Clinical trials: Corticosteroids Adverse Reaction
Systemic Lupus Erythematosus, High LDL Cholesterol Level
Efficacy and Adverse Effect of Simvastatin Compare to Rosuvastatin in Systemic Lupus Erythematosus (SLE) Patients With Corticosteroid Therapy and High Low-Density Lipoprotein (LDL) Cholesterol Level
Early statin therapy in SLE patients that have high cholesterol level and other atherosclerosis risk should reduce atherosclerosis and coronary artery events in later course of disease.
- Trial name
- NCT00866229
- Testing
- Rosuvastatin, Simvastatin
- Where
- Thailand
- Volunteers
- 140 people
- Sponsor
- Ramathibodi Hospital
Corticosteroids Adverse Reaction
Impact of Antenatal Steroids on Coagulation.
Aim of the research : 1- Detection of the presence or absence of any effect of antenatal corticosteroid administration on coagulopathy, fibrinolysis, and other haematological markers.
- Trial name
- NCT06312852
- Volunteers
- 45 people
- Sponsor
- Assiut University
Corticosteroids Adverse Reaction
Arrhythmias, Microalbuminuria and Corticosteroids
The goal of this observational design is to study the effects of intravenous corticosteroids on heart rate variability, arrhythmias and microalbuminuria.
- Trial name
- NCT03453931
- Testing
- Corticosteroid injection
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Elza Abdessater
Tuberculosis, Tuberculous Meningitis
Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial)
The investigators will conduct a randomized, double blind, placebo controlled trial of adjunctive dexamethasone in the initial (6-8 weeks) treatment of tuberculous meningitis in Vietnamese adults.
- Conditions
- Tuberculosis, Tuberculous Meningitis, Drug-Induced Liver Injury, HIV
- Trial name
- NCT03092817
- Testing
- Dexamethasone
- Where
- 6 sites in Indonesia, Vietnam
- Volunteers
- 520 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Pulmonary Disease, Chronic Obstructive, Adverse Effect of Glucocorticoids and Synthetic Analogues
Reduction of Corticosteroid Use in Outpatient Treatment of Exacerbated COPD
Background Chronic obstructive pulmonary disease (COPD) is a major public health issue with no curative treatment. In Switzerland estimated 5-7% of the total population are suffering from this chronic disease.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Adverse Effect of Glucocorticoids and Synthetic Analogues, Disease Exacerbation
- Trial name
- RECUT (NCT02386735)
- Testing
- Prednisone
- Where
- Switzerland
- Volunteers
- 133 people
- Sponsor
- Prof. Dr. Jörg Leuppi
Reumatoid Arthritis, Corticosteroids Adverse Reaction
Prevalence of Adrenal Insufficiency and Associated Factors in Rheumatoid Arthritis Patients Using Low-dose Corticosteroids.
This study aims to investigate the prevalence of adrenal insufficiency in rheumatoid arthritis (RA) patients receiving low-dose corticosteroid therapy and to identify the factors influencing adrenal insufficiency.
- Conditions
- Reumatoid Arthritis, Corticosteroids Adverse Reaction, Adrenal Insufficiency
- Trial name
- NCT07866326
- Testing
- ACTH stimulation test, Cortisol
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Drug Rash With Eosinophilia and Systemic Symptoms
Comparison Between Corticosteroid and Topical Steroids in the DRESS
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and severe multiorgan adverse drug reaction occurring within 2 to 6-8 weeks after a new drug intake.
- Trial name
- DRESSCODE (NCT01987076)
- Testing
- Prednisone, Clobetasol
- Where
- France
- Volunteers
- 112 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Transplants and Implants
Myfortic or CellCept Gastrointestinal Effects in African American Kidney Recipients
Myfortic (enteric-coated mycophenolate sodium) has been shown to have similar effectiveness to CellCept (mycophenolate mofetil) in preventing rejection in kidney transplant recipients.
- Trial name
- NCT00522548
- Testing
- Enteric coated mycophenolate sodium, Mycophenolate mofetil
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Pennsylvania
Hepatitis, Drug-Induced
Treatment Efficacy of Corticosteroids and Mycophenolate Mofetil in Patients With Immune Related Hepatitis
This clinical trial is to clarify and investigate the patterns of immune-related hepatitis and the optimal treatment choice for patients who are steroid-dependent.
