Trial name
- NCT02324699
- Testing
- Prednisone, Vedolizumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
GVHD,Acute
A Study of IBI377 in Combination With Corticosteroids for the Treatment of First-Line Acute Graft-Versus-Host Disease
The purpose of this study is to evaluate itacitinib in combination with corticosteroids as first-line treatment of participants with Grade II to IV acute graft-versus-host disease (aGVHD).
- Trial name
- NCT04220632
- Testing
- Itacitinib, Prednisone, Methylprednisolone
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Adhesive Capsulitis of the Shoulder
Intra-articular Corticosteroids Are Widely Used for Adhesive Capsulitis, But Alternatives Are Required for Patients With Contraindications. Hyaluronic Acid (HA) and Ketorolac Have Shown Individual Benefits. However, Evidence on Their Combination Remains Limited.
This randomized, double-blind trial compared a single intra-articular injection of moderate-molecular-weight hyaluronic acid (HA) plus ketorolac with ketorolac alone in patients with adhesive capsulitis.
- Trial name
- NCT07183436
- Testing
- Intra-articular Hyaluronic Acid and Ketorolac, Intra-articular Ketorolac
- Where
- Thailand
- Volunteers
- 56 people
- Sponsor
- Mahidol University
Septic Shock
ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock
The purpose of this study is to find out whether adult patients admitted to the Intensive Care Unit with septic shock who are given hydrocortisone compared to placebo (a dummy solution), will have an improved rate of survival 90…
- Trial name
- ADRENAL (NCT01448109)
- Testing
- Hydrocortisone, Sterile air filled vial
- Where
- 70 sites in Australia, Denmark and 3 more
- Volunteers
- 3,800 people
- Sponsor
- The George Institute