- Trial name
- I-HEP (NCT04810156)
- Testing
- Mycophenolate Mofetil, Solu-Medrol, Ursodeoxycholic acid
- Where
- 5 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Inge Marie Svane
Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis
Phase III Clinical Trial of NPB-01 in Patients With Stevens-Johnson Syndrome/ Toxic Epidermal Necrolysis Unresponsive to Corticosteroids.
Patients diagnosed with Stevens-Johnson syndrome and Toxic Epidermal Necrolysis were confirmed based on the investigators national diagnostic criteria.
- Trial name
- NCT01696500
- Testing
- Intravenous immunoglobulin
- Where
- Japan
- Volunteers
- 10 people
- Sponsor
- Nihon Pharmaceutical Co., Ltd
Tuberculosis, Tuberculous Meningitis
Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis
The primary objective is to determine whether Leukotriene A4 hydrolase (LTA4H) genotype, defined at randomisation, determines dexamethasone's clinical effectiveness when added to the first 6-8 weeks of anti-tuberculosis treatment…
- Conditions
- Tuberculosis, Tuberculous Meningitis, Drug-Induced Liver Injury
- Trial name
- NCT03100786
- Testing
- Dexamethasone
- Where
- 3 sites in Vietnam
- Volunteers
- 702 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Tuberculosis Infection, Tuberculosis Infection, Latent
Isoniazid-Related Hepatotoxicity in Clinical Practice: Incidence and Predictors
The objective of this observational study is to determine how frequently isoniazid (INH) causes liver injury (hepatotoxicity) in adults treated for tuberculosis (TB) or latent tuberculosis infection (LTBI) and to understand which…
- Trial name
- INH-DILI (NCT07472348)
- Testing
- Standard isoniazid-based TB/LTBI therapy
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- ASST Fatebenefratelli Sacco
Cardiopulmonary Arrest, Corticosteroids Adverse Reaction
Effects of Corticosteroid Use on Restoration of Spontaneous Circulation in Cardiac Arrest Patients
We aim to investigate the effects of pre-arrest corticosteroid use for any reason on the time of return of spontaneous circulation in patients experiencing witnessed cardiac arrest, either in-hospital or out-of-hospital.
- Trial name
- NCT06515327
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Saglik Bilimleri Universitesi
Immune Checkpoint Inhibitor-Related Pneumonitis, Drug-Related Side Effects and Adverse Reactions
Nutritional + Usual Corticosteroids Randomized Trial for Immune-Related pneumoniA - Therapeutic Utilization Evaluation
This is a prospective, single-center, open-label, randomized controlled clinical trial evaluating whether the addition of a nutritional therapy regimen (Spirulina-Bifidobacterium capsules, fish oil-grape seed-blueberry soft…
- Conditions
- Immune Checkpoint Inhibitor-Related Pneumonitis, Drug-Related Side Effects and Adverse Reactions, Neoplasms
- Trial name
- NCT07554885
- Testing
- Spirulina-Bifidobacterium capsule, Fish oil-grape seed-blueberry soft capsule, Ganoderma spore oil
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Adrenal Insufficiency
Inhalation/Nasal Corticosteroids and Prevalence of Hypothalamic-pituitary-adrenal (HPA) Axis Suppression in Human Immunodeficiency Virus (HIV)-Patients
Rationale: Case reports describe suppression of the hypothalamic-pituitary-adrenal (HPA) axis caused by local corticosteroids, most often with inhalation corticosteroids. The exact prevalence is not known.
- Trial name
- Incorporate (NCT02501486)
- Testing
- ACTH stimulation test
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Adrenocortical Carcinoma
The Adverse Event of Mitotane Therapy in Patients With Adrenocortical Carcinoma
This work will evaluate the adverse effects of mitotane treatment in patients treated for ACC with mitotane therapy. All of the individuals were treated at Ruijin Hospital between May 2023 and May 2024.
- Trial name
- MEET (NCT05839886)
- Volunteers
- 50 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Drug/Agent Toxicity by Tissue/Organ, Lymphoma
Dexamethasone Followed by Denileukin Diftitox in Treating Patients With Persistent or Recurrent T-Cell Lymphoma
RATIONALE: Denileukin diftitox may be able to deliver cancer-killing substances directly to T-cell lymphoma cells. Dexamethasone may decrease the side effects of denileukin diftitox.
- Trial name
- NCT00006345
- Testing
- denileukin diftitox, dexamethasone
- Where
- 11 sites in United States
- Sponsor
- Ligand Pharmaceuticals